Journal of Alzheimer's disease : JAD最新文献_第6页

Intestinal Microflora Changes in Patients with Mild Alzheimer's Disease in a Chinese Cohort. 中国人群中轻度阿尔茨海默病患者肠道菌群的变化

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-30 DOI: 10.3233/jad-220076

Yilin Wang, Lei Li, Xiaodong Zhao, Shaomei Sui, Qi Wang, Guizhi Shi, Huilian Xu, Xiujun Zhang, Yan He, Jinsong Gu

{"title":"Intestinal Microflora Changes in Patients with Mild Alzheimer's Disease in a Chinese Cohort.","authors":"Yilin Wang, Lei Li, Xiaodong Zhao, Shaomei Sui, Qi Wang, Guizhi Shi, Huilian Xu, Xiujun Zhang, Yan He, Jinsong Gu","doi":"10.3233/jad-220076","DOIUrl":"https://doi.org/10.3233/jad-220076","url":null,"abstract":"BACKGROUND\u0000Understanding the relationship between Alzheimer's disease (AD) and intestinal flora is still a major scientific topic that continues to advance.\u0000\u0000\u0000OBJECTIVE\u0000To determine characterized changes in the intestinal microbe community of patients with mild AD.\u0000\u0000\u0000METHODS\u0000Comparison of the 16S ribosomal RNA (rRNA) high-throughput sequencing data was obtained from the Illumina MiSeq platform of fecal microorganisms of the patients and healthy controls (HC) which were selected from cohabiting caregivers of AD patients to exclude environmental and dietary factors.\u0000\u0000\u0000RESULTS\u0000We found that the abundance of several bacteria taxa in AD patients was different from that in HC at the genus level, such as Anaerostipes, Mitsuokella, Prevotella, Bosea, Fusobacterium, Anaerotruncus, Clostridium, and Coprobacillus. Interestingly, the abundance of Akkermansia, an emerging probiotic, increased significantly in the AD group compared with that in the HC group. Meanwhile, the quantity of traditional probiotic Bifidobacteria of the AD group also rose.\u0000\u0000\u0000CONCLUSION\u0000These alterations in fecal microbiome of the AD group indicate that patients with mild AD have unique gut microbial characteristics. These specific AD-associated intestinal microbes could serve as novel potential targets for early intervention of AD.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130033041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Secular Trends in Dementia Free Cognitive Function in Older Adults: A Systematic Review. 老年人无痴呆认知功能的长期趋势:系统回顾。

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-28 DOI: 10.3233/jad-220162

B. Stephan, E. Tang, Eduwin Pakpahan, B. Biswas, Alisha Gupta, A. McGrattan, A. Bosco, C. Richardson, L. Robinson, M. Siervo

{"title":"Secular Trends in Dementia Free Cognitive Function in Older Adults: A Systematic Review.","authors":"B. Stephan, E. Tang, Eduwin Pakpahan, B. Biswas, Alisha Gupta, A. McGrattan, A. Bosco, C. Richardson, L. Robinson, M. Siervo","doi":"10.3233/jad-220162","DOIUrl":"https://doi.org/10.3233/jad-220162","url":null,"abstract":"BACKGROUND\u0000Although numerous studies have reported a decrease in dementia risk in the last two decades, it is unclear whether dementia-free cognitive function is also changing across generations.\u0000\u0000\u0000OBJECTIVE\u0000The objective was to systematically evaluate the published data on generational differences in cognitive function in the older population.\u0000\u0000\u0000METHODS\u0000Searches were performed on PubMed, Embase, and PsychInfo for articles published in English before 20 June 2021. Included studies were from population-based samples that reported generational differences in cognition in individuals without dementia, aged ≥60 years.\u0000\u0000\u0000RESULTS\u000028,101 studies were identified and 15 selected covering the period from 1971 to 2015: including studies from China, Europe, and the USA. The results show generally consistent findings of improvements or stability in dementia free cognitive function in later versus earlier born generations, but not for all cognitive domains. Prevalence of mild cognitive impairment and cognitive impairment no dementia has remained stable in the USA, UK, and China over the last two decades.\u0000\u0000\u0000RESULTS\u0000Prevalence of vascular related mild cognitive impairment has increased in China. Improvements in cognition may only partially be explained by increased educational attainment across generations.\u0000\u0000\u0000CONCLUSION\u0000This review provides evidence for generational effects in dementia-free cognitive function, predominately stability or improvements in performance, in later compared to earlier born individuals across different world regions. There is an urgent need to determine the factors driving such changes and whether they are being experienced in all world regions, particularly low- and middle-income countries where the burden of cognitive impairment is greatest and rising.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134544084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Relationship Between Prior Cancer Diagnosis and All-Cause Dementia Progression Among US Adults. 美国成年人既往癌症诊断与全因痴呆进展之间的关系

