Tanta Medical Journal最新文献_第2页

Amniotic membrane transplantation with intra-stromal Voriconazole versus amniotic membrane transplantation with argon laser photocoagulation for treatment of resistant fungal keratitis 间质伏立康唑羊膜移植与氩激光光凝羊膜移植治疗难治性真菌性角膜炎的比较

Tanta Medical Journal Pub Date : 2023-01-01 DOI: 10.4103/tmj.tmj_40_22

M. Khater, Amr Sharaf

{"title":"Amniotic membrane transplantation with intra-stromal Voriconazole versus amniotic membrane transplantation with argon laser photocoagulation for treatment of resistant fungal keratitis","authors":"M. Khater, Amr Sharaf","doi":"10.4103/tmj.tmj_40_22","DOIUrl":"https://doi.org/10.4103/tmj.tmj_40_22","url":null,"abstract":"Background Fungal keratitis is a serious problem that may affect vision. Many procedures like argon laser, voriconazole injection, and amniotic membrane transplantation (AMT) may be used to control infection. Aim To compare between intrastromal voriconazole injection with AMT and argon laser photocoagulation with AMT as treatment for fungal keratitis. Patients and methods Mycotic keratitis cases were divided in two groups, with 15 cases each. In one group, intrastromal voriconazole injection and AMT in the same setting was done, and in the other group, argon laser photocoagulation and AMT in the same setting was done. The studied cases included 21 cases with mixed infection and nine cases were pure fungal keratitis according to culture results. In the voriconazole group, intrastromal injection followed by AMT was done, whereas in the argon group, the corneal ulcer was irradiated with argon after fluorescein staining followed by AMT in the same settings. Results Healing was achieved in both groups in 2–6 weeks in all cases. Less than 50% of cases of the voriconazole group healed by the third week, whereas 80% of cases of the argon laser group healed by the third week. Vision was increased in four (26.7%) patients in the voriconazole group, whereas in six (40%) cases in the argon laser group. Conclusions Argon laser with AMT gives better results than intrastromal voriconazole injection with AMT for the treatment of resistant mycotic keratitis.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126913638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of intraoperative single dose of dexamethasone on posttonsillectomy pain in children: a systematic review and meta-analysis 术中单剂量地塞米松对儿童扁桃体切除术后疼痛的影响:一项系统回顾和荟萃分析

Tanta Medical Journal Pub Date : 2023-01-01 DOI: 10.4103/tmj.tmj_80_21

Mohamed Sakr, Ahmed El-Guindy, Mohamed Khalefa, Mahmoud Mandour

{"title":"Effect of intraoperative single dose of dexamethasone on posttonsillectomy pain in children: a systematic review and meta-analysis","authors":"Mohamed Sakr, Ahmed El-Guindy, Mohamed Khalefa, Mahmoud Mandour","doi":"10.4103/tmj.tmj_80_21","DOIUrl":"https://doi.org/10.4103/tmj.tmj_80_21","url":null,"abstract":"Background Tonsillectomy is one of the commonest operative techniques done universally. In spite of developments in anesthetic and operative procedures, posttonsillectomy pain remains a vital clinical problem. Posttonsillectomy pain is perhaps the consequence of muscle spasm caused by inflammation and irritation of the pharyngeal muscular structure. Postoperatively cases frequently have significant odynophagia, alteration of diet, and reduced activity. The recovery interval of kids frequently continues from 4 to 7 days, whereas adults might continue being symptomatic up to 2 weeks. The odynophagia may be sufficiently severe to control oral intakes, which in occasional cases can lead to dehydration needing admittance for intravenous fluids. Aim This work aimed to evaluate the consequence of intraoperative single dosage of dexamethasone on posttonsillectomy pains in kids and to verify its significance. Patients and methods A systematic review of presently accessible randomized controlled trials via a one-dose, intravenous corticoid throughout pediatric tonsillectomy has been done. Visual analog pain score information was obtained with reviewers blinded to findings. Results Seven randomized trials have been involved in posttonsillectomy pain analysis. A significant decrease in pain as determined by visual analog pain score on the first-day postoperatively was found. Conclusions A single, intraoperative dosage of dexamethasone can decrease posttonsillectomy pain on the first day postoperatively by a factor of 1 on a 10-point pain scale. As the adverse effects and price of dexamethasone dosage seem negligible, considerations of routine usage appear acceptable.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134430842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of platelet-derived growth factor receptor beta in bone marrow biopsy samples of patients with multiple myeloma 多发性骨髓瘤患者骨髓活检样本中血小板衍生生长因子受体β的研究

