SmartMat最新文献_第2页

iSKIN: Integrated application of machine learning and Mondrian conformal prediction to detect skin sensitizers in cosmetic raw materials iSKIN：综合应用机器学习和蒙德里安保形预测技术检测化妆品原料中的皮肤致敏物质

SmartMat Pub Date : 2024-02-15 DOI: 10.1002/smm2.1278

Weikaixin Kong, Jie Zhu, Peipei Shan, Huiyan Ying, Tongyu Chen, Bowen Zhang, Chao Peng, Zihan Wang, Yifan Wang, Liting Huang, Suzhen Bi, Weining Ma, Zhuo Huang, Sujie Zhu, Xueyan Liu, Chun Li

{"title":"iSKIN: Integrated application of machine learning and Mondrian conformal prediction to detect skin sensitizers in cosmetic raw materials","authors":"Weikaixin Kong, Jie Zhu, Peipei Shan, Huiyan Ying, Tongyu Chen, Bowen Zhang, Chao Peng, Zihan Wang, Yifan Wang, Liting Huang, Suzhen Bi, Weining Ma, Zhuo Huang, Sujie Zhu, Xueyan Liu, Chun Li","doi":"10.1002/smm2.1278","DOIUrl":"https://doi.org/10.1002/smm2.1278","url":null,"abstract":"Animal experiments traditionally identify sensitizers in cosmetic materials. However, with growing concerns over animal ethics and bans on such experiments globally, alternative methods like machine learning are gaining prominence for their efficiency and cost‐effectiveness. In this study, to develop a robust sensitizer detector model, we first constructed benchmark data sets using data from previous studies and a public database, then 589 sensitizers and 831 nonsensitizers were collected. In addition, a graph‐based autoencoder and Mondrian conformal prediction (MCP) were combined to build a robust sensitizer detector, iSKIN. In the independent test set, the Matthews correlation coefficient (MCC) and the area under the receiver operating characteristic curve (ROCAUC) values of the iSKIN model without MCP were 0.472 and 0.804, respectively, which are higher than those of the three baseline models. When setting the significance level in MCP at 0.7, the MCC and ROCAUC values of iSKIN could achieve 0.753 and 0.927, respectively. Regrouping experiments proved that the MCP method is robust in the improvement of model performance. Through key structure analysis, seven key substructures in sensitizers were identified to guide cosmetic material design. Notably, long chains with halogen atoms and phenyl groups with two chlorine atoms at ortho‐positions were potential sensitizers. Finally, a user‐friendly web tool (http://www.iskin.work/) of the iSKIN model was deployed to be used by other researchers. In summary, the proposed iSKIN model has achieved state‐of‐the‐art performance so far, which can contribute to the safety evaluation of cosmetic raw materials and provide a reference for the chemical structure design of these materials.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139836093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

iSKIN: Integrated application of machine learning and Mondrian conformal prediction to detect skin sensitizers in cosmetic raw materials iSKIN：综合应用机器学习和蒙德里安保形预测技术检测化妆品原料中的皮肤致敏物质

SmartMat Pub Date : 2024-02-15 DOI: 10.1002/smm2.1278

Weikaixin Kong, Jie Zhu, Peipei Shan, Huiyan Ying, Tongyu Chen, Bowen Zhang, Chao Peng, Zihan Wang, Yifan Wang, Liting Huang, Suzhen Bi, Weining Ma, Zhuo Huang, Sujie Zhu, Xueyan Liu, Chun Li

