Seminars in respiratory and critical care medicine最新文献_第4页

Early Diagnosis of Sepsis: The Role of Biomarkers and Rapid Microbiological Tests. 败血症的早期诊断：生物标志物和快速微生物检验的作用。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1055/s-0044-1787270

Erika P Plata-Menchaca, Juan Carlos Ruiz-Rodríguez, Ricard Ferrer

引用次数: 0

Informative Subtyping of Patients with Sepsis. 对败血症患者进行信息亚型分类。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-08 DOI: 10.1055/s-0044-1787992

John Cafferkey, Manu Shankar-Hari

引用次数: 0

Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors. 败血症中宿主与病原体相互作用的失调：与宿主相关的因素。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1055/s-0044-1787554

Sebastiaan C M Joosten, Willem J Wiersinga, Tom van der Poll

引用次数: 0

Acute Management of Sepsis beyond 24 Hours. 败血症 24 小时后的急性处理。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-05 DOI: 10.1055/s-0044-1787991

Antoine Premachandra, Nicholas Heming

{"title":"Acute Management of Sepsis beyond 24 Hours.","authors":"Antoine Premachandra, Nicholas Heming","doi":"10.1055/s-0044-1787991","DOIUrl":"10.1055/s-0044-1787991","url":null,"abstract":"Sepsis manifests as a dysregulated immune response to an infection, leading to tissue damage, organ failure, and potentially death or long-term health issues. Sepsis remains a major health challenge globally, causing approximately 50 million cases and 11 million deaths annually. Early management of sepsis focuses on source control, antimicrobial treatment, and supporting vital organ function. Subsequent care includes metabolic, nutritional, and immune therapies to address the complex needs of septic patients. Metabolic management is based on obtaining moderate glucose targets. Nutritional support aims to mitigate hypercatabolism and muscle wasting, but aggressive early nutrition does not improve outcomes and could even be harmful. Immune modulation is crucial due to the dual nature of sepsis-induced immune responses. Corticosteroids have shown benefits in shock and organ dysfunction reversal and in mortality reduction with current guidelines recommending them in vasopressor therapy-dependent patients. In conclusion, sepsis management beyond the initial hours requires a multifaceted approach, focusing on metabolic, nutritional, and immune system support tailored to individual patient needs to enhance survival and recovery.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"510-515"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Mechanisms in Sepsis-Associated Acute Kidney Injury. 败血症相关急性肾损伤的表观遗传机制

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-08-29 DOI: 10.1055/s-0044-1789240

Marco Fiorentino, Reginald Philippe, Carmen A Palumbo, Stefania Prenna, Vincenzo Cantaluppi, Silva De Rosa

{"title":"Epigenetic Mechanisms in Sepsis-Associated Acute Kidney Injury.","authors":"Marco Fiorentino, Reginald Philippe, Carmen A Palumbo, Stefania Prenna, Vincenzo Cantaluppi, Silva De Rosa","doi":"10.1055/s-0044-1789240","DOIUrl":"https://doi.org/10.1055/s-0044-1789240","url":null,"abstract":"Sepsis, the dysregulated immune response of the host to infections, leads to numerous complications, including multiple organ dysfunction with sepsis-associated acute kidney injury (SA-AKI) being a frequent complication associated with increased risk of mortality and the progression toward chronic kidney disease (CKD). Several mechanisms have been widely investigated in understanding the complex pathophysiology of SA-AKI, including hemodynamic alterations, inflammation, oxidative stress, and direct cellular injury driven by pathogens or cell-derived products (pathogen-associated molecular patterns and damage-associated molecular patterns). Despite advancements in the management of septic patients, the prognosis of SA-AKI patients remains significantly poor and is associated with high in-hospital mortality and adverse long-term outcomes. Therefore, recent research has focused on the early identification of specific SA-AKI endotypes and subphenotypes through epigenetic analysis and the use of potential biomarkers, either alone or in combination with clinical data, to improve prognosis. Epigenetic regulation, such as DNA methylation, histone modifications, and noncoding RNA modulation, is crucial in modulating gene expression in response to stress and renal injury in SA-AKI. At the same time, these modifications are dynamic and reversible processes that can alter gene expression in several pathways implicated in the context of SA-AKI, including inflammation, immune response, and tolerance status. In addition, specific epigenetic modifications may exacerbate renal damage by causing persistent inflammation or cellular metabolic reprogramming, leading to progression toward CKD. This review aims to provide a comprehensive understanding of the epigenetic characteristics that define SA-AKI, also exploring targeted therapies that can improve patient outcomes and limit the chronic progression of this syndrome.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":"45 4","pages":"491-502"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five Questions to Help Prompt End-of-Life Planning in Neuromuscular Disease. 帮助神经肌肉疾病患者制定生命终结计划的五个问题。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-07-19 DOI: 10.1055/s-0044-1787994

