Sleep and Biological Rhythms最新文献

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Association between sleep quality and living environment among Chinese older persons: a cross-sectional study 中国老年人睡眠质量与居住环境的关系:一项横断面研究
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2024-01-17 DOI: 10.1007/s41105-023-00510-z
Yan Wang, Mengjie Guo, Jianan Li, Yan Zhang, Jing Cheng, Linhai Zhao, Lidan Wang, Guixia Fang, Guimei Chen, Zhongliang Bai, Han Liang, Ren Chen, Li Wang
{"title":"Association between sleep quality and living environment among Chinese older persons: a cross-sectional study","authors":"Yan Wang, Mengjie Guo, Jianan Li, Yan Zhang, Jing Cheng, Linhai Zhao, Lidan Wang, Guixia Fang, Guimei Chen, Zhongliang Bai, Han Liang, Ren Chen, Li Wang","doi":"10.1007/s41105-023-00510-z","DOIUrl":"https://doi.org/10.1007/s41105-023-00510-z","url":null,"abstract":"<p>Sleep quality significantly affects the quality of life of older persons. Therefore, this study explored the relationship between sleep quality and living environment of older persons in China to provide a theoretical basis for therapies to alleviate sleep disorders in older persons. A total of 6211 subjects &gt; 60 years of age in Anhui Province, China, were evaluated using the Pittsburgh Sleep Quality Index and a self-reported questionnaire. Multivariate logistic regression analysis revealed that living alone (OR = 1.26, 95% CI 1.09–1.46) and living in a rural area (OR = 1.19, 95% CI 1.06–1.34) were significantly associated with a high incidence of sleep disorders in older persons. Living near a park or foot paths suitable for exercise or walking was significantly associated with a lower incidence of sleep disorders in older persons (OR = 0.87, 95% CI 0.77–0.96). Individual factors such as female sex (OR = 1.30, 95% CI 1.14–1.48) and depression (OR = 2.80, 95% CI 2.47–3.19) were also associated with sleep quality in older persons. These data indicate a correlation exists between living environment and sleep quality.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"212 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139497478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of an exercise program on inflammation in adults who differ according to obstructive sleep apnea severity 运动计划对阻塞性睡眠呼吸暂停严重程度不同的成年人炎症的影响
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-30 DOI: 10.1007/s41105-023-00505-w
Devon A. Dobrosielski, Karla A. Kubitz, Mary F. Walter, Hyunjeong Park, Christopher Papandreou, Susheel P. Patil
{"title":"The effects of an exercise program on inflammation in adults who differ according to obstructive sleep apnea severity","authors":"Devon A. Dobrosielski, Karla A. Kubitz, Mary F. Walter, Hyunjeong Park, Christopher Papandreou, Susheel P. Patil","doi":"10.1007/s41105-023-00505-w","DOIUrl":"https://doi.org/10.1007/s41105-023-00505-w","url":null,"abstract":"<p>Exercise improves chronic inflammation and is recommended as a first-line medical or behavioral treatment for OSA with obesity. We examined whether the effects of an exercise program on inflammatory blood markers differed according to severity of OSA among obese adults. Overweight (BMI &gt; 27 kg/m<sup>2</sup>) adults were evaluated for OSA using overnight polysomnography and subsequently classified as exhibiting no-to-mild OSA (AHI &lt; 15 events/hour) or moderate-to-severe OSA (AHI ≥ 15 events/hour). Cardiorespiratory fitness, body composition assessed by DXA, fasting metabolic parameters and adipokines (i.e., glucose, insulin, leptin and adioponectin), and multiple markers of inflammation (i.e., CRP, IL-4, IL-8 and TNF-α) were measured at baseline (Pre) and following a 6-week (3 days per week) comprehensive exercise program (Post). Ten adults (Age: 48 ± 8 years; W:6; M:4) with no/mild OSA and 12 adults (Age: 54 ± 8 years; W:5; M:7) with moderate/severe OSA completed all aspects of the trial. No significant differences in age, cardiorespiratory fitness, body composition, fasting metabolic parameters and most inflammatory markers were observed between groups at baseline. Exercise training decreased total fat mass (Pre: 41,167 ± 13,315 g; Post: 40,311 ± 12,657 g; <i>p</i> = 0.008), leptin (Pre: 26.7 ± 29.6 pg/ml; Post: 22.7 ± 19.4 pg/ml; <i>p</i> = 0.028) and adiponectin (Pre: 16.6 ± 10.9 µg/ml; Post: 11.0 ± 10.6 µg/ml; <i>p</i> = 0.004) in those with moderate/severe OSA. Among those with no/mild OSA, exercise training resulted in a decrease in total fat mass (Pre = 37,332 ± 20,258 g; Post: 37,068 ± 18,268 g, <i>p</i> = 0.037). These data suggest that while 6 weeks of exercise reduced adipokines in those with moderate-to-severe OSA, it was not sufficient to improve common markers of inflammation among overweight adults with OSA.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"7 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139067614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unintended consequences: college students’ melatonin usage, sleep disturbance, and depressive symptoms 意外后果:大学生使用褪黑激素、睡眠障碍和抑郁症状
