Journal of Alzheimer's disease : JAD最新文献

Improving Regression Analysis with Imputation in a Longitudinal Study of Alzheimer's Disease. 在阿尔茨海默氏症纵向研究中利用估算改进回归分析。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-17 DOI: 10.3233/JAD-231047

Ganesh Chandrasekaran, Sharon X Xie

{"title":"Improving Regression Analysis with Imputation in a Longitudinal Study of Alzheimer's Disease.","authors":"Ganesh Chandrasekaran, Sharon X Xie","doi":"10.3233/JAD-231047","DOIUrl":"https://doi.org/10.3233/JAD-231047","url":null,"abstract":"Background\u0000Missing data is prevalent in the Alzheimer's Disease Neuroimaging Initiative (ADNI). It is common to deal with missingness by removing subjects with missing entries prior to statistical analysis; however, this can lead to significant efficiency loss and sometimes bias. It has yet to be demonstrated that the imputation approach to handling this issue can be valuable in some longitudinal regression settings.\u0000\u0000\u0000Objective\u0000The purpose of this study is to demonstrate the importance of imputation and how imputation is correctly done in ADNI by analyzing longitudinal Alzheimer's Disease Assessment Scale -Cognitive Subscale 13 (ADAS-Cog 13) scores and their association with baseline patient characteristics.\u0000\u0000\u0000Methods\u0000We studied 1,063 subjects in ADNI with mild cognitive impairment. Longitudinal ADAS-Cog 13 scores were modeled with a linear mixed-effects model with baseline clinical and demographic characteristics as predictors. The model estimates obtained without imputation were compared with those obtained after imputation with Multiple Imputation by Chained Equations (MICE). We justify application of MICE by investigating the missing data mechanism and model assumptions. We also assess robustness of the results to the choice of imputation method.\u0000\u0000\u0000Results\u0000The fixed-effects estimates of the linear mixed-effects model after imputation with MICE yield valid, tighter confidence intervals, thus improving the efficiency of the analysis when compared to the analysis done without imputation.\u0000\u0000\u0000Conclusions\u0000Our study demonstrates the importance of accounting for missing data in ADNI. When deciding to perform imputation, care should be taken in choosing the approach, as an invalid one can compromise the statistical analyses.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease. 颅底形态测量可预测轻度认知障碍向阿尔茨海默病的转化。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-17 DOI: 10.3233/JAD-231192

G. Sighinolfi, Micaela Mitolo, Fabrizio Pizzagalli, M. Stanzani‐Maserati, D. Remondini, M. Rochat, Elena Cantoni, Greta Venturi, Gianfranco Vornetti, Fiorina Bartiromo, Sabina Capellari, R. Liguori, C. Tonon, C. Testa, Raffaele Lodi

{"title":"Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease.","authors":"G. Sighinolfi, Micaela Mitolo, Fabrizio Pizzagalli, M. Stanzani‐Maserati, D. Remondini, M. Rochat, Elena Cantoni, Greta Venturi, Gianfranco Vornetti, Fiorina Bartiromo, Sabina Capellari, R. Liguori, C. Tonon, C. Testa, Raffaele Lodi","doi":"10.3233/JAD-231192","DOIUrl":"https://doi.org/10.3233/JAD-231192","url":null,"abstract":"Background\u0000Being able to differentiate mild cognitive impairment (MCI) patients who would eventually convert (MCIc) to Alzheimer's disease (AD) from those who would not (MCInc) is a key challenge for prognosis.\u0000\u0000\u0000Objective\u0000This study aimed to investigate the ability of sulcal morphometry to predict MCI progression to AD, dedicating special attention to an accurate identification of sulci.\u0000\u0000\u0000Methods\u0000Twenty-five AD patients, thirty-seven MCI and twenty-five healthy controls (HC) underwent a brain-MR protocol (1.5T scanner) including a high-resolution T1-weighted sequence. MCI patients underwent a neuropsychological assessment at baseline and were clinically re-evaluated after a mean of 2.3 years. At follow-up, 12 MCI were classified as MCInc and 25 as MCIc. Sulcal morphometry was investigated using the BrainVISA framework. Consistency of sulci across subjects was ensured by visual inspection and manual correction of the automatic labelling in each subject. Sulcal surface, depth, length, and width were retrieved from 106 sulci. Features were compared across groups and their classification accuracy in predicting MCI conversion was tested. Potential relationships between sulcal features and cognitive scores were explored using Spearman's correlation.\u0000\u0000\u0000Results\u0000The width of sulci in the temporo-occipital region strongly differentiated between each pair of groups. Comparing MCIc and MCInc, the width of several sulci in the bilateral temporo-occipital and left frontal areas was significantly altered. Higher width of frontal sulci was associated with worse performances in short-term verbal memory and phonemic fluency.\u0000\u0000\u0000Conclusions\u0000Sulcal morphometry emerged as a strong tool for differentiating HC, MCI, and AD, demonstrating its potential prognostic value for the MCI population.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"111 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Dementia, Change in Home-Care Use, and Depressive Symptoms During the COVID-19 Pandemic: A Longitudinal Study Using Data from Three Cohort Studies. COVID-19 大流行期间痴呆症、家庭护理使用变化与抑郁症状之间的关系：使用三项队列研究数据的纵向研究。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-17 DOI: 10.3233/JAD-240097