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-28 DOI: 10.3233/jad-220054

Mackenzie E. Fowler, N. Wright, K. Triebel, G. Rocque, R. Irvin, R. Kennedy

{"title":"The Relationship Between Prior Cancer Diagnosis and All-Cause Dementia Progression Among US Adults.","authors":"Mackenzie E. Fowler, N. Wright, K. Triebel, G. Rocque, R. Irvin, R. Kennedy","doi":"10.3233/jad-220054","DOIUrl":"https://doi.org/10.3233/jad-220054","url":null,"abstract":"BACKGROUND\u0000Cancer-related cognitive impairment (CRCI), a frequent effect of cancer and its treatments, shares common cognitive symptoms with dementia syndromes. Cross-sectional studies demonstrate an inverse relationship between cancer and dementia. However, the longitudinal relationship between dementia decline and cancer has not been investigated.\u0000\u0000\u0000OBJECTIVE\u0000To evaluate the association between cancer and longitudinal progression of dementia.\u0000\u0000\u0000METHODS\u0000We extracted electronic health record data from July 2003 to February 2020 from a single academic medical center. We identified dementia and cancer history prior to dementia using ICD-9/10 codes. We measured cognitive decline with the Alabama Brief Cognitive Screener (ABCs). We used adjusted linear mixed models to estimate baseline cognition and rate of progression by cancer history, including differences by race.\u0000\u0000\u0000RESULTS\u0000The study included 3,809 participants with dementia, of which 672 (17.6%) had cancer history. Those with cancer history had higher baseline cognition (β: 0.62, 95% CI: -0.02-1.25), but similar rate of decline. Non-Hispanic Blacks had lower cognitive scores at baseline and throughout follow-up regardless of cancer status compared to non-Hispanic Whites and other races/ethnicities with and without cancer history.\u0000\u0000\u0000CONCLUSION\u0000In this longitudinal retrospective study, participants with cancer history demonstrate better cognition at dementia diagnosis and no difference in cognitive decline than those without cancer history. Smoking and comorbidities attenuate this association and results indicate non-Hispanic Blacks have worse cognitive outcomes in dementia regardless of cancer history than other race/ethnicity groups. Further exploration of the role of smoking, comorbidities, and race/ethnicity on cancer and dementia-related cognitive decline is needed.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123788326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Distinct Patterns Link the BDNF Val66Met Polymorphism to Alzheimer's Disease Pathology. 不同的模式将BDNF Val66Met多态性与阿尔茨海默病病理联系起来

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-28 DOI: 10.3233/jad-215353

Joost M. Riphagen, R. V. Van Hooren, G. Kenis, F. Verhey, H. Jacobs

引用次数: 1

Erratum to: Global Perspectives on Brief Cognitive Assessments for Dementia Diagnosis. 对痴呆诊断的简短认知评估的全球视角的勘误。

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-23 DOI: 10.3233/jad-229005

E. Tsoy, A. Sideman, Stefanie D. Piña Escudero, Maritza Pintado-Caipa, Suchanan Kanjanapong, Tala Al-Rousan, Lingani Mbakile-Mahlanza, M. Oliveira, S. Zygouris, Aya Ashour Mohamed, Hany Ibrahim, Collette A. Goode, B. Miller, V. Valcour, K. Possin

