Stem Cell Reviews and Reports最新文献_第9页

HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling. HAX1过表达通过介导Hippo-Yap信号增强干细胞疗法的心脏保护功效

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-07 DOI: 10.1007/s12015-024-10729-z

Wen-Feng Cai, Lin Jiang, Jialiang Liang, Suchandrima Dutta, Wei Huang, Xingyu He, Zhichao Wu, Christian Paul, Xiang Gao, Meifeng Xu, Onur Kanisicak, Junmeng Zheng, Yigang Wang

{"title":"HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling.","authors":"Wen-Feng Cai, Lin Jiang, Jialiang Liang, Suchandrima Dutta, Wei Huang, Xingyu He, Zhichao Wu, Christian Paul, Xiang Gao, Meifeng Xu, Onur Kanisicak, Junmeng Zheng, Yigang Wang","doi":"10.1007/s12015-024-10729-z","DOIUrl":"10.1007/s12015-024-10729-z","url":null,"abstract":"Although stem/progenitor cell therapy shows potential for myocardial infarction repair, enhancing the therapeutic efficacy could be achieved through additional genetic modifications. HCLS1-associated protein X-1 (HAX1) has been identified as a versatile modulator responsible for cardio-protective signaling, while its role in regulating stem cell survival and functionality remains unknown. In this study, we investigated whether HAX1 can augment the protective potential of Sca1+ cardiac stromal cells (CSCs) for myocardial injury. The overexpression of HAX1 significantly increased cell proliferation and conferred enhanced resistance to hypoxia-induced cell death in CSCs. Mechanistically, HAX1 can interact with Mst1 (a prominent conductor of Hippo signal transduction) and inhibit its kinase activity for protein phosphorylation. This inhibition led to enhanced nuclear translocation of Yes-associated protein (YAP) and activation of downstream therapeutic-related genes. Notably, HAX1 overexpression significantly increased the pro-angiogenic potential of CSCs, as demonstrated by elevated expression of vascular endothelial growth factors. Importantly, implantation of HAX1-overexpressing CSCs promoted neovascularization, protected against functional deterioration, and ameliorated cardiac fibrosis in ischemic mouse hearts. In conclusion, HAX1 emerges as a valuable and efficient inducer for enhancing the effectiveness of cardiac stem or progenitor cell therapeutics.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1569-1586"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Onset of Intussusceptive Angiogenesis in COVID-19 Patients Might Come from the Mobilization of Stem Cell Sub-Populations Expressing the Hemangioblast Marker CD143. COVID-19患者的肠内血管生成可能来自于表达血管母细胞标记物CD143的干细胞亚群的动员。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-09 DOI: 10.1007/s12015-024-10727-1

Lou Soret, Coralie L Guerin, Guillaume Goudot, Léa Guyonnet, Jean-Luc Diehl, Aurélien Philippe, Pascale Gaussem, David M Smadja

{"title":"The Onset of Intussusceptive Angiogenesis in COVID-19 Patients Might Come from the Mobilization of Stem Cell Sub-Populations Expressing the Hemangioblast Marker CD143.","authors":"Lou Soret, Coralie L Guerin, Guillaume Goudot, Léa Guyonnet, Jean-Luc Diehl, Aurélien Philippe, Pascale Gaussem, David M Smadja","doi":"10.1007/s12015-024-10727-1","DOIUrl":"10.1007/s12015-024-10727-1","url":null,"abstract":"COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The SARS-CoV-2 pandemic has unveiled complex pathophysiological mechanisms underpinning COVID-19, notably inducing a systemic acquired vascular hemopathy characterized by endothelial dysfunction and intussusceptive angiogenesis, a rapid vascular remodeling process identified as a hallmark in severe COVID-19 cases affecting pulmonary and cardiac tissues. Stem cell migration have been proposed as significant regulators of this neoangiogenic process. In a monocentric cross-sectional study, through spectral flow cytometry analysis of peripheral blood mononuclear cells, we identified a distinct stem cell subpopulation mobilized in critical COVID-19. Indeed, by an unsupervised analysis generating a UMAP representation we highlighted eleven different clusters in critical and non-critical COVID-19 patients. Only one cluster was significantly associated to critical COVID-19 compared to non-critical patients. This cluster expressed the markers: CD45dim, CD34+, CD117+, CD147+, and CD143+, and were negative for CD133. Higher level of expression of hemangioblast markers CD143 were found in critical COVID-19 patients. This population, indicative of hemangioblast-like cells, suggests a key role in COVID-19-related neoangiogenesis, potentially driving the severe vascular complications observed. Our findings underscore the need for further investigation into the contributions of adult stem cells in COVID-19 pathology, offering new insights into therapeutic targets and interventions.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1650-1655"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies. 间充质干细胞老化框架，从机制到战略。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-10 DOI: 10.1007/s12015-024-10732-4

