Strahlentherapie und Onkologie最新文献

{"title":"Radiotherapy for painful shoulder syndrome: a retrospective evaluation.","authors":"Ronny Leist, Oliver Micke, M Heinrich Seegenschmiedt, Irenaeus A Adamietz, Kashyar Fakhrian, Ralph Muecke","doi":"10.1007/s00066-024-02302-x","DOIUrl":"https://doi.org/10.1007/s00066-024-02302-x","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the efficacy of low-dose radiotherapy for painful shoulder syndrome from an orthopedic perspective.</p><p><strong>Methods: </strong>Patients with painful shoulder syndrome were recruited for this retrospective clinical quality assessment from January 2011 to December 2017. Patients were treated with a linear accelerator or an orthovoltage device at individual doses of 0.5-1.0 Gy and total doses of 3.0-6.0 Gy. To assess response, we used the von Pannewitz score with five levels: \"worsened,\" \"unaffected,\" \"improved,\" \"significantly improved,\" and \"symptom free.\" \"Good treatment success\" was defined as \"significantly improved\" and \"symptom free.\" Within-group and between-group differences were statistically evaluated.</p><p><strong>Results: </strong>Of 236 recruited patients (150 women, 86 men; mean age 66.3 [range 31-96] years), 180 patients underwent radiotherapy with a linear accelerator and 56 with an orthovoltage device. Fractionation was 12 × 0.5 Gy in 120 patients, 6 × 0.5 Gy in 74, and 6 × 1 Gy in 42 patients. Treatments were completed in one series for 223 and in two series at least 6 weeks apart for 13 patients. Of the 236 patients, 163 patients (69.1%) agreed to be re-interviewed at a median of 10.5 (range 4-60) months after radiotherapy completion. Directly after radiotherapy, 30.9% (73 patients) had \"good treatment success,\" which had increased to 55.2% (90 patients) at follow-up.</p><p><strong>Conclusion: </strong>Protracted pain improvement with low-dose radiotherapy is possible in painful shoulder syndrome. Patients with refractory pain because of subacromial syndrome or shoulder osteoarthritis should also be evaluated for radiotherapy.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac metastasis in uterine cervical cancer","authors":"I.-M. Simek, A. Sturdza, J. Knoth, A Spannbauer, J. Bergler-Klein, M. Vögele-Kadletz, J. Widder, M. P. Schmid","doi":"10.1007/s00066-024-02274-y","DOIUrl":"https://doi.org/10.1007/s00066-024-02274-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Cardiac metastasis from cervical cancer is rare and only scarcely documented. We aim to present a new case and systematically summarize the available literature.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>PubMed, Scopus, Web of Science, Central, and ClinicalTrials.gov were systematically searched following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. Results were screened via title, abstract, and full text. Additionally, the reference lists of all papers chosen for the review were screened.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Eighty-one papers were identified, describing 86 cases in total. Cardiac metastasis occurred at all stages of cervical cancer and in all age groups. Median time from initial diagnosis to diagnosis of cardiac metastasis was 12 months. Patients mainly complained of dyspnea and chest pain, 60.8% had pathologic ECG (electrocardiographic) findings. The cardiac mass was most frequently detected by transthoracic echography. The most common tumor histology was squamous cell carcinoma. Chemotherapy and surgical interventions were the main treatment modalities. Median survival after diagnosis of cardiac metastasis was 3 months.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This largest review on cardiac metastases from cervical cancer confirmed the heart as a very infrequent site of metastasis. There are &lt; 100 cases described in the literature, with very poor prognosis and undefined clinical management.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"18 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of operative duration of image-guided brachytherapy for cervical cancer","authors":"Yoshiaki Takagawa, Masanori Machida, Ichiro Seto, Shinya Komori, Hiroki Sato, Hiromitsu Endo, Hiroko Midorikawa, Takahiro Kato, Masao Murakami, Michitaka Honda, Koji Kono","doi":"10.1007/s00066-024-02297-5","DOIUrl":"https://doi.org/10.1007/s00066-024-02297-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The present study aimed to analyze the operative duration of image-guided brachytherapy (IGBT) for cervical cancer performed at our institution.