引用次数: 0

Diet Patterns, the Gut Microbiome, and Alzheimer's Disease. 饮食模式，肠道微生物群和阿尔茨海默病。

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-23 DOI: 10.3233/jad-220205

A. McGrattan, C. Stewart, A. Cassidy, J. Woodside, C. McEvoy

{"title":"Diet Patterns, the Gut Microbiome, and Alzheimer's Disease.","authors":"A. McGrattan, C. Stewart, A. Cassidy, J. Woodside, C. McEvoy","doi":"10.3233/jad-220205","DOIUrl":"https://doi.org/10.3233/jad-220205","url":null,"abstract":"Given the complex bidirectional communication system that exists between the gut microbiome and the brain, there is growing interest in the gut microbiome as a novel and potentially modifiable risk factor for Alzheimer's disease (AD). Gut dysbiosis has been implicated in the pathogenesis and progression of AD by initiating and prolonging neuroinflammatory processes. The metabolites of gut microbiota appear to be critical in the mechanism of the gut-brain axis. Gut microbiota metabolites, such as trimethylamine-n-oxide, lipopolysaccharide, and short chain fatty acids, are suggested to mediate systemic inflammation and intracerebral amyloidosis via endothelial dysfunction. Emerging data suggest that the fungal microbiota (mycobiome) may also influence AD pathology. Importantly, 60% of variation in the gut microbiome is attributable to diet, therefore modulating the gut microbiome through dietary means could be an effective approach to reduce AD risk. Given that people do not eat isolated nutrients and instead consume a diverse range of foods and combinations of nutrients that are likely to be interactive, studying the effects of whole diets provides the opportunity to account for the interactions between different nutrients. Thus, dietary patterns may be more predictive of real-life effect on gut microbiome and AD risk than foods or nutrients in isolation. Accumulating evidence from experimental and animal studies also show potential effects of gut microbiome on AD pathogenesis. However, data from human dietary interventions are lacking. Well-designed intervention studies are needed in diverse populations to determine the influence of diet on gut microbiome and inform the development of effective dietary strategies for prevention of AD.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123142410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA). 巴尔的摩衰老纵向研究(BLSA)中每日身体活动模式作为认知诊断的窗口。

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-18 DOI: 10.3233/jad-215544

A. Wanigatunga, Fangyu Liu, Hang Wang, Jacek K. Urbanek, Y. An, A. Spira, Ryan J. Dougherty, Q. Tian, A. Moghekar, L. Ferrucci, E. Simonsick, S. Resnick, J. Schrack

{"title":"Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA).","authors":"A. Wanigatunga, Fangyu Liu, Hang Wang, Jacek K. Urbanek, Y. An, A. Spira, Ryan J. Dougherty, Q. Tian, A. Moghekar, L. Ferrucci, E. Simonsick, S. Resnick, J. Schrack","doi":"10.3233/jad-215544","DOIUrl":"https://doi.org/10.3233/jad-215544","url":null,"abstract":"BACKGROUND\u0000Gradual disengagement from daily physical activity (PA) could signal present or emerging mild cognitive impairment (MCI) or Alzheimer's disease (AD).\u0000\u0000\u0000OBJECTIVE\u0000This study examined whether accelerometry-derived patterns of everyday movement differ by cognitive diagnosis in participants of the Baltimore Longitudinal Study of Aging (BLSA).\u0000\u0000\u0000METHODS\u0000Activity patterns, overall and by time-of-day, were cross-sectionally compared between participants with adjudicated normal cognition (n = 549) and MCI/AD diagnoses (n = 36; 6 participants [17%] living with AD) using covariate-adjusted regression models.\u0000\u0000\u0000RESULTS\u0000Compared to those with normal cognition, those with MCI/AD had 2.1% higher activity fragmentation (SE = 1.0%, p = 0.036) but similar mean total activity counts/day (p = 0.075) and minutes/day spent active (p = 0.174). Time-of-day analyses show MCI/AD participants had lower activity counts and minutes spent active during waking hours (6:00 am-5:59 pm; p < 0.01 for all). Also, they had lower activity fragmentation from 12:00-5:59 am (p < 0.001), but higher fragmentation from 12:00-5:59 pm (p = 0.026).\u0000\u0000\u0000CONCLUSION\u0000Differences in the timing and patterns of physical activity throughout the day linked to MCI/AD diagnoses warrant further investigation into potential clinical utility.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"68 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115678952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Testing Visual Binding by the TMA-93 in People Aged 75 and Over. TMA-93在75岁及以上人群中检测视觉结合。

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-18 DOI: 10.3233/jad-220099

Ernesto García-Roldán, José Enrique Arriola-Infante, C. Méndez-Barrio, Fátima Montiel-Herrera, Gonzalo Mendoza-Vázquez, Alba Marta Marín-Cabañas, S. Rodrigo-Herrero, Andrea Luque-Tirado, M. B. Sánchez-Arjona, D. Maillet, E. Franco-Macías