Hongqing Zhao, Houming Zhao, Shuaifei Ji

引用次数: 0

Therapeutic Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in sepsis: a Systematic Review and Meta-Analysis of Preclinical Studies. 间充质干细胞衍生的细胞外囊泡对脓毒症的治疗效果：临床前研究的系统回顾和元分析。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1007/s12015-024-10741-3

Amir Hossein Aghayan, Yasin Mirazimi, Kosar Fateh, Abbasali Keshtkar, Mohammad Rafiee, Amir Atashi

{"title":"Therapeutic Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in sepsis: a Systematic Review and Meta-Analysis of Preclinical Studies.","authors":"Amir Hossein Aghayan, Yasin Mirazimi, Kosar Fateh, Abbasali Keshtkar, Mohammad Rafiee, Amir Atashi","doi":"10.1007/s12015-024-10741-3","DOIUrl":"10.1007/s12015-024-10741-3","url":null,"abstract":"Background: Sepsis is a life-threatening disorder with no definitive cure. Preclinical studies suggest that extracellular vesicles derived from mesenchymal stromal cells (EV-MSCs) can mitigate inflammatory conditions, potentially leading to increased survival and reduced organ dysfunction during sepsis. Our aim to conduct this systematic review and meta-analysis is assessing the EV-MSCs therapeutic efficacy in sepsis.Methods: PubMed, Embase, Scopus, WOS and ProQuest databases and also Google Scholar search engine were searched for published articles. We used hazard ratio (HR) and standardized mean difference (SMD) as effect sizes to evaluate the therapeutic effect of EV-MSCs on survival rate and determine their effect on reducing organ dysfunction, respectively. Finally, we employed GRADE tool for preclinical animal studies to evaluate certainty of the evidence.Results: 30 studies met the inclusion criteria for our article. Our meta-analysis results demonstrate that animals treated with MSC-EVs have better survival rate than untreated animals (HR = 0.33; 95% CI: 0.27-0.41). Our meta-analysis suggests that EV-MSCs can reduce organ dysfunctions in sepsis, such as the lung, kidney, and liver. Additionally, EV-MSCs decrease pro-inflammatory mediators like TNF-α, IL-1β, and IL-6.Conclusion: Our results indicate that EV-MSCs can be as promising therapy for sepsis management in animal models and leading to increased survival rate and reduced organ dysfunction. Furthermore, our study introduces a novel tool for risk of bias assessment and provides recommendations based on various analysis. Future studies with aiming to guide clinical translation can utilize the results of this article to establish stronger evidence for EV-MSC effectiveness.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1480-1500"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype. 间充质干细胞培养物的体外细胞表面标记表达并不反映其体内表型。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1007/s12015-024-10743-1

Ye Cao, Anna L Boss, Scott M Bolam, Jacob T Munro, Haemish Crawford, Nicola Dalbeth, Raewyn C Poulsen, Brya G Matthews

{"title":"In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype.","authors":"Ye Cao, Anna L Boss, Scott M Bolam, Jacob T Munro, Haemish Crawford, Nicola Dalbeth, Raewyn C Poulsen, Brya G Matthews","doi":"10.1007/s12015-024-10743-1","DOIUrl":"10.1007/s12015-024-10743-1","url":null,"abstract":"Cell surface marker expression is one of the criteria for defining human mesenchymal stem or stromal cells (MSC) in vitro. However, it is unclear if expression of markers including CD73 and CD90 reflects the in vivo origin of cultured cells. We evaluated expression of 15 putative MSC markers in primary cultured cells from periosteum and cartilage to determine whether expression of these markers reflects either the differentiation state of cultured cells or the self-renewal of in vivo populations. Cultured cells had universal and consistent expression of various putative stem cell markers including > 95% expression CD73, CD90 and PDPN in both periosteal and cartilage cultures. Altering the culture surface with extracellular matrix coatings had minimal effect on cell surface marker expression. Osteogenic differentiation led to loss of CD106 and CD146 expression, however CD73 and CD90 were retained in > 90% of cells. We sorted freshly isolated periosteal populations capable of CFU-F formation on the basis of CD90 expression in combination with CD34, CD73 and CD26. All primary cultures universally expressed CD73 and CD90 and lacked CD34, irrespective of the expression of these markers ex vivo indicating phenotypic convergence in vitro. We conclude that markers including CD73 and CD90 are acquired in vitro in most 'mesenchymal' cells capable of expansion. Overall, we demonstrate that in vitro expression of many cell surface markers in plastic-adherent cultures is unrelated to their expression prior to culture.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1656-1666"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placenta-targeted Treatment Strategies for Preeclampsia and Fetal Growth Restriction: An Opportunity and Major Challenge. 针对子痫前期和胎儿生长受限的胎盘靶向治疗策略：机遇与挑战并存

