International Journal of Pharmacy Research & Technology最新文献_第9页

Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals 利用生物信息学方法鉴定水稻金属硫蛋白结合袋及其与重金属的相互作用

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/07.02.02

Devvret, Praveen Kumar, Kumud Pant, A. Thapliyal, Neema Tufchi

{"title":"Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals","authors":"Devvret, Praveen Kumar, Kumud Pant, A. Thapliyal, Neema Tufchi","doi":"10.31838/ijprt/07.02.02","DOIUrl":"https://doi.org/10.31838/ijprt/07.02.02","url":null,"abstract":"Rice is a staple crop that is consumed by half of the worldÂs population. Paddy rice is highly prone to heavy metal toxicity. Low level of heavy metals in rice plant is beneficial for plant growth but its excess can affect the growth of the plant. Consumption of rice contaminated with heavy metal has a potential health risk to human population. Metallothionein (MT) is a metal binding proteins that comes under a class of conserved evolutionary protein molecules. It plays an essential function in the detoxification of heavy metals and homeostasis. Metals with relatively high densities, atomic weights, or atomic numbers are known as heavy metals. Cadmium (Cd), arsenic (As), chromium (Cr), lead (Pb) and zinc (Zn) are highly reactive and toxic to living cells. Plants have described two basic mechanisms such as chelation and sequestration of heavy metals by ligands to counter this problem. The two best-characterized heavy metal-binding ligands in plant cells are the phytochelatins and metallothionein. In the current study, we have generated the three dimensional structure of rice MT protein, identification of active sites of metallothionein and docking study was performed. Homology model of the metallothionein was designed through Phyre2 server. Heavy metals were docked with the metallothionein. The docking analysis and active sites were predicted through iGemDock software. The stable homology structure of the metallothionein was modelled and binding pockets were analyzed. This analysis of binding pocket will help in the in vitro study of metallothionein protein and understanding its role in metal detoxification.","PeriodicalId":225304,"journal":{"name":"International Journal of Pharmacy Research & Technology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127099554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Prevalence Of Hypertension Self Care Activities Among Hypertensive Patients Receiving Care In A Secondary Health Care Facility In Kogi State Nigeria. 在尼日利亚科吉州二级卫生保健机构接受治疗的高血压患者中高血压自我保健活动的流行程度

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/11.01.06

引用次数: 0

Feasibility Study of a Blockchain use in Nutraceuticals Supply Chain 区块链在保健品供应链中应用的可行性研究

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/11.02.06

引用次数: 0

In Silico Docking analysis of Mycobacterium tuberculosis potential targets AftB and EmbA with selected phytochemicals 结核分枝杆菌潜在靶点AftB和EmbA与选定植物化学物质的硅对接分析

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/07.02.03

Kumud Pant Ashish Thapliyal Neema Tufchi Devvret

{"title":"In Silico Docking analysis of Mycobacterium tuberculosis potential targets AftB and EmbA with selected phytochemicals","authors":"Kumud Pant Ashish Thapliyal Neema Tufchi Devvret","doi":"10.31838/ijprt/07.02.03","DOIUrl":"https://doi.org/10.31838/ijprt/07.02.03","url":null,"abstract":"Mycobacterium tuberculosis, the causative agent of tuberculosis (TB) in humans, is a devastating infectious organism that kills approximately two million people annually. The current suite of antibiotics used to treat TB faces two main difficulties: (i) the emergence of multidrug-resistant (MDR) strains of M. tuberculosis, and (ii) the persistent state of the bacterium, which is less susceptible to antibiotics and causes very long antibiotic treatment regimes. It is a disease that cannot be cured through conventional remedies. Phytochemicals have played a vital role in the discovery of drugs against infectious diseases. In the current study, homology model of the targets were designed. Thirty three ligand molecules (basically secondary metabolites) which were commonly present in the plants were docked with the selected potential target of Mycobacterium tuberculosis, AftB and EmbA. The primary docking analysis was performed through iGemDock which is then validated through AutoDockVina docking software. The active sites were also predicted through the Ligand+ tool. Among all the phytochemicals palmarin had a significant inhibitory activity with both the receptors. Binding pocket for both the targets were predicted (AftB-THR 474, ASP 522, SER 524, PHE 525, LEU 526, ARG 585 and EmbA- PRO 918, ASN 924, ARG 926, VAL 1057) forming hydrogen bonds at a very low energy value, thus forming a stable complex. Palmarin had excellent conformations showing the flexible behaviour of the ligand. The total energy of the receptor and ligand complexes has also been calculated.","PeriodicalId":225304,"journal":{"name":"International Journal of Pharmacy Research & Technology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115120409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Varicose Veins with Venous Ulcers 静脉曲张伴静脉溃疡

