Terapevticheskii Arkhiv最新文献_第8页

[Modern concept of differential diagnosis of colitis: from G.F. Lang to the present day. A review]. [结肠炎鉴别诊断的现代概念：从 G.F. Lang 到今天。综述]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202496

A I Parfenov, A V Kagramanova, S G Khomeriki, D S Kulakov

{"title":"[Modern concept of differential diagnosis of colitis: from G.F. Lang to the present day. A review].","authors":"A I Parfenov, A V Kagramanova, S G Khomeriki, D S Kulakov","doi":"10.26442/00403660.2023.12.202496","DOIUrl":"10.26442/00403660.2023.12.202496","url":null,"abstract":"The aim of the article is to improve the differential diagnosis of specific and nonspecific inflammatory bowel diseases. In Russia, this scientific direction is associated with the name of G.F. Lang, who performed in 1901-1902 the study \"On ulcerative inflammation of the large intestine caused by balantidiasis\". The etiology of specific colitis is associated with infection with parasites, bacteria and viruses that cause inflammation of the intestinal wall, diarrhea, often with an admixture of mucus, pus and blood. Specific colitis (SC) may be accompanied by fever, abdominal pain, and tenesmus. Bacterial colitis is commonly caused by Salmonella, Shigella, Escherichia coli, Clostridium difficile, Campylobacter jejuni, Yersinia enterocolitica, and Mycobacterium tuberculosis. Viral colitis is caused by rotavirus, adenovirus, cytomegalovirus, and norovirus. Parasitic colitis can be caused by Entamoeba histolytica and balantidia. In gay people, SC can cause sexually transmitted infections: Neisseria gonorrhoeae, Chlamydia trachomatis, and treponema pallidum, affecting the rectum. Stool microscopy, culture, and endoscopy are used to establish the diagnosis. Stool culture helps in the diagnosis of bacterial colitis in 50% of patients, and endoscopic studies reveal only nonspecific pathological changes. Differential diagnosis of SC should be carried out with immune-inflammatory bowel diseases (ulcerative colitis, Crohn's disease, undifferentiated colitis), radiation colitis and other iatrogenic bowel lesions. The principles of diagnosis and therapy of inflammatory bowel diseases associated with various etiological.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"1022-1030"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Predictive capability of Cys112Arg single nucleotide polymorphisms of the apolipoprotein E gene in assessing the risk of immediate and early post-traumatic seizures]. [载脂蛋白 E 基因 Cys112Arg 单核苷酸多态性在评估创伤后即刻和早期癫痫发作风险中的预测能力]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202492

K K Kriukova, E V Alexandrova, O N Voskresenskaya, V V Podlepich, A D Kravchuk, E I Rytkin, Y A Latyshev, D A Kudlay, S S Sologova, S A Albagachiev, M A Mandrik

{"title":"[Predictive capability of Cys112Arg single nucleotide polymorphisms of the apolipoprotein E gene in assessing the risk of immediate and early post-traumatic seizures].","authors":"K K Kriukova, E V Alexandrova, O N Voskresenskaya, V V Podlepich, A D Kravchuk, E I Rytkin, Y A Latyshev, D A Kudlay, S S Sologova, S A Albagachiev, M A Mandrik","doi":"10.26442/00403660.2023.12.202492","DOIUrl":"10.26442/00403660.2023.12.202492","url":null,"abstract":"This study is aimed at investigating epileptic seizures, one of the consequences of traumatic brain injury (TBI). Immediate and early post-traumatic seizures, as well as late post-traumatic epileptic seizures or post-traumatic epilepsy, can have different pathogenetic bases. The following key risk factors associated with post-traumatic epilepsy are known: duration of unconsciousness, gunshot wounds, intracranial hemorrhage, diffuse axonal injury, prolonged (more than 3 days) post-traumatic amnesia, acute subdural hematoma with surgical evacuation, immediate and early post-traumatic epileptic seizures, fracture of the skull bones. The role of genetic factors in post-traumatic seizures is poorly understood due to the complexity and multiple causal mechanisms. This paper addresses the role of genetic factors in the occurrence and severity of epileptic events in patients with TBI. In particular, we investigated the role of the Cys112Arg single nucleotide polymorphism of the apolipoprotein E gene. Apolipoprotein E is known for its role in the transport and metabolism of lipids and, therefore, the development of cardiovascular diseases; it is also associated with Alzheimer's disease and has recently been studied in the context of association with epilepsy. The study shows an association between this polymorphism and the risk of immediate and early epileptic seizures in patients with severe TBI.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"1128-1132"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning]. [标准化胎盘水解物肽对线粒体功能影响的分子机制]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202494