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1007/s12015-024-10739-x

Jianjian Cui, Zejun Yang, Ruilin Ma, Wencong He, Hui Tao, Ya'nan Li, Yin Zhao

{"title":"Placenta-targeted Treatment Strategies for Preeclampsia and Fetal Growth Restriction: An Opportunity and Major Challenge.","authors":"Jianjian Cui, Zejun Yang, Ruilin Ma, Wencong He, Hui Tao, Ya'nan Li, Yin Zhao","doi":"10.1007/s12015-024-10739-x","DOIUrl":"10.1007/s12015-024-10739-x","url":null,"abstract":"The placenta plays a crucial role in maintaining normal pregnancy. The failure of spiral artery remodeling (SAR) is a key factor leading to placental ischemia and poor perfusion which is strongly associated with obstetric diseases, including preeclampsia (PE) and fetal growth restriction (FGR). Existing interventions for PE and FGR are limited and termination of pregnancy is inevitable when the maternal or fetus condition deteriorates. Considering the safety of the mother and fetus, treatments that may penetrate the placental barrier and harm the fetus are not accepted. Developing targeted treatment strategies for these conditions is urgent and necessary. With the proven efficacy of targeted therapy in treating conditions such as endometrial cancer and trophoblastic tumors, research on placental dysfunction continues to deepen. This article reviews the studies on placenta-targeted treatment and drug delivery strategies, summarizes the characteristics proposes corresponding improvement measures in targeted treatment, provides solutions for existing problems, and makes suggestions for future studies.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1501-1511"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-coding RNAs Function in Periodontal Ligament Stem Cells. 牙周韧带干细胞中的非编码 RNA 功能

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-06-07 DOI: 10.1007/s12015-024-10731-5

Wei Zhai, Jie Gao, Wen Qin, Yuerong Xu

引用次数: 0

Role of Stem Cells in the Pathogenesis and Malignant Transformation of Oral Submucous Fibrosis. 干细胞在口腔黏膜下纤维化的发病机制和恶性转化中的作用

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1007/s12015-024-10744-0

Suvarna Kizhakkoottu, Pratibha Ramani, Wanninayake Mudiyanselage Tilakaratne

{"title":"Role of Stem Cells in the Pathogenesis and Malignant Transformation of Oral Submucous Fibrosis.","authors":"Suvarna Kizhakkoottu, Pratibha Ramani, Wanninayake Mudiyanselage Tilakaratne","doi":"10.1007/s12015-024-10744-0","DOIUrl":"10.1007/s12015-024-10744-0","url":null,"abstract":"Background: Pathogenesis and malignant potential of Oral submucous fibrosis(OSMF) have always been a topic of interest among the researchers. Despite OSMF being a collagen metabolic disorder, the alterations occurring in the connective tissue stroma affects the atrophic surface epithelium in later stages and progresses to malignant phenotypes. The present review aims to summarize the role of stem cells in the pathogenesis and malignant transformation of oral submucous fibrosis.Materials and methods: A literature search was carried out using data banks like Medline and Embase, google scholar and manual method with no time frame, pertinent to the role of mucosal stem cells in OSMF and its malignisation. The relevant literature was reviewed, critically appraised by all the authors and compiled in this narrative review.Results: Critical appraisal and evaluation of the data extracted from the selected articles were compiled in this review. The collated results highlighted the upregulation and downregulation of various stem cell markers during the progression and malignisation of OSMF were depicted in a descriptive and detail manner in the present review.Conclusion: We highlight the potential of mucosal stem cells in the regulation and malignisation of OSMF. However, future large-scale clinical studies will be needed to support whether manipulation of this stem cells at molecular level will be sufficient for the treatment and preventing the malignant transformation of OSMF.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1512-1520"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of methods for intrasplenic administration of human amniotic epithelial cells in order to perform safe and effective cell-based therapy for liver diseases. 优化人类羊膜上皮细胞的脾内给药方法，以便对肝病进行安全有效的细胞治疗。

