Statistics in Medicine最新文献_第5页

Empirical Sandwich Variance Estimator for Iterated Conditional Expectation g-Computation. 迭代条件期望 g 计算的经验三明治方差估算器。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-11-03 DOI: 10.1002/sim.10255

Paul N Zivich, Rachael K Ross, Bonnie E Shook-Sa, Stephen R Cole, Jessie K Edwards

{"title":"Empirical Sandwich Variance Estimator for Iterated Conditional Expectation g-Computation.","authors":"Paul N Zivich, Rachael K Ross, Bonnie E Shook-Sa, Stephen R Cole, Jessie K Edwards","doi":"10.1002/sim.10255","DOIUrl":"10.1002/sim.10255","url":null,"abstract":"Iterated conditional expectation (ICE) g-computation is an estimation approach for addressing time-varying confounding for both longitudinal and time-to-event data. Unlike other g-computation implementations, ICE avoids the need to specify models for each time-varying covariate. For variance estimation, previous work has suggested the bootstrap. However, bootstrapping can be computationally intense. Here, we present ICE g-computation as a set of stacked estimating equations. Therefore, the variance for the ICE g-computation estimator can be consistently estimated using the empirical sandwich variance estimator. Performance of the variance estimator was evaluated empirically with a simulation study. The proposed approach is also demonstrated with an illustrative example on the effect of cigarette smoking on the prevalence of hypertension. In the simulation study, the empirical sandwich variance estimator appropriately estimated the variance. When comparing runtimes between the sandwich variance estimator and the bootstrap for the applied example, the sandwich estimator was substantially faster, even when bootstraps were run in parallel. The empirical sandwich variance estimator is a viable option for variance estimation with ICE g-computation.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5562-5572"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Efficacy Estimation for Follow-on Companion Diagnostic Devices Through External Studies. 通过外部研究估算后续辅助诊断设备的药效。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-11-05 DOI: 10.1002/sim.10231

Jiarui Sun, Wenjie Hu, Xiao-Hua Zhou

{"title":"Drug Efficacy Estimation for Follow-on Companion Diagnostic Devices Through External Studies.","authors":"Jiarui Sun, Wenjie Hu, Xiao-Hua Zhou","doi":"10.1002/sim.10231","DOIUrl":"10.1002/sim.10231","url":null,"abstract":"A therapeutic product is usually not suitable for all patients but for only a subpopulation. The safe and effective use of such a therapeutic product requires the co-approval of a companion diagnostic device which can be used to identify suitable patients. While the first-of-a-kind companion diagnostic device is often developed in conjunction with its intended therapeutic product and simultaneously validated through a randomized clinical trial, there remains room for the innovation of new and improved follow-on companion diagnostic devices designed for the same therapeutic product. However, conducting a new randomized trial or a bridging study for the follow on companion devices may be unethical, expensive or unpractical. Hence, there arises a need for an external study to evaluate the concordance between the FDA-approved comparator companion diagnostic device (CCD) and the subsequent follow-on companion diagnostic devices (FCD), indirectly validating the latter. In this article, we introduce a novel external study design, referred to as the targeted treatment design, as an extension of the existing concordance design. Additionally, we present corresponding statistical analysis methods. Our approach combines the CCD randomized trial data and the FCD external study data, enabling the estimation of drug efficacy within the FCD+ and FCD- subpopulations-the parameters crucial for the validation of the FCD. Theoretical results and simulation studies validate the proposed methods and we further illustrate the proposed methods through an application in a real example of non-small-cell lung cancer.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5605-5617"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Quadratic Discriminant Analysis Algorithms for Correlated Audiometric Data. 用于相关听力数据的新型二次判别分析算法

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-10-25 DOI: 10.1002/sim.10257

Fuyu Guo, David M Zucker, Kenneth I Vaden, Sharon Curhan, Judy R Dubno, Molin Wang

