Selective cancer therapeutics最新文献

Phase I evaluation of crisnatol (BWA770U mesylate) on a monthly extended infusion schedule. crisnatol (BWA770U甲磺酸)每月延长输注计划的I期评估。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.85

P W Cobb, K A Havlin, J G Kuhn, J B Craig, G S Harman, J S Luther, J N Turner, G R Weiss, D A Tweedy, J Koeller

引用次数: 2

Toxicity and antitumor activity of liposome-entrapped retinoid Ro13-7410. 脂质体包裹的类维甲酸Ro13-7410的毒性和抗肿瘤活性。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.151

D J McCarthy, G R Dollar, D L Hill

{"title":"Toxicity and antitumor activity of liposome-entrapped retinoid Ro13-7410.","authors":"D J McCarthy, G R Dollar, D L Hill","doi":"10.1089/sct.1991.7.151","DOIUrl":"https://doi.org/10.1089/sct.1991.7.151","url":null,"abstract":"We compared the toxicity of free and liposome-entrapped retinoid, Ro13-7410 in C2DF1 mice. Mice received 7 daily i.p. injections of liposome-entrapped Ro13-7410 at doses of 5, 10, 100, 500, or 1000 micrograms/kg bw/day. For comparison, two groups of mice were used as controls, one group received Ro13-7410 in corn oil and a second group received liposome-entrapped Ro13-7410 that had been solubilized with detergent. The liposomes were then tested for chemotherapeutic activity against human myelocytic leukemia (HL-60/MRI) implanted in athymic NCr-nu mice. The doses used in the chemotherapy experiment (20, 50, and 100 micrograms/kg bw/day) were selected based on the results of the toxicity experiment in CD2F1 mice. CD2F1 mice were marginally protected from toxicity after receiving retinoid in liposomes relative to controls. There were 2/5 survivors in the 1000 micrograms/kg bw/day Ro13-7410-liposome group after 7 daily i.p. doses compared to 0/5 for both the corn oil and solubilized liposome groups, and 4/5 survivors in the 500 micrograms/kg bw/day Ro13-7410-liposome group after 7 daily i.p. doses compared to 2/5 for both the corn oil and solubilized liposome groups. We observed no dramatic differences in toxicity among the treatment groups over the range of doses administered. There were 2/6 long-term tumor-free survivors in athymic mice receiving liposome-entrapped retinoid, at 50 micrograms/kg bw/day for 7 days, compared with 0/6 and 0/9 survivors in groups receiving empty liposomes or no treatment.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1991.7.151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of induced acidosis on cytotoxicity of anticancer drugs. 诱导酸中毒对抗癌药物细胞毒性的影响。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.1

M Adwankar, A Juvekar, M Chitnis

引用次数: 2

Detection of P-glycoprotein with JSB-1 monoclonal antibody in B-5 fixed and paraffin-embedded cell lines and tissues. 用JSB-1单克隆抗体检测B-5固定和石蜡包埋细胞系和组织中的p -糖蛋白。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.49

Z P Pavelic, Z Sever, R N Fontaine, V V Baker, J Reising, D M Denton, L Pavelic, M Khalily

{"title":"Detection of P-glycoprotein with JSB-1 monoclonal antibody in B-5 fixed and paraffin-embedded cell lines and tissues.","authors":"Z P Pavelic, Z Sever, R N Fontaine, V V Baker, J Reising, D M Denton, L Pavelic, M Khalily","doi":"10.1089/sct.1991.7.49","DOIUrl":"https://doi.org/10.1089/sct.1991.7.49","url":null,"abstract":"We analyzed the expression of P-glycoprotein (Pgp) by immunohistochemistry using JSB-1 monoclonal antibody (MAb) on paraffin-embedded sections of the multi-drug resistant (MDR) (CHrC5 and CEM-VLB), and sensitive (AuxB1 and CEM) cell lines, and also in normal kidney, colon, adrenal and in kidney and colon carcinomas. After comparing the sensitivity of three different immunohistochemical techniques the peroxidase-antiperoxidase method was found to be the best. We then tested six different fixation methods. The MDR cell lines and human tissues demonstrated the strongest staining with B-5 fixative. Both MDR cell lines, but not the tissues fixed in 1% paraformaldehyde and Zamboni's fixative demonstrated weak staining. No immuno- reactivity could be detected in MDR cell lines and tissues fixed in 10% buffered or nonbuffered formalin or by the AMeX method of tissue processing. The present study clearly shows that the type of fixative is critical for the preservation of Pgp epitope recognized by JSB-1 MAb, and that B-5 fixative is expected to be equally applicable for the detection of Pgp in normal and neoplastic tissues.","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1991.7.49","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12885825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Decreased oral toxicity with the local use of allopurinol in patients who received high dose 5-fluorouracil. 接受大剂量5-氟尿嘧啶治疗的患者局部使用别嘌呤醇可降低口服毒性。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.113

N B Tsavaris, P Komitsopoulou, I Tzannou, P Loucatou, A Tsaroucha-Noutsou, G Kilafis, P Kosmidis