{"title":"Testing Visual Binding by the TMA-93 in People Aged 75 and Over.","authors":"Ernesto García-Roldán, José Enrique Arriola-Infante, C. Méndez-Barrio, Fátima Montiel-Herrera, Gonzalo Mendoza-Vázquez, Alba Marta Marín-Cabañas, S. Rodrigo-Herrero, Andrea Luque-Tirado, M. B. Sánchez-Arjona, D. Maillet, E. Franco-Macías","doi":"10.3233/jad-220099","DOIUrl":"https://doi.org/10.3233/jad-220099","url":null,"abstract":"BACKGROUND\u0000TMA-93 examines relational binding using images. The test has been proven to be discriminative for diagnosing early Alzheimer's disease by biomarkers. Norms for this test are available, but the elderly, at high risk for Alzheimer's disease, have not yet been widely represented.\u0000\u0000\u0000OBJECTIVE\u0000To extend normative data on the TMA-93 for people aged 75 and over.\u0000\u0000\u0000METHODS\u0000An extension of the Spanish TMA-93 normative study was undertaken. Only cognitively unimpaired people aged 75 and over were included. Age, gender, and educational attainment were registered as socio-demographic variables. Using histograms analysis, median comparisons, and linear regression analysis, we selected variables that demonstrated influence on TMA-93 total scores and provided percentile-base reference data according to combinations of those variables.\u0000\u0000\u0000RESULTS\u0000We included 431 new participants, resulting in a total sample of 657 individuals (median age = 78, interquartile range = 76-81, range = 75-93). Percentile-base reference data stratified by a combination of age ranges (75-79, n = 428; and ≥80 years, n = 229), and educational attainment (< first grade, n = 253; first grade, n = 209; > first grade, n = 195) revealed that participants achieved a minimum TMA-93 total score of 26/30 at the 50th-percentile regardless of stratum. At the 10th-percentile, a maximum of 24/30 was achieved in the more educated stratum contrasting with a minimum of 19/30 in the less educated stratum.\u0000\u0000\u0000CONCLUSION\u0000Although mitigated by lower levels of education, performance on the TMA-93 is widely preserved in cognitively unimpaired people aged 75 and over. The test could facilitate the screening of elderly patients with memory complaints.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115467900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Peripheral Inflammatory Biomarkers of Alzheimer's Disease. 阿尔茨海默病的外周炎症生物标志物。

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-18 DOI: 10.3233/jad-215422

Jing Hao, Yanping Guo, Keke Guo, Qingcheng Yang

引用次数: 2

Crosstalk Between Gut Microflora and Vitamin D Receptor SNPs Are Associated with the Risk of Amnestic Mild Cognitive Impairment in a Chinese Elderly Population. 肠道菌群与维生素D受体snp之间的串扰与中国老年人群遗忘性轻度认知障碍的风险相关

Journal of Alzheimer's disease : JAD Pub Date : 2022-05-18 DOI: 10.3233/jad-220101

Kaixia Zhang, Xiao-yuan Ma, Rui Zhang, Zanchao Liu, Lei Jiang, Y-Q Qin, Di Zhang, Pei Tian, Zhaoyu Gao, Nan Zhang, Zhongli Shi, Shunjiang Xu

{"title":"Crosstalk Between Gut Microflora and Vitamin D Receptor SNPs Are Associated with the Risk of Amnestic Mild Cognitive Impairment in a Chinese Elderly Population.","authors":"Kaixia Zhang, Xiao-yuan Ma, Rui Zhang, Zanchao Liu, Lei Jiang, Y-Q Qin, Di Zhang, Pei Tian, Zhaoyu Gao, Nan Zhang, Zhongli Shi, Shunjiang Xu","doi":"10.3233/jad-220101","DOIUrl":"https://doi.org/10.3233/jad-220101","url":null,"abstract":"BACKGROUND\u0000The interactions between environmental factors and genetic variants have been implicated in the pathogenesis of Alzheimer's disease (AD). The altered gut microbiota (GM) and vitamin D deficiency are closely associated with the higher risk of AD.\u0000\u0000\u0000OBJECTIVE\u0000This study was performed to evaluate whether the crosstalk between GM and single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) or vitamin D binding protein (VDBP) have a link with the risk of amnestic mild cognitive impairment (aMCI) in the Chinese elderly population.\u0000\u0000\u0000METHODS\u0000A total of 171 aMCI patients and 261 cognitive normal controls (NC) were enrolled in this study. Six tag SNPs of VDR and VDBP were genotyped by PCR-RFLP. The serum levels of vitamin D, Aβ1-42, and p-tau (181P) were determined by using of ELISA kits. The alterations in the GM were analyzed by full-length 16S ribosomal RNA (rRNA) gene sequencing.\u0000\u0000\u0000RESULTS\u0000The frequencies of AG genotype and A allele of VDR rs1544410 in aMCI group were significantly higher than that in NC group (genotype: p = 0.002, allele: p = 0.003). Patients with aMCI showed an abnormal GM composition compared with NC group. Interestingly, significant differences in GM composition were found between aMCI and NC group among individuals with AG genotype, as well as between individuals with AG and GG genotype of VDR rs1544410 among patients with aMCI.\u0000\u0000\u0000CONCLUSION\u0000These results implicated that the crosstalk between gut microflora and vitamin D receptor variants are associated with the risk of aMCI in Chinese elderly population.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133775879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1