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-22 DOI: 10.1007/s41105-023-00506-9
Jack S. Peltz, Ronald Rogge
{"title":"Unintended consequences: college students’ melatonin usage, sleep disturbance, and depressive symptoms","authors":"Jack S. Peltz, Ronald Rogge","doi":"10.1007/s41105-023-00506-9","DOIUrl":"https://doi.org/10.1007/s41105-023-00506-9","url":null,"abstract":"<p>With such high rates of undergraduate sleep problems, students have chosen to take melatonin, an over-the-counter supplement that can facilitate sleep. Questions remain as to the effectiveness of melatonin for sleep problems, and questions have emerged about its impact on mental health. Accordingly, the current study examined how ongoing melatonin usage might impact relative changes in college students’ sleep disturbance and ultimately their depressive symptoms. The two-wave (baseline and 2-month follow-up), online sample consisted of 331 undergraduates (86% female; M<sub>age</sub> = 21.3, <i>SD</i> = 2.4), who reported on melatonin usage, sleep disturbance, and depressive symptoms. Controlling for sleep hygiene, socio-economic status, and gender, our model demonstrated a significant indirect effect from ongoing melatonin usage to depressive symptoms. Specifically, melatonin consumption predicted relative increases in sleep disturbance, which, in turn, predicted corresponding increases in students’ depressive symptoms. Given the increasing prevalence of melatonin usage, the potential for unforeseen consequences remains high. Results suggest that the negative consequences of melatonin use can include both college students’ mental health and their sleep. Given the efficacy of addressing sleep problems with cognitive or behavioral strategies, it is essential that student support services highlight alternatives to melatonin and the potential problems associated with its use.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"84 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139027094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model 喹硫平可改善睡眠剥夺诱导大鼠模型中的感觉运动门控缺陷
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-14 DOI: 10.1007/s41105-023-00504-x
Öznur Özge Özcan, Burcu Çevreli, Arzu Temizyürek, Mesut Karahan, Muhsin Konuk
{"title":"Quetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model","authors":"Öznur Özge Özcan, Burcu Çevreli, Arzu Temizyürek, Mesut Karahan, Muhsin Konuk","doi":"10.1007/s41105-023-00504-x","DOIUrl":"https://doi.org/10.1007/s41105-023-00504-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Sleep deprivation (SD) impairs pre-stimulus inhibition, but the effect of quetiapine (QET) remains largely unknown.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>This study aimed to investigate the behavioral and cognitive effects of QET in both naïve and sleep-deprived rats.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>Seven groups (<i>n</i> = 49) of male Wistar Albino rats were used in this study. SD was performed using the modified multiple platform technique in a water tank for 72 h. Our study consists of two experiments investigating the effect of QET on pre-pulse inhibition (PPI) of the acoustic startle reflex. The first experiment tested the effect of short- and long-term administration of QET on PPI response in non-sleeping (NSD) rats. The second experiment used 72 h REM sleep deprivation as a model for SD-induced impairment of the PPI response. Here, we tested the effect of QET on the % PPI of SD rats by short- and long-term intraperitoneal injection at the last 90 min of sleep SD and immediately subsequently tested for PPI.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>72 h SD impaired PPI, reduced startle amplitude, and attenuated the PPI% at + 4 dB, + 8 dB, and + 16 dB prepulse intensities. 10 mg/kg short and long-term QET administration completely improved sensorimotor gating deficit, increased startle amplitude, and restored the impaired PPI% at + 4 dB, + 8 dB, and + 16 dB after 72 h SD in rats.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Our results showed short- and long-term administration of QET improved sensorimotor gating deficit in 72 h SD. Further research is required for the etiology of insomnia and the dose-related behavioral effects of QET.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"100 1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138691792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Effect of physical activity on sleep problems in sedentary adults: a scoping systematic review 更正为体育锻炼对久坐成年人睡眠问题的影响:范围界定系统综述
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-12 DOI: 10.1007/s41105-023-00507-8
Anushree Rai, Mosab M. Aldabbas, Zubia Veqar
{"title":"Correction to: Effect of physical activity on sleep problems in sedentary adults: a scoping systematic review","authors":"Anushree Rai, Mosab M. Aldabbas, Zubia Veqar","doi":"10.1007/s41105-023-00507-8","DOIUrl":"https://doi.org/10.1007/s41105-023-00507-8","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"76 10","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urbanisation negatively impacts sleep health and mood in adolescents: a comparative study of female students from city and rural schools of North India 城市化对青少年睡眠健康和情绪的负面影响:对印度北部城市和农村学校女生的比较研究