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We enrolled cervical cancer patients who had undergone tandem and ovoid-based intracavitary brachytherapy (ICBT) or intracavitary and interstitial brachytherapy (IC/ISBT) between 2020 and 2024. Cone beam computed tomography (CBCT), CT, or CT + MRI were used for IGBT. For each IGBT session, we retrospectively reviewed the following: application time (AT—defined as the duration from entry into the operating room to the initial image acquisition); planning time (PT—defined as the duration from the initial image acquisition to the start of irradiation); and total operation time (TOT— defined as the duration from entry to exit of the operating room).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We analyzed a total of 126 sessions in 36 patients, consisting of 99 ICBT-only sessions and 27 IC/ISBT sessions. The IC/ISBT sessions had a significantly longer mean operative duration than the ICBT-only sessions. The IC/ISBT sessions with three or more interstitial needles had significantly longer AT and TOT. However, the IC/ISBT sessions with one needle showed no significant difference in operative duration compared to ICBT-only sessions. CBCT, CT, and CT + MRI were used in 42, 76, and 8 sessions, respectively. In the ICBT patients, CT + MRI had the longest PT. However, there was no significant differences in TOT among CBCT, CT, and CT + MRI.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>IC/ISBT sessions with one needle had no significant difference in operative duration compared to ICBT-only sessions. There was no significant difference in TOT between CT + MRI-based IGBT and CT-based IGBT.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"93 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nested CNN architecture for three-dimensional dose distribution prediction in tomotherapy for prostate cancer","authors":"Maryam Zamanian, Maziar Irannejad, Iraj Abedi, Mohsen Saeb, Mahnaz Roayaei","doi":"10.1007/s00066-024-02290-y","DOIUrl":"https://doi.org/10.1007/s00066-024-02290-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>The hypothesis of changing network layers to increase the accuracy of dose distribution prediction, instead of expanding their dimensions, which requires complex calculations, has been considered in our study.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>A total of 137 prostate cancer patients treated with the tomotherapy technique were categorized as 80% training and validating as well as 20% testing for the nested UNet and UNet architectures. Mean absolute error (MAE) was used to measure the dosimetry indices of dose–volume histograms (DVHs), and geometry indices, including the structural similarity index measure (SSIM), dice similarity coefficient (DSC), and Jaccard similarity coefficient (JSC), were used to evaluate the isodose volume (IV) similarity prediction. To verify a statistically significant difference, the two-way statistical Wilcoxon test was used at a level of 0.05 (<i>p</i> &lt; 0.05).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Use of a nested UNet architecture reduced the predicted dose MAE in DVH indices. The MAE for planning target volume (PTV), bladder, rectum, and right and left femur were D_98% = 1.11 ± 0.90; D_98% = 2.27 ± 2.85, D_mean = 0.84 ± 0.62; D_98% = 1.47 ± 12.02, D_mean = 0.77 ± 1.59; D_2% = 0.65 ± 0.70, D_mean = 0.96 ± 2.82; and D_2% = 1.18 ± 6.65, D_mean = 0.44 ± 1.13, respectively. Additionally, the greatest geometric similarity was observed in the mean SSIM for UNet and nested UNet (0.91 vs. 0.94, respectively).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The nested UNet network can be considered a suitable network due to its ability to improve the accuracy of dose distribution prediction compared to the UNet network in an acceptable time.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"30 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of different radiotherapy doses on the mechanical properties and microstructure of the enamel and dentin of human premolar teeth","authors":"Yuan Tu, Liying Hao, Yi Ding, Yisi Zhong, Chengge Hua, Li Jiang","doi":"10.1007/s00066-024-02296-6","DOIUrl":"https://doi.org/10.1007/s00066-024-02296-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>Radiation therapy is applied in the treatment of head and neck cancer patients. However, oral-health-related side effects like hyposalivation and a higher prevalence of caries have been shown. This study aims to assess the influence of different radiotherapy doses on the mechanical properties, roughness, superficial microstructure, and crystallinity of the enamel and dentin of human premolar teeth.