{"title":"LncRNA LINC00665 affected gastric cancer through Mir-9-5p according to CeRNA network analysis","authors":"Dayuan Chen, Fan Chen, P. Guo, Hongbo Chen","doi":"10.1117/12.2687538","DOIUrl":"https://doi.org/10.1117/12.2687538","url":null,"abstract":"Gastric cancer (GC) is one of the most common cancers in the world. Although the incidence and mortality rates of GC have declined globally in the past decades, its prognosis is still poor. Moreover, the exact mechanism of GC has not been thoroughly studied. This study aimed to identify central genes to improve the prognostic prediction of GC and construct a regulatory network of messenger RNA (mRNA), microRNA (miRNA), and long noncoding RNA (lncRNA). Six genes (COL10A1, CTHRC1, FAP, FNDC1, INHBA, and SULF1) were found using the information in the GEO database. The expression of these genes differs between patients with GC and nontumor groups, and such difference may affect the survival rate of patients with GC. A ceRNA network consisting of mRNA (CTHRC1, FNDC1, and INHBA), miRNA (mir-9-5p), and lncRNA (LINC00665) was constructed to reverse predict the target genes related to GC prognosis. According to the ceRNA theory, LINC00665 could bind with mir-9-5p in a competitive manner, increasing the transcription of CTHRC1, FNDC1, and INHBA regulated by mir-9-5p. However, this study has many limitations. First, age, sex, tumor stage, patient classification, and other factors were not considered when examining differentially expressed genes. Second, only FNDC1 expression in mRNA was shown.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121814543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xue Cao, Miao Guo, Qingjuan Feng, Yang Wang, J. Gao
{"title":"A review of the factors influencing the infusion accuracy of medical infusion pumps","authors":"Xue Cao, Miao Guo, Qingjuan Feng, Yang Wang, J. Gao","doi":"10.1117/12.2687441","DOIUrl":"https://doi.org/10.1117/12.2687441","url":null,"abstract":"Infusion pumps are commonly used clinical medical equipment which can precisely control the speed of infusion and deliver nutrients or medications to the patients. The infusion accuracy of infusion pumps seriously affects the life and health safety of patients, and infusion accuracy is the most important factor to assess the reliability of infusion pumps. Representative researches on the factors influencing the infusion accuracy of medical infusion pumps are summarized systematically. Influencing factors are divided into four aspects: external environmental factors, internal structure of pump body (mechanical accuracy), auxiliary consumables, and parameter settings. This paper details the current status of research in these four areas and provides an outlook on future research directions for quality control of infusion pumps.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124647926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research on QRS waveform detection based on difference absolute value extreme","authors":"shun yu, Ping Zhang, Xun Zhao","doi":"10.1117/12.2687529","DOIUrl":"https://doi.org/10.1117/12.2687529","url":null,"abstract":"ECG signal is an important basis for clinical diagnosis of cardiovascular disease, and ECG signal automatic detection of cardiovascular disease is the core of automatic diagnosis. In this paper, based on the existing ECG signal detection and location algorithm, a differential absolute value extremum algorithm is proposed. This algorithm combines the original difference algorithm principle and the difference absolute value, at the same time in the final positioning abandoned the discrete sampling location method, and using the extremum positioning method, which improves the positioning accuracy. Using this algorithm, the QRS waveforms of 5 groups of ECGs were detected and the detection accuracy was 99.67%.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126491703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yixing He, Xiyang Zhang, Shengjing Hu, Suogang Wang
