The Cerebellum最新文献_第6页

Cerebellar Modulation of Mesolimbic Dopamine Transmission Is Functionally Asymmetrical 中脑边缘多巴胺传递的小脑调节功能不对称

The Cerebellum Pub Date : 2019-04-23 DOI: 10.1007/s12311-019-01074-w

Z. Holloway, Nick Paige, Josiah F. Comstock, Hunter G. Nolen, H. Sable, Deranda B. Lester

引用次数: 16

Obituary: Masao Ito (1928–2018)

The Cerebellum Pub Date : 2019-03-08 DOI: 10.1007/s12311-019-01022-8

S. Nagao

引用次数: 1

8TH SRCA SYMPOSIUM ON THE CEREBELLUM: FROM DEVELOPMENT TO DISEASE 第八届中国科学院小脑研讨会:从发育到疾病

The Cerebellum Pub Date : 2018-01-20 DOI: 10.1007/s12311-017-0915-0

引用次数: 0

In Memoriam Andrea Poretti

The Cerebellum Pub Date : 2017-04-29 DOI: 10.1007/s12311-017-0864-7

E. Boltshauser

引用次数: 0

Effects of Sustained Otolith-Only Stimulation on Post-Rotational Nystagmus 持续仅耳石刺激对旋转后眼球震颤的影响

The Cerebellum Pub Date : 2017-02-21 DOI: 10.1007/s12311-017-0847-8

A. Shaikh, D. Solomon

引用次数: 1

The Known and Missing Links Between the Cerebellum, Basal Ganglia, and Cerebral Cortex 小脑、基底神经节和大脑皮层之间已知的和缺失的联系

The Cerebellum Pub Date : 2017-02-18 DOI: 10.1007/s12311-017-0850-0

A. Cacciola, D. Milardi, P. Livrea, P. Flace, G. Anastasi, A. Quartarone

引用次数: 26

Cerebellar Neural Circuits Involving Executive Control Network Predict Response to Group Cognitive Behavior Therapy in Social Anxiety Disorder 涉及执行控制网络的小脑神经回路预测社交焦虑障碍对群体认知行为治疗的反应

The Cerebellum Pub Date : 2017-02-02 DOI: 10.1007/s12311-017-0845-x

MinlanYuan, Y. Meng, Yan Zhang, Xiao-jing Nie, Zhengjia Ren, Hongru Zhu, Yuchen Li, S. Lui, S. Lui, Q. Gong, Changjian Qiu, Wei Zhang

引用次数: 18

Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex. 共识论文：迈向小脑功能的系统水平观点：小脑、基底神经节和皮层之间的相互作用。

The Cerebellum Pub Date : 2017-02-01 DOI: 10.1007/s12311-016-0763-3

Daniele Caligiore, Giovanni Pezzulo, Gianluca Baldassarre, Andreea C Bostan, Peter L Strick, Kenji Doya, Rick C Helmich, Michiel Dirkx, James Houk, Henrik Jörntell, Angel Lago-Rodriguez, Joseph M Galea, R Chris Miall, Traian Popa, Asha Kishore, Paul F M J Verschure, Riccardo Zucca, Ivan Herreros

{"title":"Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex.","authors":"Daniele Caligiore, Giovanni Pezzulo, Gianluca Baldassarre, Andreea C Bostan, Peter L Strick, Kenji Doya, Rick C Helmich, Michiel Dirkx, James Houk, Henrik Jörntell, Angel Lago-Rodriguez, Joseph M Galea, R Chris Miall, Traian Popa, Asha Kishore, Paul F M J Verschure, Riccardo Zucca, Ivan Herreros","doi":"10.1007/s12311-016-0763-3","DOIUrl":"10.1007/s12311-016-0763-3","url":null,"abstract":"Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.","PeriodicalId":22415,"journal":{"name":"The Cerebellum","volume":"1 1","pages":"203-229"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74866867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pure Cerebellar Ataxia with Homozygous Mutations in the PNPLA6 Gene. 纯小脑共济失调伴PNPLA6基因纯合突变。

The Cerebellum Pub Date : 2017-02-01 DOI: 10.1007/s12311-016-0769-x

Sarah Wiethoff, Conceição Bettencourt, Reema Paudel, Prochi Madon, Yo-Tsen Liu, Joshua Hersheson, Noshir Wadia, Joy Desai, Henry Houlden

{"title":"Pure Cerebellar Ataxia with Homozygous Mutations in the PNPLA6 Gene.","authors":"Sarah Wiethoff, Conceição Bettencourt, Reema Paudel, Prochi Madon, Yo-Tsen Liu, Joshua Hersheson, Noshir Wadia, Joy Desai, Henry Houlden","doi":"10.1007/s12311-016-0769-x","DOIUrl":"10.1007/s12311-016-0769-x","url":null,"abstract":"Autosomal-recessive cerebellar ataxias (ARCA) are clinically and genetically heterogeneous conditions primarily affecting the cerebellum. Mutations in the PNPLA6 gene have been identified as the cause of hereditary spastic paraplegia and complex forms of ataxia associated with retinal and endocrine manifestations in a field where the genotype-phenotype correlations are rapidly expanding. We identified two cousins from a consanguineous family belonging to a large Zoroastrian (Parsi) family residing in Mumbai, India, who presented with pure cerebellar ataxia without chorioretinal dystrophy or hypogonadotropic hypogonadism. We used a combined approach of clinical characterisation, homozygosity mapping, whole-exome and Sanger sequencing to identify the genetic defect in this family. The phenotype in the family was pure cerebellar ataxia. Homozygosity mapping revealed one large region of shared homozygosity at chromosome 19p13 between affected individuals. Within this region, whole-exome sequencing of the index case identified two novel homozygous missense variants in the PNPLA6 gene at c.3847G>A (p.V1283M) and c.3929A>T (p.D1310V) in exon 32. Both segregated perfectly with the disease in this large family, with only the two affected cousins being homozygous. We identified for the first time PNPLA6 mutations associated with pure cerebellar ataxia in a large autosomal-recessive Parsi kindred. Previous mutations in this gene have been associated with a more complex phenotype but the results here suggest an extension of the associated disease spectrum.","PeriodicalId":22415,"journal":{"name":"The Cerebellum","volume":"3 1","pages":"262-267"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82749895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations 高剂量补充泛醇治疗家族性多系统萎缩伴COQ2杂合突变3年随访

The Cerebellum Pub Date : 2017-02-01 DOI: 10.1007/s12311-017-0846-9

J. Mitsui, Ken Koguchi, T. Momose, Miwako Takahashi, T. Matsukawa, T. Yasuda, Shin‐ichi Tokushige, H. Ishiura, J. Goto, S. Nakazaki, Tomoyoshi Kondo, Hidefumi Ito, Yorihiro Yamamoto, S. Tsuji

引用次数: 30