Surgery最新文献

{"title":"Letter to the editor: Predicting suicide risk in patients with digestive system tumors: A retrospective cohort study.","authors":"Pincheng Luo, Cheong Wong Ho, Yanxue Lian","doi":"10.1016/j.surg.2025.109170","DOIUrl":"10.1016/j.surg.2025.109170","url":null,"abstract":"","PeriodicalId":22152,"journal":{"name":"Surgery","volume":" ","pages":"109170"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: \"Emodin alleviates intestinal ischemia/reperfusion-induced lung injury by upregulating HO-1 expression via PI3K/AkT pathway\".","authors":"Liqi Li","doi":"10.1016/j.surg.2024.07.053","DOIUrl":"10.1016/j.surg.2024.07.053","url":null,"abstract":"","PeriodicalId":22152,"journal":{"name":"Surgery","volume":" ","pages":"108766"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding \"Vulnerable populations and the emergency ventral hernia: A retrospective cohort study\".","authors":"Guangli Cao, Huade Luo, Xiaoyan Hu, Yingying Kong","doi":"10.1016/j.surg.2024.09.011","DOIUrl":"10.1016/j.surg.2024.09.011","url":null,"abstract":"","PeriodicalId":22152,"journal":{"name":"Surgery","volume":" ","pages":"108849"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enabling future military medical education and training","authors":"Richard W. Thomas MD, DDS, MSS, FACS ,&nbsp;Jason L. Turner MD","doi":"10.1016/j.surg.2025.109315","DOIUrl":"10.1016/j.surg.2025.109315","url":null,"abstract":"<div><div>Major advances in injury care have been fostered as a natural consequence of war. Likewise, the culmination of each conflict has been associated with a subsequent decrement in trauma care knowledge and experience secondary to the impact of competing health care priorities, loss of institutional knowledge, and perhaps, most importantly, a lack of lead emphasis. This lack of emphasis by senior civilian and military leaders to effectively advocate for resources has left our US military medical forces ill-prepared to respond to the next pandemic, terrorist attacks, natural disasters, or war. For us to fight and win our nation's wars, we must have immediate support to continue to evolve and improve our medical capabilities. An essential aspect of US military medicine is the partnerships with foreign nations that enable the sharing of lessons learned and technologies that enhance health care delivery during conflicts. Only through appropriate allocation of resources, continuing partnerships between the United States and our international medical partners, and the development and application of new technologies will US military medicine be able to adequately support the warfighter in future conflicts with near-peer adversaries.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"182 ","pages":"Article 109315"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter to the editor: Predicting suicide risk in patients with digestive system tumors: A retrospective cohort study.","authors":"Weibo Li, Longjiang Chen, Wei Wang, Hong Zhou, Lulu Zhai","doi":"10.1016/j.surg.2025.109266","DOIUrl":"10.1016/j.surg.2025.109266","url":null,"abstract":"","PeriodicalId":22152,"journal":{"name":"Surgery","volume":" ","pages":"109266"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A population-based analysis of primary colonic lymphoma: Patterns of care and outcomes","authors":"Lindsay L. Welton MD ,&nbsp;Julia F. Kohn MD ,&nbsp;Alexander M. Troester MD ,&nbsp;Wyatt Tarter MS ,&nbsp;Schelomo Marmor PhD, MPH ,&nbsp;Jacob C. Cogan MD ,&nbsp;Genevieve B. Melton MD, PhD ,&nbsp;Paolo Goffredo MD","doi":"10.1016/j.surg.2025.109346","DOIUrl":"10.1016/j.surg.2025.109346","url":null,"abstract":"<div><h3>Background</h3><div>Primary colorectal lymphoma is a rare malignancy (∼1%) with a rising incidence over the last 3 decades. Treatment is not standardized and includes combinations of chemotherapy, surgery, and radiation. The aim of this study was to describe patterns of care and outcomes of primary colorectal lymphoma in a US population-based cohort.