M. Nakanishi, S. Yamasaki, T. Nakashima, Yuki Miyamoto, Claudia Cooper, Marcus Richards, D. Stanyon, Mai Sakai, Hatsumi Yoshii, Atsushi Nishida

{"title":"Association Between Dementia, Change in Home-Care Use, and Depressive Symptoms During the COVID-19 Pandemic: A Longitudinal Study Using Data from Three Cohort Studies.","authors":"M. Nakanishi, S. Yamasaki, T. Nakashima, Yuki Miyamoto, Claudia Cooper, Marcus Richards, D. Stanyon, Mai Sakai, Hatsumi Yoshii, Atsushi Nishida","doi":"10.3233/JAD-240097","DOIUrl":"https://doi.org/10.3233/JAD-240097","url":null,"abstract":"Background\u0000The emotional impact of the coronavirus disease 2019 (COVID-19) pandemic on people with dementia has been quantified. However, little is known about the impact of change in home-care use owing to the pandemic.\u0000\u0000\u0000Objective\u0000To determine the longitudinal association between dementia, change in home-care use, and depressive symptoms during the pandemic.\u0000\u0000\u0000Methods\u0000We included data of 43,782 home-dwelling older adults from the English Longitudinal Study of Ageing (ELSA), Study of health, Ageing and Retirement in Europe (SHARE), and National Health and Aging Trends Study (NHATS). This study considered the latest main wave survey prior to the pandemic as the baseline, and the COVID-19 survey as follow-up. In a series of coordinated analyses, multilevel binomial logistic regression model was used to examine the association between baseline dementia, change in home-care use at follow-up, and presence of depressive symptoms.\u0000\u0000\u0000Results\u0000Dementia, using the ELSA, SHARE, and NHATS datasets, was identified in 2.9%, 2.3%, and 6.5% of older adults, and home-care use reduced in 1.7%, 2.8%, and 1.1% of individuals with dementia, respectively. Dementia was significantly associated with the increased risk of depressive symptoms in all three cohorts. However, the interaction between dementia and period (follow-up) was non-significant in SHARE and NHATS. Across all three cohorts, home-care use during the pandemic, regardless of change in amount, was significantly associated with increased depressive symptoms, compared to the non-use of home care.\u0000\u0000\u0000Conclusions\u0000These results highlight the need for tailoring dementia care at home to promote independence and provide sustainable emotional support.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":" 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies. 雷帕霉素对阿尔茨海默病动物模型认知缺陷的影响和机制：临床前研究的系统回顾和元分析》。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-17 DOI: 10.3233/JAD-231249

Jie Cai, Danni Xie, Fanjing Kong, Zhenwei Zhai, Zhishan Zhu, Yanru Zhao, Ying Xu, Tao Sun