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Specimens (<i>n</i> = 25) were categorized into five groups based on the radiation dose received (0, 10, 30, 50, and 70 Gy). The enamel and dentin of these specimens were subjected to a microhardness tester, profilometer, atomic force microscopy (AFM), scanning electron microscopy (SEM), and X‑ray diffraction (XRD) before and after different irradiation doses and compared to hydroxylapatite in each group. The data were analyzed using repeated-measures analysis of variance (ANOVA).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Therapeutic radiation doses of 30, 50, and 70 Gy led to a decrease in the microhardness and an increase in the average roughness of the enamel, and rougher surfaces were observed in the mixed three-dimensional images. Moreover, in the dentin, a similar outcome could be observed for more than 10 Gy. The main crystalline phase structure remained hydroxylapatite, but the crystallinity decreased and the crystalline size increased above 10 Gy. The superficial micromorphology revealed granulation, fissures, and cracks in a dose-dependent manner. Radiation below 70 Gy had little effect on the hydroxylapatite concentration during the whole experiment.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Above a radiation dose of 30 Gy, the micromorphology of the tooth enamel changed. This occurred for dentin above 10 Gy, which indicates that dentin is more sensitive to radiotherapy than enamel. The radiation dose had an effect on the micromorphology of the hard tissues of the teeth. These results illustrate the possible mechanism of radiation-related caries and have guiding significance for clinical radiotherapy.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"34 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing stereotactic arrhythmia radioablation with STOPSTORM.eu consortium support: intermediate results of a prospective Israeli single-institutional trial","authors":"Egor Borzov, Roi Efraim, Mahmoud Suleiman, Raquel Bar-Deroma, Salem Billan, Jingyang Xie, Stephan Hohmann, Oliver Blanck, Tomer Charas","doi":"10.1007/s00066-024-02300-z","DOIUrl":"https://doi.org/10.1007/s00066-024-02300-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Ventricular tachycardia (VT) is a life-threatening arrhythmia originating from the heart’s ventricles. Traditional treatments include antiarrhythmic medications, implantable cardioverter-defibrillators (ICDs), and catheter ablation. Stereotactic body radiation therapy (SBRT) targeting the arrhythmogenic focus in the left ventricle—stereotactic arrhythmia radioablation (STAR)—is an emerging treatment and may offer a potential solution for patients with refractory VT.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>We designed an interventional prospective clinical trial in Israel aligned with the STOPSTORM.eu consortium’s benchmarks, recommendations, and directives to assess the safety and efficacy of STAR in patients with refractory VT.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Our phase I/II single-institutional trial was approved by the Ministry of Health of Israel for 10 patients, initially assessing safety in the first 3 patients. We included patients with ICDs experiencing symptomatic monomorphic VT after an inadequate response to previous therapies. The primary endpoints were treatment-related serious adverse events and a reduction in VT burden as assessed by ICD interrogation. Secondary outcomes included a reduction in antiarrhythmic medications and changes in quality of life.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>From August 2023 to August 2024, 3 patients underwent STAR treatment. The prescription dose was a single fraction of 25 Gy. Planning target volumes were 47.8, 49.7, and 91.8 cc, and treatment was successfully delivered with no grade 3 or higher adverse events reported. Over a follow-up period of 12 months for the first patient and 8 months for the second one, no VT events were recorded after treatment. The third patient died from progressive heart failure 3 months after treatment. Left ventricular ejection fraction remained stable, and no significant radiation-induced inflammatory changes were noted.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The initial results of this trial suggest that STAR can reduce VT episodes in patients with refractory VT without severe adverse effects. The study highlights the importance of international collaboration and standardization in pioneering new treatments. Further follow-up and additional patient data will be necessary to confirm these findings and evaluate long-term outcomes, including potential adjustments to antiarrhythmic medication regimens.