Surgical infections最新文献

{"title":"Targeted Antimicrobial Agent Prophylaxis Fails to Reduce Peristomal Infections by Multi-Drug-Resistant Bacteria Following Percutaneous Endoscopic Gastrostomy: A Prospective Cohort Study.","authors":"Blanca Marzo-Escartín, Miguel Villamarín-Melio, Ester Márquez-Algaba, Fiorella Ximena Palmas-Candía, Alba Zabalegui, Rosa Burgos-Peláez, Mayli Lung-Suárez, Joan Dot, Mercedes Pérez-Lafuente, Óscar Len","doi":"10.1177/10962964261438723","DOIUrl":"https://doi.org/10.1177/10962964261438723","url":null,"abstract":"<p><strong>Background: </strong>Peristomal infection (PI) is the most frequent complication following percutaneous gastrostomy, and the increase of multi-drug-resistant (MDR) bacteria poses a therapeutic challenge. We evaluated whether targeted antimicrobial agent prophylaxis (TAP), on the basis of pre-procedure rectal screening, reduces the incidence of MDR PIs compared with standard prophylaxis.</p><p><strong>Methods: </strong>We conducted a single-center, single-arm, open-label trial, comparing a prospective cohort (July 2021-July 2022) receiving TAP based on MDR screening results with a retrospective cohort (June 2020-June 2021) that received standard prophylaxis. A total of 118 patients were included, 60 in the intervention group and 58 in the historical cohort. TAP patients underwent a pre-procedure screening tactic, using nasal, axillary, inguinal, pharyngo-tonsillar, and rectal swabs. Patients with positive cultures received prophylaxis with an antibiotic agent active against the isolated bacteria, along with coverage for methicillin-sensitive <i>Staphylococcus aureus</i>. Patients with negative cultures received standard prophylaxis with amoxicillin-clavulanate. Both regimens were administered as a single dose one hour before the procedure.</p><p><strong>Results: </strong>MDR colonization was detected in 36.4% of screened patients. The 30-day PI incidence was comparable in both cohorts [20.7% (12/58) in the historical cohort vs. 16.7% (10/60) in the intervention group; p = 0.64]. Among TAP patients who developed PI, 7/10 had negative MDR screening, 3/10 had infections caused by pathogens different from those identified in screening, and 2/10 developed infections with the same MDR bacteria despite appropriate prophylaxis.</p><p><strong>Conclusions: </strong>In patients undergoing percutaneous gastrostomy, TAP based on MDR colonization status did not reduce the incidence of PIs or MDR etiology compared with standard prophylaxis. Our findings question the role of colonization-guided prophylaxis in percutaneous gastrostomy and underscore the need for alternative preventive tactics in surgical site infection control.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261438723"},"PeriodicalIF":1.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Recent Antibiotic Therapy on Post-Thyroidectomy Wound Complications.","authors":"Nir Zontag, Maya Korem, Jonathan Zontag, Nir Hirshoren","doi":"10.1177/10962964261445328","DOIUrl":"https://doi.org/10.1177/10962964261445328","url":null,"abstract":"<p><strong>Background: </strong>To assess the association between antibiotic use, for any indication, within 30 days prior to thyroidectomy and the incidence of surgical site infections (SSIs) using a large global electronic medical records database.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the TriNetX Global Collaborative Network. Adults who underwent thyroidectomy were stratified into two groups: those who received antibiotics within 30 days prior to the surgical procedure and those who did not. Propensity score matching (PSM) was employed to adjust for demographic and clinical variables. The primary outcome was the development of SSIs up to 90 days following the surgical procedure. Secondary outcomes included wound dehiscence, emergency department (ED) visits, and the use of post-operative antibiotics.</p><p><strong>Results: </strong>After 1:1 PSM, each cohort consisted of 3,518 patients. At 30 days following thyroidectomy, patients who received antibiotics prior to the surgical procedure exhibited significantly higher risks of SSI (risk ratio [RR] 1.75, 95% confidence interval [CI]: 1.136-2.695), wound dehiscence (RR 2.571, 95% CI: 1.389-4.759), ED visits (RR 1.367, 95% CI: 1.126-1.661), and post-operative antibiotic use (RR 4.205, 95% CI: 3.702-4.775) compared to patients without pre-operative antibiotic exposure. These elevated risks were also observed at 60 and 90 days post-surgical procedure.