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-21 DOI: 10.1007/s12015-024-10735-1

Piotr Czekaj, Mateusz Król, Emanuel Kolanko, Patrycja Wieczorek, Edyta Bogunia, Mateusz Hermyt, Aniela Grajoszek, Agnieszka Prusek

{"title":"Optimization of methods for intrasplenic administration of human amniotic epithelial cells in order to perform safe and effective cell-based therapy for liver diseases.","authors":"Piotr Czekaj, Mateusz Król, Emanuel Kolanko, Patrycja Wieczorek, Edyta Bogunia, Mateusz Hermyt, Aniela Grajoszek, Agnieszka Prusek","doi":"10.1007/s12015-024-10735-1","DOIUrl":"10.1007/s12015-024-10735-1","url":null,"abstract":"In animal experimental models the administration of stem cells into the spleen should ensure high effectiveness of their implantation in the liver due to a direct vascular connection between the two organs. The aim of this study was to update the methods of experimental intrasplenic cell transplantation using human amniotic epithelial cells (hAECs) which are promising cells in the treatment of liver diseases. BALB/c mice were administered intrasplenically with 0.5, 1, and 2 million hAECs by direct bolus injection (400 µl/min) and via a subcutaneous splenic port by fast (20 μl/min) and slow (10 μl/min) infusion. The port was prepared by translocating the spleen to the skin pocket. The spleen, liver, and lungs were collected at 3 h, 6 h, and 24 h after the administration of cells. The distribution of hAECs, histopathological changes in the organs, complete blood count, and biochemical markers of liver damage were assessed. It has been shown that the method of intrasplenic cell administration affects the degree of liver damage. The largest number of mice showing significant liver damage was observed after direct administration and the lowest after slow administration through a port. Liver damage increased with the number of administered cells, which, paradoxically, resulted in increased liver colonization efficiency. It was concluded that the administration of 1 × 106 hAECs by slow infusion via a subcutaneous splenic port reduces the incidence of complications at the expense of a slight decrease in the effectiveness of implantation of the transplanted cells in the liver.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1599-1617"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Amniotic Epithelial Stem Cells Alleviate Autoimmune Premature Ovarian Insufficiency in Mice by Targeting Granulosa Cells via AKT/ERK Pathways. 人羊膜上皮干细胞通过 AKT/ERK 通路靶向颗粒细胞缓解小鼠自身免疫性早发性卵巢发育不全症

IF 4.5 3区医学

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-06-04 DOI: 10.1007/s12015-024-10745-z

Xiaohang Ye, Yifeng Lin, Yanyun Ying, Xuezhi Shen, Feida Ni, Feixia Wang, Jianpeng Chen, Wei Zhao, Xiaoming Yu, Dan Zhang, Yifeng Liu

{"title":"Human Amniotic Epithelial Stem Cells Alleviate Autoimmune Premature Ovarian Insufficiency in Mice by Targeting Granulosa Cells via AKT/ERK Pathways.","authors":"Xiaohang Ye, Yifeng Lin, Yanyun Ying, Xuezhi Shen, Feida Ni, Feixia Wang, Jianpeng Chen, Wei Zhao, Xiaoming Yu, Dan Zhang, Yifeng Liu","doi":"10.1007/s12015-024-10745-z","DOIUrl":"10.1007/s12015-024-10745-z","url":null,"abstract":"Autoimmune factors play an important role in premature ovarian insufficiency (POI). Human amniotic epithelial stem cells (hAESCs) have recently shown promising treatment effects on chemotherapy-induced POI. However, the therapeutic efficacy and underlying mechanisms of hAESCs in autoimmune POI remain to be investigated. In this study, we showed for the first time that intravenous transplantation of hAESCs could reside in the ovary of zona pellucida 3 peptide (pZP3) induced autoimmune POI mice model for at least 4 weeks. hAESCs could improve ovarian function and fertility, alleviate inflammation and reduce apoptosis of granulosa cells (GCs) in autoimmune POI mice. The transcriptome analysis of mice ovaries and in vitro co-cultivation experiments suggest that activation of the AKT and ERK pathways may be the key mechanism in the therapeutic effect of hAESCs. Our work provides the theoretical and experimental foundation for optimizing the administration of hAESCs, as well as the clinical application of hAESCs in autoimmune POI patients.","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":"1618-1635"},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0