The Egyptian Journal of Bronchology最新文献

{"title":"Prognostic value of laboratory markers in patients with acute pulmonary embolism","authors":"Amany Omar Mohamed Omar, Yousef Ahmed Yousef Ahmed, Abd-Elazim Ahmed Abo Elfadl, Abeer Houssein Ali, Amal Abdallah Abdelrahman, Khaled Mohamed Khaled Ali","doi":"10.1186/s43168-024-00293-y","DOIUrl":"https://doi.org/10.1186/s43168-024-00293-y","url":null,"abstract":"Acute pulmonary embolism (APE) is a serious illness. Identifying prognostic factors for APE may help in the management of those patients. This study’s objective was to evaluate the prognostic value of laboratory markers in predicting right ventricular dysfunction (RVD) and 30-day mortality in pulmonary embolism patients. Eighty patients with APE were enrolled and followed up for 30 days. Detailed echocardiography was done to evaluate RVD. All patients were subjected to arterial blood gas analysis, complete blood count (CBC), plasma concentration of C-reactive protein (CRP), serum D-dimer level, and serum troponin I level, and the following ratio were calculated: neutrophil-to-lymphocytic ratio (NLR), platelet to lymphocytic ratio (PLR), red cell distribution width (RDW), mean platelet volume (MPV), and alveolar to arterial gradient. Our results analysis revealed significantly elevated levels of median NLR, PLR, CRP, D-dimer, and troponin in both the RVD and non-survivor groups (P value < 0.001). The blood markers that showed the highest predictive ability for right ventricular dysfunction (RVD) and 30-day mortality, as determined by receiver operating characteristic (ROC) analysis and logistic regression, were A-a O2 gradient, serum troponin, CRP, D-dimer, NLR, and PLR (P value < 0.001). Evaluation of different serum markers including NLR, PLR, RDW, CRP, D-dimer, troponin, and A-a O2 gradient is a simple and available marker for predicting right ventricular dysfunction (RVD) and 30-day mortality in patients with APE. ClinicalTrials.gov ID: NCT04237974.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"161 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141573880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical predictors of obstructive sleep apnea among residents of Sagamu local government area of Ogun State","authors":"S. O. Olalekan, I. O. Osonuga, P. G. Okwute, O. E. Atekoja, M. M. Adeyanju, B.O. Adegbesan, E.N. Ezima, O. D. Odufejo, B. Tayo, V.B. Edema, D. D. Taiwo","doi":"10.1186/s43168-024-00299-6","DOIUrl":"https://doi.org/10.1186/s43168-024-00299-6","url":null,"abstract":"<p><b>Correction</b><b>: </b><b>Egypt J Bronchol 18, 43 (2024)</b></p><p><b>https://doi.org/10.1186/s43168-024-00290-1</b></p><br/><p>Following the publication of the original article [1], the authors identified errors in the author names affiliated with institution 4.</p><p>The incorrect author names are: B. Adegbesan, E. Ezima, V. Edema</p><p>The correct author names are: B.O. Adegbesan, E.N. Ezima, V.B. Edema</p><p>The author group has been updated above and the original article has been corrected.</p><ol data-track-component=\"outbound reference\" data-track-context=\"references section\"><li data-counter=\"1.\"><p>Olalekan SO, Osonuga IO, Okwute PG et al (2024) Clinical predictors of obstructive sleep apnea among residents of Sagamu local government area of Ogun State. Egypt J Bronchol 18:43. https://doi.org/10.1186/s43168-024-00290-1</p><p>Article Google Scholar </p></li></ol><p>Download references<svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-download-medium\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></p><h3>Authors and Affiliations</h3><ol><li><p>Department of Physiology, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria</p><p>S. O. Olalekan, I. O. Osonuga, O. D. Odufejo, V.B. Edema &amp; D. D. Taiwo</p></li><li><p>Department of Physiology, Babcock University Teaching Hospital, Ilishan, Ogun State, Nigeria</p><p>P. G. Okwute</p></li><li><p>Department of Nursing Science, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria</p><p>O. E. Atekoja</p></li><li><p>Department of