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/11.01.03

引用次数: 0

A Case Report on Naproxen Induced Psoriasis: The Immunosuppressant and Corticosteroid Therapy 萘普生致银屑病1例:免疫抑制剂和皮质类固醇治疗

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/11.01.07

引用次数: 0

Recent Advances in Tuberculosis Drug Development 结核病药物开发的最新进展

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/08.02.01

M. Kotadiya, Olinirina Nisha Andriambololona

{"title":"Recent Advances in Tuberculosis Drug Development","authors":"M. Kotadiya, Olinirina Nisha Andriambololona","doi":"10.31838/ijprt/08.02.01","DOIUrl":"https://doi.org/10.31838/ijprt/08.02.01","url":null,"abstract":"The emergence of drug-resistant tuberculosis is a growing disease worldwide. The lack of safe and effective drugs, together with the frequent development of adverse drug reactions could result in worse condition. Therefore, new drugs able to booster the current tuberculosis treatment regimen are urgently required. Novel drugs that are effective and safe against Mycobacterium tuberculosis are required to reduce the number of drugs and the duration of treatment in both drug-susceptible tuberculosis and multi-drug-resistant tuberculosis. Due to increased number of multidrugresistant and extensively drug-resistant strains and the ineffectiveness of the current treatment against latent tuberculosis are challenges to be overcome in future. The scenario of drug discovery becomes upsetting when it is considered that the number of new drugs does not increase proportionally to the emergence of drug resistance. In this review, we will demonstrate the recent advances in anti-tubercular drug discovery, centre of attention on the research of compounds with potent anti-tuberculosis activity against multidrug-resistant tuberculosis strains. Although, the best treatment regimen for achieving better results and preventing adverse drug reactions remains yet to be determined, with safety concerns regarding cardiac events due to QT prolongation still to be addressed. Therefore a simple and short treatment with higher efficacy, and lesser adverse drug reactions and drug-drug interaction is expected for patients with multidrug-resistant and extensively drug-resistant tuberculosis.","PeriodicalId":225304,"journal":{"name":"International Journal of Pharmacy Research & Technology","volume":"352 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124460797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

FORMULATION AND CHARACTERIZATION OF LONG CIRCULATING LIPOSOMES OF ANTI FUNGAL DRUG 抗真菌药物长循环脂质体的制备与表征

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/08.02.04

Aarti Patel, Pooja Rasiklal Modiya, G. Shinde, Rakesh Patel

{"title":"FORMULATION AND CHARACTERIZATION OF LONG CIRCULATING LIPOSOMES OF ANTI FUNGAL DRUG ","authors":"Aarti Patel, Pooja Rasiklal Modiya, G. Shinde, Rakesh Patel","doi":"10.31838/ijprt/08.02.04","DOIUrl":"https://doi.org/10.31838/ijprt/08.02.04","url":null,"abstract":"Voriconazole is an effective antifungal drug, used as first line treatment for Invasive Aspergillosis. The present work focusses on formulation of PEGylated liposomes to achieve longer circulation in the blood, prevent the liposomes from opsonisation by mononuclear phagocytic system of RES. The higher plasma concentration of voriconazole leads to visual disturbance and dermatological side effect, which are minimized by PEGylation. Compatibility studies like FTIR (Fourier Transform IR) and DSC (Differential Scanning Calorimetry) showed that lipids or drug do not interact and are highly compatible. Liposomes were prepared by thin lipid film hydration method, applying 32 full factorial design with various molar ratio of phospholipids like DPPC /Cholesterol /DSPE mPEG2000. Vesicular size and zeta potential was found within desired range of 100-300 nm to effectively pass through intra venous circulation. Long circulating liposomes were found to have entrapment efficiency of 75-85%. TEM (Transmission Electron Microscopy) showed distinctive spherical shaped vesicles. Long circulatory effect was confirmed from biodistribution study. Stability studies of long circulating liposomes were carried out and Pegylated liposomes successfully showed long circulatory action inside the body and minimized side effect of drug with appreciable antifungal activity determined by microbiological assay (zone of inhibition).","PeriodicalId":225304,"journal":{"name":"International Journal of Pharmacy Research & Technology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123588262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Case Report On Non Diabetic Foot Ulcer With Cellulitis: Split Thickness Grafting Technique (Stgt ) 非糖尿病足溃疡合并蜂窝织炎1例:劈厚移植术(Stgt)

International Journal of Pharmacy Research & Technology Pub Date : 1900-01-01 DOI: 10.31838/ijprt/11.02.08

引用次数: 0