Technological Innovation in Pharmaceutical Research Vol. 10最新文献

{"title":"Study on Eco Friendly, Economically Viable Plant Protection Products","authors":"P. S. Verghese, D. Jain","doi":"10.9734/bpi/tipr/v10/4795d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/4795d","url":null,"abstract":"Beans are one of the world's most consumed and widely grown vegetable crops, but their yield is hampered by a variety of diseases caused by whiteflies and other insects.Whiteflies can also spread a variety of viral diseases to beans. Bean Common Mosaic Virus (BCMV), Bean Yellow Mosaic Virus (BYMV), Bean Golden Mosaic Virus (BGMV) etc. A variety of synthetic pesticides have been used in agriculture to control insects, which damage the plant and have a negative impact on the environment; however, their negative impact on the environment necessitates the use of more environmentally friendly methods for pest management. This paper discusses the synthesis, physicochemical characterization, and application of a mixture of potassium palmitate and pyrethroids; pyrethroids, and potassium stearate as non- persistent insecticides against whiteflies found on bean plants, as well as the use of the T-test to compare the efficacy of prepared insecticidal formulations.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91001342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the effect of Aqueous Extract of Bitter Leaf (Vernonia amygdalina) Against Acetaminophen-Induced Liver Damage in Rats","authors":"I. Uchendu","doi":"10.9734/bpi/tipr/v10/11083d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/11083d","url":null,"abstract":"Objective: To study the hepatoprotective effect of aqueous extract of Vernonia amygdalina on acetaminophen-induced liver damage in abino wistar rats. \u0000Methods: Twenty five (25) albino rats weighing (120±20 g) were randomly divided into five (5) groups with five (5) rats per group. Group A served as normal control and received no treatment. Group B received only a single dose of acetaminophen (750 mg/kg, i.p) and served as negative control . Group C served as positive control and received Vitamin C (200 mg/kg, oral)  for 2 weeks, while  Group D and E served as the test groups and received aqueous bitter leaf extract; high dose (500mg/kg,oral) and low dose (250mg/kg, oral) separately for 2 weeks following acetaminophen challenge. \u0000Results: The administration of single dose of acetaminophen (750 mg/kg, i.p) resulted in liver damage with AST, ALT and ALP levels: 48.33±10.14U/L, 60.00±13.23U/L and 229.67±23.38U/L respectively. The treatment with bitter leaf resulted in a reversal of the acetaminophen-induced liver damage with AST, ALT and ALP levels: 20.67±1.76U/L (P<0.05), 16.67±3.52U/L (P<0.01) and 131.67±7.27U/L (P<0.01) respectively when compared with acetaminophen alone. Histopathological results also showed minor or non significant hepatocellular damage in the test groups; hence hepatoprotection by Vernonia amygdalina. \u0000Conclusion: The aqueous extract of Vernonia amygdalina possesses hepatoprotective properties against acetaminophen-induced liver damage.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76568074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Efficacy and Safety of Teneligliptin and Metformin Versus Glimepiride and Metformin in Patients of Type-2 Diabetes Mellitus Uncontrolled with Monotherapy","authors":"N. Hans","doi":"10.9734/bpi/tipr/v10/11701d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/11701d","url":null,"abstract":"","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90116494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Performance Liquid Chromatography (HPLC) Partially Purified Lantadene B Bioactive Pentacylic Triterpenoid from Lantana camara var. aculeate Leaves and It’s Trypanicidal Activity","authors":"Shaba Peter, S. Prakash, Pandy Nitish Nerender, Sahab Dey, J. Rao, Singh Raj Kumar, Bhanuprakash Veerakyathappa, Chaudary Pauload","doi":"10.9734/bpi/tipr/v10/7218d-1","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/7218d-1","url":null,"abstract":"","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90071646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concept of Poison in Ayurveda","authors":"D. Goswami","doi":"10.9734/bpi/tipr/v10/10852d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/10852d","url":null,"abstract":"Poison is a substance that is harmful to the living organisms in all respects. It can even cause immediate