German Journal of Microbiology最新文献_第3页

COVID-19: Risk assessment and mitigation measures in healthcare and non-healthcare workplaces COVID-19:卫生保健和非卫生保健工作场所的风险评估和缓解措施

German Journal of Microbiology Pub Date : 1900-01-01 DOI: 10.51585/gjm.2021.2.0007

M. Fawzy, Ahmed Hasham, Mohamed H Houta, M. Hasham, Yosra A. Helmy

{"title":"COVID-19: Risk assessment and mitigation measures in healthcare and non-healthcare workplaces","authors":"M. Fawzy, Ahmed Hasham, Mohamed H Houta, M. Hasham, Yosra A. Helmy","doi":"10.51585/gjm.2021.2.0007","DOIUrl":"https://doi.org/10.51585/gjm.2021.2.0007","url":null,"abstract":"The coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is the third emerging human coronavirus, leading to fatal respiratory distress and pneumonia. The disease originated in December 2019 in Wuhan City, Hubei province, China. As of 23 November 2021, over 258 million cases and 5.1 million deaths have been reported in more than 222 countries and territories worldwide. The COVID-19 is under biological hazards group 4 of high risk of spreading to the community with the potential to overwhelm the health system, especially in resource limited countries. Transmission of COVID-19 within healthcare and non-healthcare facilities has been recorded. Therefore, several authorities such as the World Health Organization (WHO), the Centers for Disease Control and Prevention (CDC), and other global partners issued guidance to mitigate the COVID-19 pandemic in these facilities. A global emergency due to the COVID-19 pandemic requires various studies of mitigation measures and risk assessment. The Failure Mode and Effects Analysis (FMEA) was used as a tool for risk assessment in healthcare and clinical fields that assigns a numerical value to each risk associated with failure. Therefore, in this review, the FMEA procedure was used to evaluate the COVID-19 risks and risk groups in health care and non-healthcare workplaces. Proposed mitigation measures and risk ranking tools were also summarized. The COVID-19 transmission risk should be theoretically and practically reduced by applying the best hygienic practices. However, providing safe work practices must be improved for infection control measures in healthcare and non-healthcare workplaces. Additionally, it is recommended to reassess the risk of COVID-19 infection from time to time, especially after vaccines availability.","PeriodicalId":222095,"journal":{"name":"German Journal of Microbiology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126547669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Comparative study on Toxoplasma gondii dense granule protein 7, peroxiredoxin 1 and 3 based on bioinformatic analysis tools 基于生物信息学分析工具的刚地弓形虫致密颗粒蛋白7、过氧化物还氧蛋白1和3的比较研究

German Journal of Microbiology Pub Date : 1900-01-01 DOI: 10.51585/gjm.2022.1.0013

Ragab M Fereig, H. Abdelbaky

{"title":"Comparative study on Toxoplasma gondii dense granule protein 7, peroxiredoxin 1 and 3 based on bioinformatic analysis tools","authors":"Ragab M Fereig, H. Abdelbaky","doi":"10.51585/gjm.2022.1.0013","DOIUrl":"https://doi.org/10.51585/gjm.2022.1.0013","url":null,"abstract":"Toxoplasmosis remains a devastating protozoan disease induced by Toxoplasma gondii (T. gondii) that induces extreme hazards in both medical and veterinary fields. Our previous studies revealed the high immunogenicity and antigenicity of T. gondii peroxiredoxin (TgPrx) 1, 3, and TgGRA7. Herein, the comparison of TgPrx1, TgPrx3, and TgGRA7 was conducted using bioinformatics analysis tools. In this computational comparison, the physico-chemical, morphometric, immunogenic, and antigenic properties were analyzed. Analyses of complete coding sequences showed the probability of signal peptides and transmembrane domains only in the case of TgGRA7. NetPhos server-based prediction revealed 23, 11, and 39 phosphorylation sites in TgGRA7, TgPrx1, and TgPrx3 proteins, respectively. The secondary structure of TgGRA7, TgPrx1, and TgPrx3 proteins were analyzed by PSIPRED servers. The percentage of the random coil and alpha-helix amino acids was higher in TgGRA7 (99.15%), followed by TgPrx3 (85.87%) and TgPrx1 (77.55%). The antigenic epitopes of the protein were predicted by analyzing the features of the IEDB server. The linear B-cell epitope regions prediction of TgGRA7 showed the maximum estimated length (118 amino acid residues). In addition, antigenicity and hydrophilicity index showed similar tendencies among the three tested proteins, TgGRA7, TgPrx1, and TgPrx3. Thus, the current computational analyses represented TgGRA7, TgPrx1, and TgPrx3 proteins as efficient diagnostic and vaccine candidates suggesting further research and assessments. Additional validation of bioinformatic analysis tools in predicting potent diagnostic and vaccine antigens will greatly contribute to the success of control policies against T. gondii and other infectious agents.","PeriodicalId":222095,"journal":{"name":"German Journal of Microbiology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122039048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Influenza and coronavirus zoonoses: an overview on pandemic events, viral genome, replication and emergency preparedness 流感和冠状病毒人畜共患病:大流行事件、病毒基因组、复制和应急准备概述

German Journal of Microbiology Pub Date : 1900-01-01 DOI: 10.51585/gjm.2022.3.0016

R. Parvin, I. Hossain, Alamgir Hasan, S. Afrin, A. Shehata

{"title":"Influenza and coronavirus zoonoses: an overview on pandemic events, viral genome, replication and emergency preparedness","authors":"R. Parvin, I. Hossain, Alamgir Hasan, S. Afrin, A. Shehata","doi":"10.51585/gjm.2022.3.0016","DOIUrl":"https://doi.org/10.51585/gjm.2022.3.0016","url":null,"abstract":"Influenza and coronaviruses, zoonotic respiratory RNA viruses, cause global pandemics with major public health issues. These viruses exist as quasispecies due to the to rapid evolution driven by their error-prone viral RNA polymerases and/or genomic organizations. They also show similar waves of infections/cases during the pandemic. However, there are some dissimilarities like severe disease in coronaviruses is due to cytokine-induced hyperactivity of the immune system, while secondary bacterial infection is a significant cause of death in influenza. Furthermore, unlike coronavirus, the segmented nature of influenza virus genome makes it easier for new strains to emerge through genetic reassortment, making its prevention and control more difficult. In this mini-review, we summarize the historical events of influenza and coronavirus pandemics or epidemics and the roles played by RNA viral genomes and pathogenesis in modulating viral evolution and generation of pandemic strains. Collectively, influenza and coronavirus diagnostics, vaccination, and other measures are critical for mitigating and controlling future pandemics. These pandemics might be regarded as a wake-up call to prepare us for future disasters","PeriodicalId":222095,"journal":{"name":"German Journal of Microbiology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125321813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The German Journal of Microbiology; towards dissemination and globalization of microbiology research 德国微生物学杂志;迈向微生物学研究的传播和全球化

German Journal of Microbiology Pub Date : 1900-01-01 DOI: 10.51585/gjm.2021.0001

引用次数: 0

Special Issue: Existence Battle: Viruses vs. Creatures 特刊:生存之战:病毒与生物

German Journal of Microbiology Pub Date : 1900-01-01 DOI: 10.51585/gjm.2021.2

引用次数: 0