引用次数: 12

Suppression of tumor vascular activity by radioantibody therapy: implications for multiple cycle treatments. 放射抗体治疗对肿瘤血管活性的抑制:多周期治疗的意义。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.9

R D Blumenthal, R M Sharkey, R Kashi, D M Goldenberg

引用次数: 16

Extravasation of doxorubicin from vascular access devices. 阿霉素从血管通路装置外渗。

Selective cancer therapeutics Pub Date : 1991-01-01

C Davis

引用次数: 0

Microscopic analysis of arterial microsphere distribution in rabbit liver and hepatic VX2 tumor. 兔肝脏及肝VX2肿瘤动脉微球分布的显微分析。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.39

K M Pillai, P E McKeever, C A Knutsen, P A Terrio, D M Prieskorn, W D Ensminger

{"title":"Microscopic analysis of arterial microsphere distribution in rabbit liver and hepatic VX2 tumor.","authors":"K M Pillai, P E McKeever, C A Knutsen, P A Terrio, D M Prieskorn, W D Ensminger","doi":"10.1089/sct.1991.7.39","DOIUrl":"https://doi.org/10.1089/sct.1991.7.39","url":null,"abstract":"Microspheres conjugated to radioisotopes and chemotherapeutic agents are playing an important investigative and clinical role in the management of metastatic neoplasms. The purpose of our investigation was to histologically assess the basis for regional intra-arterial microsphere therapy, by comparing the spatial distribution of microspheres in the tumor and liver of experimental models of hepatic metastases. Three New Zealand white rabbits with hepatic VX2 tumor implants were arterially injected with hepatic doses of either 15 or 30 million blue-dyed, polystyrene microspheres (27 microns-diameter). Microscopic examination of random liver and tumor samples revealed that 6-12 times as many microspheres were embolized within tumor than in normal liver (p less than 0.002). The majority of microspheres aggregated into clusters of various size within liver and tumor vasculature, though analysis of cluster sizes illustrated an exponentially skewed distribution toward isolated microspheres. Approximately eight times as many clusters were observed in tumor than in liver (p less than 0.008). Finally, a morphometric analysis was used to quantitate the minimal distances separating microsphere clusters, the intercluster distance (ICD). Analysis of over three thousand intercluster measurements revealed a median ICD approximately five times lower in tumor than in liver (p less than 1 x 10(-8)). This microquantitative analysis provides a fundamental description of how regional intra-arterial microsphere therapy allows the targeted delivery of microspheres to neoplastic tissue, to potentially improve the therapeutic index in the treatment of hepatic metastases.","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1991.7.39","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12917848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery. 单克隆抗体偶联的合成聚合物:肿瘤靶向药物递送的载体。

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.59

L W Seymour, P A Flanagan, A al-Shamkhani, V Subr, K Ulbrich, J Cassidy, R Duncan

{"title":"Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery.","authors":"L W Seymour, P A Flanagan, A al-Shamkhani, V Subr, K Ulbrich, J Cassidy, R Duncan","doi":"10.1089/sct.1991.7.59","DOIUrl":"https://doi.org/10.1089/sct.1991.7.59","url":null,"abstract":"(N-(2-Hydroxypropyl)methacrylamide (HPMA)) copolymers have seen extensive development as sophisticated lysosomotropic drug carriers. They can be used for site-specific drug delivery by incorporation of appropriate targeting groups and here we report their conjugation to antitumour monoclonal antibodies (the murine IgG, antibody B72.3 and its Fab' and Fab'2 fragments) and assessment as vehicles for tumour-specific drug delivery. Conjugates were synthesised containing an average 5 copolymer units (Mw 20kD) per antibody molecule. Kinetics of elimination and body distribution of radiolabelled conjugates in mice were substantially modified compared with native antibody and fragments, showing prolonged circulation in the bloodstream. Notably, the half-time for bloodclearance of the Fab' fragment (35min) was extended ten-fold following conjugation (6h). The conjugates provoked only a low immune response in A/J mice, following three injections in adjuvant (IgG titre-1 less than 100), and were resistant (up to 50%) to proteolytic degradation by preparations of rat liver lysosomal enzymes. The parent antibody targeted efficiently to human colorectal carcinoma (LS174T) xenografts in nude mice (up to 25%/g); the conjugates, however, showed no tumour-targeting, probably due to masking by polymer chains (which are attached by non-specific aminolysis). Conjugates designed to maintain immunoreactivity following linkage through oxidised carbohydrates are currently being synthesised. Nevertheless, the conjugates display increased rates of extravasation, compared with proteins of the same hydrodynamic size, and the decreased charge is anticipated to accelerate diffusion through tumour interstitium.","PeriodicalId":21792,"journal":{"name":"Selective cancer therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/sct.1991.7.59","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12917852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Single and combination treatment with vitamin K3 and adriamycin: in vitro effects on cell survival and DNA damage in human chronic myeloid leukemia cells. 维生素K3和阿霉素单独和联合治疗:对人慢性髓性白血病细胞存活和DNA损伤的体外影响

Selective cancer therapeutics Pub Date : 1991-01-01 DOI: 10.1089/sct.1991.7.127

H Parekh, S Chavan, S Advani, M Chitnis

引用次数: 5