Tabari Biomedical Student Research Journal最新文献

Investigating the Combinational Effect of Micellar Curcumin and Metformin on the Invasion of PC3 Prostate Cancer Cell Line 研究微囊姜黄素和二甲双胍对 PC3 前列腺癌细胞株侵袭的协同作用

Tabari Biomedical Student Research Journal Pub Date : 2023-12-01 DOI: 10.32598/tbsrj.v5i3.10537

Nazanin Ghahari, Shadi Abkhiz, Hamed Montazeri, Parastoo Tarighi

{"title":"Investigating the Combinational Effect of Micellar Curcumin and Metformin on the Invasion of PC3 Prostate Cancer Cell Line","authors":"Nazanin Ghahari, Shadi Abkhiz, Hamed Montazeri, Parastoo Tarighi","doi":"10.32598/tbsrj.v5i3.10537","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i3.10537","url":null,"abstract":"Introduction: Adverse side effects, non-specific function, and increasing tolerability of tumor cells to chemotherapy demand therapeutic strategies with fewer side effects and better efficacy. Curcumin and metformin have been shown to have anticancer properties, according to emerging research. Therefore, micellar curcumin and metformin were combined and analyzed on cancer cell line PC3. Material and Methods: Cell viability after drug treatment, individually and in combination, was evaluated using an MTT assay. In order to determine the type of interaction between micellar curcumin and metformin, the median-effect method was employed. Subsequently, the expression of MMP-2 and MMP-9 of cells treated with single drugs and a synergistic combination of compounds was assessed using Gelatin Zymography test. Moreover, evaluating the number of invasive cells under treatment with drugs alone and in combination through matrigel invasion assay. Results: The results demonstrated that the cell proliferation treated with micellar curcumin and metformin alone and in combination decreased significantly (P<0.05) during 24 and 48 h. Besides, co-treatment of compounds showed synergy within 48 h. Although all the cells treated, whether with single drugs or the synergistic combination of both, showed a decline in expressing MMP-2, MMP-9, and the number of migrated cells, the maximum reduction was seen when micellar curcumin and metformin were combined. Conclusion: This study showed that metformin and micellar curcumin together have a synergistic effect on cell proliferation inhibition in the PC3 cell line. Metformin and micellar curcumin were more effective as a combination in decreasing the PC3 cell line invasion by reducing MMP-2 and MMP-9.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Magnetic Resonance Imaging Findings in Chronic Kidney Disease Patients with and without Parkinsonism: A Case-Control Study 伴有或不伴有帕金森症的慢性肾病患者的脑磁共振成像结果：病例对照研究

Tabari Biomedical Student Research Journal Pub Date : 2023-12-01 DOI: 10.32598/tbsrj.v5i3.10539

Mehran Frouzanian, Sedigheh Varyani, H. Cheraghmakani, S. Baghbanian, Atieh Makhlough, Rohollah Abdi, Alireza Karimi Varaki

{"title":"Brain Magnetic Resonance Imaging Findings in Chronic Kidney Disease Patients with and without Parkinsonism: A Case-Control Study","authors":"Mehran Frouzanian, Sedigheh Varyani, H. Cheraghmakani, S. Baghbanian, Atieh Makhlough, Rohollah Abdi, Alireza Karimi Varaki","doi":"10.32598/tbsrj.v5i3.10539","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i3.10539","url":null,"abstract":"Introduction: Chronic kidney disease (CKD) poses a major public health concern on a global scale. Patients with CKD have a heightened risk of developing multiple movement disorders like parkinsonism. Timely diagnosis through imaging and effective management may hold the key to mitigating disease symptoms. Material and Methods: Twenty-eight individuals with CKD were categorized into two groups, nine patients showing signs of parkinsonism and a control group of nineteen patients without parkinsonism. All participants underwent non-contrast brain magnetic resonance imaging (MRI) scans, including T1, T2, DWI, and FLAIR sequences. The data were statistically analyzed using SPSS-24 and STATA software. Results: Nine patients exhibited parkinsonism symptoms, while nineteen did not. Brain MRI revealed hypointensities in structures like the putamen, globus pallidus, and cerebellar dentate nucleus in both groups. Comparative analysis showed no statistically significant differences in the percentages of these findings (P>0.05). Similarly, the presence of cerebral atrophy and cerebrovascular disease did not significantly differ between the groups. Factors such as diabetes, hypertension, and history of dialysis also failed to show significant distinctions (P>0.05 for all). Conclusion: The correlation between brain MRI alterations in CKD patients with parkinsonism symptoms and those without was not significant. Nevertheless, there was a strong association between the duration of CKD in patients and the presence of parkinsonism-related signs.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Level of Knowledge and Attitude towards Basic Life Supports and Related Factors in Surgical Technologists and Nurses of Anesthesia at Imam Khomeini Hospital at Tehran during COVID-19 Pandemic 调查 COVID-19 大流行期间德黑兰 Imam Khomeini 医院外科技术员和麻醉护士对基本生命支持及相关因素的了解程度和态度