{"title":"New Quadratic Discriminant Analysis Algorithms for Correlated Audiometric Data.","authors":"Fuyu Guo, David M Zucker, Kenneth I Vaden, Sharon Curhan, Judy R Dubno, Molin Wang","doi":"10.1002/sim.10257","DOIUrl":"10.1002/sim.10257","url":null,"abstract":"Paired organs like eyes, ears, and lungs in humans exhibit similarities, and data from these organs often display remarkable correlations. Accounting for these correlations could enhance classification models used in predicting disease phenotypes. To our knowledge, there is limited, if any, literature addressing this topic, and existing methods do not exploit such correlations. For example, the conventional approach treats each ear as an independent observation when predicting audiometric phenotypes and is agnostic about the correlation of data from the two ears of the same person. This approach may lead to information loss and reduce the model performance. In response to this gap, particularly in the context of audiometric phenotype prediction, this paper proposes new quadratic discriminant analysis (QDA) algorithms that appropriately deal with the dependence between ears. We propose two-stage analysis strategies: (1) conducting data transformations to reduce data dimensionality before applying QDA; and (2) developing new QDA algorithms to partially utilize the dependence between phenotypes of two ears. We conducted simulation studies to compare different transformation methods and to assess the performance of different QDA algorithms. The empirical results suggested that the transformation may only be beneficial when the sample size is relatively small. Moreover, our proposed new QDA algorithms performed better than the conventional approach in both person-level and ear-level accuracy. As an illustration, we applied them to audiometric data from the Medical University of South Carolina Longitudinal Cohort Study of Age-related Hearing Loss. In addition, we developed an R package, PairQDA, to implement the proposed algorithms.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5473-5483"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose Individualization for Phase I Cancer Trials With Broadened Eligibility. 扩大癌症 I 期试验的剂量个体化资格。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-10-31 DOI: 10.1002/sim.10264

Rebecca B Silva, Bin Cheng, Richard D Carvajal, Shing M Lee

{"title":"Dose Individualization for Phase I Cancer Trials With Broadened Eligibility.","authors":"Rebecca B Silva, Bin Cheng, Richard D Carvajal, Shing M Lee","doi":"10.1002/sim.10264","DOIUrl":"10.1002/sim.10264","url":null,"abstract":"Broadening eligibility criteria in cancer trials has been advocated to represent the intended patient population more accurately. The advantages are clear in terms of generalizability and recruitment, however there are some important considerations in terms of design for efficiency and patient safety. While toxicity may be expected to be homogeneous across these subpopulations, designs should be able to recommend safe and precise doses if subpopulations with different toxicity profiles exist. Dose-finding designs accounting for patient heterogeneity have been proposed, but existing methods assume that the source of heterogeneity is known. We propose a broadened eligibility dose-finding design to address the situation of unknown patient heterogeneity in phase I cancer clinical trials where eligibility is expanded, and multiple eligibility criteria could potentially lead to different optimal doses for patient subgroups. The design offers a two-in-one approach to dose-finding by simultaneously selecting patient criteria that differentiate the maximum tolerated dose (MTD), using stochastic search variable selection, and recommending the subpopulation-specific MTD if needed. Our simulation study compares the proposed design to the naive approach of assuming patient homogeneity and demonstrates favorable operating characteristics across a wide range of scenarios, allocating patients more often to their true MTD during the trial, recommending more than one MTD when needed, and identifying criteria that differentiate the patient population. The proposed design highlights the advantages of adding more variability at an early stage and demonstrates how assuming patient homogeneity can lead to unsafe or sub-therapeutic dose recommendations.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5534-5547"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Brief Introduction on Latent Variable Based Ordinal Regression Models With an Application to Survey Data. 基于潜变量的序数回归模型简介及在调查数据中的应用。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-10-28 DOI: 10.1002/sim.10208

Johannes Wieditz, Clemens Miller, Jan Scholand, Marcus Nemeth

{"title":"A Brief Introduction on Latent Variable Based Ordinal Regression Models With an Application to Survey Data.","authors":"Johannes Wieditz, Clemens Miller, Jan Scholand, Marcus Nemeth","doi":"10.1002/sim.10208","DOIUrl":"10.1002/sim.10208","url":null,"abstract":"The analysis of survey data is a frequently arising issue in clinical trials, particularly when capturing quantities which are difficult to measure. Typical examples are questionnaires about patient's well-being, pain, or consent to an intervention. In these, data is captured on a discrete scale containing only a limited number of possible answers, from which the respondent has to pick the answer which fits best his/her personal opinion. This data is generally located on an ordinal scale as answers can usually be arranged in an ascending order, for example, \"bad\", \"neutral\", \"good\" for well-being. Since responses are usually stored numerically for data processing purposes, analysis of survey data using ordinary linear regression models are commonly applied. However, assumptions of these models are often not met as linear regression requires a constant variability of the response variable and can yield predictions out of the range of response categories. By using linear models, one only gains insights about the mean response which may affect representativeness. In contrast, ordinal regression models can provide probability estimates for all response categories and yield information about the full response scale beyond the mean. In this work, we provide a concise overview of the fundamentals of latent variable based ordinal models, applications to a real data set, and outline the use of state-of-the-art-software for this purpose. Moreover, we discuss strengths, limitations and typical pitfalls. This is a companion work to a current vignette-based structured interview study in pediatric anesthesia.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5618-5634"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogeneous Mediation Analysis for Cox Proportional Hazards Model With Multiple Mediators. 具有多个中介因子的 Cox 比例危害模型的异质性中介分析