Biochemistry, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun State, Nigeria</p><p>M. M. Adeyanju, B.O. Adegbesan &amp; E.N. Ezima</p></li><li><p>Department of Medical Microbiology and Parasitology, Babcock University Teaching Hospital, Ilishan, Ogun State, Nigeria</p><p>B. Tayo</p></li></ol><span>Authors</span><ol><li><span>S. O. Olalekan</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>I. O. Osonuga</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>P. G. Okwute</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>O. E. Atekoja</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>M. M. Adeyanju</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>B.O. Adegbesan</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>E.N. Ezima</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><l","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual presentation of lung cancer in young patient: case report","authors":"Tamer Awad El Sayed, Taha Taha Abd El Gawad","doi":"10.1186/s43168-024-00297-8","DOIUrl":"https://doi.org/10.1186/s43168-024-00297-8","url":null,"abstract":"This case report describes the diagnostic journey of a 35-year-old patient presenting with interstitial lung disease (ILD). The patient underwent a bronchoscopy, which revealed the presence of cancer. This case highlights the importance of considering malignancy as a potential cause of ILD, even in younger patients, and emphasizes the role of bronchoscopy in the diagnostic process.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of transthoracic ultra-sonography in early detection of patients with interstitial lung diseases in Aswan University Hospital","authors":"Shazly Ahmed, Suzan Salama Sayed, Mostafa Gharib, Sayed Abdelsabour Kinawy","doi":"10.1186/s43168-024-00262-5","DOIUrl":"https://doi.org/10.1186/s43168-024-00262-5","url":null,"abstract":"Recently, the diagnosis and follow-up of numerous pulmonary diseases such as pneumothorax, pneumonia, and pleural effusion were easily by use of conventional ultrasound, and the maximum usefulness of transthoracic ultrasonography (TUS) in pulmonary diseases especially diffuse parenchymal lung disease has not been detected yet. This study was conducted to determine the value of transthoracic ultrasonography in patients with interstitial lung disease (ILD). Moreover, the viable correlations of the ultrasound findings with the functional and radiological findings of ILDs had been assessed. TUS diagnosis was positive in 73 cases, there was a substantial variation between the two groups classified according to ultrasonographic diagnosis regarding age and smoking history (p = 0.003 and 0.013 respectively). All the patients with usual interstitial pneumonia (n = 42) and Indeterminate UIP (n = 49) had positive ultra-sonographic findings [p = 0.041 and 0.001 accordingly]. Regarding pulmonary function tests, there was a considerable variance between both groups regarding FVC, PEF, FEF25-75, FEV1/VC (p = 0.037, 0.029, 0.015, and 0.000 accordingly). The most positive US diagnosis areas were upper lateral, lateral basal, and interscapular areas. There was a weak negative correlation between TUS diagnosis and FVC [r = − 0.25, p = 0.026]. We concluded the great significant value of TUS in the diagnosis and follow-up of patients with interstitial lung diseases. It had an extremely thoughtful role in the diagnosis of ILD by detection of multiple B-lines distribution emerging from pleura and extending in the entire lung surface. The use of TUS in early detection and follow-up of ILDs reduced the cost.