{"title":"Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies.","authors":"Jie Cai, Danni Xie, Fanjing Kong, Zhenwei Zhai, Zhishan Zhu, Yanru Zhao, Ying Xu, Tao Sun","doi":"10.3233/JAD-231249","DOIUrl":"https://doi.org/10.3233/JAD-231249","url":null,"abstract":"Background\u0000Alzheimer's disease (AD), the most common form of dementia, remains long-term and challenging to diagnose. Furthermore, there is currently no medication to completely cure AD patients. Rapamycin has been clinically demonstrated to postpone the aging process in mice and improve learning and memory abilities in animal models of AD. Therefore, rapamycin has the potential to be significant in the discovery and development of drugs for AD patients.\u0000\u0000\u0000Objective\u0000The main objective of this systematic review and meta-analysis was to investigate the effects and mechanisms of rapamycin on animal models of AD by examining behavioral indicators and pathological features.\u0000\u0000\u0000Methods\u0000Six databases were searched and 4,277 articles were retrieved. In conclusion, 13 studies were included according to predefined criteria. Three authors independently judged the selected literature and methodological quality. Use of subgroup analyses to explore potential mechanistic effects of rapamycin interventions: animal models of AD, specific types of transgenic animal models, dosage, and periodicity of administration.\u0000\u0000\u0000Results\u0000The results of Morris Water Maze (MWM) behavioral test showed that escape latency was shortened by 15.60 seconds with rapamycin therapy, indicating that learning ability was enhanced in AD mice; and the number of traversed platforms was increased by 1.53 times, indicating that the improved memory ability significantly corrected the memory deficits.\u0000\u0000\u0000CONCLUSIONS\u0000Rapamycin therapy reduced age-related plaque deposition by decreasing AβPP production and down-regulating β-secretase and γ-secretase activities, furthermore increased amyloid-β clearance by promoting autophagy, as well as reduced tau hyperphosphorylation by up-regulating insulin-degrading enzyme levels.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omics Approaches in Alzheimer's Disease Research. 阿尔茨海默病研究中的 Omics 方法。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-16 DOI: 10.3233/jad-240272

Sudeshna Das

引用次数: 0

Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases. 医院诊断感染和自身免疫性疾病后患主要类型痴呆症的风险。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-16 DOI: 10.3233/jad-231349

J. Janbek, T. M. Laursen, Niels Frimodt-Møller, Melinda Magyari, J. Haas, Richard Lathe, Gunhild Waldemar

{"title":"Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases.","authors":"J. Janbek, T. M. Laursen, Niels Frimodt-Møller, Melinda Magyari, J. Haas, Richard Lathe, Gunhild Waldemar","doi":"10.3233/jad-231349","DOIUrl":"https://doi.org/10.3233/jad-231349","url":null,"abstract":"Background\u0000Population-based studies have shown an increased risk of dementia after infections, but weaker links were reported for autoimmune diseases. Evidence is scarce for whether the links may be modified by the dementia or exposure subtype.\u0000\u0000\u0000Objective\u0000We aimed to investigate the association between infections and/or autoimmune diseases and rates of major types of dementias in the short- and long terms.\u0000\u0000\u0000Methods\u0000Nationwide nested case-control study of dementia cases (65+ years) diagnosed in Denmark 2016-2020 and dementia-free controls. Exposures were hospital-diagnosed infections and autoimmune diseases in the preceding 35 years. Two groups of dementia cases were those diagnosed in memory clinics (MC) and those diagnosed outside memory clinics (non-memory clinic cases, NMC).\u0000\u0000\u0000Results\u0000In total, 26,738 individuals were MC and 12,534 were NMC cases. Following any infection, the incidence rate ratio (IRR) for MC cases was 1.23 (95% CI 1.20-1.27) and 1.70 for NMC cases (1.62-1.76). Long-term increased rates were seen for vascular dementia and NMC cases. IRRs for autoimmune diseases were overall statistically insignificant.\u0000\u0000\u0000Conclusions\u0000Cases with vascular dementia and not Alzheimer's disease, and a subgroup of cases identified with poorer health have increased long-term risk following infections. Autoimmune diseases were not associated with any type of dementia. Notably increased risks (attributed to the short term) and for NMC cases may indicate that immunosenescence rather than de novo infection explains the links. Future focus on such groups and on the role of vascular pathology will explain the infection-dementia links, especially in the long term.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"89 8","pages":"1503-1514"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer's Disease. 阿尔茨海默氏症患者的前脑基底体积与淀粉样蛋白、Tau 和认知能力的关系

