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The Brown University Child & Adolescent Psychopharmacology Update最新文献

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Off-label LAI antipsychotics effective for treating bipolar disorder in teens
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30943
Alison Knopf
{"title":"Off-label LAI antipsychotics effective for treating bipolar disorder in teens","authors":"Alison Knopf","doi":"10.1002/cpu.30943","DOIUrl":"https://doi.org/10.1002/cpu.30943","url":null,"abstract":"<p>Treating adolescents with long-acting injectable (LAI) antipsychotics which are approved for adults is an effective solution to nonadherence to oral medications, researchers have found. Oral antipsychotics are approved for mania, but adherence is often poor for various reasons, including aversion to side effects, cognitive dysfunction, impulsivity, anosognosia, and substance use. For adolescents with bipolar mania or schizoaffective disorder, the conditions these medications are approved for in adults, the LAI antipsychotics show that bipolar mania in adolescents is effectively treated based on Young Mania Rating Scale (YMRS) assessments.</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parents and clinicians disagree on extent of developmental problems in their preterm babies
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30947
Alison Knopf
{"title":"Parents and clinicians disagree on extent of developmental problems in their preterm babies","authors":"Alison Knopf","doi":"10.1002/cpu.30947","DOIUrl":"https://doi.org/10.1002/cpu.30947","url":null,"abstract":"<p>Do parents know what it means when their babies are born preterm? Not always, according to a recent study. Unfortunately, this can have life-or-death consequences if the risk of neurodevelopmental impairment (NDI) is overestimated by clinicians, according to the multicenter study, led by clinicians and researchers in Canada. The study showed that parents' views should be incorporated into definitions of NDI, according to the authors. The main problem is that definitions of NDI were developed without the perspectives of parents, the researchers note. So there is little agreement between parental and medical classification of NDI in preterm children. The study involved parents of 1098 children, and the children, born at under 29 weeks gestation.</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AAP urges caution in diagnosing, treating PANS
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30946
Alison Knopf
{"title":"AAP urges caution in diagnosing, treating PANS","authors":"Alison Knopf","doi":"10.1002/cpu.30946","DOIUrl":"https://doi.org/10.1002/cpu.30946","url":null,"abstract":"<p>The American Academy of Pediatrics (AAP) last year released a clinical report on Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). Noting that PANS is “likely” a valid diagnosis, the AAP was concerned about the lack of evidence to guide clinicians in diagnosing it. And the validity of the diagnosis itself, therefore, isn't always clear.</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabis prevention is suicide prevention
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30944
Alison Knopf
{"title":"Cannabis prevention is suicide prevention","authors":"Alison Knopf","doi":"10.1002/cpu.30944","DOIUrl":"https://doi.org/10.1002/cpu.30944","url":null,"abstract":"<p>An article in <i>Psychiatric News</i> published in January summed up mounting evidence linking the use of cannabis by young people to depression and suicide. Quoting experts from the annual meeting of the American Academy of Child and Adolescent Psychiatry (AACAP), the article looks at the expanded types of products, increasing potency, and legalization are contributing to “unprecedented exposure to young people during a critical period of brain development,” said Jesse D. Hinckley, M.D., associate clinical professor of psychiatry and co-founder of the addiction biology laboratory at the University of Colorado School of Medicine, at the meeting. “Cannabis prevention and early intervention are suicide prevention,” Hinckley said. “There's an even greater need for these programs in states that have passed recreational or medical cannabis laws, where youth cannabis use is more prevalent.”</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Information Sheet
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30949
{"title":"Patient Information Sheet","authors":"","doi":"10.1002/cpu.30949","DOIUrl":"https://doi.org/10.1002/cpu.30949","url":null,"abstract":"<p>Atomoxetine hydrochloride (generic) — Strattera (brand)</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"9-10"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric obesity treatment yields long-lasting health effects
