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Emerging Topical Therapies and Skin Care Management for Hidradenitis Suppurativa. 化脓性汗腺炎的新兴局部治疗和皮肤护理管理。
Skin therapy letter Pub Date : 2026-09-01
Amber Fielding, Lauren Lam
{"title":"Emerging Topical Therapies and Skin Care Management for Hidradenitis Suppurativa.","authors":"Amber Fielding, Lauren Lam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a painful, chronic inflammatory condition that forms recurring nodules and abscesses in skin folds, leading to severe scarring. While the exact pathogenesis is still being determined, it is thought to involve follicular occlusion and rupture, driven by multifactorial influences such as genetics, environment, hormones, microbiome, and immune dysregulation. The complex nature of this disease entails complicated management and has led to the development of various therapies targeting these different factors. While moderate-to-severe HS has seen growing therapeutic options in recent years, mild early-stage forms of the disease lack any approved treatments. This review examines the most recent developments in topical therapies specifically for mild HS, along with advancements in daily HS skin care and post de-roofing wound management. These emerging therapies offer the potential for more effective, personalized care to reduce the disease burden for patients living with HS.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 5","pages":"5-7"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delgocitinib Cream for Chronic Hand Dermatitis: Efficacy, Safety and Clinical Application. 德尔古替尼乳膏治疗手部慢性皮炎的疗效、安全性及临床应用。
Skin therapy letter Pub Date : 2026-09-01
Yash Jani, Austinn Miller
{"title":"Delgocitinib Cream for Chronic Hand Dermatitis: Efficacy, Safety and Clinical Application.","authors":"Yash Jani, Austinn Miller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic hand dermatitis (CHD), also referred to as chronic hand eczema, is a persistent inflammatory skin disorder characterized by erythema, fissuring, scaling, lichenification, and significant pruritus and pain. The condition is often debilitating, particularly because the hands are constantly exposed to mechanical friction, detergents, irritants, and environmental stressors. Traditional treatments such as topical corticosteroids, calcineurin inhibitors, phototherapy, and systemic immunomodulators are limited by safety concerns, incomplete efficacy, or poor long-term tolerability. Delgocitinib 2% cream, a non-steroidal, topical pan-Janus kinase (JAK) inhibitor, represents the first targeted therapy specifically approved for moderate-to-severe CHD in adults. Through inhibition of JAK1, JAK2, JAK3, and tyrosine kinase 2, delgocitinib broadly suppresses multiple cytokine pathways involved in hand eczema pathogenesis. Clinical trials have demonstrated significant improvement in Investigator's Global Assessment scores, Hand Eczema Severity Index, pruritus, pain, and quality of life, along with sustained benefit in long-term extension studies. Safety data reveal minimal systemic absorption, no steroid-associated skin atrophy, and a favorable tolerability profile without box warnings. This review examines the pathophysiology of CHD and the clinical evidence supporting delgocitinib as an effective, steroid-sparing therapeutic option.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 5","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More Than Skin Deep: Understanding the Skin-Bone Axis. 超越皮肤深层：理解皮肤-骨骼轴。
Skin therapy letter Pub Date : 2026-07-01
Santina Conte, Vu Le, Monica K Li
{"title":"More Than Skin Deep: Understanding the Skin-Bone Axis.","authors":"Santina Conte, Vu Le, Monica K Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The skin's role as a mirror of internal disease has long been established, with clear associations to several internal organs. However, its relationship with bone is less well known. There are clear physiological links between the two organ systems, with their shared factors crucial to maintain structural integrity and homeostasis. Collagen, vitamin D homeostasis, aging, medications, and the gut microbiome are all factors that impact both skin and bone. It is of utmost importance that the skin-bone axis be adequately understood to support a healthy aging process. In this review, we discuss the multiple facets related to skin and bone health, their interconnectivity, as well as the importance of promoting whole body health.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 4","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molluscum Contagiosum: A Review and Update on New Treatments. 传染性软疣：新治疗方法的回顾与进展。
Skin therapy letter Pub Date : 2026-07-01
Priyenka Khatiwada, Mariana Phillips
{"title":"Molluscum Contagiosum: A Review and Update on New Treatments.","authors":"Priyenka Khatiwada, Mariana Phillips","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 4","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zasocitinib: New Frontier in Tyrosine Kinase 2 Inhibition. 扎索替尼：酪氨酸激酶2抑制的新领域。
Skin therapy letter Pub Date : 2026-05-01
Samantha R Adam, Maxwell Sauder
{"title":"Zasocitinib: New Frontier in Tyrosine Kinase 2 Inhibition.","authors":"Samantha R Adam, Maxwell Sauder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Zasocitinib is a novel highly selective tyrosine kinase 2 (TYK2) inhibitor that is in late phase development for the treatment of psoriasis and psoriatic arthritis. This article will review its efficacy, safety and tolerability. Currently, deucravacitinib is the only TYK2 inhibitor with regulatory approval from most major authorities. Zasocitinib offers potential benefits, as it has higher target selectivity and affinity of the Janus homology 2 (JH2) domain of TYK2 as compared to deucravacitinib. This selectivity leads to minimal inhibition of Janus kinase (JAK) 1, JAK2 and JAK3 (JAK1-3), and therefore may result in less off-target effects that have been associated with other molecules.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 3","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes in Dermatology. 皮肤病学中的外泌体。