Tanta Medical Journal Pub Date : 2023-01-01 DOI: 10.4103/tmj.tmj_18_19

Ghada Musallam, Rasha A. Elkholy, B. Elgamal, Aisha Ahmed

{"title":"Study of platelet-derived growth factor receptor beta in bone marrow biopsy samples of patients with multiple myeloma","authors":"Ghada Musallam, Rasha A. Elkholy, B. Elgamal, Aisha Ahmed","doi":"10.4103/tmj.tmj_18_19","DOIUrl":"https://doi.org/10.4103/tmj.tmj_18_19","url":null,"abstract":"Background Multiple myeloma (MM) is a malignant neoplastic disease manifested by uncontrolled proliferation of plasma cells in the bone marrow, production of monoclonal immunoglobulins, and associated organ dysfunction. Platelet-derived growth factor receptor beta (PDGFR-β) has demonstrated an important role in angiogenesis and neoplastic diseases. Aim The aim of this work was to calculate the expression of PDGFR-β in bone marrow trephine biopsy samples of newly diagnosed patients with MM and its clinical significance. Patients and methods A total of 20 newly diagnosed patients with MM were enrolled in this study. The expression of PDGFR-β on plasma cells in bone marrow trephine biopsy samples was assessed by immunohistochemical staining. Results Our results showed a statistically significant increase in lactate dehydrogenase, beta 2 microglobulin, and clonal plasma cell percentage in bone marrow of patients with high PDGFR-β expression in comparison with patients with negative and intermediate PDGFR-β expression and statistical significant decrease in albumin and prognostic-free survival in patients with high PDGFR-β expression in comparison with patients with negative and intermediate PDGFR-β expression. Conclusion Patients with MM with high PDGFR-β expression had unfavorable prognosis in terms of prognostic-free survival and advanced disease stage compared with intermediate and low PDGFR-β expressions.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128819376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of nanoparticles loaded with pirfenidone after bleomycin-induced lung fibrosis in adult male albino rats: a histological study 载吡非尼酮纳米颗粒在博莱霉素诱导成年雄性白化大鼠肺纤维化后的作用:组织学研究

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_22_22

A. Kamel, M. Mahmoud, Doaa A. Haiba, A. Azzam

{"title":"Role of nanoparticles loaded with pirfenidone after bleomycin-induced lung fibrosis in adult male albino rats: a histological study","authors":"A. Kamel, M. Mahmoud, Doaa A. Haiba, A. Azzam","doi":"10.4103/tmj.tmj_22_22","DOIUrl":"https://doi.org/10.4103/tmj.tmj_22_22","url":null,"abstract":"Background Lung fibrosis is a severe form of idiopathic interstitial pneumonia. Targeting cells is a good approach in drug delivery. Pirfenidone is an antifibrotic drug ‘used’ for the treatment of idiopathic pulmonary fibrosis. Aim The aim of the present work was to study the effect of nanoparticles (niosomes) loaded with pirfenidone on bleomycin-induced lung fibrosis in adult male albino rats with different histological techniques. Material and methods A total of 40 rats were divided into six groups: group I, control (five rats); group II pirfenidone treated (five rats); group III, encapsulated-pirfenidone treated (five rats); group IV, bleomycin treated (five rats); group V, bleomycin-pirfenidone treated (10 rats), which was then subdivided into two subgroups, that is, subgroup Va (five rats) and subgroup Vb (five rats); and group VI, bleomycin-encapsulated-pirfenidone treated (10 rats), which was then subdivided into two subgroups, that is, subgroup VI a (five rats) and subgroup VIb (five rats). Lung specimens were stained using hematoxylin and eosin-stained, Masson’s trichrome, anti-transforming growth factor beta 1 (TGF-β1), and toluidine blue for light microscopic examination and transmission electron microscopy. Assessments of mean area % of the stained collagen fibers and intensity of TGF-β1 and the mean thickness of blood–air barrier of ultrathin sections were performed and then subjected to statistical analysis. Results Encapsulated pirfenidone-treated subgroups showed more patent alveoli, sacs, and ducts; patent bronchioles; blood vessels; and more type I pneumocytes and less type II. The blood–air barrier had thin basal lamina. There were better results in collagen deposition and TGF-β1 in lung tissues with encapsulated pirfenidone treatment. Conclusion Encapsulated pirfenidone resulted in better improvement than using pirfenidone only.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130413839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum B-cell maturation antigen level in multiple myeloma 多发性骨髓瘤患者血清b细胞成熟抗原水平

