Archives of Clinical Trials and Case Reports最新文献

{"title":"Motor Screenings for Primary School Children-A Review","authors":"Andrea Dincher","doi":"10.37191/mapsci-actcr-2(1)-19","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-2(1)-19","url":null,"abstract":"Importance: Motor deficits must be detected as early as possible to avoid negative consequences for the affected child. Within the framework of a sequential diagnostic strategy, screening should be used first in order to keep the testing effort for all children as low as possible. Objective: The present study investigates the question of whether such motor screening procedures exist for primary school children and meet all necessary psychometric properties. Evidence review: The literature search was conducted by January and February 2023. The electronic sources Dialnet, ERIC, PSYNDEX, PubMed, and SpoLit were systematically searched (publications in English, German, French and Spanish). Results: A total of 1092 publications were found based on the selected keywords. After removing duplicates and screening the articles for eligibility, 433 publications were included in further analysis. In this process, 11 putative screenings were found. However, only one of them meets all the required psychometric properties in a high degree. Conclusions: Actually, only MobiScreen 6-8 fulfills all criteria and can be recommended for the first step in a sequential diagnostic strategy. An appropriate screening for children between eight and ten years is lacking.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127777940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiari Malformations: A Review of the Current Literature","authors":"Erik Muñoz Rodríguez","doi":"10.37191/mapsci-actcr-2(1)-20","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-2(1)-20","url":null,"abstract":"Chiari malformations (CM) are a group of malformations involving the posterior fossa and rhombencephalic structures that may have other associated intra- or extracranial defects. Initially, the 4 classic varieties were described by the Austrian pathologist Hans Chiari towards the end of the 19th century; years later, the Swiss pathologist Julius Arnold described a case of type II CM with associated myelomeningocele. years later, two of his students used the term \"Arnold-Chiari Malformation\", this term is often misused for all types. Currently it is estimated that the incidence and prevalence data are underestimated due to the asymptomatic presentation of the pathology in many cases and the limited access to health services of different populations at a global level, for this reason the epidemiological data vary between the literature. The original classification has been modified by contributions from various authors in order to more precisely describe the variety of morphological findings; currently the classification includes CM types 0, I, 1.5, II, III and IV. The symptoms and associated pathological conditions vary for each type and type III and IV are the most severe forms. Diagnosis requires that secondary causes of cerebellar tonsillar ectopy (main finding of CM) be ruled out, along with a physical examination, neurological evaluation, and complementary tests; however, diagnosis requires resonance neuroimaging to demonstrate the findings. The management basically consists of performing a decompression of the posterior fossa and whose main indication is to reduce the symptoms, however, it should be noted that there is no global agreement among specialists on the subject of surgical management, for which each patient must be individualized by your treating physician and the decision made is subject to individual criteria.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123797053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonates Extended New Ballard Score and Parkin Score Comparison for Gestational Age Assessment","authors":"Venugopal Reddy I","doi":"10.37191/mapsci-actcr-2(1)-21","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-2(1)-21","url":null,"abstract":"This study aims to estimate the gestational age in neonates admitted to NICU and postnatal wards within the first 24 hours of life using Parkin score. All newborns had their ENBS and PS Scores calculated, and the appropriate GA listed in the chart was assigned. After gathering the aforementioned data, comparisons were done between other sets of data, including the correlation between LMP/USG and ENBS, LMP/USG and Parkin score, ENBS and Parkin score, and the time required for ENBS and PS. The gestational age ranged from 27 to 42 weeks, while the Parkin's score ranged from 1 to 12. The condition, birth weight, and maturity of the infants were evaluated. Parkin score with GA determined by LMP/USG has a Pearson correlation of zero for healthy and ill newborns. The Pearson connection between PS and gestational age as determined by LMP/USG is zero for newborns with AGA, LGA, and SGA. For term and preterm neonates, the LMP/USG-estimated Pearson correlation for PS with GA is 0. The average deviation from LMP, as measured by Parkin Score, was 9 or 10. 5 days, 11 days for babies with AGA, LGA, and SGA. The average deviation from LMP for Preterm, Full Term, and Post Terms, respectively, was 12 days, 8 days, and 9 days while taking PS's definition of maturity into account. Parkin's Score is therefore simple to administer, especially in neonates who are ill, requires little time, and is simple to teach other paramedical workers.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133001494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mccune Albright Syndrome/Craniofacial Fibrous Dysplasia and Postcraniectomy Syndrome: Case Report and Literature Review","authors":"Erick E. Muñoz Rodríguez","doi":"10.37191/mapsci-actcr-1(3)-18","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-1(3)-18","url":null,"abstract":"Introduction: McCune Albright syndrome (MAS) is a rare pathology caused by a genetic mutation of the GNAS1 gene that causes fibrous dysplasia (FD) among other endocrinological and metabolic manifestations (1). Here is presented a case report, in which craniofacial dysplasia (CFFD) produces functional alteration, its treatment, and the management of underlying complications.