Selective cancer therapeutics最新文献_第5页

Ambulatory infusion of bleomycin in patients receiving chemotherapy for germ cell tumors. 生殖细胞肿瘤化疗患者动态输注博来霉素。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.93

J A Green, P Hammond, S W Watkin

引用次数: 0

Preclinical toxicity study of mitomycin C infused into the internal carotid artery of beagle dogs. 比格犬颈动脉输注丝裂霉素C的临床前毒性研究。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.23

P M Kanter, G A Bullard, Z P Pavelic, C R West

引用次数: 0

Doxorubicin-loaded nanoparticles: increased efficiency in murine hepatic metastases. 负载阿霉素的纳米颗粒:提高小鼠肝转移的效率。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.1

N Chiannilkulchai, Z Driouich, J P Benoit, A L Parodi, P Couvreur

引用次数: 93

Arrest and retention of multilamellar liposomes in the brain of normal mice or mice bearing experimental brain metastases. 正常小鼠或实验性脑转移小鼠脑内多层脂质体的阻滞和滞留。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.73

G Schackert, D Fan, R Nayar, I J Fidler

{"title":"Arrest and retention of multilamellar liposomes in the brain of normal mice or mice bearing experimental brain metastases.","authors":"G Schackert, D Fan, R Nayar, I J Fidler","doi":"10.1089/sct.1989.5.73","DOIUrl":"https://doi.org/10.1089/sct.1989.5.73","url":null,"abstract":"The blood-brain barrier presents a major obstacle to the systemic treatment of malignant brain tumors and brain metastases. We investigated whether the direct injection of liposomes into the internal carotid artery of normal mice or mice with experimental brain-melanoma metastases could allow delivery of anticancer drugs across this barrier. Liposomes of different sizes (greater than 5 microns, less than 1 micron, 40-80 nm) and lipid compositions were injected i.v. or into the internal carotid artery. The retention of liposomes in the brain of normal C3H/HeN mice was similar to that observed in mice with experimental brain cancer metastasis. The highest accumulation of liposomes in the brain occurred with large multilamellar vesicles, which also produced severe toxicity presumably due to embolism. Smaller liposomes were not toxic but did not accumulate in the brain. Liposomes injected i.v. did not accumulate in the brain, either. Thus, neither i.v. nor intracarotid administration of liposomes produce results suitable for therapy of brain tumors/metastases.","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":"5 2","pages":"73-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1989.5.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13911515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Utility of topical formulations of morphine hydrochloride containing azone and N-methyl-2-pyrrolidone. 含有氮酮和n -甲基-2-吡咯烷酮的盐酸吗啡外用制剂的实用性。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.119

K Sugibayashi, C Sakanoue, Y Morimoto

{"title":"Utility of topical formulations of morphine hydrochloride containing azone and N-methyl-2-pyrrolidone.","authors":"K Sugibayashi, C Sakanoue, Y Morimoto","doi":"10.1089/sct.1989.5.119","DOIUrl":"https://doi.org/10.1089/sct.1989.5.119","url":null,"abstract":"In order to develop the transdermal formulations of morphine hydrochloride with high skin permeation rate and prolonged action, several gels and patches containing potent penetration enhancer, laurocapram (Azone), were prepared. Since there was a long lag time period for morphine permeation through the excised hairless rat skin in Azone treatment, N-methyl-2-pyrrolidone was added to the Azone gel or patch as a co-enhancer to increase the skin permeation of morphine hydrochloride, especially in the early phase. The mixed solvent of N-methyl-2-pyrrolidone and water showed cosolvency of morphine hydrochloride, and the co-enhancer could shorten the lag time period of skin permeation of morphine hydrochloride. However, the co-enhancer alone had little effect on the skin permeation of morphine hydrochloride. It was effective only when using with Azone. Coadministration of Azone with the co-enhancer showed high in vitro skin permeation and in vivo blood level of the drug. A marked analgesic effect was found after application of morphine hydrochloride patch containing Azone and N-methyl-2-pyrrolidone. The pharmacological effect was much more prolonged than that after the conventional s.c. injection. From these results, it was predicted that the topical formulations of morphine hydrochloride containing Azone and N-methyl-2-pyrrolidone might be useful for the relief of severe chronic pain in patients.","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":"5 3","pages":"119-28"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1989.5.119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13951559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