{"title":"A quantitative analysis of training effects for the touch screen-based flashcard game attention training","authors":"Yixing He, Xiyang Zhang, Shengjing Hu, Suogang Wang","doi":"10.1117/12.2687395","DOIUrl":"https://doi.org/10.1117/12.2687395","url":null,"abstract":"Attention problems are common problems in adolescents and even adults. In this study, a training protocol based on flashcard game paradigm was designed, and reaction time and eye movement data were recorded during the training. The subjects received attention training twice a week for one month. Subjects took the IVA-CPT attention test before and after training. The study compared and analysed parameters such as reaction time, fixation distribution, fixation time, scanning length, etc. The experimental results showed that the task reaction time of the subjects was significantly shortened after attention training, and various parameters of eye movements were improved and statistically different. After training the attention quotients of IVA-CPT test were greatly improved and statistically different from those before training. This study provides a theoretical basis and technical support for the study of attention training and training effects.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128020565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intelligent detection and classification of Alzheimer's disease based on machine learning","authors":"Jiaming Song, Zhenhao Wei, Jiayi Yi, Siyi Liu","doi":"10.1117/12.2687379","DOIUrl":"https://doi.org/10.1117/12.2687379","url":null,"abstract":"Alzheimer's disease is a form of mental loss that causes memory loss, slow and gradual changes in brain function. Early diagnosis and prediction of Alzheimer's disease can delay the onset of the disease and possibly prolong the life span of patients, which has important scientific significance for the whole society. We used the multiple linear regression model and established a statistical model according to the obtained test results and past experience to reveal the evolution patterns of different categories of Alzheimer's disease over time. The corresponding variables were predicted and controlled. The regression coefficient was calculated, and the correlation coefficient was 0.82, thus demonstrating the accuracy of the model. Secondly, since the diagnosis and characteristic indicators of patients are contingent to a certain extent, this paper draws the time series images of relevant personnel through random extraction, compares the predicted results with the real results and tests the residual error, with an accuracy of 80.8%.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"204 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115783390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MRMHNet: a new convolutional neural network approach for decoding electroencephalogram motor imagery signals","authors":"Menghao Liu, Dong-Lun Wu, Xue-hua Tang, Zhiyong Zhou, Pengfei Zhao, Xiangmin Li, Xu Zhang","doi":"10.1117/12.2687404","DOIUrl":"https://doi.org/10.1117/12.2687404","url":null,"abstract":"The decoding of electroencephalogram (EEG) signals plays an extremely important role in brain-computer interfaces (BCI). However, the processing of physiological signals, particularly the decoding of multi-channel EEG signals, still poses significant challenges. Past deep learning methods often relied on subject-dependent settings, which resulted in new users needing to perform complex calibration procedures before they could use BCI devices. Therefore, we proposed a novel end-to-end deep learning model, MRMHNet, for motor imagery (MI) classification. Firstly, we utilized a feature extraction block based on a Multi-Resolution convolutional neural network (MRCNN) to extract features in both frequency and spatial domains. Secondly, we utilized a block based on the Multi-Head Attention (MHA) to extract global temporal information of the features. Finally, we validated the classification performance of our method using OpenBMI datasets, and the results showed that our method achieved the highest accuracy in both subject-dependent and subject-independent settings. Specifically, in the subject-independent setting, our method achieved the highest accuracy and F1-score, with values of 73.74±13.35% and 73.33±14.87%, respectively. This indicates that our method has good classification performance and high practical value in the field of BCI.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131232279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of natural products as dual sphingosine kinase-1 and programmed cell-death 1-inhibitors by virtual screening and molecular dynamics simulation","authors":"Jin Liu, Huilin Zhao, Lei He, Ri-lei Yu, C. Kang","doi":"10.1117/12.2687726","DOIUrl":"https://doi.org/10.1117/12.2687726","url":null,"abstract":"Anti-PD-1 have demonstrated significant clinical efficacy in tumor by reversing T-cell dysfunction and exhaustion, therapy enhancing anti-tumoral properties. However, the overall response rate of anti-PD-1 is not high, and responder experience tumor relapse within 2 years. The combination of targeting sphingosine kinase-1 and programmed cell death 1 as a potential therapy way to overcome the problems of immune checkpoint resistance and non-response. Therefore, the primary goal of this study was to discovery natural compounds for dual targeting sphingosine kinase-1 and programmed cell death 1 ligand 1. A natural product database was constructed, and ADMET was used to evaluate natural products for primary screening. Molecular docking and Molecular Mechanics/Generalized Born Surface Area found candidate natural products, three natural products docking conformation were performed 100 ns molecular dynamics simulation. Natural compound 2, 3, 4 have further study value as dual targeting Sphk1 and PD-1 inhibitors.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131308570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xing Wu, Dongbao Tang, Luxuan Liu, Zhaoyuan Jia, Yuyu Tan