</div></div><div><h3>Methods</h3><div>The Surveillance, Epidemiology, and End Results Database was queried to identify adults diagnosed with primary colorectal lymphoma, 2000–2015. Logistic regression and cox proportional hazard models estimated the effects of patient factors on treatment received, and survival, respectively.</div></div><div><h3>Results</h3><div>Of 1,721 patients (52% aged ≥65 years, 62% male, 80% White) 21% underwent chemotherapy alone, 31% surgery only, 22% surgery + chemotherapy, 8% radiation, and 18% no treatment. Multinomial analysis showed age, race, marital status, stage, histology, and lymphoma location were significantly associated with treatment received. No treatment was associated with older age. Proximal lesions more often underwent surgery + chemotherapy. After adjustment, factors associated with worse overall and disease-specific survival included age, sex, race, stage, and histology. No treatment was associated with lower overall survival when compared to chemotherapy, whereas surgery + chemotherapy had better prognosis.</div></div><div><h3>Conclusion</h3><div>In this population-based cohort, ∼20% of patients did not receive any treatment, which was associated with increasing age and worse survival. Patients with proximal lesions were more likely to undergo surgery + chemotherapy, with improved prognosis, possibly suggesting localized disease amenable to surgical resection and systemic treatment may lead to better oncologic outcomes, and elderly and Black individuals had worse survival rates, suggesting potential disparities extending to these subsets of patients.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"182 ","pages":"Article 109346"},"PeriodicalIF":3.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma","authors":"Katsuya Sakashita MD ,&nbsp;Shimpei Otsuka MD, PhD ,&nbsp;Ryo Ashida MD, PhD ,&nbsp;Katsuhisa Ohgi MD ,&nbsp;Yoshiyasu Kato MD, PhD ,&nbsp;Hideyuki Dei MD ,&nbsp;Akifumi Notsu PhD ,&nbsp;Katsuhiko Uesaka MD, PhD ,&nbsp;Teiichi Sugiura MD, PhD","doi":"10.1016/j.surg.2025.109344","DOIUrl":"10.1016/j.surg.2025.109344","url":null,"abstract":"<div><h3>Background</h3><div>The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.</div></div><div><h3>Methods</h3><div>We retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated as follows: (skeletal muscle index × albumin level)/neutrophil-to-lymphocyte ratio, with sex-specific cutoff values determined via receiver operating characteristic curves on the basis of 3-year survival data. Clinicopathologic characteristics and survival outcomes were compared between the low-cachexia index (<em>n</em> = 95) and high-cachexia index (<em>n</em> = 141) groups. Multivariable analyses were performed to identify prognostic factors for overall survival and relapse-free survival.</div></div><div><h3>Results</h3><div>The low-cachexia index group was characterized by greater carbohydrate antigen 19–9 level (56 vs 31 U/mL, <em>P</em> = .024) and greater proportion of preoperative biliary drainage (84% vs 70%, <em>P</em> = .013). The low-cachexia index group underwent vascular resection and reconstruction more frequently (47% vs 29%, <em>P</em> = .006) and had a greater rate of lymph node metastasis (54% vs 35%, <em>P</em> = .005). The median overall survival and relapse-free survival times of the low-cachexia index group were significantly worse than those of the high-cachexia index group (overall survival, 29.0 vs 47.4 months, <em>P</em> &lt; .001; relapse-free survival, 17.2 vs 33.1 months, <em>P</em> &lt; .001). Multivariable analysis revealed that a preoperative cachexia index (hazard ratio for overall survival, 0.95, <em>P</em> = .008; hazard ratio for relapse-free survival, 0.95, <em>P</em> = .017) and high preoperative carbohydrate antigen 19-9 level (hazard ratio for overall survival, 1.01, <em>P</em> = .002; hazard ratio for relapse-free survival, 1.01, <em>P</em> = .012) were prognostic factors.</div></div><div><h3>Conclusion</h3><div>The cachexia index may be a useful biomarker for the prediction of tumor aggressiveness and prognosis before perihilar cholangiocarcinoma resection.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"182 ","pages":"Article 109344"},"PeriodicalIF":3.