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-16 DOI: 10.3233/jad-230975

H. S. Yoo, Han-Kyeol Kim, Jae-Hoon Lee, Joong‐Hyun Chun, Hye Sun Lee, M. Grothe, Stefan J. Teipel, E. Cavedo, A. Vergallo, Harald Hampel, Young Hoon Ryu, Hanna Cho, C. Lyoo

{"title":"Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer's Disease.","authors":"H. S. Yoo, Han-Kyeol Kim, Jae-Hoon Lee, Joong‐Hyun Chun, Hye Sun Lee, M. Grothe, Stefan J. Teipel, E. Cavedo, A. Vergallo, Harald Hampel, Young Hoon Ryu, Hanna Cho, C. Lyoo","doi":"10.3233/jad-230975","DOIUrl":"https://doi.org/10.3233/jad-230975","url":null,"abstract":"Background\u0000Degeneration of cholinergic basal forebrain (BF) neurons characterizes Alzheimer's disease (AD). However, what role the BF plays in the dynamics of AD pathophysiology has not been investigated precisely.\u0000\u0000\u0000Objective\u0000To investigate the baseline and longitudinal roles of BF along with core neuropathologies in AD.\u0000\u0000\u0000Methods\u0000In this retrospective cohort study, we enrolled 113 subjects (38 amyloid [Aβ]-negative cognitively unimpaired, 6 Aβ-positive cognitively unimpaired, 39 with prodromal AD, and 30 with AD dementia) who performed brain MRI for BF volume and cortical thickness, 18F-florbetaben PET for Aβ, 18F-flortaucipir PET for tau, and detailed cognitive testing longitudinally. We investigated the baseline and longitudinal association of BF volume with Aβ and tau standardized uptake value ratio and cognition.\u0000\u0000\u0000Results\u0000Cross-sectionally, lower BF volume was not independently associated with higher cortical Aβ, but it was associated with tau burden. Tau burden in the orbitofrontal, insular, lateral temporal, inferior temporo-occipital, and anterior cingulate cortices were associated with progressive BF atrophy. Lower BF volume was associated with faster Aβ accumulation, mainly in the prefrontal, anterior temporal, cingulate, and medial occipital cortices. BF volume was associated with progressive decline in language and memory functions regardless of baseline Aβ and tau burden.\u0000\u0000\u0000Conclusions\u0000Tau deposition affected progressive BF atrophy, which in turn accelerated amyloid deposition, leading to a vicious cycle. Also, lower baseline BF volume independently predicted deterioration in cognitive function.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease. 勘误：泛素特异性蛋白酶 13 在阿尔茨海默病模型中调控 Tau 的积累和清除

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-16 DOI: 10.3233/jad-249007

引用次数: 0

Multi-Ethnic Norms for Volumes of Subcortical and Lobar Brain Structures Measured by Neuro I: Ethnicity May Improve the Diagnosis of Alzheimer's Disease1. 用神经 I 测量皮层下和脑叶结构体积的多种族规范种族可改善阿尔茨海默病的诊断1。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-16 DOI: 10.3233/jad-231182

Y. Choi, J. Lee, Jan te Nijenhuis, K. Y. Choi, Jongseong Park, Jongmyoung Ok, I. Choo, Hoowon Kim, Min-Kyung Song, Seong-Min Choi, Soo Hyun Cho, Youngshik Chae, Byeong C. Kim, Kun Ho Lee