death of the exposed. Ayurvedic authors mention one terminology \"BISHA\" that has close similarity with \"POISON\" mentioned in the modern toxicology. A vivid description of Bisha is available in the Ayurvedic classics starting from definition, classification, properties, mode of action, signs and symptoms, treatment etc. The discussion on the route of entry and media through which poison can be given to a targetted human / animal is also attractive. The Ayurvedic authors also have given guidance to the Toxicologists (Bishavaidya) on the procedures of prognostitization of a patient of poisoning. Each and every principle of the Ayurvedic scholars needs study and evaluation through the modern techniques to make the modern socity convinced .","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80090717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on Synthesis of N-1 Fused Heterocyclic Derivatives Using Potassium Carbonate and PEG- 400 as Green Catalyst","authors":"Anjali M. Wanegaonkar, M. Bhitre","doi":"10.9734/bpi/tipr/v10/11966d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/11966d","url":null,"abstract":"Due to their synthetic utility and extensive variety of pharmacological effects, indole and benzimidazole, as well as their substituted derivatives, help to draw interest. The N-substituted fused heterocyclic compounds are usually physiologically active and could be employed as antitumor medicines. The various reactions reported that reactions of K2CO3 showing its essentiality for a particular reaction due to its characteristics like solubility in water, mild base character, easy availability, eco-friendly, and nontoxic in nature. In the presence and absence of phase transfer catalyst such as PEG-400 and TEBAC, the effect of the ratio of catalyst used anhydrous K2CO3 for its N-1 alkylation or arylation of indole-3-carboxaldehyde and 2-acetylbenzimidazole is observed. The ratio 1:4 of anhydrous K2CO3 along with PEG-400 gives, ease of catalyst handling, mild reaction conditions and reactions carried out at 10-15oC temperature with excellent yields. The simplicity of the approach makes it attractive for the synthesis of N-fused heterocyclic derivatives that could be employed as biological substitutes.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73855097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tomato (Lycopersicon esculentum) Extracts Elicit Anti-Hepatotoxic Effects on Acetaminophen-Induced Liver Injury in Albino Wistar Rat","authors":"I. Uchendu, C. Agu, O. C. Orji, Ebuka Bitrus Nnedu, C. Arinze, A. Uchenna, U. Okongwu","doi":"10.9734/bpi/tipr/v10/11084d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/11084d","url":null,"abstract":"Introduction: It has been extensively reported that drug-overdose is the leading cause of liver injury in the world today. Diets rich in natural antioxidants have been observed to offer substantial remedy to drug-induced organ injuries. \u0000Objective: The aim of this study was to investigate the hepatoprotective effects of tomato extract against Acetaminophen-induced acute hepatotoxicity in rats. \u0000Methods: Phytochemical analyses were performed. A total of 24 albino rats weighing (110±10 g) were randomly allocated to four groups (A-D), with six rats per group. Group A was the normal control and received no treatment. Group B was the negative control and received a single dose of acetaminophen (750 mg/kg, i.p) only. Group C served as test group and received a single dose of acetaminophen (750 mg/kg, i.p.) before treatment with tomato extract (30 mg/kg, oral) for 14 consecutive days. Group D received simultaneous administration of tomato extract (30 mg/kg, oral) and acetaminophen (750 mg/kg, i.p) for 14days. \u0000Results: The single dose of Acetaminophen caused liver cell injuries with significant increase in the levels of the liver enzymes: AST (67.67±11.41U/L); ALT (46.33±10.59U/L) and ALP (223.70±23.31U/L) in rats in negative control when compared with normal (p<0.05 or p<0.01). The daily administration of the tomato extract was able to attenuate the acetaminophen-induced hepatotoxicity on the liver enzyme marker levels: In Group C: AST (23.00± 3.61U/L, P<0.01); ALT (17.67± 3.48U/L, P<0.05) and ALP (121.30±8.11U/L, P<0.01). In Group D, AST (26.67±2.91U/L, P<0.01); ALT (18.67±1.76 U/L, P<0.05) and ALP (124.72±9.33U/L, P<0.01) when compared with negative control group. The histological results also revealed no significant liver injury in the groups that received tomato extract when compared with the normal control. \u0000Conclusion: Tomato extract possesses hepatoprotective ability against acetaminophen-induced liver injury.