Sexual health最新文献

{"title":"Corrigendum to: Culture yield of Neisseria gonorrhoeae: culture yield varies by anatomical site and time to culture collection.","authors":"Jun Jung, Marcus Y Chen, Norelle L Sherry, Vesna De Petra, Christopher K Fairley, Eric P F Chow","doi":"10.1071/SH25242_CO","DOIUrl":"10.1071/SH25242_CO","url":null,"abstract":"","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"23 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel and validated survey explores quality of life outcomes in transgender women following vaginoplasty.","authors":"Alyxandra Ramsay, Martha MacDonald, Lily Leibner, Lara Finnerty-Haggerty, Jo Blankson, Joshua D Safer, Andrew Yang, John Henry Pang","doi":"10.1071/SH25169","DOIUrl":"10.1071/SH25169","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate patient-reported outcomes following vaginoplasty in transgender individuals using a novel and validated Affirming Surgery Form and Function Individual Reporting Measure.</p><p><strong>Methods: </strong>A total of 279 transgender patients completed the Affirming Surgery Form and Function Individual Reporting Measure survey, reporting on their experiences with feminizing gender-affirming surgery outcomes (F-GAS). Surveys were given to patients via email before F-GAS, at 2 weeks, 6 months and 12 months post-operatively. Pre- and post-F-GAS responses were compared using Wilcoxon signed-rank tests. All participants voluntarily completed the same survey using the Visiontree platform to eliminate bias.</p><p><strong>Results: </strong>Before F-GAS, ~3% of respondents reported positive feelings about their genitals, ~18% reported comfort with a sexual partner seeing their genitals, ~1% reported the absence of embarrassment regarding their genitals and ~1% reported that their genitals matched their gender identity. Six months after surgery, the percentages rose to ~85% (P < 0.001), ~77% (P < 0.001), 66% (P < 0.001) and ~85% (P < 0.001), respectively. Before F-GAS, ~78% of respondents reported they could not dress as desired because of the appearance of their genitals, and 83% reported the appearance of their genitals prevented them from doing some enjoyable activities. Six months after surgery, the percentages fell to ~3% (P < 0.001), and ~7% respectively (P < 0.001).</p><p><strong>Conclusions: </strong>Gender-affirming surgeries, such as vaginoplasty, are associated with dramatic quality of life improvement in transgender people. All six gender identity metrics measured by the validated Affirming Surgery Form and Function Individual Reporting Measure survey showed unequivocal benefits following vaginoplasty.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anal symptoms and high-grade squamous intraepithelial lesions in patients from the Anal Neoplasia Clinic of Puerto Rico.","authors":"Maribel Tirado-Gómez, Jeslie M Ramos-Cartagena, Tanialy Rivera-Santiago, Darilyn Rivera-Collazo, Cristina Muñoz, Ana P Ortiz","doi":"10.1071/SH25075","DOIUrl":"10.1071/SH25075","url":null,"abstract":"<p><strong>Background: </strong>Anal cancer can cause several symptoms, such as anal bleeding, pain or lumps. Although high-grade squamous intraepithelial lesions (HSIL) are precursors of anal cancer, scarce information exists regarding its association with anal symptomatology. This study aims to assess anal symptoms and their association between anal squamous intraepithelial lesions and HSIL in a Hispanic high-risk population, as well as predictors of anal symptoms.</p><p><strong>Methods: </strong>Data from the baseline visit of patients attending the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center (September 2016-December 2023) was analyzed. Anal cancer screening was performed and the presence of seven self-reported anal symptoms were assessed at the clinical visit. Logistic regression analyses were performed to evaluate the association of anal symptoms with HSIL by HIV status, as well as predictors of anal symptoms.</p><p><strong>Results: </strong>Among 872 patients, 69.0% were people living with HIV. HSIL prevalence was 41.7%. Prevalence of self-reported anal symptoms was 19.5%; the most common symptoms were bleeding (6.6%), pain or discomfort (5.3%) and lump (4.2%). On multivariable adjusted analysis, HSIL was not associated with having anal symptoms. However, current smoking (OR 1.12, 95% CI 1.04-1.20), having hemorrhoids (OR 1.08, 95% CI 1.02-1.14) and anal warts (OR 1.15, 95% CI 1.07-1.23) were associated with higher odds of anal symptoms.