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-11 DOI: 10.1007/s41105-023-00503-y
Nisha Singh, Neelu Anand Jha, Vinod Kumar
{"title":"Urbanisation negatively impacts sleep health and mood in adolescents: a comparative study of female students from city and rural schools of North India","authors":"Nisha Singh, Neelu Anand Jha, Vinod Kumar","doi":"10.1007/s41105-023-00503-y","DOIUrl":"https://doi.org/10.1007/s41105-023-00503-y","url":null,"abstract":"<p>This study investigated the impact of social settings on sleep, physical and mental health in female adolescents of North India (latitude 29.5 <sup>o</sup>N; longitude 77.5 <sup>o</sup>E). Using a battery of questionnaires, we compared the chronotype, sleep–wake pattern, sleep health (e.g. sleep quality, daytime sleepiness and fatigue) and mood (via depression, anxiety and stress symptoms) in female students (age 14–18 years) from rural (<i>N</i> = 719) and urban (<i>N</i> = 1033) schools separated by about 35 km, but families had almost similar socio-demographic details. The morning type was prevalent amongst rural, whilst the evening type was prevalent amongst urban students who also had access to smart phones, suggesting a possible greater use of the internet. There were greater negative sleep effects, daytime sleepiness, overall poor sleep quality, higher fatigue and anxiety levels in urban than the rural cohort. Interestingly, these measures also differed between school days and free days, suggesting an impact of the conflict between internal biological and social timings (= social jet lag). We also found a significant relationship between chronotype, internet addiction, mood-related parameters and measures of sleep health. Overall, these results suggest a possible impact of social settings on sleep health and mood-related behaviours in female adolescents.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"81 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138573365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of cognitive behavioral therapy for insomnia in the perinatal period: a meta-analysis of randomized controlled trials 认知行为疗法对围产期失眠症的疗效:随机对照试验荟萃分析
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-10 DOI: 10.1007/s41105-023-00502-z
Shuya Feng, Bingqin Dai, Huawei Li, Huili Fu, Yunping Zhou
{"title":"Efficacy of cognitive behavioral therapy for insomnia in the perinatal period: a meta-analysis of randomized controlled trials","authors":"Shuya Feng, Bingqin Dai, Huawei Li, Huili Fu, Yunping Zhou","doi":"10.1007/s41105-023-00502-z","DOIUrl":"https://doi.org/10.1007/s41105-023-00502-z","url":null,"abstract":"<p>The meta-analysis aims to explore the effect of cognitive behavioral therapy for insomnia (CBT-I) in the perinatal period. Randomized controlled trials (RCTs) assessed the effects of CBT-I in perinatal women with insomnia, published in English, were eligible. Electronic searches were performed using PubMed<b>,</b> Embase (Elsevier), PsycINFO (Ebsco), and Web of Science (Clarivate Analytics)<b>.</b> Insomnia Severity Index (ISI) as the primary outcome was used to estimate the pooled effects and durable efficacy of CBT-I. The secondary outcome measures were Edinburgh Postnatal Depression Scale (EPDS) and Pittsburgh Sleep Quality Index (PSQI). Of 46 studies reviewed, seven studies met the inclusion criteria. The meta-analysis indicated significant improvement in insomnia as measured with the ISI (standardized mean difference (SMD) = − 0.62, 95% confidence intervals (CI) − 0.77, − 0.47, <i>I</i><sup>2</sup> = 28%). At the follow-up time point, the meta-analysis indicated the durable efficacy of CBT-I (SMD = − 0.47, 95% CI − 0.90, − 0.03, <i>I</i><sup>2</sup> = 73%). Definite improvement of CBT-I on EPDS (SMD = -0.31, 95% CI − 0.55, − 0.06, <i>I</i><sup>2</sup> = 33%) and PSQI (SMD = − 0.82, 95% CI − 1.27, − 0.38, <i>I</i><sup>2</sup> = 68%) score change post-intervention were found. In sub-analyses, CBT-I had similar effect sizes, independent of possible modifiers (study population, comparison group, delivery format, etc.). This meta-analysis demonstrates that CBT-I is effective in alleviating insomnia, depression, and sleep quality among perinatal women. It is equally important to find that CBT-I has a durable efficacy on insomnia in the perinatal period. However, it is necessary to include larger samples and conduct rigorous RCTs to further explore this issue.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"69 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review for the impacts of circadian disturbance on urological cancers 昼夜节律紊乱对泌尿系统肿瘤影响的研究进展
IF 1.1 4区 医学
Sleep and Biological Rhythms Pub Date : 2023-12-05 DOI: 10.1007/s41105-023-00500-1