\u0000\u0000Case report: A 10-year-old female patient who presented with CFD with progressive involvement of the orbital cavity, compression of the optic nerve and right oculomotor cranial nerves, associated with precocious puberty and the appearance of ‘’café-au-lait’’ spots on the skin and finally, the diagnosis of MAS is made. Right front-parieto-temporal craniectomy and intracanalicular decompression of the optic nerve was performed getting partial improvement of functional alteration. Subsequently, cranioplasty is performed to manage postcraniectomy/trephined syndrome.\u0000\u0000Discussion: MAS is a genetic postzygotic disease that occurs in early stages of embryonic development, which explains its mosaicism. Among its manifestation is FD, which is explained by the hyperfunctioning nature of the mutation. In the case of DCF, continuous surveillance is required by a multidisciplinary team that includes a neurosurgeon, whose intervention is reserved for cases in which functional alterations occur, following the recommendations given by medical literature regarding the approach and type of surgery. Decompressive craniectomy can be associated with complications such as postcraniectomy/trephined syndrome, which shows improvement or resolution with cranioplasty.\u0000\u0000Conclusion: The diagnosis of MAS is clinical, and its mosaicism is explained by its early presentation in embryonic development. In the case of FCD with functional compromise, neurosurgical intervention is required, seeking the recovery and preservation of the compromised cranial nerves, avoiding prophylactic decompressions. In case of complications such as postcraniectomy/trephination syndrome, timely cranioplasty should be performed as it turns out to be highly effective as a treatment, however, the need for studies aimed at its characterization and diagnosis arises.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116394063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Endocrine Neoplasia 2a: Case Report and Review of Literature","authors":"Cecilia Nehmad Misri","doi":"10.37191/mapsci-actcr-1(3)-16","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-1(3)-16","url":null,"abstract":"Multiple endocrine neoplasia is a hereditary, autosomal dominant disease. It is created predominantly by RET germline mutations and is considered rare, with a frequency of 1 in 30,000 people. In particular, medullary thyroid cancer associated to this pathology presents at a younger age in relation to sporadic cases. Pheochromocytoma is linked to metastatic disease in only 4% of cases and it is a disease which requires high clinical suspicion. The age of presentation when related to multiple endocrine neoplasia is lower than that of the general population, 38 and 47 years of age respectively. RET proto-oncogene mutation on Codon 634 in exon 11 is the most frequent genetic alteration, present in 85% of cases of MEN2A. Its penetrance for pheochromocytoma is 25% at 30 years and 88% at 77. The objective of this article is to present a case of a patient with MEN2A with bilateral pheochromocytoma and medullary thyroid cancer, discovered in a hypertensive man as an incidental finding.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129799687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report on Uncontrolled Arterial Hypertension as an Underlying Cause of Conn´s Syndrome","authors":"José Martínez","doi":"10.37191/mapsci-actcr-1(3)-17","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-1(3)-17","url":null,"abstract":"A 24-year-old woman who consulted for uncontrolled high blood pressure. Four years ago, was diagnosed with high blood pressure and was treated with many medications without achieving adequate control. On treatment with irbesartan, hydrochlorothiazide, amlodipine. Patient has not family history. Blood pressure of 180/110mmHg was found upon evaluation. Examinations showed evidence of hypokalemia and normal renal function. Chest X-rays and electrocardiogram were normal. Ultrasound Doppler of renal arteries without alterations. Blood aldosterone was measured with values of 22ng/dl and an abdominal tomography showed the presence of a left adrenal adenoma. Spironolactone was orally given at a dosage of 25mg every day, titration every week, reaching a dose of 100mg every day, an education plan with a salt-restricted diet and adequate physical activity was provided. So, it is concluded that Primary aldosteronism is the primary endocrinological cause of secondary hypertension and only 30% of patients have hypokalemia.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116140395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Anxiety/Depression Mood Disorders and Insomnia in Patients with Pain Syndromes in Primary Health Care: A Cohort Study","authors":"Erik Muñoz Rodríguez","doi":"10.37191/10.37191/mapsci-actcr-1(3)-14","DOIUrl":"https://doi.org/10.37191/10.37191/mapsci-actcr-1(3)-14","url":null,"abstract":"Introduction: Chronic pain and mental health disorders are common in the general population, prevalence of chronic pain ranges from 2% to 40%, and the prevalence of mental health disorders ranges from 17% to 29%. Chronic pain is associated with irritability, depression, anxiety and sleep problems such as insomnia. However, the appearance of anxiety and depression has been described as a consequence of chronic pain.\u0000\u0000Aims: To determine the sociodemographic characteristics and the association between pain syndromes and mood disorders in individuals treated in primary care.\u0000\u0000Materials and methods: A prospective cohort study was undertaken in a primary care medical center for four months with patients whose pain was the reason for consultation. Scales such as DN4, VAS, Beck's criteria, and DSM-V were applied, and the sociodemographic characteristics of these individuals were determined.