</p><p><strong>Conclusion: </strong>Exposure to pre-surgical antibiotics, for any reason, is associated with post-thyroidectomy complications for at least 90 days. This finding should be considered in the decision-making process regarding the timing of the surgical procedure, particularly for elective, non-urgent procedures such as thyroidectomy.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261445328"},"PeriodicalIF":1.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Novel Diagnostic Nomogram to Differentiate Between Spinal Tuberculosis and Pyogenic Spinal Infection.","authors":"Tiantian Xu, Hui Yang, Ning Qu, Ali Haider, Qihua Qi, Meisong Zhu","doi":"10.1177/10962964261444991","DOIUrl":"https://doi.org/10.1177/10962964261444991","url":null,"abstract":"<p><strong>Background: </strong>Differentiating spinal tuberculosis (STB) from pyogenic spinal infection (PSI) remains a critical diagnostic challenge, and misdiagnosis can lead to inappropriate treatment, prolonged morbidity, and poor clinical outcome.</p><p><strong>Objective: </strong>This study aims to develop a convenient, practical model on the basis of routinely available clinical data to accurately differentiate between STB and PSI.</p><p><strong>Patients and methods: </strong>We retrospectively reviewed 211 patients (59 STB, 152 PSI) with pathological confirmation in our hospital's orthopedic department, collecting general data (age, gender, BMI, tuberculosis history), laboratory indices (T-SPOT.TB, white blood cell, NP, C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], hemoglobin, etc.), and imaging findings (intervertebral disc destruction [IDD], vertebral body destruction [VBD], sclerotic bone and sequestrum formation [SBSF], intraspinal abscess [ITA], injection abscess). Univariate and multivariate regressions identified independent factors to construct a nomogram, whose performance was assessed via receiver operating characteristic curves, calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>Univariate analysis revealed that the T-SPOT.TB, CRP, ESR, albumin, albumin-to-globulin ratio, IDD, VBD, SBSF, and ITA were statistically significant. Multifactorial logistic regression analysis revealed that the T-SPOT. TB, CRP, ESR, and albumin were strongly associated with STB. The nomogram model was established via R software on the basis of risk factors. The area under the receiver operating characteristic of the subjects in the modeling group was 0.770. According to the nomogram model, the predicted value of the calibration curve was consistent with the actual value.</p><p><strong>Conclusion: </strong>This nomogram provides a reliable, simple, economical, practical tool for differentiating STB from PSI. By enabling accurate and timely distinction between these two infectious entities, the model facilitates the development of targeted and more effective treatment strategies.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261444991"},"PeriodicalIF":1.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Developing Candidemia after Gastrointestinal Perforation and/or Ischemia and Its Outcomes: A Matched Case-Control Study.","authors":"Myeongji Kim, Nischal Ranganath, Sofia Molina Garcia, Kemar O Barrett, Khalid H Mahmoud, Ryan W Stevens, Allison M LeMahieu, Veljko Strajina, Aditya Shah","doi":"10.1177/10962964261445330","DOIUrl":"https://doi.org/10.1177/10962964261445330","url":null,"abstract":"<p><strong>Background: </strong>Candidemia is a serious complication after gastrointestinal (GI) perforation and/or ischemia, yet most evidence pools candidemia with intra-abdominal candidiasis (IAC). We sought candidemia-specific risk factors after GI perforation and/or ischemia and evaluated associated outcomes.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective matched case-control study of adults undergoing emergency surgical procedure for GI perforation and/or ischemia and admitted to a surgical intensive care unit. Cases with candidemia during index admission were matched 4:1 to controls by age, Charlson Comorbidity Index, and surgical procedure year. Conditional logistic regression assessed pre-specified risk factors, and exploratory outcomes included mortality, length of stay, and days on invasive ventilation.