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-10-28 DOI: 10.1002/sim.10239

Rongqian Sun, Xinyuan Song

{"title":"Heterogeneous Mediation Analysis for Cox Proportional Hazards Model With Multiple Mediators.","authors":"Rongqian Sun, Xinyuan Song","doi":"10.1002/sim.10239","DOIUrl":"10.1002/sim.10239","url":null,"abstract":"This study proposes a heterogeneous mediation analysis for survival data that accommodates multiple mediators and sparsity of the predictors. We introduce a joint modeling approach that links the mediation regression and proportional hazards models through Bayesian additive regression trees with shared typologies. The shared tree component is motivated by the fact that confounders and effect modifiers on the causal pathways linked by different mediators often overlap. A sparsity-inducing prior is incorporated to capture the most relevant confounders and effect modifiers on different causal pathways. The individual-specific interventional direct and indirect effects are derived on the scale of the logarithm of hazards and survival function. A Bayesian approach with an efficient Markov chain Monte Carlo algorithm is developed to estimate the conditional interventional effects through the Monte Carlo implementation of the mediation formula. Simulation studies are conducted to verify the empirical performance of the proposed method. An application to the ACTG175 study further demonstrates the method's utility in causal discovery and heterogeneity quantification.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5497-5512"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparison of Variance Estimators for Logistic Regression Models Estimated Using Generalized Estimating Equations (GEE) in the Context of Observational Health Services Research. 观察性健康服务研究中使用广义估计方程 (GEE) 估计的 Logistic 回归模型方差估计器的比较》（A Comparison of Variance Estimators for Logistic Regression Models Estimated Using Generalized Estimating Equations (GEE) in the Context of Observational Health Services Research）。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-10-31 DOI: 10.1002/sim.10260

Peter C Austin

{"title":"A Comparison of Variance Estimators for Logistic Regression Models Estimated Using Generalized Estimating Equations (GEE) in the Context of Observational Health Services Research.","authors":"Peter C Austin","doi":"10.1002/sim.10260","DOIUrl":"10.1002/sim.10260","url":null,"abstract":"In observational health services research, researchers often use clustered data to estimate the independent association between individual outcomes and several cluster-level covariates after adjusting for individual-level characteristics. Generalized estimating equations are a popular method for estimating generalized linear models using clustered data. The conventional Liang-Zeger variance estimator is known to result in estimated standard errors that are biased low when the number of clusters in small. Alternative variance estimators have been proposed for use when the number of clusters is low. Previous studies focused on these alternative variance estimators in the context of cluster randomized trials, which are often characterized by a small number of clusters and by an outcomes regression model that often consists of a single cluster-level variable (the treatment/exposure variable). We addressed the following questions: (i) which estimator is preferred for estimating the standard errors of cluster-level covariates for logistic regression models with multiple binary and continuous cluster-level variables in addition to subject-level variables; (ii) in such settings, how many clusters are required for the Liang-Zeger variance estimator to have acceptable performance for estimating the standard errors of cluster-level covariates. We suggest that when estimating standard errors: (i) when the number of clusters is < 15 use the Kauermann-Carroll estimator; (ii) when the number of clusters is between 15 and 40 use the Fay-Graubard estimator; (iii) when the number of clusters exceeds 40, use the Liang-Zeger estimator or the Fay-Graubard estimator. When estimating confidence intervals, we suggest using the Mancl-DeRouen estimator with a t-distribution.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5548-5561"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian Safety and Futility Monitoring in Phase II Trials Using One Utility-Based Rule. 使用一个基于效用的规则对 II 期试验进行贝叶斯安全性和有效性监测。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-20 Epub Date: 2024-11-05 DOI: 10.1002/sim.10254