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on: \"The effects of socioeconomic status on complex ventral hernia repair operative decision-making and outcomes\".","authors":"Zain Ul Abideen, Areena Fatima, Muhammad Junaid","doi":"10.1016/j.surg.2025.109338","DOIUrl":"https://doi.org/10.1016/j.surg.2025.109338","url":null,"abstract":"","PeriodicalId":22152,"journal":{"name":"Surgery","volume":" ","pages":"109338"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta-catenin/sirtuin 1/farnesoid X receptor pathway promotion of portal vein ligation and parenchymal transection-induced rapid liver regeneration","authors":"Yifan Tong PhD ,&nbsp;Qiuxia Gu PhD ,&nbsp;Bingzhi Dong PhD ,&nbsp;Hanning Ying PhD ,&nbsp;Tong Ji PhD ,&nbsp;Xiaoyun Shen PhD ,&nbsp;Bo Shen PhD ,&nbsp;Hong Yu MD ,&nbsp;Lifeng Feng PhD ,&nbsp;Xiujun Cai MD ,&nbsp;Zheyong Li PhD","doi":"10.1016/j.surg.2025.109343","DOIUrl":"10.1016/j.surg.2025.109343","url":null,"abstract":"<div><h3>Background</h3><div>By accelerating the regeneration of the future liver remnant, portal vein ligation and parenchymal transection allows for more extensive hepatectomy. Given that the mechanism remains poorly understood, the aim of this study was to investigate the mechanism of portal vein ligation and parenchymal transection–induced liver regeneration.</div></div><div><h3>Methods</h3><div>A portal vein ligation and parenchymal transection–induced liver regeneration mouse model was established, followed by RNA microarray analysis to identify candidate molecules. Genomic deletion and chemical manipulation of target molecules were used to explore their functions in portal vein ligation and parenchymal transection–induced liver regeneration. Validation was conducted using a diseased liver model and human samples.</div></div><div><h3>Results</h3><div>Portal vein ligation and parenchymal transection–induced liver regeneration was significantly accelerated compared with that in sham-operated mice (<em>P</em> &lt; .05). An RNA microarray revealed that Sirtuin 1 is a crucial molecule in the proliferation of the future liver remnant. Regardless of whether Sirtuin 1 is inhibited chemically or through genetic deletion, portal vein ligation and parenchymal transection-induced liver regeneration is distinctly attenuated. Further investigation revealed that Sirtuin 1 promoted portal vein ligation and parenchymal transection–induced liver regeneration via the farnesoid X receptor. In addition, beta-catenin also was found to participate in the process of future liver remnant proliferation. Chemical inhibition of beta-catenin markedly impaired but activation of WNT/beta-catenin mildly enhanced portal vein ligation and parenchymal transection–induced liver regeneration (<em>P</em> &lt; .05). Deletion of Sirtuin 1 blocked the facilitating effect of beta-catenin on portal vein ligation and parenchymal transection–induced liver regeneration. These findings were validated in diseased liver models and patient samples, confirming the correlation between the beta-catenin/Sirtuin 1/farnesoid X receptor pathway and portal vein ligation and parenchymal transection-induced liver regeneration.</div></div><div><h3>Conclusion</h3><div>Activation of the beta-catenin/Sirtuin 1/farnesoid X receptor pathway offers critical mechanistic insights into accelerating portal vein ligation and parenchymal transection-induced liver regeneration. Modulation of beta-catenin/Sirtuin 1/farnesoid X receptor may therefore improve clinical outcomes in patients receiving staged hepatectomy.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"182 ","pages":"Article 109343"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: \"Deep sternal wound infection after cardiac surgery: A combination of 2 distinct infection types, deep incisional surgical-site infection and mediastinitis: Results of a retrospective study\".","authors":"Yangbiao Chen, Tingting Chen, Liangchen Qu","doi":"10.1016/j.surg.2025.109340","DOIUrl":"https://doi.org/10.1016/j.surg.2025.109340","url":null,"abstract":"","PeriodicalId":22152,"journal":{"name":"Surgery","volume":" ","pages":"109340"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}