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical predictors of obstructive sleep apnea among residents of Sagamu local government area of Ogun State","authors":"S. O. Olalekan, I. O. Osonuga, P. G. Okwute, O. E. Atekoja, M. M. Adeyanju, B. Adegbesan, E. Ezima, O. D. Odufejo, B. Tayo, V. Edema, D. D. Taiwo","doi":"10.1186/s43168-024-00290-1","DOIUrl":"https://doi.org/10.1186/s43168-024-00290-1","url":null,"abstract":"Obstructive sleep apnea (OSA) is the most commonly diagnosed sleep-associated pulmonary disorder in the world. So many risk factors have been attributed to OSA; however, conflicting results exist on how these factors contribute to OSA. This study hypothesized that increasing the number of risk factors for OSA, as reflected in the STOP-BANG questionnaire, increases the probability of having OSA but also increases the likelihood of having other severe diseases such as hypertension in a Nigerian population and that the severity of OSA might be dependent on specific anthropometric indices. This study involved 110 male and female residents of Sagamu Local Government Area of Ogun State. Data was collected using a standardized instrument and the STOP-BANG questionnaire. Analysis involved descriptive statistics, parametric test of independent t-test to characterize data based on gender, and multinomial regressions to determine predictive factors of the various parameters of study on the severity of OSA. The association of the male gender with higher risk of OSA was confirmed by this study. Diastolic blood pressure (DBP) and heart rate (HR) predicted the risk of OSA, with an increase in DBP and HR implying higher risk of OSA. Of the anthropometric tests examined in this study, body mass index (BMI), neck circumference (NC), and neck height ratio (NHtR) predicted the risk of OSA in comparing low risk and medium risk to high risk, an increase in BMI and NC implying a higher risk of OSA while an increase in NHtR implying a lower risk of OSA.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of exhaled carbon monoxide in assessment of chronic obstructive airway disease severity","authors":"Menna Helmy Mohamed Abdel Gawad, Mohamed Galal Morsi, Hussien Fayiad","doi":"10.1186/s43168-024-00295-w","DOIUrl":"https://doi.org/10.1186/s43168-024-00295-w","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a critical public health issue. Spirometric measurements are used to diagnose chronic obstructive lung disease, as per the guidelines of the GOLD initiative. Post-bronchodilator forced expiratory volume in 1 s (FEV1) is a predictor of mortality from COPD and helps to classify the disease’s severity. Smoking contributes to the high levels of exhaled CO. Evidence suggests that the exhaled CO level in COPD patients varies with degree of blockage and can be used to assess treatment response. Estimating the exhaled CO level can help assess airway inflammation and severity of airflow obstruction in individuals with COPD. Evaluate role of exhaled CO in assessment of severity of COPD. This cross-sectional study included 132 patients who visited the outpatient clinics or were admitted to the Chest Department, Kasr Alainy Hospital, Faculty of Medicine, Cairo University. The study participants were divided into three groups: group 1 nonsmoker healthy control, group 2 smoker non-COPD, and group 3 smoker COPD which further divided according to GOLD 2023 into mild, moderate, and severe COPD. The smoking status, exhaled CO, and spirometry test including FEV1/FVC and FEV1 were measured for each patient. Exhaled CO was significantly increased in the smoker group (mean 9.69, SD 3.11) compared to the nonsmoker group (mean 2.19, SD 0.98) with p-value < 0.001. Exhaled CO was also statistically significantly higher in the smoker COPD group (mean 10.45, SD 3.03) compared to the smoker non-COPD group (mean 7.05, SD 1.56) with p-value < 0.001. Although exhaled CO was increased in the severe COPD group compared to the mild and moderate group, there is no statistically significant difference between them. Exhaled CO is a fast, sensitive, noninvasive, and well-established method test that can be used to identify smokers from nonsmokers with 98.9% sensitivity at 4.5 cutoff value. Also, exhaled CO levels in COPD patients vary with different degrees of airway obstruction.