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_36_20

Hend El Shewaikh, Dina El-Shahat, A. Taha, Nagwa Abdo

{"title":"Serum B-cell maturation antigen level in multiple myeloma","authors":"Hend El Shewaikh, Dina El-Shahat, A. Taha, Nagwa Abdo","doi":"10.4103/tmj.tmj_36_20","DOIUrl":"https://doi.org/10.4103/tmj.tmj_36_20","url":null,"abstract":"Background Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in the bone marrow producing excessive amounts of monoclonal immunoglobulins (Ig) and suppression of other normal polyclonal Igs, leading to bone destruction and marrow failure. B-cell maturation antigen (BCMA) is known to bind to B-cell-activating factor (BAFF) or a proliferation-inducing ligand (APRIL), leading to the activation of cell proliferation pathways and upregulation of antiapoptotic proteins, which is considered the main step in the pathogenesis of MM. Aim This study was planned to evaluate serum BCMA levels in MM patients and its clinical significance. Patients and methods This study was carried out on 40 newly diagnosed MM patients and 40 apparently healthy individuals served as the control. The two studied groups were compared as regards serum BCMA levels using the enzyme-linked immunosorbent assay technique. Results Results showed that there was a statistically significant increase in MM patients when compared with the control group, and there was a significant positive correlation between BCMA level and plasma cells in bone marrow, M protein, number of bone lesions, and beta-2 microglobulin. However there was no correlation between BCMA level and age, creatinine, and hemoglobin. Conclusion Serum BCMA level was significantly elevated in MM patients compared with healthy controls that may suggest the role of BCMA in the pathogenesis of MM. The high sensitivity of BCMA suggests that it may be a novel diagnostic marker, and its level was positively correlated with other prognostic markers. It may be used as a prognostic marker in MM patients.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122352945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different modalities for management of peripheral corneal ulcer 周围性角膜溃疡的不同治疗方式

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_18_22

Sarah Elshahawy, Mohamed H Nasef, M. Shaheen, Mohamed S ElShorbagy

{"title":"Different modalities for management of peripheral corneal ulcer","authors":"Sarah Elshahawy, Mohamed H Nasef, M. Shaheen, Mohamed S ElShorbagy","doi":"10.4103/tmj.tmj_18_22","DOIUrl":"https://doi.org/10.4103/tmj.tmj_18_22","url":null,"abstract":"Background The peripheral cornea has unique features, which make it more vulnerable to inflammatory reactions and necrosis. Peripheral corneal ulcer is caused by various infectious and noninfectious ocular and systemic diseases. It may impair vision by inducing astigmatism and ulcer progression to the center or threaten the eyeball integrity by spontaneous perforation. So, early diagnosis and proper treatment prevent blindness. Aim To evaluate different modalities for management of peripheral corneal ulcer. Patients and methods In this prospective study, 30 eyes of 29 patients having peripheral corneal ulcer were evaluated and treated with medical treatment and surgical intervention as adjunctive therapy in resistant cases. The duration of the study was 6 months with a follow-up period of 3 months. Results Of 30 eyes, 14 responded to medical treatment, with complete epithelial healing ranging from 2 to 6 weeks, with a mean of 3.36 ± 1.34 weeks. On the contrary, 16 of 30 eyes were resistant within 2 weeks and underwent surgical interference. A total of seven eyes were managed by amniotic membrane transplantation, and nine eyes were treated with tectonic keratoplasty. Time of healing ranged from 4 to 14 weeks, with a mean of 9.38 ± 3.91. All eyes showed anatomically successful outcomes. Conclusion Mild infectious peripheral keratitis heals on medical treatment. Cases of moderate infectious peripheral keratitis with history of diabetes mellitus or exposure keratitis need amniotic membrane transplantation as adjunctive therapy. Severe noninfectious cases with history of rheumatoid arthritis or Mooren’s ulcer need systemic treatment and tectonic keratoplasty.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122633048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of adenoidal enlargement on development of otitis media with effusion 腺样体肿大对分泌性中耳炎发展的影响