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30945
Alison Knopf
{"title":"Pediatric obesity treatment yields long-lasting health effects","authors":"Alison Knopf","doi":"10.1002/cpu.30945","DOIUrl":"https://doi.org/10.1002/cpu.30945","url":null,"abstract":"<p>Researchers in Sweden, funded by a pharmaceutical company which makes diabetes and weight-loss medications, have found that the long-term effect of pediatric obesity treatment has benefits for critical health outcomes in young adulthood. However, the study also found that the earlier treatment is begun, the better, as adolescents do not have as good outcomes as younger children to obesity treatment.</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA proposes limiting level of nicotine in cigarettes
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-02-11 DOI: 10.1002/cpu.30948
{"title":"FDA proposes limiting level of nicotine in cigarettes","authors":"","doi":"10.1002/cpu.30948","DOIUrl":"https://doi.org/10.1002/cpu.30948","url":null,"abstract":"<p>The Food and Drug Administration (FDA) has issued a proposed rule that, if finalized, would make cigarettes and certain other combusted tobacco products minimally or nonaddictive by limiting the level of nicotine in those products.</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 3","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Link between psychiatric symptoms and cognition
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-01-11 DOI: 10.1002/cpu30939
Alison Knopf
{"title":"Link between psychiatric symptoms and cognition","authors":"Alison Knopf","doi":"10.1002/cpu30939","DOIUrl":"https://doi.org/10.1002/cpu30939","url":null,"abstract":"<p>Researchers have found both positive and negative associations between mental symptom severity and general cognition. Prior studies showed mixed findings. But this study, by noting that the associations were nonlinear, reconciled those prior studies, which assumed that symptom severity tracked with cognitive ability. In fact, the association between cognition and symptoms may be the opposite in low vs. high symptom severity samples. The study shows that it's necessary to use clinical information in studies of cognitive impairment. Because mental illnesses are a leading cause of disability, and cognitive impairments often play a role across psychiatric disorders. The researchers wanted to determine if the association between general cognition and mental health symptoms diverges at different symptom severities in children. For the study, researchers used the ongoing Adolescent Brain and Cognitive Development (ABCD) study to assess 5175 child at age 9 to 11 years. They evaluated aggregate cognitive test scores (general cognition) in relation to total and subscale-specific symptoms reported from the Child Behavioral Checklist. Linear models showed differing associations between general cognition and mental health symptoms, depending on the range of symptom severities queried. Nonlinear models confirm that internalizing symptoms were significantly positively associated with cognition at low symptom burdens and significantly negatively associated with cognition at more severe symptoms. [Pines A, Tozzi L, Bertrand C, et al. Psychiatric symptoms, cognition, and symptom severity in children. <i>JAMA Psychiatry</i> 2024 Dec; 81(12):1236-1245. https://doi.org/10.1001/jamapsychiatry.2024.2399.]</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 2","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Information Sheet
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-01-11 DOI: 10.1002/cpu30942
{"title":"Patient Information Sheet","authors":"","doi":"10.1002/cpu30942","DOIUrl":"https://doi.org/10.1002/cpu30942","url":null,"abstract":"<p>Metformin hydrochloride, extended-release (generic) - Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet (brand)</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 2","pages":"9-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substance use by teens stays low: MTF study
The Brown University Child & Adolescent Psychopharmacology Update Pub Date : 2025-01-11 DOI: 10.1002/cpu30938
Alison Knopf
{"title":"Substance use by teens stays low: MTF study","authors":"Alison Knopf","doi":"10.1002/cpu30938","DOIUrl":"https://doi.org/10.1002/cpu30938","url":null,"abstract":"<p>Adolescent substance use remains low, according to the most recent Monitoring the Future (MTF) study. Results released by the National Institute on Drug Abuse (NIDA) show the fourth year of continued lowered levels for this age group.</p>","PeriodicalId":22496,"journal":{"name":"The Brown University Child & Adolescent Psychopharmacology Update","volume":"27 2","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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