{"title":"iSKIN: Integrated application of machine learning and Mondrian conformal prediction to detect skin sensitizers in cosmetic raw materials","authors":"Weikaixin Kong, Jie Zhu, Peipei Shan, Huiyan Ying, Tongyu Chen, Bowen Zhang, Chao Peng, Zihan Wang, Yifan Wang, Liting Huang, Suzhen Bi, Weining Ma, Zhuo Huang, Sujie Zhu, Xueyan Liu, Chun Li","doi":"10.1002/smm2.1278","DOIUrl":"https://doi.org/10.1002/smm2.1278","url":null,"abstract":"Animal experiments traditionally identify sensitizers in cosmetic materials. However, with growing concerns over animal ethics and bans on such experiments globally, alternative methods like machine learning are gaining prominence for their efficiency and cost‐effectiveness. In this study, to develop a robust sensitizer detector model, we first constructed benchmark data sets using data from previous studies and a public database, then 589 sensitizers and 831 nonsensitizers were collected. In addition, a graph‐based autoencoder and Mondrian conformal prediction (MCP) were combined to build a robust sensitizer detector, iSKIN. In the independent test set, the Matthews correlation coefficient (MCC) and the area under the receiver operating characteristic curve (ROCAUC) values of the iSKIN model without MCP were 0.472 and 0.804, respectively, which are higher than those of the three baseline models. When setting the significance level in MCP at 0.7, the MCC and ROCAUC values of iSKIN could achieve 0.753 and 0.927, respectively. Regrouping experiments proved that the MCP method is robust in the improvement of model performance. Through key structure analysis, seven key substructures in sensitizers were identified to guide cosmetic material design. Notably, long chains with halogen atoms and phenyl groups with two chlorine atoms at ortho‐positions were potential sensitizers. Finally, a user‐friendly web tool (http://www.iskin.work/) of the iSKIN model was deployed to be used by other researchers. In summary, the proposed iSKIN model has achieved state‐of‐the‐art performance so far, which can contribute to the safety evaluation of cosmetic raw materials and provide a reference for the chemical structure design of these materials.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139776107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing mechanically robust, efficient self‐healing, high‐energy, and recyclable energetic composites by hybrid dynamic lock strategy 通过混合动态锁定策略构建机械坚固、高效自愈合、高能量和可回收的高能量复合材料

SmartMat Pub Date : 2024-01-31 DOI: 10.1002/smm2.1277

Zhe Sun, Yuhang Cheng, Borao Wan, Xiaoming Jin, Tianfu Zhang, Hongyi Zhu, Qi Xue, Lei Xiao, Guigao Liu, Wei Jiang, Guangpu Zhang

{"title":"Constructing mechanically robust, efficient self‐healing, high‐energy, and recyclable energetic composites by hybrid dynamic lock strategy","authors":"Zhe Sun, Yuhang Cheng, Borao Wan, Xiaoming Jin, Tianfu Zhang, Hongyi Zhu, Qi Xue, Lei Xiao, Guigao Liu, Wei Jiang, Guangpu Zhang","doi":"10.1002/smm2.1277","DOIUrl":"https://doi.org/10.1002/smm2.1277","url":null,"abstract":"It is still a huge challenge to introduce effective crack‐healing ability into energetic composites with a high oxidizer content. In this article, a poly(urea‐urethane) energetic elastomer was prepared by the polycondensation reaction of glycidyl azido polymer (GAP), isophorone diisocyanate (IPDI), and 2‐aminophenyl disulfide (2‐APD). In the poly(urea‐urethane) elastomer structure, the hybrid dynamic lock, including multilevel H‐bonds and disulfide bonds, not only provides abundant dynamic interactions and promotes chain diffusion, but also enhances physical crosslinking density. Such a unique design fabricated the energetic elastomer with robust tensile strength (0.72 MPa), high stretchability (1631%), and outstanding toughness (8.95 MJ/m3) in the field of energetic polymers. Meanwhile, this energetic elastomer exhibited high self‐healing efficiency (98.4% at 60 °C) and heat release (Q = 1750.46 J/g). Experimental and theoretical results adequately explain the self‐healing mechanism, particularly the role of azido units. The high‐solid content (80 wt%) energetic composites based on the energetic elastomer presented outstanding micro‐defect self‐healing (97.8%) and recycling without loss of mechanical performance. The development of smart energetic composites with excellent self‐healing and recyclable ability provides a meaningful way for a wide range of applications in the field of energetic materials.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140475314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco‐friendly materials for next‐generation vaccination: From concept to clinical reality 用于下一代疫苗接种的环保材料：从概念到临床现实

SmartMat Pub Date : 2024-01-31 DOI: 10.1002/smm2.1274

Neha Kaushik, Paritosh Patel, Ravi Gupta, Apurva Jaiswal, Manorma Negi, Shweta B Borkar, Yogendra Kumar Mishra, June Hyun Kim, Eun Ha Choi, N. Kaushik

