G. Pîrcălăbioru, B. Tihauan, Mădălina Axinie, A. Ivanof, S. Maier
{"title":"NANOFIBER MESHES FOR ABDOMINAL HERNIA REPAIR – \u0000CHALLENGES AND OPPORTUNITIES","authors":"G. Pîrcălăbioru, B. Tihauan, Mădălina Axinie, A. Ivanof, S. Maier","doi":"10.35530/tt.2019.40","DOIUrl":"https://doi.org/10.35530/tt.2019.40","url":null,"abstract":"Implantation of any prosthetic material triggers a cascade of events that mark the \u0000initiation of the healing process. In the case of abdominal mesh implantation, the course of \u0000inflammation and wound healing are paramount. The biomaterials employed as a medical device\u0000are in close proximity with devitalized tissue parts which can promote microbial colonization \u0000resulting in infection and subsequently impaired wound healing. The advent of nanofiber \u0000based systems provides novel opportunities to develop hernia meshes with increased \u0000biocompatibility and good material strength. Electrospun nanofiber matrices exhibit morphological \u0000similarities to the natural extra-cellular matrix (ECM), with ultrafine continuous fibers, high \u0000porosity high surface-to-volume ratio, and variable pore-size distribution. This mini review \u0000summarizes the advantages and challenges associated to nanofiber systems.","PeriodicalId":22214,"journal":{"name":"TEXTEH Proceedings","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78122688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}