</p><p><strong>Conclusion: </strong>Our results suggest that anal symptoms are not good predictors for HSIL, and that smokers and those with benign anal conditions have increased anal symptomatology. These results highlight the importance of systematic anal cancer screening for prevention and early detection.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Youth advisory board engagement in HIV research in low- and middle-income countries: a scoping review and additional youth perspectives.","authors":"Kelechi P Chima, Jenna R Durham, Chelsea Mazonde, Evergisrael Kyalo, Rachel Mtei, Sarah Ndelema Owino, Angelina Goi, Chibeka Mukuka, Susan Vorkoper","doi":"10.1071/SH25178","DOIUrl":"10.1071/SH25178","url":null,"abstract":"<p><strong>Background: </strong>Engaging young people (10-24 years old) in research has been shown to improve the uptake and impact of HIV interventions in youth. However, how youth are engaged in Youth Advisory Boards (YABs) in low- and middle-income countries (LMICs) remains under-explored. Therefore, we conducted a scoping review and reflected on YAB members' experiences to examine YABs in youth HIV research.</p><p><strong>Methods: </strong>We conducted this study using a two-phase process. In phase one, we conducted a scoping review searching seven literature databases for peer-reviewed articles published in English between 2014 and 2024 that reported on YABs embedded within youth HIV research focused on people aged 10-24 years in LMICs. Data were synthesised to describe YAB composition, roles, and activities as well as the extent and timing of youth engagement. Phase two included integrating the lived experiences of co-authors, youth advocates and early-career researchers with prior YAB involvement, to supplement and contextualise the findings.</p><p><strong>Results: </strong>Of 248 unique citations, 10 studies from five countries met the inclusion criteria. Most YABs (67%) included more than 10 members, and the majority (87%) consisted exclusively of youth. Membership age, where specified, ranged mostly 10-24 years old (80%). YAB activities included providing feedback on intervention design, community engagement, and implementation activities. Most studies reflected shared decision-making between youth and adults. However, youth involvement was typically limited to the 'Planning' and 'Conducting' phases of research. Youth engagement was not formally evaluated in any study.</p><p><strong>Conclusions: </strong>YABs are often used to support youth HIV research in LMICs, yet the nature and influence of their engagement remain under-evaluated. By integrating youth co-author reflections with published findings, this review highlights the need for more intentional, theory-informed, and sustained youth participation across all stages of research, as well as for the development and practical application of tailored evaluation frameworks.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"23 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual and gender minority stigma, and associations with perceived barriers to HIV testing and HIV testing behaviors among adolescents and young adults in Kazakhstan.","authors":"Hao Wen, Yihang Sun, Sara Landers, Gaukhar Mergenova, Olga Balabekova, Denis Gryazev, Alissa Davis","doi":"10.1071/SH25099","DOIUrl":"10.1071/SH25099","url":null,"abstract":"<p><strong>Background: </strong>Kazakhstan is experiencing a rising HIV epidemic, with adolescents and young adults (AYA) accounting for nearly one-quarter of new infections. However, HIV testing rates remain low, partly due to stigma, especially sexual and gender minority (SGM) stigma.</p><p><strong>Methods: </strong>We examined the prevalence and associations between SGM stigma, perceived barriers to HIV testing, and testing behaviors among 216 AYA in Almaty, Kazakhstan. The analysis used baseline survey data from enrolled RCT participants.</p><p><strong>Results: </strong>Results showed that male and heterosexual AYA reported significantly higher SGM stigma than female or SGM AYA. Regression analyses found that higher SGM stigma was associated with greater perceived barriers to HIV testing (β = 0.72, P < 0.001), but not with HIV testing uptake.