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"18 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging-based radiomics for predicting infiltration levels of CD68+ tumor-associated macrophages in glioblastomas","authors":"Qing Zhou, Bin Zhang, Caiqiang Xue, Jialiang Ren, Peng Zhang, Xiaoai Ke, Jiangwei Man, Junlin Zhou","doi":"10.1007/s00066-024-02289-5","DOIUrl":"https://doi.org/10.1007/s00066-024-02289-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Tumor-associated macrophages (TAMs) are important biomarkers of tumor invasion and prognosis in patients with glioblastoma. We combined the imaging and radiomics features of preoperative MRI to predict CD68+ macrophage infiltration.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Clinical, MRI image, and pathology data of 188 patients with glioblastoma were analyzed. Overall, 143 patients were included in the training (<i>n</i> = 101) and validation (<i>n</i> = 42) sets, whereas 45 patients were included in an independent test set. The optimal cut-off value (14.8%) was based on the minimum <i>p</i>-value formed by the Kaplan–Meier survival analysis and log-rank tests which divided patients into groups with high CD68+ TAMs (≥ 14.8%) and low CD68+ TAMs (&lt; 14.8%). Regions of interest and radiomics features extraction were based on contrast-enhanced T1-weighted images (CE-T1WI) and T2WI. Multi-parameter stepwise regression was used to create the clinical, radiomics, and combined models, each evaluated using the receiver operating characteristic curve. Decision curve analysis was used to assess the clinical applicability of the nomogram.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A clinical model based on the minimum apparent diffusion coefficient (ADCmin) revealed an area under the curve (AUC) of 0.768, 0.764, and 0.624 for the training set, validation set, and test set, respectively. The 2D radiomics model, based on two features, revealed an AUC of 0.783, 0.724, and 0.789 for the training, validation, and test sets, respectively. The 3D radiomics model, based on three features, revealed AUCs of 0.823, 0.811, and 0.787 for the training, validation, and test sets, respectively. The combined model, with ADCmin and radiomics features, showed the best performance, with AUCs of 0.865, 0.822, and 0.776 for the training, validation, and test sets, respectively. The calibration curve of the combined model nomogram showed good agreement between the estimated and actual probabilities.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The combined model constructed using ADCmin, a quantitative imaging parameter, combined with five key radiomics features can be used to evaluate the extent of CD68+ macrophages before surgery.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"22 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is intensive training with a time interval between instruction and planning CT necessary for deep inspiration breath-hold radiotherapy in breast cancer?","authors":"M. Sonnhoff, R.-M. Hermann, K. Aust, A.-C. Knöchelmann, M. Nitsche, B. Ernst, H. Christiansen, R.-M. Blach","doi":"10.1007/s00066-024-02295-7","DOIUrl":"https://doi.org/10.1007/s00066-024-02295-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Breathing instruction and exercises and a time gap between training and planning CT scans (pCT) is recommended as part of deep inspiration breath-hold (DIBH) assisted radiotherapy (RT). However, this is associated with additional time expenditure.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>In two of the authors’ treatment centers (TC), patient training took place before the planning CT of DIBH-assisted therapy. In TC 1, a further appointment was made with a minimum interval of 2 days to perform the planning CT. At TC 2, the planning CT was performed immediately after the first patient instruction. A retrospective evaluation of the clinical parameters of the therapy was carried out to investigate the relevance of the time gap between DIBH exercises and pCT.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 72 patients were included, 35 of whom were treated in TC 1 and 37 in TC 2. In TC 1, an average interval of ~4 days was observed between patient training and planning CT, while in TC 2, training and CT were performed immediately after each other. No significant differences in radiation dose exposure of the lung on the treated side, the whole lung, or the heart were found between the two centers. Furthermore, there was no significant difference in the application of the daily RT fraction. The requirement for daily positioning checks was also the same at both treatment centers.