Tabari Biomedical Student Research Journal Pub Date : 2023-12-01 DOI: 10.32598/tbsrj.v5i3.10540

Fereshteh Farzanmehr, Ebrahim Nasiri Formi, Shahram Samadi

{"title":"Investigating the Level of Knowledge and Attitude towards Basic Life Supports and Related Factors in Surgical Technologists and Nurses of Anesthesia at Imam Khomeini Hospital at Tehran during COVID-19 Pandemic","authors":"Fereshteh Farzanmehr, Ebrahim Nasiri Formi, Shahram Samadi","doi":"10.32598/tbsrj.v5i3.10540","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i3.10540","url":null,"abstract":"Introduction: Cardiorespiratory arrest is one of the most dangerous conditions that requires immediate action. Therefore, it is important for healthcare staff to have the necessary knowledge and skills. The purpose of this study was to determine the level of knowledge and attitude of basic life supports (BLS) in the surgical technologists and nurses of anesthesia of Imam Khomeini Hospital in Tehran during the COVID-19 pandemic in 2022. Material and Methods: In this descriptive-analytical cross-sectional study, all surgical technologists and nurses of anesthesia working at Imam Khomeini Hospital in Tehran participated during the COVID-19 pandemic. The data was collected using a questionnaire designed by the authors. Parametric and non-parametric statistical tests were used for data analysis via SPSS 24 software (α=0.05). Results: The results of the study in 195 participants showed that the average knowledge score of anesthesia nurses was significantly higher than surgical technologists (4.99 ± 1.20 vs. 4.12 ± 1.39, P=0.001). The average score of the attitude of anesthesia nurses and surgical technologists were 12.62 ± 1.92 and 12.43 ± 2.34, respectively, which were not significantly different from each other (P=0.624). Conclusion: The level of knowledge of the majority of surgical technologists and anesthesia nurses about basic resuscitation was not appropriate, and considering the importance of BLS and the above disciplines, it is necessary to make arrangements for its training by educational policy makers.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138611333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate Change and the Looming Threat of Cardiovascular Diseases in Iran: A Narrative Review 气候变化与伊朗迫在眉睫的心血管疾病威胁：叙述性综述

Tabari Biomedical Student Research Journal Pub Date : 2023-12-01 DOI: 10.32598/tbsrj.v5i3.10542

A. Goudarzian

引用次数: 0

Examining the Knowledge, Attitude, and Performance of Operating Room Personnel about the Use of Personal Communication Devices 考察手术室人员对使用个人通讯设备的认识、态度和表现

Tabari Biomedical Student Research Journal Pub Date : 2023-12-01 DOI: 10.32598/tbsrj.v5i3.10541

Tayebeh Azarmehr, Fatemeh Pouladkhay, Ebrahim Nasiri Formi, Rana Abjar, Fereshte Sargolzaei