</p><p><strong>Results: </strong>Twenty-four cases were matched to 99 controls. Factors identified to be independently associated with candidemia include the presence of IAC (adjusted OR [aOR]: 5.51, 95% CI: 1.61, 18.89; p = 0.007), upper GI injury (aOR: 4.28, 95% CI: 1.52-12.08; p = 0.006), and diffuse intra-abdominal contamination, compared with contained/none (aOR: 3.21, 95% CI: 1.06-9.74; p = 0.040). Among candidemia cases, species distribution was <i>Candida albicans</i> 41.7%, <i>C. glabrata</i> 33.3%, <i>C. parapsilosis</i> 12.5%, with single cases of <i>C. tropicalis, C. krusei</i>, and <i>C. dubliniensis</i>. Candidemia was associated with a longer hospital length of stay (+13.97 d; 95% CI: 0.90-27.04; p = 0.036), without significant differences in ICU stay, duration of invasive ventilation, or mortality.</p><p><strong>Conclusions: </strong>After GI perforation and/or ischemia, the risk of candidemia is highest in patients with upper GI injury and diffuse contamination, independent of IAC. These readily identifiable operative features may guide targeted surveillance and selective early antifungal strategies. Prospective validation is warranted.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261445330"},"PeriodicalIF":1.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymicrobial Infection Is Associated with Failure of DAIR in Acute Hip Periprosthetic Joint Infection.","authors":"José María Lamo-Espinosa, Álvaro Suárez-López Del Amo, Francisco Carmona-Torre, Telmo García-Orueta, Mikel San-Julián, José Luis Del Pozo","doi":"10.1177/10962964261444963","DOIUrl":"https://doi.org/10.1177/10962964261444963","url":null,"abstract":"<p><strong>Background: </strong>Debridement, antibiotics, and implant retention (DAIR) is a commonly used tactic for the management of acute periprosthetic joint infection (PJI) following total hip arthroplasty. However, patient selection remains challenging, and predictors of treatment failure are not clearly defined.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was conducted in a single center including 48 patients treated with DAIR for acute hip PJI between 2000 and 2019. Clinical characteristics, comorbidities, microbiological findings, and perioperative variables were analyzed. Treatment failure was defined as the need for implant removal or exchange, resection arthroplasty, or chronic suppressive antibiotic therapy. Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed to explore factors associated with DAIR failure.</p><p><strong>Results: </strong>The mean age was 69.3 years. At a mean follow-up of 23.7 months, infection control was achieved in 83.3% of cases. Polymicrobial infection was significantly associated with treatment failure compared with monomicrobial infection (57.1% vs. 87.5%, p = 0.049). An exploratory predictive model demonstrated acceptable to good discriminatory performance in this exploratory cohort for DAIR outcome (area under the curve = 0.87).</p><p><strong>Conclusions: </strong>DAIR is an effective treatment option for selected patients with acute hip PJI. Polymicrobial infection was associated with treatment failure and should prompt careful consideration of alternative surgical strategies. Exploratory risk stratification models may assist in preoperative decision-making; however, validation in larger cohorts is required.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261444963"},"PeriodicalIF":1.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Pyelonephritis in Patients with Urolithiasis: A Retrospective Case-Control Study.","authors":"Vahibe Aydın Sarıkaya, Recep Balık, Kemal Kayar, İlker Artuk, Sebahat Aksaray, Rıza Adaleti, Şule Kocabıçak, Seniha Şenbayrak, Serpil Erol, Asuman İnan, Burak Sarıkaya, Nurgül Ceran","doi":"10.1177/10962964261445349","DOIUrl":"https://doi.org/10.1177/10962964261445349","url":null,"abstract":"<p><strong>Purpose: </strong>Pyelonephritis is quite common in patients with urolithiasis. This condition not only complicates the management of urolithiasis but also makes the treatment of associated urinary tract infections more challenging. The aim of this study is to identify the risk factors for pyelonephritis in patients with urolithiasis.</p><p><strong>Materials and methods: </strong>A total of 8,273 patients with urolithiasis were retrospectively screened (2016-2025). From this cohort, 302 patients who developed pyelonephritis and 302 age- and gender-matched controls without pyelonephritis were randomly selected, forming a matched case-control study population. Demographic and clinical variables, including age, gender, stone size and location, number of stones, comorbidities, prior urinary operation, presence of a double-J ureteral stent, and urinary tract obstruction, were analyzed as potential risk factors.