I Y Torshin, O A Gromova, O V Tikhonova, A G Chuchalin

{"title":"[Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning].","authors":"I Y Torshin, O A Gromova, O V Tikhonova, A G Chuchalin","doi":"10.26442/00403660.2023.12.202494","DOIUrl":"10.26442/00403660.2023.12.202494","url":null,"abstract":"Background: Human placenta hydrolysates (HPH), the study of which was initiated by the scientific school of Vladimir P. Filatov, are currently being investigated using modern proteomic technologies. HPH is a promising tool for maintaining the function of mitochondria and regenerating tissues and organs with a high content of mitochondria (liver, heart muscle, skeletal muscles, etc.). The molecular mechanisms of action of HPH are practically not studied.Aim: Identification of mitochondrial support mitochondrial function-supporting peptides in HPH (Laennec, produced by Japan Bioproducts).Materials and methods: Data on the chemical structure of the peptides were collected through a mass spectrometric experiment. Then, to establish the amino acid sequences of the peptides, de novo peptide sequencing algorithms based on the mathematical theory of topological and metric analysis of chemographs were applied. Bioinformatic analysis of the peptide composition of HPH was carried out using the integral protein annotation method.Results: The biological functions of 41 peptides in the composition of HPH have been identified and described. Among the target proteins, the activity of which is regulated by the identified peptides and significantly affects the function of mitochondria, are caspases (CASP1, CASP3, CASP4) and other proteins regulating apoptosis (BCL2, CANPL1, PPARA), MAP kinases (MAPK1, MAPK3, MAPK4, MAPK8, MAPK9 , MAPK10, MAPK14), AKT1/GSK3B/MTOR cascade kinases, and a number of other target proteins (ADGRG6 receptor, inhibitor of NF-êB kinase IKKE, pyruvate dehydrogenase 2/3/4, SIRT1 sirtuin deacetylase, ULK1 kinase).Conclusion: HPH peptides have been identified that promote inhibition of mitochondrial pore formation, apoptosis, and excessive mitochondrial autophagy under conditions of oxidative/toxic stress, chronic inflammation, and/or hyperinsulinemia.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"1133-1140"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Current antiretroviral therapy: A review]. [当前的抗逆转录病毒疗法：综述]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202499

A V Kravchenko, V V Maleyev

{"title":"[Current antiretroviral therapy: A review].","authors":"A V Kravchenko, V V Maleyev","doi":"10.26442/00403660.2023.12.202499","DOIUrl":"10.26442/00403660.2023.12.202499","url":null,"abstract":"The article presents an overview of clinical recommendations for currant antiretroviral therapy. Currently, the current preferred first-line antiretroviral therapy regimens are combinations of 2 or 3 antiretroviral drugs (ARVs) in one tablet with a frequency of administration 1 time per day and, as a rule, include drugs of the 2nd generation (integrase inhibitors or non-nucleoside reverse transcriptase inhibitors). These schemes have high efficiency and a good genetic barrier in the development of HIV resistance mutations. HIV protease inhibitors are used as alternative regimens. Schemes with the least number and spectrum of side effects, no effect on metabolic processes and minimal drug interactions have advantages. Switching patients to injectable therapy regimens with a frequency of administration of drugs once every 2 months can significantly improve the quality of life of patients and, accordingly, adherence to their treatment. The development and introduction of new classes of ARVs into clinical practice ensures the suppression of HIV replication in most patients with HIV strains resistant to drugs of the main groups of ARVs (nucleoside/nucleotide reverse transcriptase.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"625324"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Inflammatory bowel diseases: Transformation of representations. A review]. [炎症性肠病：表象的转变。综述]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202507