\u0000\u0000Results: A total of 132 patients who met the inclusion criteria were recruited. Of these, 81.81% (108) were women, 18.18% were men (24). The mean age for both sexes was 37.9 and the mean duration in hours of each painful episode was 14.35 hours. The proportion of the disorders that was noted were as follows: insomnia in 0.303, anxiety 0.265, depression 0.090. Those who presented with anxiety or depression and another disorder was 0.053. Patients who did not develop any of the diseases of interest in this study 0.185.\u0000\u0000Discussion: The coexistence and overlap of mood disorders and insomnia in patients suffering from pain syndromes, which have little or no importance when assessing patients in primary health care centers, are under-diagnosed. However, broadening the clinical history, and correctly using diagnostic tools for mood disorders increases their diagnosis rate, ignoring the positive relationship that exists between these disorders.\u0000\u0000Conclusions: Pain disorders trigger neuropsychiatric complications. Depression, anxiety, and insomnia worsen episodes of pain. However, the correct diagnostic approach and the application of adequate management greatly reduce the complications of these types of disorders.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123129322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilonidal Cyst with Malignant Degeneration: A Case Report","authors":"Liliana Cuevas López","doi":"10.37191/mapsci-actcr-1(3)-13","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-1(3)-13","url":null,"abstract":"Introduction: Pilonidal cyst is a frequent surgical pathology with low risk of malignancy.Here, we present a case of a chronic pilonidal cyst with transformation to skin squamous cell carcinoma.\u0000\u0000Case presentation: A 67-year-old male patient with a chronic presentation of injury in the sacrococcygeal region with occasional bleeding that got worse with progressive growth and purulent discharge. Initially was treated as a soft tissue infection with oral antibiotics but did not solve.A skin biopsy reported a squamous cell carcinoma, extension studies showed no secondary disease of the lesion. The patient was treated as if he was diagnosed a squamous cell carcinoma of the anal margin. Treatment was initiated with Nigro protocol chemoradiotherapy and wide local resection of the lesion with oncological margins of 1cm with success.\u0000\u0000Discussion: The pilonidal cyst is an episodic inflammatory disease in the sacrococcygeal zone that usually responses to antibiotic treatment and surgery if it’s necessary, malignant degeneration is rare, might it be related with chronic inflammation that affects repair mechanisms and create a predisposition for malignancy. The optimal treatment is in bloc surgical resection with tumor-free margins and complementary treatment depends on the histology.\u0000\u0000Conclusion: This is an uncommon case of a Pilonidal cyst with transformation to skin squamous cell carcinoma managed with Nigro protocol chemoradiotherapy and wide local resection. This case will give surgeons another tool to treat this condition.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124039224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics of Primary Tumors 0f the Central Nervous System According to Anatomical Location and Type of Lesion in a Level IV Hospital in Colombia in the Period Between 2008-2019","authors":"Erik Muñoz Rodríguez","doi":"10.37191/mapsci-actcr-1(3)-15","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-1(3)-15","url":null,"abstract":"Introduction: According to figures from GLOBOCAN 2020, tumors of the central nervous system have an incidence of 1.6% with a mortality of 2.5%. For Colombia, 1,901 new cases were registered, with an incidence of 1.7% and 1,650 deaths, with a mortality of 3%.\u0000\u0000Aim: To describe the epidemiological characteristics of patients diagnosed with primary tumors of the central nervous system at a central military hospital in the period between 2008-2019.\u0000\u0000Materials and methods: A cross-sectional descriptive study was proposed, collecting data from the period between 2008 and 2019. 177 cases met these criteria, of which the sociodemographic variables were estimated, and the survival for these was determined through the Kaplan-Meyer analysis of the tumors.\u0000\u0000Results: The average 5-year survival for men is 22% and for women 27%. 18.6% of the 177 patients diagnosed with primary brain tumors in the study died after histopathological diagnosis, of which 60.6% were men and 39.4% women.\u0000\u0000Conclusions: The highlighted sociodemographic aspects represent a contribution to the generation of new evidence for primary tumors of the central nervous system in our country.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128862926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudotumor Cerebri in a Paediatric Patient with Renal Transplantation","authors":"S. Taner","doi":"10.37191/mapsci-actcr-1(2)-12","DOIUrl":"https://doi.org/10.37191/mapsci-actcr-1(2)-12","url":null,"abstract":"Pseudotumor cerebri (PTC) is an increase in intracranial pressure in the absence of intracranial space or venous occlusion. Patients present with headache, double vision, or visual field problems. In this case, a 12-year-old patient following up with renal transplantation diagnosed with PTC is reported. PTC can cause long-term damage such as permanent vision loss, if not detected and treated early. PTC should be kept in mind in the differential diagnosis of kidney transplant patients with headache and vomiting.","PeriodicalId":223531,"journal":{"name":"Archives of Clinical Trials and Case Reports","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133607817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}