{"title":"Examining the Knowledge, Attitude, and Performance of Operating Room Personnel about the Use of Personal Communication Devices","authors":"Tayebeh Azarmehr, Fatemeh Pouladkhay, Ebrahim Nasiri Formi, Rana Abjar, Fereshte Sargolzaei","doi":"10.32598/tbsrj.v5i3.10541","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i3.10541","url":null,"abstract":"Introduction: There is a growing concern about the impact of personal electronic devices (PEDs), including mobile phones, on healthcare, particularly in the operating room, as they can lead to distractions and reduced focus, compromising patient safety. Material and Methods: This cross-sectional descriptive study involved 127 healthcare personnel and anesthesiologists working in teaching hospitals affiliated with Mazandaran University of Medical Sciences. The study aimed to investigate their awareness, attitude, and performance regarding the use of PEDs. Questionnaires were administered, and data analysis was carried out using statistical tests. Results: All participants used mobile phones as their personal communication devices in the operating room. Most participants used their devices for various purposes, such as making calls, sending messages, and emails, playing games, and internet browsing. The mean attitude score was 65.34 ± 38.9, the mean performance score was 33.30 ± 32.4, and the mean awareness score was 88.5 ± 77.29. Factors like age, gender, field of study, educational level, and work experience did not significantly affect attitude, performance, or awareness scores. Conclusion: It is essential for healthcare professionals to strike a balance between using personal electronic devices to enhance patient care and managing potential distractions. These findings can inform strategies to prevent distractions caused by mobile phone use and ensure patient safety in healthcare settings. Further research is needed in this area to provide effective solutions and mitigate risks associated with PED use in healthcare.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid Nodule Correlation with Serum Prolactin and TPO Antibody Levels: A Case-Control Study 甲状腺结节与血清泌乳素和 TPO 抗体水平的相关性：病例对照研究

Tabari Biomedical Student Research Journal Pub Date : 2023-12-01 DOI: 10.32598/tbsrj.v5i3.10538

Maedeh Mataji, Mehran Frouzanian, Zahra Kashi, A. Abdollahi, A. Bahar, Reza Ali Mohammadpour

{"title":"Thyroid Nodule Correlation with Serum Prolactin and TPO Antibody Levels: A Case-Control Study","authors":"Maedeh Mataji, Mehran Frouzanian, Zahra Kashi, A. Abdollahi, A. Bahar, Reza Ali Mohammadpour","doi":"10.32598/tbsrj.v5i3.10538","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i3.10538","url":null,"abstract":"Introduction: The prevalence of thyroid nodules poses a grave clinical concern as they may lead to malignancy. Prolactin has been found to have anti-cell death properties and stimulates the growth of breast and prostate cells, as has been discovered in exploratory examinations. In light of this, the current research was designed to investigate whether a possible relationship exists between thyroid nodules and serum prolactin levels. Material and Methods: Ninety participants were enrolled in this study, of which 60 presented with thyroid nodules (30 antithyroid peroxidase antibody (TPO-Ab) positive and 30 TPO-Ab negative) and 30 without thyroid nodules (control group). Patients' serum prolactin, TPO-Ab, thyroid-stimulating hormone (TSH), T4 values, and thyroid ultrasound reports were scrutinized. Statistically significant outcomes were determined by a P-value less than 0.05. Results: Serum TSH, prolactin, and TPO-Ab levels were significantly higher in the case group than in the control group (P=0.041, 0.050, and 0.000, respectively). The case group had more instances of hyperprolactinemia than the control group (35% vs. 13.3%) (OR=3.5, CI 95%=1.08-11.38, P=0.031). Furthermore, the TPO-Ab positive group demonstrated greater solidity than the TPO-Ab negative group (93.3% vs. 73.3%, P=0.038). Conclusion: The present study confirmed the presence of a positive correlation between thyroid nodules and increased serum TSH, prolactin, and TPO-Ab levels. Furthermore, TPO-Ab positive nodules exhibited greater solidity and elevated TSH levels.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stigma and Human Rights Violations against Mental Patients 对精神病人的污名和侵犯人权行为

Tabari Biomedical Student Research Journal Pub Date : 2023-05-31 DOI: 10.32598/tbsrj.v5i1.10523

A. Goudarzian

引用次数: 0

Pharmacological and Biological Activities of Artemisia persica: A Review 桃艾的药理和生物学活性研究进展

Tabari Biomedical Student Research Journal Pub Date : 2023-05-31 DOI: 10.32598/tbsrj.v5i1.10527

M. Hosseinzadeh, Amirhosein Arab, Naghmeh Emad, Faezeh Bodaghabadi, Meshkat Boroughani, Fatemeh Rajabzadeh, Minoo Sheikhy, Aida Taghipour, Bahareh Shourabi, M. Eghbali, Parmida Zahedi, M. Ebrahimzadeh