{"title":"Eco‐friendly materials for next‐generation vaccination: From concept to clinical reality","authors":"Neha Kaushik, Paritosh Patel, Ravi Gupta, Apurva Jaiswal, Manorma Negi, Shweta B Borkar, Yogendra Kumar Mishra, June Hyun Kim, Eun Ha Choi, N. Kaushik","doi":"10.1002/smm2.1274","DOIUrl":"https://doi.org/10.1002/smm2.1274","url":null,"abstract":"The vaccine is a premier healthcare intervention strategy in the battle against infectious infections. However, the development and production of vaccines present challenges in terms of complexity, cost, and time consumption. Alternative methodologies, such as nonthermal plasma and plant‐based technologies, have emerged as potential alternatives for conventional vaccine manufacturing processes. While plasma‐based approaches offer a rapid and efficient pathogen inactivation method devoid of harsh reagents, plant‐based techniques present a more economically viable and scalable avenue for vaccine production. The imperative urges these approaches to address pressing global health challenges posed by emerging and recurring infectious diseases, surpassing the limitations of traditional vaccine fabrication methods. The primary goal of this review is to provide a comprehensive overview of the current research landscape, covering conceptualization, production, and potential advantages of plasma‐based and plant‐based vaccines. Furthermore, exploring the obstacles and opportunities intrinsic to these strategies is undertaken, elucidating their potential impact on vaccination strategies. This systematic presentation specifies a detailed outline of recent vaccine research and developments, emphasizing the possibility of advanced green approaches to produce effective and secure vaccination programs.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140477726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal‐organic framework‐based nanofibrous film for two different modes of triboelectric nanogenerators 用于两种不同模式三电纳米发电机的基于金属有机框架的纳米纤维膜

SmartMat Pub Date : 2024-01-25 DOI: 10.1002/smm2.1270

R. Tabassian, Araz Rajabi-Abhari, Manmatha Mahato, H. Yoo, Hong Yeon Yoon, Jeong Young Park, Il‐Kwon Oh

{"title":"Metal‐organic framework‐based nanofibrous film for two different modes of triboelectric nanogenerators","authors":"R. Tabassian, Araz Rajabi-Abhari, Manmatha Mahato, H. Yoo, Hong Yeon Yoon, Jeong Young Park, Il‐Kwon Oh","doi":"10.1002/smm2.1270","DOIUrl":"https://doi.org/10.1002/smm2.1270","url":null,"abstract":"Metal‐organic frameworks (MOFs) are nanomaterials with engineered chemical structures, offering remarkable properties. However, their limited film‐formation capability hinders their integration into triboelectric nanogenerators (TENGs). This study proposes a simple yet effective solution to overcome this challenge by employing electrospinning techniques to integrate the zeolitic imidazolate framework (ZIF‐8) into an easy‐to‐use nanofibrous mat. ZIF‐8 has high surface potential, a unique cubical structure, and an easy fabrication process that makes it an ideal material for TENGs. By incorporating ZIF‐8 into the electrospinning solution, significant improvements are achieved in the electropositivity of the resulting nanofibers. It leads to notable changes in the shape, morphology, and roughness of electrospun fibers, consequently enhancing the overall performance of the TENG. The results indicate that utilizing the ZIF‐based electrospun mat as a tribo‐positive material can increase transferred charges between electrodes by more than 100%. Utilizing the MOF‐based nanofibrous mat, this study also introduces a novel rotary TENG that works based on a mode of TENG operation called rolling mode. The reliable charge generation by the proposed rolling system reveals that this mode of TENG operation could be a superb alternative for traditional TENG modes, like contact/separation or sliding, which cause high levels of mechanical stress due to harsh physical impact or friction.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139596616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable microcarrier‐hydrogel composite for dental stem cell delivery and tissue regeneration 用于牙科干细胞输送和组织再生的可注射微载体-水凝胶复合材料

SmartMat Pub Date : 2024-01-22 DOI: 10.1002/smm2.1268

Yu Jie Soh, Ruby Yu‐Tong Lin, Gopu Sriram, Wei Seong Toh, Victoria Soo Hoon Yu, Nileshkumar Dubey

{"title":"Injectable microcarrier‐hydrogel composite for dental stem cell delivery and tissue regeneration","authors":"Yu Jie Soh, Ruby Yu‐Tong Lin, Gopu Sriram, Wei Seong Toh, Victoria Soo Hoon Yu, Nileshkumar Dubey","doi":"10.1002/smm2.1268","DOIUrl":"https://doi.org/10.1002/smm2.1268","url":null,"abstract":"Conventional methods of stem cell therapy for tissue regeneration often face challenges, such as poor cell viability and integration posttransplantation. To address this, we proposed transplanting cells within synthetic microenvironments that maintain viability, cell phenotype, support extracellular matrix (ECM) secretion, and promote differentiation to enhance the regeneration of damaged host tissue. This hypothesis was tested in dental tissue regeneration using dental pulp stem cell‐laden microcarriers (MCs) mixed in a gelatin methacrylate (GelMA) hydrogel as a delivery system. The combination of MCs and GelMA exhibited similar physical properties and favorable biological properties compared to GelMA alone. Specifically, cell‐laden MC mixed into GelMA enhanced cell proliferation and ECM secretion and maintained a normal phenotype. Notably, MC‐modified GelMA amplified odontogenic differentiation, mineralization, and vascular endothelial growth factor release. Moreover, the storage of MC‐modified GelMA showed no detrimental effects on its injection force, cell viability, and mineralization potential, which demonstrates that the composite hydrogel is a promising injectable vehicle for therapeutic stem cell delivery. This strategy may be broadly applied to various tissues and organ systems, in which the provision and instruction of a cell population to participate in regeneration may be clinically useful.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible organic integrated circuits free of parasitic capacitance fabricated through a simple dual self‐alignment method 通过简单的双自对准法制造出无寄生电容的柔性有机集成电路