</p><p><strong>Conclusions: </strong>These findings suggest that SGM stigma contributes to perceived barriers that discourage HIV testing. Given that current HIV stigma interventions may not adequately address gendered or sexual identity-related stigma, targeted strategies that address the intersection of SGM and HIV stigma among AYA, especially among males, are timely needed.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-screening for sexually transmissible infections and blood-borne viruses in New South Wales, Australia: a cost analysis.","authors":"Arthur Wong, Frances Turner, Rebecca Houghton, Rick Varma, Hteinn Linn Aung, Arun Menon, Charlotte Bell, Caroline Watts","doi":"10.1071/SH25107","DOIUrl":"10.1071/SH25107","url":null,"abstract":"<p><strong>Background: </strong>MyCheck is an e-testing pathway, first implemented at Sydney Sexual Health Centre, which enhances access to STI/HIV testing via telehealth and off-site sample collection; thus, reducing clinic visits. This study evaluates MyCheck's direct and indirect costs versus standard in-person screening (Xpress).</p><p><strong>Methods: </strong>A 12-month bottom-up cost analysis from a societal perspective compared MyCheck and Xpress. Direct medical (health system), direct non-medical (patient travel) and indirect non-medical (productivity) costs were calculated using retrospective Sydney Sexual Health Centre data. Costs included pathology, staff time, overheads, consumables, patient travel and forgone productivity. Statewide scale-up costs were estimated, with sensitivity analyses adjusting for inflation, minimum wage and an increase in the proportion of MyCheck users with productivity loss.</p><p><strong>Results: </strong>From January to July 2023, Sydney Sexual Health Centre conducted 2548 screening episodes (45% MyCheck, 55% Xpress), with MyCheck attracting more men who have sex with men/transgender and gender diverse patients. MyCheck's shorter appointments (median 5 min vs Xpress's 15 min) led to lower staff costs (A$5 vs A$16). MyCheck had higher overall health system cost (A$127/patient) compared with Xpress (A$91/patient), mostly due to pathology costs. However, considering patient travel cost and productivity loss for Xpress, MyCheck's societal cost (A$137) was lower than Xpress (A$146), yielding A$104,260 annual savings. Statewide scale-up provides significant societal savings (A$419,077/year).</p><p><strong>Conclusion: </strong>This analysis of MyCheck's direct and indirect costs compared with traditional in-person screening demonstrates significant societal savings, despite higher direct pathology costs. It underscores the importance of a broader societal perspective in cost analyses. Lowering private pathology costs could further enhance MyCheck's cost-effectiveness. MyCheck, an innovative e-screening pathway, reduces barriers for STI/blood-borne virus screening by improving patient convenience and reduced opportunity costs. Despite higher direct pathology costs, its societal cost savings support statewide scale-up for improved screening accessibility.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"23 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predicting STI-positive cervicitis and pelvic inflammatory disease, and implications on antibiotic use: a cross-sectional analysis.","authors":"Shreya Chawla, Rick Varma, Arthur Ka Chun Wong","doi":"10.1071/SH25221","DOIUrl":"10.1071/SH25221","url":null,"abstract":"<p><strong>Background: </strong>Clinical diagnoses of cervicitis and pelvic inflammatory disease (PID) are often subjective, and not all are associated with sexually transmitted infections (STI). Presumptive treatment for these syndromes may lead to unnecessary antibiotics in those subsequently found to be STI-negative. We investigated patient and clinician characteristics associated with accurately diagnosing bacterial STI-positive cervicitis and PID. We quantified the amount of unnecessary antibiotics prescribed in STI-negative cases.</p><p><strong>Methods: </strong>A cross-sectional study of 243 cervicitis and 179 PID patients presenting to Sydney Sexual Health Centre between January 2020 and 2023 was conducted. Patient demographics, sexual behaviours, symptoms, examination, results and clinician type were extracted from electronic medical records.