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141520720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and predictors of metabolic syndrome among obstructive sleep apnea patients","authors":"Mahmood D. Al-Mendalawi","doi":"10.1186/s43168-024-00296-9","DOIUrl":"https://doi.org/10.1186/s43168-024-00296-9","url":null,"abstract":"<p>To the Editor,</p><p>Kaddah and colleagues [1] in their recently released study, employed metabolic syndrome definition elements (MetSDE) of the International Diabetes Federation (IDF) to study MetS prevalence and its predictors in Egyptian patients with obstructive sleep apnea (OSA). They found that 66.3% of OSA patients exhibited MetS and the relevant MetS predictors were SPO2 &lt; 90%, body mass index, and neck, hip, and waist circumferences [1]. In addition to the few limitations addressed by Kaddah and colleagues [1], we present a noteworthy limitation, which is linked to MetSDE employed in the research. The optimum definition of MetS remains controversial. Over several years, numerous MetS definitions have been developed by scientific bodies. Though these definitions vary to some degree in their elements and threshold values, they generally endorse the essential parameters of the syndrome, notably abdominal obesity, dyslipidemia, hypertension, and insulin resistance. In research and clinical fields, numerous MetSDE are usually used such as IDF, American Heart Association (AHA), adult treatment panel-III (ATP-III), and finally joint interim statement (JIS). There is a significant conflicting agreement on the accuracy of these MetSDE for MetS characterization as noticed by numerous observational studies [2, 3]. Different results were obtained when measuring MetS prevalence among adult Egyptians using various MetSDE, namely 44.3% (IDF elements), 43.8% (AHA elements), 42.5% (ATP-III elements), and 41.5% (JIS elements with Egyptian cut-offs) [4]. To overcome the variations in estimating MetS prevalence by using different MetSDE, numerous nations have developed their diagnostic MetSDE and proved effective in yielding validated results in research and practice [5, 6]. The formulation of the Egyptian MetSDE is deemed critical as it can measure more readily MetS prevalence in OSA patients. Regardless of the study limitations, the recorded MetS prevalence in the studied OSA patients (66.3%) [1] is troublesome and it calls for the urgent implementation of strategic interventions to lessen the negative health effects of MetS, decrease healthcare visits and costs, and improve OSA patients’ quality of life.</p><dl><dt style=\"min-width:50px;\"><dfn>IDF:</dfn></dt><dd>\u0000<p>International Diabetes Federation</p>\u0000</dd><dt style=\"min-width:50px;\"><dfn>OSA:</dfn></dt><dd>\u0000<p>Obstructive sleep apnea</p>\u0000</dd><dt style=\"min-width:50px;\"><dfn>MetS:</dfn></dt><dd>\u0000<p>Metabolic syndrome</p>\u0000</dd><dt style=\"min-width:50px;\"><dfn>MetSDE:</dfn></dt><dd>\u0000<p>MetS definition elements</p>\u0000</dd><dt style=\"min-width:50px;\"><dfn>AHA:</dfn></dt><dd>\u0000<p>American Heart Association</p>\u0000</dd><dt style=\"min-width:50px;\"><dfn>ATP-III:</dfn></dt><dd>\u0000<p>Adult Treatment Panel-III</p>\u0000</dd><dt style=\"min-width:50px;\"><dfn>JI:</dfn></dt><dd>\u0000<p>Joint Interim Statement</p>\u0000</dd></dl><ol data-track-component=\"outbound reference\" data-track-context=\"references section\"><li data-counter=\"1","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"321 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological profiles and mortality risk in critically ill and drug-resistant tuberculosis patients: insights from a longitudinal study","authors":"Asmaa Ali, Liang Wu, Eman Moazen, S. Elsawy, Khadiga S. M. Salama, Kalim Ullah, Seham Ezzat Fathy Elfeky, Sami H. Alharbi, Mai M. Saleh","doi":"10.1186/s43168-024-00294-x","DOIUrl":"https://doi.org/10.1186/s43168-024-00294-x","url":null,"abstract":"","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141347249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of EBUS in lymphoma presenting as superior vena cava syndrome: bronchoscopic and sonographic findings: a case report","authors":"Ancy Elsa Thomas, Balamugesh Thangakunam, Benjamin Barsouma Mathew, Thomas Alex Kodiatte","doi":"10.1186/s43168-024-00292-z","DOIUrl":"https://doi.org/10.1186/s43168-024-00292-z","url":null,"abstract":"The clinical description of superior vena cava syndrome has been