Skin therapy letter Pub Date : 2026-05-01
Annabel Shen, Fyona Okundia, Stephen K Tyring
{"title":"Exosomes in Dermatology.","authors":"Annabel Shen, Fyona Okundia, Stephen K Tyring","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Exosomes are nanosized extracellular vesicles increasingly recognized as regulators of cutaneous biology with direct clinical relevance. In dermatology, they influence keratinocyte and fibroblast proliferation, pigmentation pathways, and immune modulation in disorders such as atopic dermatitis and cutaneous lupus. Their strongest evidence lies in wound healing, where exosomes accelerate closure by dampening proinflammatory cytokines (tumor necrosis factor-α, interleukin-6, matrix metalloproteinase-9), enhancing angiogenesis through vascular endothelial growth factor signaling, and improving collagen deposition and scar quality. Early studies also support their role in regenerative skin care, including reversal of photoaging, improved elasticity, and stimulation of hair follicle growth. Although current use is limited to cosmetic applications without United States Food and Drug Administration (FDA) approval, international experience suggests therapeutic potential in chronic wounds, inflammatory dermatoses, and pigmentation disorders. For clinicians, exosomes represent a novel biologic platform that may soon complement established therapies, underscoring the importance of ongoing translational research and regulatory clarity.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 3","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Deuruxolitinib for Alopecia Areata. Deuruxolitinib治疗斑秃。
Skin therapy letter Pub Date : 2026-04-30
Alexander Robbins, Mariana Phillips
{"title":"Erratum to: Deuruxolitinib for Alopecia Areata.","authors":"Alexander Robbins, Mariana Phillips","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 3","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical Ruxolitinib for the Treatment of Hidradenitis Suppurativa. 局部鲁索利替尼治疗化脓性汗腺炎。
Skin therapy letter Pub Date : 2026-03-01
Claire Fason, Stephen Tyring
{"title":"Topical Ruxolitinib for the Treatment of Hidradenitis Suppurativa.","authors":"Claire Fason, Stephen Tyring","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterized by painful nodules, abscesses, sinus tracts, and scarring, with significant impact on quality of life. Although biologics have expanded treatment options for moderate to severe disease, there are currently no approved therapies specifically indicated for mild HS. Emerging evidence implicates dysregulation of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in HS pathophysiology, suggesting JAK inhibition as a promising therapeutic strategy. This review summarizes current evidence on JAK inhibition in HS, with a focus on topical ruxolitinib. Early clinical trials in patients with mild to moderate HS have demonstrated encouraging efficacy, including significant improvements in Hidradenitis Suppurativa Clinical Response (HiSCR) rates and histologic reductions in epidermal and dermal inflammation, alongside a favorable safety profile. Existing data support topical ruxolitinib as a promising, targeted, and potentially safer treatment option for early-stage HS.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 2","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Management of Hyperhidrosis. 多汗症的治疗进展。
Skin therapy letter Pub Date : 2026-03-01
Morgan Parker, Mariana Phillips
{"title":"Advances in the Management of Hyperhidrosis.","authors":"Morgan Parker, Mariana Phillips","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hyperhidrosis (HH), a condition characterized by excessive sweating beyond thermoregulation, significantly impairs quality of life. Conventional medications to treat HH include aluminum chloride hexahydrate, systemic anticholinergics, and botulinum toxin injections. New treatments have emerged including glycopyrronium bromide, sofpironium bromide, targeted alkali thermolysis, and microwave devices. This paper reviews the mechanism of action, efficacy, safety, and practical considerations associated with these treatments.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 2","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Icotrokinra: A Promising Oral IL-23 Receptor Inhibitor for Moderate-to-Severe Plaque Psoriasis. Icotrokinra：一种治疗中重度斑块型银屑病的口服IL-23受体抑制剂。
Skin therapy letter Pub Date : 2026-01-01
Fyona Okundia, Muna Shakhashiro, Stephen K. Tyring
{"title":"Icotrokinra: A Promising Oral IL-23 Receptor Inhibitor for Moderate-to-Severe Plaque Psoriasis.","authors":"Fyona Okundia, Muna Shakhashiro, Stephen K. Tyring","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Biologics have emerged in recent years as relatively safe and effective options for managing plaque psoriasis, however, a subset of patients remain reluctant to initiate biologic therapy. Icotrokinra is a novel, first-in-class oral peptide that targets the interleukin-23 receptor and has demonstrated a favorable safety and efficacy profile comparable to that of injectable biologics in individuals aged 12 years and older. This review summarizes the clinical trial data regarding the safety and efficacy of icotrokinra.</p>","PeriodicalId":21829,"journal":{"name":"Skin therapy letter","volume":"31 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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