</p><p><strong>Results: </strong>Pyelonephritis developed in 302 patients (53.3% female). Hydronephrosis was the strongest independent risk factor, increasing risk nearly ninefold. Other significant risk factors included hypertension, diabetes mellitus, chronic kidney disease, malignant disease, immunosuppression, larger stone burden, multiple and bilateral stones, ureteral stent presence, and prior urinary operation. Each 1-mm increase in stone size was associated with a 2.3% increase in the risk of developing pyelonephritis. Bacteremia was detected in 66 patients, and urine cultures were positive in 229 patients. <i>Escherichia coli</i> was the most common pathogen, followed by <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i>.</p><p><strong>Conclusions: </strong>Hydronephrosis, ureteral stent presence, a history of open or laparoscopic intervention, hypertension, and higher stone burden were independently associated with the development of pyelonephritis in patients with urolithiasis. Gram-negative bacilli were the most frequently isolated pathogens. Identification of these risk factors may support earlier recognition of high-risk patients and guide preventive and therapeutic decision-making. Prospective multi-center studies are needed to confirm these findings.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261445349"},"PeriodicalIF":1.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Risk Factors and Construction of a Nomogram Prediction Model for Surgical Site Infection after Modified Radical Mastoidectomy.","authors":"Yuanye Li, Zhongyan Li, Dongdong Huo","doi":"10.1177/10962964261444924","DOIUrl":"https://doi.org/10.1177/10962964261444924","url":null,"abstract":"<p><strong>Background: </strong>Modified radical mastoidectomy (MRM) is a common surgical procedure in otology. However, postoperative surgical site infection (SSI) will lengthen hospital stay, raise healthcare expenses, and even lead to the death of patients. At present, there is relatively little research on the risk factors of SSI after MRM, especially the lack of an established risk prediction model.</p><p><strong>Patients and methods: </strong>Patients who underwent MRM at Jining NO.1 People's Hospital from 2020 to 2024 were selected. Univariate analysis and multivariate logistic regression analysis were used to identify the risk factors for SSI after MRM. On the basis of these factors, a Nomogram prediction model was constructed. The predictive value of the model was evaluated by constructing receiver operating characteristic (ROC) curve, calibration curve, and decision curve.</p><p><strong>Results: </strong>A total of 278 MRM patients met the inclusion criteria, 19 (6.83%) had developed SSI, and 259 (93.17%) had not. Multivariate logistic regression analysis confirmed diabetes, hypoproteinemia, neutrophil-to-lymphocyte ratio, antibiotic prophylaxis administered 0.5-1 h preoperatively, and operative time as independent factors (all p <0.05). The prediction model demonstrated excellent discriminative ability. Area under the curve of the ROC curve was 0.856, validated by Hosmer-Lemeshow testing (χ² = 6.265, p = 0.618), calibration curve, and decision curve analysis. These findings highlight the model's robust accuracy and clinical utility in stratifying the risk of SSI after MRM.</p><p><strong>Conclusions: </strong>The Nomogram prediction model constructed based on logistic regression can effectively predict the risk of SSI after MRM, which is helpful for early clinical intervention and reducing the occurrence of nosocomial infection.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261444924"},"PeriodicalIF":1.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> Limitations of Pre-Operative Urine Culture Alone in Predicting Post-Operative UTI after Radical Prostatectomy.","authors":"Akif Erbin, Batu Akalin","doi":"10.1177/10962964261444955","DOIUrl":"https://doi.org/10.1177/10962964261444955","url":null,"abstract":"","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261444955"},"PeriodicalIF":1.