SmartMat Pub Date : 2024-01-22 DOI: 10.1002/smm2.1273

Baichuan Jiang, Xiao Han, Yu Che, Wenbin Li, Hong-wei Zheng, Jun Li, Cailing Ou, Nannan Dou, Zixiao Han, Tingyu Ji, Chuanhui Liu, Zhiyuan Zhao, Yunlong Guo, Yunqi Liu, Lei Zhang

{"title":"Flexible organic integrated circuits free of parasitic capacitance fabricated through a simple dual self‐alignment method","authors":"Baichuan Jiang, Xiao Han, Yu Che, Wenbin Li, Hong-wei Zheng, Jun Li, Cailing Ou, Nannan Dou, Zixiao Han, Tingyu Ji, Chuanhui Liu, Zhiyuan Zhao, Yunlong Guo, Yunqi Liu, Lei Zhang","doi":"10.1002/smm2.1273","DOIUrl":"https://doi.org/10.1002/smm2.1273","url":null,"abstract":"In integrated circuits (ICs), the parasitic capacitance is one of the crucial factors that degrade the circuit dynamic performance; for instance, it reduces the operating frequency of the circuit. Eliminating the parasitic capacitance in organic transistors is notoriously challenging due to the inherent tradeoff between manufacturing costs and interlayer alignment accuracy. Here, we overcome such a limitation using a cost‐effective method for fabricating organic thin‐film transistors and rectifying diodes without redundant electrode overlaps. This is achieved by placing all electrodes horizontally and introducing sub‐100 nm gaps for separation. A representative small‐scale IC consisting of five‐stage ring oscillators based on the obtained nonparasitic transistors and diodes is fabricated on flexible substrates, which performs reliably at a low driving voltage of 1 V. Notably, the oscillator exhibits signal propagation delays of 5.8 μs per stage at a supply voltage of 20 V when utilizing pentacene as the active layer. Since parasitic capacitance has been a common challenge for all types of thin‐film transistors, our approach may pave the way toward the realization of flexible and large‐area ICs based on other emerging and highly performing semiconductors.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor cell dissociation‐enhanced intravesical chemotherapy of orthotopic bladder cancer 肿瘤细胞解离增强型膀胱癌膀胱内化疗

SmartMat Pub Date : 2024-01-22 DOI: 10.1002/smm2.1276

Zhaoyu Ma, Zhiduo Sun, Zhichao Ye, Kai Cai, Wenbin Zhong, Weiguang Yuan, Weiyun Zhang, Jin Zhang, Kai Zhang, Huageng Liang, Heyou Han, Yanli Zhao

{"title":"Tumor cell dissociation‐enhanced intravesical chemotherapy of orthotopic bladder cancer","authors":"Zhaoyu Ma, Zhiduo Sun, Zhichao Ye, Kai Cai, Wenbin Zhong, Weiguang Yuan, Weiyun Zhang, Jin Zhang, Kai Zhang, Huageng Liang, Heyou Han, Yanli Zhao","doi":"10.1002/smm2.1276","DOIUrl":"https://doi.org/10.1002/smm2.1276","url":null,"abstract":"Frequent intravesical chemotherapy is still the adopted clinical option after bladder cancer surgery with low adhesion, poor selectivity, low permeability, and drug resistance. Herein, we develop an ingenious bladder cancer dissociation method to enhance intravesical chemotherapy and tumor self‐exclusion with urine. Ethylene diamine tetraacetic acid (EDTA), a common Ca2+ chelator, is loaded with the typical clinical bladder instillation drug doxorubicin (Dox) in chitosan‐modified hollow gold nanorods and subsequently coated with cancer cell membranes. After bladder perfusion, the nanoplatform exhibits high affinity toward bladder tumors under homologous targeting, assisting in long‐term retention. Under NIR‐II laser irradiation, the photothermal effect accelerates the unloading of cargo, and the released EDTA then disrupts intratumoral junctions by depriving and chelating Ca2+ from the intercellular calcium‐dependent connexin. The consequential intertumoral dissociation gives access to the deeper penetration of Dox and allows the exclusion of the shed small tumor masses from the body with the urine. This distinctive tumor dissociation concept holds great promise for modern clinical intravesical chemotherapy and perhaps for other gastrointestinal malignancies.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticoagulant therapy without bleeding: A novel molybdenum‐based nanodots alleviate lethal coagulation in bacterial sepsis by inhibiting ROS‐facilitated caspase‐11 activation 抗凝治疗不出血：新型钼基纳米点通过抑制 ROS 促成的 caspase-11 激活缓解细菌性败血症中的致命凝血作用