{"title":"Multi-Ethnic Norms for Volumes of Subcortical and Lobar Brain Structures Measured by Neuro I: Ethnicity May Improve the Diagnosis of Alzheimer's Disease1.","authors":"Y. Choi, J. Lee, Jan te Nijenhuis, K. Y. Choi, Jongseong Park, Jongmyoung Ok, I. Choo, Hoowon Kim, Min-Kyung Song, Seong-Min Choi, Soo Hyun Cho, Youngshik Chae, Byeong C. Kim, Kun Ho Lee","doi":"10.3233/jad-231182","DOIUrl":"https://doi.org/10.3233/jad-231182","url":null,"abstract":"Background\u0000We previously demonstrated the validity of a regression model that included ethnicity as a novel predictor for predicting normative brain volumes in old age. The model was optimized using brain volumes measured with a standard tool FreeSurfer.\u0000\u0000\u0000Objective\u0000Here we further verified the prediction model using newly estimated brain volumes from Neuro I, a quantitative brain analysis system developed for Korean populations.\u0000\u0000\u0000Methods\u0000Lobar and subcortical volumes were estimated from MRI images of 1,629 normal Korean and 786 Caucasian subjects (age range 59-89) and were predicted in linear regression from ethnicity, age, sex, intracranial volume, magnetic field strength, and scanner manufacturers.\u0000\u0000\u0000Results\u0000In the regression model predicting the new volumes, ethnicity was again a substantial predictor in most regions. Additionally, the model-based z-scores of regions were calculated for 428 AD patients and the matched controls, and then employed for diagnostic classification. When the AD classifier adopted the z-scores adjusted for ethnicity, the diagnostic accuracy has noticeably improved (AUC = 0.85, ΔAUC = + 0.04, D = 4.10, p < 0.001).\u0000\u0000\u0000Conclusions\u0000Our results suggest that the prediction model remains robust across different measurement tool, and ethnicity significantly contributes to the establishment of norms for brain volumes and the development of a diagnostic system for neurodegenerative diseases.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye Tracking During Visual Paired-Comparison Tasks: A Systematic Review and Meta-Analysis of the Diagnostic Test Accuracy for Detecting Cognitive Decline. 视觉配对比较任务中的眼动追踪：检测认知能力衰退的诊断测试准确性的系统回顾和元分析》。

Journal of Alzheimer's disease : JAD Pub Date : 2024-04-16 DOI: 10.3233/jad-240028

M. Boujelbane, Khaled Trabelsi, Atef Salem, A. Ammar, Jordan M Glenn, O. Boukhris, Maha M. AlRashid, Haitham A. Jahrami, Hamdi Chtourou

{"title":"Eye Tracking During Visual Paired-Comparison Tasks: A Systematic Review and Meta-Analysis of the Diagnostic Test Accuracy for Detecting Cognitive Decline.","authors":"M. Boujelbane, Khaled Trabelsi, Atef Salem, A. Ammar, Jordan M Glenn, O. Boukhris, Maha M. AlRashid, Haitham A. Jahrami, Hamdi Chtourou","doi":"10.3233/jad-240028","DOIUrl":"https://doi.org/10.3233/jad-240028","url":null,"abstract":"Background\u0000Alzheimer's disease and mild cognitive impairment (MCI) progress silently, making early diagnosis challenging, especially in less educated populations. The visual paired comparison (VPC) task, utilizing eye-tracking movement (ETM) technology, offers a promising alternative for early detection of memory decline.\u0000\u0000\u0000Objective\u0000This systematic review and meta-analysis evaluated the efficacy of the VPC task, utilizing ETM as a tool for assessing age-related cognitive changes.\u0000\u0000\u0000Methods\u0000A comprehensive search across five databases and grey literature focused on healthy and impaired memory participants assessed through the ETM-based VPC task. The primary outcomes were novelty preference scores and eye movement metrics. The risk of bias of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2). Random-effects meta-analyses calculated Hedges' g effect size. Sensitivity and specificity of the VPC were meta-analytically pooled.\u0000\u0000\u0000Results\u0000The systematic review included 12 articles, involving 1,022 participants (aged 18 to 90 years, with education ranging from 6.5 to 20.0 years), with a low risk of bias and minimal applicability concerns across all items. Five studies contributed to the meta-analysis, revealing a significant effect favoring the VPC task for recognition memory detection (k = 9, g = -1.03). Pooled sensitivity and specificity analyses demonstrated VPC effectiveness as a recognition memory assessment tool (0.84 and 0.75, respectively).\u0000\u0000\u0000Conclusions\u0000The VPC task, utilizing ETM, may serve as a biomarker for early memory decline detection. Its use as a digital eye-tracking tool presents a possible alternative to traditional tests, warranting further research for application in neurodegenerative disease diagnosis.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"25 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140696270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0