</p><p><strong>Results: </strong>A total of 70 cervicitis (28.8%) and 28 PID (15.6%) patients were bacterial-STI positive. Age <25 years (aOR 2.78, 95% CI 1.25-6.25, P < 0.001) was associated with bacterial STI-positive cervicitis; presence of endocervical mucopurulent discharge on examination (aOR 6.05, 95% CI 2.20-16.68, P < 0.001) and current use of contraception (aOR 7.69, 95% CI 2.13-25.00, P = 0.002) were associated with bacterial STI-positive PID. For cervicitis, there were 139 doxycycline, 11 azithromycin and 5 ceftriaxone courses that were given to STI-negative patients. For PID, there were 148 doxycycline, 7 azithromycin and 152 ceftriaxone courses that were given to STI-negative patients.</p><p><strong>Conclusions: </strong>This study identified several characteristics that predicted STI-positive cervicitis and PID. However, none predicted STI-positivity with high degrees of confidence. Presumptive treatment leads to significant unnecessary antibiotic use, but ceftriaxone may have additional coverage beyond gonorrhoea. Rapid molecular point-of-care testing should be trialled to reduce unnecessary antibiotics for these syndromes - starting with cervicitis.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"23 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-creation and evaluation of people-centered mobile health messages to promote PrEP adherence among GBMSM in China: a feasibility study.","authors":"Zhuoheng Yin, Chunyan Li, Nachuan Wu, Haojie Huang, Quanmin Li, Songjie Wu, Linghua Li, Ke Liang, Aniruddha Hazra, Jonathan Lio, Renslow Sherer, Joseph D Tucker, Weiming Tang","doi":"10.1071/SH25111","DOIUrl":"10.1071/SH25111","url":null,"abstract":"<p><strong>Background: </strong>Co-creation has the potential to generate people-centered mobile health (mHealth) interventions to improve PrEP adherence. This study generated people-centered mHealth messages with Chinese gay, bisexual and other men who have sex with men (GBMSM) via a structured co-creation approach, and evaluated the messages quality, and assessed the feasibility of the co-creation approach.</p><p><strong>Methods: </strong>A three-step co-creation framework was implemented with 19 GBMSM PrEP users and six HIV researchers between 2021 and 2023. Messages were assessed via 10-point scales, and the degree of usefulness by co-creators and 783 participants from a PrEP demonstration trial. Thematic analysis identified PrEP adherence barriers and participants' reflections from meeting notes and materials, with descriptive statistics summarizing evaluation results.</p><p><strong>Results: </strong>Four levels of PrEP adherence barriers were identified (insufficient education, efficacy concerns, inadequate behavioral skills, PrEP stigma). Based on these barriers, 25 mHealth messages (19 posters, three videos, three text messages) were co-created, covering nine themes (e.g. missed dose coping, side-effect management). Seventeen high-quality messages were selected, with mean scores of 8.25 (relevance), 7.86 (appropriateness) and 7.25 (elaboration). Among GBMSM PrEP users who received the messages, 90.4% (708/783) valued the co-created messages as helpful. Reflections from the co-creators highlighted the value of the participatory process, confirming that co-creation effectively engages GBMSM PrEP users.</p><p><strong>Conclusions: </strong>Co-creation groups are feasible for Chinese GBMSM to identify context-specific PrEP adherence barriers and develop people-centered mHealth messages, supporting the value of co-creation for PrEP adherence intervention development in this population.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences for emerging modalities of HIV pre-exposure prophylaxis among sexual and gender diverse populations in Malaysia: implications for person-centred HIV prevention.","authors":"Norman Chong, Curtis Chan, Andrew Tan Tze Tho, Heather-Marie A Schmidt, Jason J Ong, Jeremy Fok Jun Tan, Kimberly E Green, Lei Zhang, Michael M Cassell, Midnight Poonkasetwattana, Nicky Suwandi, Nittaya Phanuphak, Wan Mohd Ikhtiaruddin, Warittha Tieosapjaroen, Weiming Tang, Benjamin R Bavinton, Iskandar Azwa","doi":"10.1071/SH25092","DOIUrl":"10.1071/SH25092","url":null,"abstract":"<p><strong>Background: </strong>In Malaysia, HIV pre-exposure prophylaxis (PrEP) uptake remains low. Emerging formulations (e.g. injectable, long-acting oral, and event-driven PrEP) may help overcome barriers such as daily pill burden and adherence. This study examined PrEP preferences among men who have sex with men (MSM), transgender women, and gender-diverse individuals, and assessed how socio-demographic, sexual history, and substance use influence these preferences.