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79255346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Phytochemical Screening and Antifungal Activity of Stem of Argyreia speciosa Linn. F","authors":"Bharti Khichi, Ravindra Sunaniya, Prachi Mehta, Hemant M Joshi","doi":"10.9734/bpi/tipr/v10/11594d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/11594d","url":null,"abstract":"In Indian medicine, Argyreia speciosa is a highly effective medicinal plant.It has traditionally been used to treat a variety of human ailments and disorders. The antifungal activity of aqueous, ethanolic, chloroform, and petroleum ether extracts of A. speciosa against Candila albicans was investigated in this study. The ethanolic extract and petroleum ether extract were shown to have high activity against the tested fungal strain, whereas the aqueous extract had very little activity and the chloroform extract had no activity. Ethanolic extract showed the potent antifungal activity as compared to other extract and the Zone of inhibition of test drug is compared to standard.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79900920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Utilization Study in a Tertiary Care Hospital of Tribal Area in South India","authors":"Ajay Khade, J. Khade, M. Bashir","doi":"10.9734/bpi/tipr/v10/2876f","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/2876f","url":null,"abstract":"Due to the irrational use of drugs, we are facing numerous problems of overuse, misuse, increased cost, antibiotic resistance etc. The present study was conducted in a tertiary hospital in which the patients are referred from surrounding rural and tribal areas. It is a retrospective study that included the patients admitted in clinical departments. A total of 200 patients (Males 41.5% and Females 58.5%) were included and their case records were reviewed. Most of the patients belong to age group < 30 years. The average No. of drugs per prescription was 4.76.Intravenous route was commonly used. The dose of the drug was inappropriate in 38% patients and inappropriate frequency in 3% cases. It was found that the most commonly prescribed group of drugs was antimicrobial agents (41.53%) with Ampicillin (53.01%) as the most commonly prescribed antimicrobial agent. Culture and Sensitivity was not conducted in any of the patient. Single antimicrobial agent was prescribed in 42% cases and combination of 2 antimicrobial agents in 38% cases. Thus, the drug utilisation in patients included in the study is not rational and hence, many recommendations were suggested.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90607219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Cannabis Compounds: An approach to Pharmacotherapy for Epilepsy in Children","authors":"M. Babayeva, P. Basu, Z. Loewy","doi":"10.9734/bpi/tipr/v10/3581f","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v10/3581f","url":null,"abstract":"Epilepsy in children is a complex disease, with a variety of distinct syndromes and many alternative treatment options. Even with a plethora of available treatment options, childhood epilepsies are commonly associated with seizures that are resistant to existing treatment methods. Treatment of pediatric epilepsy is challenging and requires more effective therapy to avoid short-term and long-term neurological disorders. Marijuana has been used to treat disease since ancient times. Marijuana ingredients Cannabidiol (CBD) and D9-Tetrahydrocannabinol (THC) have created a significant research interest as potential therapy options in epilepsy treatment. THC is the major psychoactive component of marijuana that aids in reducing epileptic seizures. CBD has proven to have anticonvulsant effect not only in experimental models but also in clinical studies. Research studies have provided strong evidence for safety and anticonvulsant properties of medical marijuana. Principal concerns regarding the use of medical marijuana in children include lack of standardization and regulation, imprecise dosing, possible adverse side effects and medication interactions.","PeriodicalId":22326,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 10","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86147365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}