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_8_22

A. Metwally, M. Amer, M. Hagras, H. Elsherif

{"title":"Effect of adenoidal enlargement on development of otitis media with effusion","authors":"A. Metwally, M. Amer, M. Hagras, H. Elsherif","doi":"10.4103/tmj.tmj_8_22","DOIUrl":"https://doi.org/10.4103/tmj.tmj_8_22","url":null,"abstract":"Background Adenoid hypertrophy has a major effect on development of middle ear effusion not due to the large volume but through combination of factors including local immune regulation, biofilm, and immunoglobulin E allergic reaction. Aim To assess the correlation between adenoid tissue volume and development of middle ear effusion. Patients and methods This was a sequential analysis study including a sample size of 195 patients from 4 to 12 years. They were diagnosed with adenoid hypertrophy, confirmed by flexible nasopharyngeal endoscopy (FNE) and lateral neck radiographs. They were evaluated by tympanometry to assess otitis media with effusion. Results We found that 59 (29.2%) patients had FNE grade 1, 68 (35.4%) patients had FNE grade 2, 68 (35.4%) patients had FNE grade 3, and no patients had grade 4. A total of 101 (52.6%) patients had a tympanogram type A and 94 (47.4%) patients had a tympanogram type B. There was no statistically significant correlation between tympanogram groups in relation to the FNE (P=0.762). Conclusion We suggested that there was no valuable correlation between change in size or volume of adenoid tissue and development of middle ear effusion.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116314669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous nephrolithotomy in patients with or without previous open nephrolithotomy from the same side 经皮肾镜取石术适用于有或没有同侧开放性肾镜取石术的患者

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_214_20

Nader Qohaf, Ayman Hagres, M. Taha, Mohammed H. Omer

{"title":"Percutaneous nephrolithotomy in patients with or without previous open nephrolithotomy from the same side","authors":"Nader Qohaf, Ayman Hagres, M. Taha, Mohammed H. Omer","doi":"10.4103/tmj.tmj_214_20","DOIUrl":"https://doi.org/10.4103/tmj.tmj_214_20","url":null,"abstract":"Background Reintervention is typically difficult owing to perinephric anatomical changes in individuals with a history of open stone surgery. Aim The aim of the current study was to see what effect open renal surgery may have on the effectiveness and morbidity of later percutaneous nephrolithotomy (PCNL). Patients and methods PCNL was performed on 100 patients between March 2017 and March 2018. Overall, 20 of these patients were eliminated (tubeless or bilateral simultaneous PCNL). The remaining 80 patients were divided into two groups: 40 primary patients and the rest (history of open nephrolithotomy). Before intervention, a standard preoperative assessment was conducted. Statistical analysis was performed using SPSS v. 20 with the χ2 test and the independent samples t-test. P value <0.05 was considered statistically significant. Results In terms of demographics and stone load, both groups were comparable. Group 1 had fewer attempts to access the pelvicalyceal system than group 2 (1.2 ± 0.5 vs. 2.7 ± 0.9, respectively), which was statistically significant (P=0.001FNx01). Moreover, there was a statistically significant difference in the mean operational time between the two groups (85.24 ± 19.47 vs. 128.39 ± 17.45 min, respectively), with a statistically significant difference (P=0.001FNx01). The rate of blood transfusion was similar in both groups (P=0.396). The remaining problems in both groups were similar. Conclusion Patients with renal stone surgery might require additional attempts to reach the pelvicalyceal system and may have difficulties with tract dilatation owing to retroperitoneal fibrosis. However, the overall morbidity and efficacy are the same in both groups.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123907076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vitamin D replacement therapy on laboratory parameters in hepatitis C virus cirrhotic patients 维生素D替代治疗对丙型肝炎肝硬化患者实验室参数的影响