A randomized study of inpatient versus outpatient continuous intravenous infusion chemotherapy: psychosocial aspects. 住院患者与门诊患者持续静脉输注化疗的随机研究:心理社会方面。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.137

D M Magid, E E Vokes, R L Schilsky, C M Guarnieri, S M Whaling, R R Weichselbaum, W R Panje

{"title":"A randomized study of inpatient versus outpatient continuous intravenous infusion chemotherapy: psychosocial aspects.","authors":"D M Magid, E E Vokes, R L Schilsky, C M Guarnieri, S M Whaling, R R Weichselbaum, W R Panje","doi":"10.1089/sct.1989.5.137","DOIUrl":"https://doi.org/10.1089/sct.1989.5.137","url":null,"abstract":"This study was designed to test whether previously untreated patients with head and neck cancer could effectively manage home continuous infusion chemotherapy, and to compare their acceptance and adjustment to home versus inpatient treatment. Twenty-two patients received 3-4 cycles of induction chemotherapy and a 5-day continuous intravenous infusion (CVI). Patients were randomized to receive the CVI portion of cycle 1 either in the hospital via a standard chemotherapy delivery device or at home via the Travenol Infusor, a portable and disposable drug delivery system. For their second cycle of chemotherapy, patients crossed over to the alternate drug delivery method. Patients who did not want to receive their treatment at home received their chemotherapy as inpatients via the Infusor. Therefore, all patients received treatment with both drug delivery methods. Nineteen patients were evaluable for this study. Eleven patients received at least one cycle of home CVI chemotherapy, and adjusted well to this method of drug delivery. Levels of psychological distress decreased for this group of patients when receiving outpatient chemotherapy compared to their inpatient cycles. The eight patients who received all chemotherapy cycles as inpatients (refused home treatment) were found to be less educated and reported greater physical impairment prior to study entry than future home CVI acceptors. Levels of psychological distress in this group increased with each inpatient chemotherapy cycle. We conclude that home CVI chemotherapy may be an alternative to inpatient treatment for patients who have had at least one cycle of inpatient chemotherapy. The best candidates for home treatment are patients with unimpaired daily functioning and a minimum high school education.","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":"5 3","pages":"137-45"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1989.5.137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13824082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Targeted drug delivery: a two-compartment growth inhibition assay demonstrates that fluorodeoxyuridine and fluorodeoxyuridine monophosphate are liposome-independent drugs. 靶向药物递送:一项双室生长抑制试验表明，氟脱氧尿嘧啶和单磷酸氟脱氧尿嘧啶是脂质体不依赖的药物。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.179

T D Heath, C S Brown

引用次数: 6

Differential tumor regression in patients with bilobar hepatic metastases and dual arterial supply: evidence supporting the advantage of intra-arterial over intravenous route of drug delivery. 双叶肝转移和双动脉供应患者的差异肿瘤消退:支持动脉内给药优于静脉给药的证据。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.37

G M Mavlight, Y Z Patt, T P Haynie, C H Carrasco, C Charnsangavej, S Wallace

引用次数: 3

A new in vitro screening system for anticancer drugs for the treatment of non-small cell lung cancer. 一种治疗非小细胞肺癌的抗癌药物体外筛选新系统。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.97

U Hanauske, A R Hanauske, G M Clark, D Tsen, J Buchok, D D von Hoff

引用次数: 4

Immobilized adriamycin: toxic potential in vivo and in vitro. 固定化阿霉素:体内外毒性潜势。

Selective cancer therapeutics Pub Date : 1989-01-01 DOI: 10.1089/sct.1989.5.67

M P Hacker, J S Lazo, C A Pritsos, T R Tritton

引用次数: 2