I V Maev, I G Bakulin, M I Skalinskaya, E V Skazyvaeva

{"title":"[Inflammatory bowel diseases: Transformation of representations. A review].","authors":"I V Maev, I G Bakulin, M I Skalinskaya, E V Skazyvaeva","doi":"10.26442/00403660.2023.12.202507","DOIUrl":"10.26442/00403660.2023.12.202507","url":null,"abstract":"The global burden of inflammatory bowel disease (IBD) is currently significant and continues to grow due to the increasing prevalence of ulcerative colitis (UC) and Crohn's disease (CD), the increasing costs of diagnosis and treatment, and the high level of disability in patients with this disease. Categories, which leads to the search for risk factors and predictors of aggressive course and extraintestinal manifestations. According to the latest data, the prevalence of UC in Russia is 16.6 per 100 000 population, the annual registered increase is 11.3%; the prevalence of CD is 5.6 per 100 000 population, and the increase is 13.7%. In the Russian population of patients with IBD, the average age of disease onset is 35.3 years for UC and 31.2 years for CD. Moreover, in 89.3% of patients with UC, it took at least 2 years to verify the diagnosis, and in CD, within 2 years from the onset of clinical symptoms, the diagnosis was established in only 72.6% of patients. One of the dominant characteristics of IBD is its multisystem nature, which leads to the development of extraintestinal manifestations (ECM), which can be observed in 50-60% of patients, while up to 25% of patients with IBD have several EMC and the most common variants are joint lesions. A higher frequency of extraintestinal manifestations is observed in CD (up to 45% of patients), in female patients, in smokers and with a longer duration of the disease. To predict clinical remission, the level of fecal calprotectin and CRP, the need for glucocorticosteroids are important, to predict endoscopic remission - the level of fecal calprotectin, and to predict histological remission, an endoscopic Schroeder index value of ≤1 is important. The absolute risk of developing colorectal cancer in IBD remains relatively low, ranging from 1.1 to 5.4% after 20 years of disease. The main risk factors for IBD are total intestinal damage, high inflammatory activity, the stricturing phenotype of CD and the presence of primary sclerosing cholangitis.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"1064-1074"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Vascular complications of diabetes mellitus worldwide and in Russia: The path of 100 years. A review]. [全世界和俄罗斯的糖尿病血管并发症：百年之路。综述]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202498

M V Shestakova, A S Severina

引用次数: 0

[Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report]. [肾上腺皮质癌：一个临床病例的晚期诊断。病例报告]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202430

E A Starostina, N V Molashenko, A R Levshina, N V Pachuashvili, A Chevais, M P Isaeva, K V Getazheev, D G Beltsevich, N M Platonova, E A Troshina