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This study does not show any advantages for a time gap between instruction/training and pCT. Skipping the time break does not deteriorate any clinically relevant endpoints.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"45 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of liposomal gel with and without chamomile to prevent radiation dermatitis in breast cancer patients: a randomized controlled trial","authors":"Amanda Gomes de Meneses, Elaine Barros Ferreira, Larissa Aparecida Corrêa Vieira, Priscila de Souza Maggi Bontempo, Eliete Neves Silva Guerra, Marcia Aparecida Ciol, Paula Elaine Diniz dos Reis","doi":"10.1007/s00066-024-02293-9","DOIUrl":"https://doi.org/10.1007/s00066-024-02293-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To compare a liposomal gel with and without chamomile extract for the prevention of radiation dermatitis in breast cancer patients undergoing radiotherapy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This study was a double-blind randomized clinical trial. A total of 100 participants undergoing radiotherapy for breast cancer were recruited. The primary outcome was the occurrence of dry desquamation. Cumulative dose of ionizing radiation at the first occurrence of dry desquamation, occurrence of erythema, moist desquamation, global radiation dermatitis, and any signs and symptoms self-reported by participants were secondary outcomes.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Dry desquamation occurred in 6.0% of the participants using chamomile liposomal gel and 12.2% of those using liposomal gel (<i>p</i> = 0.32). The mean cumulative dose of ionizing radiation for the first occurrence of dry desquamation was 45.1 Gy in the chamomile liposomal gel group and 43.7 Gy in the liposomal gel group. There were no differences between the two gels in the occurrence of erythema, dry desquamation, moist desquamation, and radiation dermatitis compared to liposomal gel. There was a lower proportion of reported symptoms in the chamomile liposomal gel group compared to liposomal gel group in the first 3 weeks of radiation, especially for itching (<i>p</i> = 0.05).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>No statistically significant differences between the two gels were found in radiation dermatitis occurrence and dose at first occurrence. Comparing to the literature, it seems that both interventions may be effective, which might explain the lack of statistical difference between the groups.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"7 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical monitoring of radiation-induced brain injury via GluCEST MRI and resting-state fMRI at 7 T: an exploratory study on MRI-guided OAR avoidance","authors":"Guodong Li, Hao Li, Na Weng, Caiyun Liu, Xianglin Li, Qinglong Li, Li Bin, Kai Zhu, Danqi Huang, Jia Liu, Yan Liu, Xu Wang","doi":"10.1007/s00066-024-02292-w","DOIUrl":"https://doi.org/10.1007/s00066-024-02292-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To assess the value of glutamate chemical exchange saturation transfer (GluCEST) after whole-brain radiotherapy (WBRT) as an imaging marker of radiation-induced brain injury (RBI) and to preliminarily show the feasibility of multiparametric MRI-guided organ at risk (OAR) avoidance.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Rats were divided into two groups: the control (CTRL) group (<i>n</i> = 9) and the RBI group (<i>n</i> = 9). The rats in the RBI group were irradiated with an X‑ray radiator and then subjected to a water maze experiment 4 weeks later. In combination with high-performance liquid chromatography (HPLC), we evaluated the value of GluCEST applied to glutamate changes for RBI and investigated the effect of such changes on glutamatergic neuronal function.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The average GluCEST values were markedly lower in the hippocampus and cerebral cortex. Positive correlations were observed between GluCEST values and regional homogeneity (ReHo) values in both the hippocampus and the cerebral cortex. HPLC showed a positive correlation with GluCEST values in the hippocampus. GluCEST values were positively correlated with spatial memory.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>GluCEST MRI provides a visual assessment of glutamate changes in RBI rats for monitoring OAR cognitive toxicity reactions and may be used as a biomarker of OAR avoidance as well as metabolism to facilitate monitoring and intervention in radiation damage that occurs after radiotherapy.</p>","PeriodicalId":21998,"journal":{"name":"Strahlentherapie und Onkologie","volume":"4 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}