SmartMat Pub Date : 2024-01-19 DOI: 10.1002/smm2.1264

Chuang Yuan, Qicai Xiao, Qiaohui Chen, Qiong Huang, K. Ai, Xinyu Yang

{"title":"Anticoagulant therapy without bleeding: A novel molybdenum‐based nanodots alleviate lethal coagulation in bacterial sepsis by inhibiting ROS‐facilitated caspase‐11 activation","authors":"Chuang Yuan, Qicai Xiao, Qiaohui Chen, Qiong Huang, K. Ai, Xinyu Yang","doi":"10.1002/smm2.1264","DOIUrl":"https://doi.org/10.1002/smm2.1264","url":null,"abstract":"Sepsis is a leading cause of death worldwide. This syndrome is commonly accompanied by overactivation of coagulation, excessive reactive oxygen species (ROS), and inflammatory cytokine storm. Notably, disseminated intravascular coagulation (DIC) accounts for around 40% of sepsis‐associated deaths. However, anticoagulant therapy is still difficult for sepsis treatment because of the lethal bleeding side effects. Although the relationship between ROS and inflammatory cytokine storm has been described clearly, the pathogenic role of ROS in DIC, however, is still unclear, which renders novel therapeutic approaches hard to achieve bedside for inhibiting DIC. Herein, our new finding reveals that ROS greatly facilitates the entry of lipopolysaccharide (LPS) into the macrophage cytoplasm, which subsequently activates the caspase‐11/gasdermin D pathway, and finally induces DIC through phosphatidylserine exposure. Based on this finding, novel gallic acid‐modified Mo‐based polyoxometalate dots (M‐dots) with outstanding antioxidant activity are developed to provide ideal and efficient inhibition of DIC. As expected, M‐dots are capable of markedly inhibiting sepsis‐caused coagulation, organ injury, and death in sepsis. This therapeutic strategy, blocking the upstream pathway of coagulation rather than coagulation itself, can avoid the side effects of extensive bleeding caused by conventional anticoagulation therapy, and will provide a new avenue for the efficient treatment of sepsis.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139613450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knee function assessment of anterior cruciate ligament injury with a Kirigami buckling‐resistant stretchable sensor 利用 Kirigami 抗扣压可拉伸传感器评估前十字韧带损伤的膝关节功能

SmartMat Pub Date : 2024-01-17 DOI: 10.1002/smm2.1271

Xiaopeng Yang, Menglun Zhang, Pengfei Niu, Wenlan Guo, Chen Sun, Wei Pang, Guoqing Cui, Qiang Liu

{"title":"Knee function assessment of anterior cruciate ligament injury with a Kirigami buckling‐resistant stretchable sensor","authors":"Xiaopeng Yang, Menglun Zhang, Pengfei Niu, Wenlan Guo, Chen Sun, Wei Pang, Guoqing Cui, Qiang Liu","doi":"10.1002/smm2.1271","DOIUrl":"https://doi.org/10.1002/smm2.1271","url":null,"abstract":"Continuous and quantitative monitoring of knee joint function has clinical value in rehabilitation assessment and the timing of return to play for anterior cruciate ligament injury patients. However, the existing approaches, including clinical examination, arthrometry and inertial solutions, can only be used for qualitative, off‐line and low‐quality evaluations, respectively. Burgeoning Kirigami stretchable sensors could be a disruptive candidate solution, but they usually suffer from structural buckling issues when used for large strain applications, such as knee joint motion capture where the buckling degrades sensor reliability and repeatability. Here, we propose a buckling‐resistant stretchable and wearable sensor for knee joint motion capture. It enables continuous and precise motion signal capture of the knee joint and provides high wearing comfort and reliability. Clinical tests were conducted on 30 patients in the field, tracking data provided by the sensor from their initial hospitalization to later surgery. And the full rehabilitation of one subject was recorded and analyzed. The test results show that our sensor can dynamically assess knee function in real time and recommend the best timing for return to play, which paves the way for personalized and telerehabilitation.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0