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_61_20

Amira Radwan, M. Tawfik, H. Nagy, N. Kotb

{"title":"Effect of vitamin D replacement therapy on laboratory parameters in hepatitis C virus cirrhotic patients","authors":"Amira Radwan, M. Tawfik, H. Nagy, N. Kotb","doi":"10.4103/tmj.tmj_61_20","DOIUrl":"https://doi.org/10.4103/tmj.tmj_61_20","url":null,"abstract":"Background Liver is a crucial organ for vitamin D metabolism, so vitamin D deficiency is prevalent in liver cirrhosis patients. Hepatitis C is also a global infective disease caused by hepatitis C virus (HCV) and chronic hepatitis leads to liver cirrhosis. Aim To evaluate vitamin D replacement therapy effect through laboratory parameters in HCV cirrhotic patients. Patients and methods Actual enrollment of 25 HCV cirrhotic patients (compensated and decompensated) with a 25(OH)D level of less than 30 ng/ml. All study population are subjected to be investigated at the baseline visit for 25(OH)D, ionized calcium, parathyroid hormone, complete blood count, random blood sugar, glycated hemoglobin (HbA1C), renal function tests, and liver function tests. Study participants received appointments for follow-up visits during the 12 weeks of vitamin D replacement therapy. Results After 3 months of vitamin D replacement therapy, the vitamin D level significantly improved (P=0.001), with significant increase in ionized calcium (P=0.001) and HbA1C (P=0.001). Vitamin D was significantly decreased as the Child score progressed from A to C (P=0.001). There was a significantly negative correlation among vitamin D level, Child score, and prothrombin time. However there was significant positive correlation among vitamin D level, platelet count, albumin, and ionized calcium. These correlations were before and after treatment. Conclusion In HCV cirrhotic patients, supplementation with vitamin D significantly increased 25(OH)D level and ionized calcium. Also, this was associated with improvement of HbA1C, but there was no significant effect on liver function parameters.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133790583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of CXCR5+ CD4+T-follicular helper cells in idiopathic thrombocytopenic purpura CXCR5+ CD4+ t滤泡辅助细胞在特发性血小板减少性紫癜中的作用

Tanta Medical Journal Pub Date : 2022-10-01 DOI: 10.4103/tmj.tmj_19_19

N. El-Sayed, M. Fouda, M. El-Shanshory, F. Ghaith

{"title":"The role of CXCR5+ CD4+T-follicular helper cells in idiopathic thrombocytopenic purpura","authors":"N. El-Sayed, M. Fouda, M. El-Shanshory, F. Ghaith","doi":"10.4103/tmj.tmj_19_19","DOIUrl":"https://doi.org/10.4103/tmj.tmj_19_19","url":null,"abstract":"Background Primary immune thrombocytopenic purpura (ITP) is an autoimmune illness characterized by increased platelet breakdown in the peripheral blood as well as impaired platelet production and it is also characterized by platelet counts less than 100 × 109/L. T-follicular helper (TFH) cells have been linked to the pathogenesis of autoimmune conditions. Aim The study’s aim was to study the role of TFH cells and their function in ITP children. Patients and methods This research involved 25 ITP patients and 20 age-matched and sex-matched controls, with the frequency of circulating TFH cells measured by BD FACS Calibur Flowcytometer in both ITP patients and healthy controls. Results The results showed that the ratio of circulating CD4+ CXCR5+ PD1+ (TFH) in ITP (+) patients, that is, (ITP patients with antiplatelet antibody-positive results) was dramatically higher than those of ITP (−) patients, that is, (ITP patients with antiplatelet antibody-negative results) and it was discovered that the ratios of circulating CD4+ CXCR5+ PD1+ (TFH) were dramatically higher in ITP (+) patients than the control group. However, the ratio of circulating CD4+ CXCR5 +PD1+ (TFH) was not dramatically different between ITP (−) patients and the control group. Conclusion Patients with ITP have an increased number of TFH cells, which prove its critical role in B-cell proliferation, resulting in the development of autoantibodies that contribute to the pathophysiology of ITP.","PeriodicalId":223545,"journal":{"name":"Tanta Medical Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132531500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0