引用次数: 0

Prevalence of Recurrent Aphthous Stomatitis among Children Studying at Public Elementary Schools in Sari County in 2019 2019年沙里县公立小学学生复发性口腔炎患病率调查

Tabari Biomedical Student Research Journal Pub Date : 2023-05-31 DOI: 10.32598/tbsrj.v5i1.10525

Haleh Hali, Maedeh Salehi Sarookollaei, T. Molania, Sh Gohardehi, M. Moosazadeh, Melika Mollaei

{"title":"Prevalence of Recurrent Aphthous Stomatitis among Children Studying at Public Elementary Schools in Sari County in 2019","authors":"Haleh Hali, Maedeh Salehi Sarookollaei, T. Molania, Sh Gohardehi, M. Moosazadeh, Melika Mollaei","doi":"10.32598/tbsrj.v5i1.10525","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i1.10525","url":null,"abstract":"Introduction: Recurrent aphthous stomatitis (RAS) is a painful condition regarded as one of the most prevalent oral mucosal lesions. Few studies have been conducted to investigate the prevalence of this disease in Iranian children. Therefore, this study aimed to assess the prevalence as well as the risk factors of RAS among children attending public elementary schools in Sari County. Material and Methods: In the current descriptive-analytical cross-sectional study, a total number of 2399 elementary students attending public schools in Sari were examined. Of which 1780 of them completed the procedure and filled out a questionnaire about to their demographic and RAS related features. Data were analyzed using SPSS 24. Results: Although 32.8% of the population reported a previous history of RAS, the prevalence of this disease was 9.2% at the time of examination. RAS was significantly more frequent in boys compared to girls; however, the history of RAS was reported more in girls. In the present study, the prevalence of RAS was not significantly associated with age, social status, and economic status of the samples. Conclusion: Based on these findings, RAS appears to be a relatively common disease. As a result, providing families with appropriate training and basic healthcare seems to be effective.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79826175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Different Manifestations of Crouzon Syndrome Crouzon综合征不同表现的综述

Tabari Biomedical Student Research Journal Pub Date : 2023-05-31 DOI: 10.32598/tbsrj.v5i1.10528

Negareh Salehabadi, A. Lotfizadeh, A. Mazandarani, Iman Misagh Toupkanloo, Mehdi Aryana

{"title":"A Review on Different Manifestations of Crouzon Syndrome","authors":"Negareh Salehabadi, A. Lotfizadeh, A. Mazandarani, Iman Misagh Toupkanloo, Mehdi Aryana","doi":"10.32598/tbsrj.v5i1.10528","DOIUrl":"https://doi.org/10.32598/tbsrj.v5i1.10528","url":null,"abstract":"Introduction: Crouzon syndrome (CS), the most common craniosynostosis condition, which could lead to several developmental complications. This study aimed to review the different manifestations of CS. Material and Methods: In order to find the relevant articles, the databases of PubMed, Scopus, Web of Science, and Cochrane Library were searched using the term “Craniofacial Dysostosis” and its relevant entry terms. All English-language articles regarding the CS were included in the study. After removing the duplicate articles, two authors independently screened the title and abstracts of the included articles. Disagreements were resolved through voting and discussion with the third author. Then full-text of articles were screened and the articles were categorized depending on regarding their main topic. Results: The search yielded 449 results in different databases. After removing the duplicates, 331 results remained. Then, 182 were excluded as not completely relevant by screening the abstracts. The remaining 149 studies were assessed for the eligibility criteria. Of them, 74 were excluded due to the following reasons: (1) unavailable full text; (2) discussing other types of craniosynostoses syndromes; and (3) not having clear results. Finally, 75 studies which were included in this study. Conclusion: CS is caused by mutations in the FGFR2 gene and is inherited in an autosomal dominant pattern. Diagnosis is based on the characteristic physical features, as well as imaging studies and genetic testing. Treatment involves surgery to correct the craniosynostosis and facial abnormalities. Early and appropriate treatment can help to improve the quality of life for affected individuals.","PeriodicalId":22117,"journal":{"name":"Tabari Biomedical Student Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90347460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0