</p><p><strong>Methods: </strong>We conducted the PrEP APPEAL survey among 663 individuals in Malaysia from 10 May 2022 to 30 November 2022. Multivariable binary and multinomial logistic regressions identified factors associated with PrEP preferences, including 6-monthly injection, monthly oral pill and, event-driven (ED-PrEP) oral pill relative to the bi-monthly injection, yearly slow-releasing removable implant, daily oral pill, and other options.</p><p><strong>Results: </strong>Our findings showed diverse PrEP preferences: 167 (25.2%) preferred monthly oral; 138 (20.8%) preferred event-driven; 137 (20.7%) preferred 6-monthly injectable; and 82 preferred daily oral pill (12.4%). PrEP profiles (relative risk ratios (RRR) 2.47-9.54, P < 0.05), education (RRR 2.00, P = 0.005), the number of sexual partners (RRR 1.75, P = 0.03), and willingness-to-pay (RRR 3.13-6.45, P < 0.05) were significant predictors of these preferences.</p><p><strong>Conclusions: </strong>These findings highlight the importance of diverse, person-centred PrEP delivery models to improve uptake and affordability. Strategies should reflect differences in education, sexual behaviour, and willingness to pay. Limitations include self-reported data, sample variability, cross-sectional design, and potential selection bias, which should be considered when interpreting results.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"23 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline prophylaxis is effective as pre-exposure and post-exposure regimens in the prevention of sexually transmitted infections: an updated systematic review and meta-analysis.","authors":"Peipei Zhao, Qian Zou, Joseph Tucker, Tomas Fitzpatrick, Weiming Tang","doi":"10.1071/SH25227","DOIUrl":"10.1071/SH25227","url":null,"abstract":"<p><strong>Background: </strong>Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexually transmitted infections (STIs) in randomised controlled trials (RCTs). In this review, we updated evidence from RCTs and non-RCTs and compared the effectiveness of doxycycline as pre- (doxy PrEP) and post-prophylaxis (doxy PEP) across different groups.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, Embase, Cochrane Library, and two conference abstract archives for publications from January 2010 to April 2025. Eligible RCT and non-RCT studies on doxy PrEP and doxy PEP to prevent STIs were included in the analysis. Pooled risk ratios were calculated using fixed-effects and random-effects models. This study was registered with PROSPERO (CRD42024568934).</p><p><strong>Results: </strong>Fourteen eligible studies (4 doxy PrEP, 10 doxy PEP) were included for analysis. Participants were primarily men who have sex with men (MSM) and transgender women (TGW). Doxycycline (either PrEP or PEP) reduced the risk of acquiring any STIs by 60% (risk ratio (RR), 0.40; 95% CI, 0.30-0.52) in RCT and non-RCT trials. Doxycycline was associated with fewer incidences of chlamydia (RR, 0.18; 95% CI, 0.11-0.28), gonorrhoea (RR, 0.61; 95% CI: 0.44-0.86), and syphilis (RR, 0.20; 95% CI; 0.12-0.33). Meta-analysis of seven RCTs showed 76% decrease on chlamydia (RR: 0.24; 95% CI: 0.13-0.45), 33% decrease on gonorrhoea (RR, 0.67; 95% CI; 0.45-0.98), and 78% decrease on syphilis (RR, 0.22; 95% CI; 0.14-0.36). HIV-positive and HIV-negative people benefited from using doxy PrEP and PEP regimens prevented bacterial STIs.</p><p><strong>Conclusions: </strong>RCT and non-RCT data demonstrated the effectiveness of doxy PrEP and doxy PEP in reducing STIs among MSM/TGW. Integrating doxy PrEP or doxy PEP as a biomedical tool into STI prevention strategies should be considered.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"23 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}