{"title":"Improvement of printed circuit-board-based digital microfluidic chip and its application in peptide screening","authors":"Xing Wu, Dongbao Tang, Luxuan Liu, Zhaoyuan Jia, Yuyu Tan","doi":"10.1117/12.2687405","DOIUrl":"https://doi.org/10.1117/12.2687405","url":null,"abstract":"This paper proposes an improved digital microfluidics (DMF) chip based on a printed circuit board (PCB) to realize the precise control of droplets. Solder mask layer was introduced to the chip as the dielectric layer, and this way can simplify the preparation processes of the chip, and the chip offers reasonable control of the droplet. Combined with the external module, the S protein peptide was screened on the chip. As a result, this PCB-based chip provided a new tool for droplet manipulation. It may have potential applications in drug screening, especially in the field with many repetitive operations.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115469019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary nodule detection based on 3D multi-scale and semantic context heterogeneity","authors":"Yunchang Zhang, Xiaoqing Luo","doi":"10.1117/12.2687875","DOIUrl":"https://doi.org/10.1117/12.2687875","url":null,"abstract":"Automated lung nodule detection methods are challenged by the fact that pulmonary nodules often present multiple morphologies and scales and by the low differentiation of nodules from surrounding tissues. To address the above issues, we propose a pulmonary nodule detection method based on 3D multiscale and semantic context heterogeneity. The method uses dilated convolutions with different dilation rates to construct a Context Fusion Module (CFM) to extract pulmonary nodule multiscale fused features, thus enhancing the detection ability of non-significant and small nodules. The Channel Semantic Context Heterogeneity Model (CSHM) is proposed to address the problem of noise and redundant information in multi-scale fusion features, to suppress noise and redundant information from feature channel-level contextual relevance and redundancy, to enhance potential discriminative features, and to reduce the interference of useless information, so as to enhance the ability of nodule detection and localization. Experiments were conducted on a publicly available dataset (Luna Nodule Analysis 16, LUNA16) with a high sensitivity and an average sensitivity of 83.6% over eight false alarm numbers, which is better than the other method, validating the superiority of the proposed method.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115822133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An efficient hybrid XGBLR-IMBODE model for heart disease prediction","authors":"Weijun Gao, Pengfei Fu, Zhenyu Wang","doi":"10.1117/12.2687815","DOIUrl":"https://doi.org/10.1117/12.2687815","url":null,"abstract":"Heart disease is one of the world’s deadliest health problems. An efficient and accurate approach to early prevention and detection of heart disease is becoming critical. Machine learning (ML) technology has demonstrated the capability and effectiveness to assist decision making in many fields. ML techniques have also been applied in heart disease prediction, but a single ML model usually cannot achieve good performance. Therefore, to improve the performance of the prediction model, a hybrid XGBoost and logistic regression (XGBLR) using improved hybridization of differential evolution and monarch butterfly optimization (IMBODE) are proposed. XGBLR reduces the complexity of feature engineering and enhances the predictive performance of the model, and IMBODE strengthens the ability to optimize model hyperparameters to achieve better solutions. The evaluation results demonstrate that the XGBLR is advanced in the prediction of heart disease, with an accuracy of 96.72% on the Cleveland dataset.","PeriodicalId":217687,"journal":{"name":"International Conference on Biomedical and Intelligent Systems","volume":"95 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125977244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}