Tao Li, Yiting Jiang, Yunjin Bai, Kehua Jiang, Guangshi Du, Peng Chen, Chao Luo, Lei Li, Jun Qiao, Jun Shen
{"title":"A review for the impacts of circadian disturbance on urological cancers","authors":"Tao Li, Yiting Jiang, Yunjin Bai, Kehua Jiang, Guangshi Du, Peng Chen, Chao Luo, Lei Li, Jun Qiao, Jun Shen","doi":"10.1007/s41105-023-00500-1","DOIUrl":"https://doi.org/10.1007/s41105-023-00500-1","url":null,"abstract":"<p>Circadian rhythm is an internal timing system and harmonizes a variety of cellular, behavioral, and physiological processes to daily environment. Circadian disturbance caused by altered life style or disrupted sleep patterns inevitably contributes to various disorders. As the rapidly increased cancer occurrences and subsequent tremendous financial burdens, more researches focus on reducing the morbidity rather than treating it. Recently, many epidemiologic studies demonstrated that circadian disturbance was tightly related to the occurrence and development of cancers. For urinary system, numerous clinical researches observed the incidence and progress of prostate cancer were influenced by nightshift work, sleep duration, chronotypes, light exposure, and meal timing, this was also proved by many genetic and fundamental findings. Although the epidemiological studies regarding the relationship between circadian disturbance and kidney/bladder cancers were relative limited, some basic researches still claimed circadian disruption was closely correlated to these two cancers. The role of circadian chemotherapy on cancers of prostate, kidney, and bladder were also explored, however, it has not been regularly recommended considering the limited evidence and poor standard protocols. Finally, the researches for the impacts of circadian disturbance on cancers of adrenal gland, penis, testis were not found at present. In general, a better understanding the relationship between circadian disturbance and urological cancers might help to provide more scientific work schedules and rational lifestyles which finally saving health resource by reducing urological tumorigenesis, however, the underlying mechanisms are complex which need further exploration.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"3 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138540006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Link between insomnia, cognitive impairment and stroke 失眠、认知障碍和中风之间的联系
4区 医学
Sleep and Biological Rhythms Pub Date : 2023-11-10 DOI: 10.1007/s41105-023-00501-0
Keisuke Suzuki
{"title":"Link between insomnia, cognitive impairment and stroke","authors":"Keisuke Suzuki","doi":"10.1007/s41105-023-00501-0","DOIUrl":"https://doi.org/10.1007/s41105-023-00501-0","url":null,"abstract":"","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"114 42","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135136229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in Per2, Bcl2 gene expression, and oxidative status in aged rats liver after light pulse at night 夜间光脉冲对老龄大鼠肝脏Per2、Bcl2基因表达及氧化状态的影响
4区 医学
Sleep and Biological Rhythms Pub Date : 2023-11-05 DOI: 10.1007/s41105-023-00495-9
Rehab E. El-Hennamy, Heba A. Elmasry
{"title":"Alterations in Per2, Bcl2 gene expression, and oxidative status in aged rats liver after light pulse at night","authors":"Rehab E. El-Hennamy, Heba A. Elmasry","doi":"10.1007/s41105-023-00495-9","DOIUrl":"https://doi.org/10.1007/s41105-023-00495-9","url":null,"abstract":"Abstract The aging process is characterized by circadian rhythm disruption, in physiology and behavior, which could result from weak entrainment. Light is the most potent cue that entrains the central circadian clock, which in turn synchronizes peripheral clocks in animal tissues. Period 2 (Per2 ) is one of the clock genes that respond to light. Moreover, oxidative stress could entrain the clock. Therefore, the present work aimed to investigate the role of light when applied late at night on the Per2 , B cell lymphoma 2 ( Bcl2 ) gene expression, and oxidative status in aged rats. Aged rats were divided into a control group and a group exposed to a 30-min light pulse applied daily during the subjective night at 5 am (ZT 22) for 4 weeks. Per2 and Bcl2 gene expression were quantified in liver tissue. To evaluate oxidative status, Glutathione (GSH), nitric oxide (NO), and malondialdehyde (MDA) were estimated. The light pulse reduced the expression levels of Per2 and Bcl2 mRNA. Although it diminished the levels of malondialdehyde (MDA), nitric oxide (NO) levels were elevated and the glutathione (GSH) levels were declined. In conclusion, the light pulse late at night abolished Per2 mRNA circadian rhythm and reduced its expression in the liver of the aged rat. Similarly, it diminished the anti-apoptotic gene expression, Bcl2 . Moreover, it might attenuate oxidative stress through the reduction in MDA levels.","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"138 26","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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