Juhee Lee, Peter F Thall

{"title":"Bayesian Safety and Futility Monitoring in Phase II Trials Using One Utility-Based Rule.","authors":"Juhee Lee, Peter F Thall","doi":"10.1002/sim.10254","DOIUrl":"10.1002/sim.10254","url":null,"abstract":"For phase II clinical trials that determine the acceptability of an experimental treatment based on ordinal toxicity and ordinal response, most monitoring methods require each ordinal outcome to be dichotomized using a selected cut-point. This allows two early stopping rules to be constructed that compare marginal probabilities of toxicity and response to respective upper and lower limits. Important problems with this approach are loss of information due to dichotomization, dependence of treatment acceptability decisions on precisely how each ordinal variable is dichotomized, and ignoring association between the two outcomes. To address these problems, we propose a new Bayesian method, which we call U-Bayes, that exploits elicited numerical utilities of the joint ordinal outcomes to construct one early stopping rule that compares the mean utility to a lower limit. U-Bayes avoids the problems noted above by using the entire joint distribution of the ordinal outcomes, and not dichotomizing the outcomes. A step-by-step algorithm is provided for constructing a U-Bayes rule based on elicited utilities and elicited limits on marginal outcome probabilities. A simulation study shows that U-Bayes greatly improves the probability of determining treatment acceptability compared to conventional designs that use two monitoring rules based on marginal probabilities.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":"5583-5595"},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Longitudinal Lupus Data Using Multivariate t-Linear Models. 用多元t-线性模型分析狼疮的纵向数据。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-19 DOI: 10.1002/sim.10248

Eun Jin Jang, Anbin Rhee, Soo-Kyung Cho, Keunbaik Lee

{"title":"Analysis of Longitudinal Lupus Data Using Multivariate t-Linear Models.","authors":"Eun Jin Jang, Anbin Rhee, Soo-Kyung Cho, Keunbaik Lee","doi":"10.1002/sim.10248","DOIUrl":"https://doi.org/10.1002/sim.10248","url":null,"abstract":"Analysis of healthcare utilization, such as hospitalization duration and medical costs, is crucial for policymakers and doctors in experimental and epidemiological investigations. Herein, we examine the healthcare utilization data of patients with systemic lupus erythematosus (SLE). The characteristics of the SLE data were measured over a 10-year period with outliers. Multivariate linear models with multivariate normal error distributions are commonly used to evaluate long series of multivariate longitudinal data. However, when there are outliers or heavy tails in the data, such as those based on healthcare utilization, the assumption of multivariate normality may be too strong, resulting in biased estimates. To address this, we propose multivariate t-linear models (MTLMs) with an autoregressive moving-average (ARMA) covariance matrix. Modeling the covariance matrix for multivariate longitudinal data is difficult since the covariance matrix is high dimensional and must be positive-definite. To address these, we employ a modified ARMA Cholesky decomposition and hypersphere decomposition. Several simulation studies are conducted to demonstrate the performance, robustness, and flexibility of the proposed models. The proposed MTLMs with ARMA structured covariance matrix are applied to analyze the healthcare utilization data of patients with SLE.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonparametric Estimation for Propensity Scores With Misclassified Treatments. 误分类治疗倾向得分的非参数估计。

IF 1.8 4区医学

Statistics in Medicine Pub Date : 2024-12-18 DOI: 10.1002/sim.10306

Li-Pang Chen

{"title":"Nonparametric Estimation for Propensity Scores With Misclassified Treatments.","authors":"Li-Pang Chen","doi":"10.1002/sim.10306","DOIUrl":"https://doi.org/10.1002/sim.10306","url":null,"abstract":"In the framework of causal inference, average treatment effect (ATE) is one of crucial concerns. To estimate it, the propensity score based estimation method and its variants have been widely adopted. However, most existing methods were developed by assuming that binary treatments are precisely measured. In addition, propensity scores are usually formulated as parametric models with respect to confounders. However, in the presence of measurement error in binary treatments and nonlinear relationship between treatments and confounders, existing methods are no longer valid and may yield biased inference results if these features are ignored. In this paper, we first analytically examine the impact of estimation of ATE and derive biases for the estimator of ATE when treatments are contaminated with measurement error. After that, we develop a valid method to address binary treatments with misclassification. Given the corrected treatments, we adopt the random forest method to estimate the propensity score with nonlinear confounders accommodated and then derive the estimator of ATE. Asymptotic properties of the error-eliminated estimator are established. Numerical studies are also conducted to assess the finite sample performance of the proposed estimator, and numerical results verify the importance of correcting for measurement error effects.","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0