一种治疗中重度痤疮的新型固定剂量三联疗法（IDP-126）。

Q1 Medicine

Skin therapy letter Pub Date : 2025-05-01

Karen Michael, Jaefer Mohamad, Nuha Nasir, Jerry Tan

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引用次数: 0

摘要

克林霉素磷酸1.2%/过氧化苯甲酰3.1%/阿达帕烯0.15% （IDP-126）是一种新型固定剂量三合一凝胶组合，已于2023年10月获得美国FDA批准，并于2024年8月获得加拿大卫生部批准，用于治疗12岁及以上患者的寻常性痤疮。IDP-126对中度至重度痤疮有效，在2期和3期随机对照研究中，IDP-126比载体和成分局部双药有效。疗效结果是炎症性和非炎症性病变计数和评估者的整体严重程度评分。IDP-126也具有良好的耐受性和安全性。

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A Novel Fixed Dose Triple Combination Therapy (IDP-126) for Moderate to Severe Acne.

Clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% (IDP-126) is a novel fixed-dose triad gel combination approved by the US FDA October 2023 and by Health Canada August 2024 for the treatment of acne vulgaris in patients aged 12 years and older. IDP-126 was efficacious in moderate to severe acne compared to vehicle and component topical dyads in phase 2 and to vehicle in phase 3 randomized controlled studies. Efficacy outcomes were inflammatory and noninflammatory lesion counts and Evaluator's Global Severity Score. IDP-126 also had a favorable tolerability and safety profile.

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来源期刊

Skin therapy letter Medicine-Medicine (all)

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The premier international journal on the latest advances, techniques and practice in conservation and restoration from around the world.