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverticulitis in Pregnancy Is Associated with High Complication Rates.","authors":"Dayle Colpitts, Allyson M Hynes, Jarrett Santorelli, Alan Smith, Jessica L Weaver","doi":"10.1177/10962964261441488","DOIUrl":"https://doi.org/10.1177/10962964261441488","url":null,"abstract":"<p><strong>Background: </strong>National trends toward earlier onset of diverticulitis combined with more advanced maternal age may converge, making diverticulitis an increasingly important etiology of obstetric abdominal infection. However, there is little data on this topic, and no specific guidelines on how to treat pregnant patients with the disease. The purpose of this study was to identify the frequency of hospitalization for diverticulitis in pregnant patients and the common complications associated with this disease process.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the National Readmissions Database (NRD) to evaluate maternal and fetal complications among pregnant patients diagnosed with diverticulitis. The NRD was queried for all visits in the first 3 quarters of each year, 2016-2019, that included a patient with an International Classification of Diseases-10 code for diverticulitis and pregnancy. These entries were then further investigated for demographics, gestational age, rates of intervention, readmissions, and maternal and fetal complications.</p><p><strong>Results: </strong>A total of 470 patients were identified with a diagnosis of diverticulitis and pregnancy. Most patients (n = 340, 72.3%) were in the third trimester of pregnancy at presentation. 160/470 (34.0%) of admissions led to fetal delivery within 48 h. Of these, 3.8% of patients (n = 18) had complicated diverticulitis on index admission. The 90-day readmission rate for perforation or abscess was 1.3%. There were no reported maternal deaths. The overall rate of maternal complications was 41.3% and fetal complications was 41%, including a 1.9% rate of fetal loss.</p><p><strong>Conclusions: </strong>Diverticulitis is associated with significant rates of maternal and fetal complications when it occurs during pregnancy. Further investigation is warranted to better define the outcomes and guide best practices in this population.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261441488"},"PeriodicalIF":1.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Maximum Amplitude as a Potential Parameter to Predict the Likelihood of Mortality in Complicated Intra-Abdominal Infection Patients with Thrombocytopenia.","authors":"Tao Tian, Danhua Yao, Yuhua Huang, Pengfei Wang, Yousheng Li","doi":"10.1177/10962964261441210","DOIUrl":"https://doi.org/10.1177/10962964261441210","url":null,"abstract":"<p><strong>Background: </strong>Thrombocytopenia is one of the common serious complications among complicated intra-abdominal infection (cIAI) patients. Maximum amplitude (MA), a thromboelastography parameter, represents fibrinogen levels, platelet count, and platelet function. Our study aimed to elucidate the association between decreased MA and mortality among cIAI patients with thrombocytopenia.</p><p><strong>Methods: </strong>cIAI patients with thrombocytopenia were enrolled-in. Clinical data and various laboratory values were collected. Uni-variable analysis and multi-variable logistic regression were used to evaluate the correlation between decreased MA and mortality. The area under the curve (AUC) was calculated to evaluate the predictive performance.</p><p><strong>Results: </strong>A total of 58 cIAI patients with thrombocytopenia were included. According to the uni-variable analysis, decreased MA was significantly associated with patient mortality (odds ratio [OR]: 15.41, 95% confidence interval [CI]: 4.03-58.91; p < 0.001). In the multi-variable analysis model 1, which was adjusted for age and gender, decreased MA remained significantly associated with increased patient mortality (OR: 10.96, 95% CI: 2.44-49.20; p = 0.002). After adjusting for age, gender, platelet count, acute physiology and chronic health evaluation II score, and sequential organ failure assessment score (model 2), decreased MA was also a risk factor for patient mortality (OR: 12.66, 95% CI: 1.81-88.78; p = 0.011). MA levels were significantly lower in non-survivors than in survivors (all p < 0.05). The AUC of MA for predicting mortality was 0.72 (95% CI: 0.58-0.87; p = 0.0036).</p><p><strong>Conclusion: </strong>Decreased MA may be a potential parameter to help predict the likelihood of mortality in cIAI patients with thrombocytopenia.</p>","PeriodicalId":22109,"journal":{"name":"Surgical infections","volume":" ","pages":"10962964261441210"},"PeriodicalIF":1.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}