{"title":"[Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report].","authors":"E A Starostina, N V Molashenko, A R Levshina, N V Pachuashvili, A Chevais, M P Isaeva, K V Getazheev, D G Beltsevich, N M Platonova, E A Troshina","doi":"10.26442/00403660.2023.12.202430","DOIUrl":"10.26442/00403660.2023.12.202430","url":null,"abstract":"Adrenocortical carcinoma (ACC) is a rare malignant tumor originating in the adrenal cortex and characterized by poor 5-year survival. It occurs with a frequency of 2-4 cases per 2 million in the population. Women are more frequently affected than men and it is mostly detected in the fourth and fifth decades. In the most of cases, the cancerogenesis occurs sporadically because of gene driver mutations in somatic adrenocortical cells, in other cases it can be found as part of a genetically determined syndrome such as Li-Fraumeni syndrome or Wermer's syndrome (multiple endocrine adenomatosis type I). ACC most frequently happens occurs without symptoms in the initial stages leading to poor diagnoses. Because of this lack of early detection, the tumor is not considered malignant reducing the benefits of further treatment. Sometimes the fact that the resected tumor is indeed adrenocortical carcinoma becomes clear only after recurrence, or after the appearance of metastases. We present a case of adrenocortical carcinoma in a 46-year-old woman who went to the doctor in 1.5 year after symptoms were manfested. This clinical case illustrates the consequences of late diagnosis of a malignant tumor. We would like to emphasize the importance of timely detection of a neoplasm, using all of the potential of laboratory-instrumental and genomic analysis. Due to low oncological awareness, our patient was slow to seek medical help, which in turn led not only to metastases, but also to complications in the cardiovascular system.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"1179-1184"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D₃ and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint]. [未变性 II 型胶原蛋白、乳香酸、甲磺酰甲烷、维生素 C 和 D3 复方制剂与硫酸软骨素和盐酸氨基葡萄糖复方制剂在治疗膝关节原发性骨关节炎方面的疗效比较]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202540

V I Mazurov, I B Belyaeva, E A Trofimov, I E Itskovich, A L Burulev

{"title":"[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D3 and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint].","authors":"V I Mazurov, I B Belyaeva, E A Trofimov, I E Itskovich, A L Burulev","doi":"10.26442/00403660.2023.12.202540","DOIUrl":"10.26442/00403660.2023.12.202540","url":null,"abstract":"Aim: To evaluate the efficacy of Artneo (AN) in comparison with a combination of glucosamine hydrochloride and chondroitin sulfate (GC) in patients with osteoarthritis (OA) of the knee joint (KJ).Materials and methods: 70 patients with stages I-III of primary knee OA were randomized into 2 groups. Participants in the 1st (n=35) took AN 1 caps/day, in the 2nd (n=35) GC according to the standard regimen. After 7, 30, 90, 180 days, the Lequesne index (severity of OA), pain when moving according to VAS, WOMAC score were assessed, after 1, 3, 6 months - quality of life SF-36 and morning stiffness, after 6 months - MRI with T2 mapping, laboratory safety indicators.Results: Over the course of 6 months of use, an improvement in the WOMAC index and a decrease in pain were observed without intergroup differences, and a greater decrease in stiffness in the AN group. After 3 months, the severity of OA decreased from moderate to mild in the AN group and was significantly lower compared to the GC group; quality of life (physical component of SF-36) was higher in the AN group. After 6 months, there was an improvement in cartilage ultrastructure (T2 relaxation time) in both groups and a more pronounced reduction of the synovitis area (MRI) in the AN group (2.95 and 1.37 times in the AN and GC group, respectively). There were no clinically significant adverse reactions observed in both groups.Conclusion: The use of AN in patients with stage I-III primary knee OA was not inferior in efficacy to the combination of GC. Further studies with greater statistical power (sample size) and follow-up period are warranted including in real clinical practice.","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"95 12","pages":"1141-1150"},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[On the use of type I tropocollagen for local injection therapy of spine, upper and lower extremity disorders]. [关于使用 I 型托品胶原蛋白对脊柱、上肢和下肢疾病进行局部注射治疗]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202533

S Y Biryukov, N A Vinogradova, Y G Kolesnikov, L A Levashova, O V Markovskaya, D I Moroz, V B Pastel, A V Chantsev, V A Shirokov, G I Shcherbakov

引用次数: 0

[Pulmonary heart: A review]. [肺心病：综述]。

IF 0.3 4区医学

Terapevticheskii Arkhiv Pub Date : 2023-12-28 DOI: 10.26442/00403660.2023.12.202497

A G Chuchalin

引用次数: 0