widely studied; however, there is limited information on bronchoscopic findings in clinical practice. A 57-year-old man presented with facial and neck swelling and pedal edema of 6 months duration. Computed tomography showed mediastinal lesions in the right paratracheal stations with thrombosis of the right internal jugular vein and superior vena cava (SVC). Without establishing a diagnosis, he was started on oral steroids elsewhere and his symptoms progressed. He did not receive anticoagulation therapy. Bronchoscopy showed edematous supraglottic and glottic regions with hyperemia of the airway mucosa. Endobronchial Ultrasonography revealed a mediastinal mass of heterogeneous echotexture in the lower right paratracheal region, with mediastinal collateral blood vessels. He underwent EBUS-guided aspiration cytology and intranodal forceps biopsy, which confirmed the diagnosis of non-Hodgkin’s. In cases with an unconfirmed diagnosis of lymphoma, it is prudent to refrain from administering glucocorticoids, as these medications can exhibit lympholytic properties and may hinder the diagnostic process. Due to extensive collateral formation in superior vena cava syndrome, utilizing Doppler during endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) can identify numerous mediastinal collateral vessels, thus minimizing the risk of bleeding.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141258514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role and predictive value of microRNAs 204 and 210 in the diagnosis of pulmonary arterial hypertension and the distinction between idiopathic, systemic sclerosis, and schistosomiasis-associated pulmonary arterial hypertension","authors":"Mark O. Dimitry, Yosef M. Amin, Reem I. ElKorashy, Hala M. Raslan, Solaf A. Kamel, Eman M. Hassan, Rasha N. Yousef, Eman A. Awadallah","doi":"10.1186/s43168-024-00288-9","DOIUrl":"https://doi.org/10.1186/s43168-024-00288-9","url":null,"abstract":"Pulmonary arterial hypertension is most of the time diagnosed late in the course of the disease and necessitates right cardiac catheterization which is an invasive and costly tool. MicroRNAs have a role in the pathogenesis of pulmonary hypertension, systemic sclerosis, and schistosomiasis and their dosages are easy and non-expensive. Therefore, determining their levels in the blood may be helpful in detecting PAH and differentiating its idiopathic form from those caused by systemic sclerosis and schistosomiasis. To evaluate the role of microRNA (miR) 204 and miR-210 in the diagnosis of PAH and to distinguish between idiopathic PAH (IPAH), systemic sclerosis-associated PAH (SSc-PAH), and schistosomiasis-associated PAH (Sch-PAH) and to identify patients who may benefit from simple non-expensive and non-invasive methods in diagnosis of PAH. Sixty patients with PAH and 30 subjects as control were enrolled in the study. PAH was diagnosed by right heart catheterization, echocardiography, and laboratory tests. Blood samples were taken from all patients for measuring miR-204 and miR-210. MiR-204 was downregulated in PAH and there was a highly significant difference between PAH and control (p = 0.003) with cut-off predictive value ≤ 0.15 µM and 70% sensitivity, 85% specificity with AUC (0.749). However, miR-204 failed to distinguish between IPAH, SSc-PAH, and Sch-PAH. MiR-210 was upregulated in PAH with a highly significant difference between PAH and control (p < 0.001) with cut-off predictive value ≥ 1.16 µM and 93.33% sensitivity, 85% specificity with AUC (0.917). MiiR-210 showed a significant difference between SSc-PAH and idiopathic PAH (P = 0.012) and between SSc-PAH and Sch-PAH (P = 0.035). MiR-204 and miR-210 are useful non-invasive and non-expensive markers for the diagnosis of PAH, miR-210 is an excellent predictor in the diagnosis of PAH and also miR-210 might be used to distinguish SSc-PAH from idiopathic PAH and Sch-PAH.","PeriodicalId":22426,"journal":{"name":"The Egyptian Journal of Bronchology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141197563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}