The clinical investigator最新文献_第5页

News from around the world 来自世界各地的新闻

The clinical investigator Pub Date : 2004-01-01 DOI: 10.1007/BF00180297

引用次数: 0

The awful German language 可怕的德语

The clinical investigator Pub Date : 2004-01-01 DOI: 10.1007/BF00210968

Prof. Dr. F. C. Luft

引用次数: 20

News from around the world 来自世界各地的新闻

The clinical investigator Pub Date : 2004-01-01 DOI: 10.1007/BF00210976

引用次数: 0

News from around the world 来自世界各地的新闻

The clinical investigator Pub Date : 2004-01-01 DOI: 10.1007/BF00252841

引用次数: 0

Cryoglobulinemia: a complication of infectious disease. 冷球蛋白血症:传染病的并发症。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577753

O Witzke, J Kassubek, E Bonmann, E Musch

引用次数: 1

Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects. I. Uric acid kinetics. 正常人长期口服别嘌呤醇和氢氯噻嗪时的相互作用。1 .尿酸动力学。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577758

W Löffler, R Landthaler, J X de Vries, I Walter-Sack, A Ittensohn, A Voss, N Zöllner

{"title":"Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects. I. Uric acid kinetics.","authors":"W Löffler, R Landthaler, J X de Vries, I Walter-Sack, A Ittensohn, A Voss, N Zöllner","doi":"10.1007/BF00577758","DOIUrl":"https://doi.org/10.1007/BF00577758","url":null,"abstract":"The interaction of allopurinol (300 mg/day) and hydrochlorothiazide (50 mg/day) was studied in seven healthy male volunteers during prolonged coadministration of the two drugs using defined dietary conditions. A formula diet was administered with the allopurinol throughout the 24-day study, while hydrochlorothiazide was added during days 11-21. After the addition of hydrochlorothiazide both plasma uric acid and plasma oxipurinol rose for 6 days--24% and 30%, respectively, compared to steady-state levels during allopurinol alone (P < 0.01 each). In neither substance were variations in renal excretion significant. By the end of combined treatment (day 21), the changes induced by hydrochlorothiazide had already been reversed to a considerable extent. It is concluded that both in normal individuals and in patients with normal renal clearance of uric acid the effect of hydrochlorothiazide on the plasma concentration and renal excretion of oxipurinol is small. When taking both drugs, there is no increased risk during long-term treatment, and a risk is even questionable during the first days.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":"72 12","pages":"1071-5"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18712640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Insulin-dependent diabetes mellitus following pentamidine therapy in a patient with AIDS. 1例艾滋病患者喷他脒治疗后胰岛素依赖型糖尿病。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577749

U Liegl, J R Bogner, F D Goebel

引用次数: 11

The prognostic value of hypocholesterolemia in hospitalized patients. 住院患者低胆固醇血症的预后价值。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577732

E Windler, U Ewers-Grabow, J Thiery, A Walli, D Seidel, H Greten

{"title":"The prognostic value of hypocholesterolemia in hospitalized patients.","authors":"E Windler, U Ewers-Grabow, J Thiery, A Walli, D Seidel, H Greten","doi":"10.1007/BF00577732","DOIUrl":"https://doi.org/10.1007/BF00577732","url":null,"abstract":"Clinical observations show that severe illness often leads to hypocholesterolemia. To verify this finding and to define the relationship between serum cholesterol and a patient's prognosis, a study was conducted in two large hospital populations. Of 24,000 and 61,463 adult patients (populations I and II) an average of 3.8% and 3.6% died in hospital, respectively. The mean serum cholesterol levels of patients who died was significantly lower than that of those who survived (163.6 mg/dl versus 217.8 mg/dl; P < 0.0001). The average cholesterol of surviving patients was similar to that of 6,543 healthy controls. During hospitalization serum cholesterol levels of < or = 100 mg/dl were encountered in 1.2% and 3.6% of patients of populations I and II, respectively. The mortality of these hypocholesterolemic patients was about tenfold higher than average and showed a strong, inverse, linear relationship with serum cholesterol concentrations. Patients whose serum cholesterol level dropped to less than 45 mg/dl did not survive. These data show that in severely ill patients serum cholesterol may decline to very low concentrations, and the prognosis is reflected by the degree of hypocholesterolemia, which thus may serve as a clinically useful prognostic parameter.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":"72 12","pages":"939-43"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18713213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Kidney transplantation in hepatitis B surface antigen carriers. 乙型肝炎表面抗原携带者的肾移植。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577744

V Kliem, B Ringe, K Holhorst, U Frei

{"title":"Kidney transplantation in hepatitis B surface antigen carriers.","authors":"V Kliem, B Ringe, K Holhorst, U Frei","doi":"10.1007/BF00577744","DOIUrl":"https://doi.org/10.1007/BF00577744","url":null,"abstract":"Chronic hepatitis B surface antigen (HBsAg) carriers run a high risk of developing chronic liver disease after renal transplantation. To determine the impact of liver disease on long-term morbidity and mortality of HBsAg carriers following kidney transplantation we analyzed 1977 patients, including 76 HBsAg carriers, who underwent renal transplantation during the period 1968-1992. Although the HBsAg carriers had a better 5-year patient and graft survival rate (94% and 83%) than HBsAg-negative patients (87% and 61%), the prognosis was poor after the tenth year of transplantation. Transplant loss is more frequently caused by death of the HBsAg carriers, in contrast to the total population (34% vs 17% for HBsAg-negative patients). Death occurs in 73% of cases due to complications of hepatitis B. In the HBsAg-negative patients, the predominant cause of death is cardiovascular failure (51% vs 11% in HBsAg carriers), whereas only 2% died of liver disease. Kidney transplantation in HBsAg carriers with normal liver function appears to be justified because of rare graft loss due to acute rejection, low early morbidity and mortality, and late onset of fatal hepatic deterioration.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":"72 12","pages":"1000-6"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18715361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection. 慢性乙型肝炎和晚期人类免疫缺陷病毒感染患者血清中乙型肝炎病毒的持续消除。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577750

T Wölfel, P Schirmacher, J Schlaak, P Knolle, H P Dienes, W Dippold, K H Meyer zum Büschenfelde, G Gerken

{"title":"Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection.","authors":"T Wölfel, P Schirmacher, J Schlaak, P Knolle, H P Dienes, W Dippold, K H Meyer zum Büschenfelde, G Gerken","doi":"10.1007/BF00577750","DOIUrl":"https://doi.org/10.1007/BF00577750","url":null,"abstract":"A 48-year-old male patient was admitted with acquired immunodeficiency syndrome (stage III, Centers for Disease Control 1993) and viremic hepatitis B. Blood CD4 count was 15/microliters. Discontinuation of prednisolone, previously prescribed by the patient's family practitioner because of elevated liver enzymes, resulted in severe hepatitis (alanine aminotransferase > 300U/l). Administration of interferon-alpha (9 x 10(6) U s.c. 3 x weekly) was initiated. Serum markers of viral replication disappeared, and aminotransferase levels returned to normal within a few weeks. The patient's serum was found negative for HBsAg after 3 months. Immunohistochemical analysis of liver biopsies before and during interferon therapy showed disappearance of all hepatitis B virus antigens and a marked reduction in inflammatory activity. Hepatitis B virus seroconversion remained stable until the patient died from the syndrome 2 years later. This case shows that in spite of severe HIV-associated immune deficiency with CD4 counts constantly below 100/microliters, interferon-alpha can lead to sustained serological and histological improvement of viremic hepatitis B. Previous administration and discontinuation of cortisone may have helped to reach this effect.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":"72 12","pages":"1030-6"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18712686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3