Benjamin J Lipanot, Gabriel Bosslet

引用次数: 0

Novel Therapeutic Approaches in Connective Tissue Disease-Associated Interstitial Lung Disease. 结缔组织病相关间质性肺病的新型治疗方法

IF 3.2 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-06-01 Epub Date: 2024-05-13 DOI: 10.1055/s-0044-1786155

Erica Mulcaire-Jones, Janelle Vu Pugashetti, Justin M Oldham, Dinesh Khanna

引用次数: 0

Approach to Pulmonary Nodules in Connective Tissue Disease. 结缔组织病肺部结节的治疗方法。

IF 3.2 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1055/s-0044-1782656

Brian Gaffney, David J Murphy

引用次数: 0

Pulmonary Hypertension in Connective Tissue Diseases Other than Systemic Sclerosis. 系统性硬化症以外的结缔组织疾病中的肺动脉高压。

IF 3.2 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-06-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1782217

Brandon Budhram, Jason Weatherald, Marc Humbert

{"title":"Pulmonary Hypertension in Connective Tissue Diseases Other than Systemic Sclerosis.","authors":"Brandon Budhram, Jason Weatherald, Marc Humbert","doi":"10.1055/s-0044-1782217","DOIUrl":"10.1055/s-0044-1782217","url":null,"abstract":"Pulmonary hypertension (PH) is a known complication of certain connective tissue diseases (CTDs), with systemic sclerosis (SSc) being the most common in the Western world. However, PH in association with non-SSc CTD such as systemic lupus erythematous, mixed connective tissue disease, and primary Sjögren's syndrome constitutes a distinct subset of patients with inherently different epidemiologic profiles, pathophysiologic mechanisms, clinical features, therapeutic options, and prognostic implications. The purpose of this review is to inform a practical approach for clinicians evaluating patients with non-SSc CTD-associated PH.The development of PH in these patients involves a complex interplay between genetic factors, immune-mediated mechanisms, and endothelial cell dysfunction. Furthermore, the broad spectrum of CTD manifestations can contribute to the development of PH through various pathophysiologic mechanisms, including intrinsic pulmonary arteriolar vasculopathy (pulmonary arterial hypertension, Group 1 PH), left-heart disease (Group 2), chronic lung disease (Group 3), chronic pulmonary artery obstruction (Group 4), and unclear and/or multifactorial mechanisms (Group 5). The importance of diagnosing PH early in symptomatic patients with non-SSc CTD is highlighted, with a review of the relevant biomarkers, imaging, and diagnostic procedures required to establish a diagnosis.Therapeutic strategies for non-SSc PH associated with CTD are explored with an in-depth review of the medical, interventional, and surgical options available to these patients, emphasizing the CTD-specific considerations that guide treatment and aid in prognosis. By identifying gaps in the current literature, we offer insights into future research priorities that may prove valuable for patients with PH associated with non-SSc CTD.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"419-434"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Pulmonary Manifestations in Antisynthetase Syndrome. 抗合成代谢酶综合征肺部表现回顾。

IF 3.2 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-06-01 Epub Date: 2024-05-06 DOI: 10.1055/s-0044-1785536

Mohammad I Ghanbar, Sonye K Danoff

{"title":"Review of Pulmonary Manifestations in Antisynthetase Syndrome.","authors":"Mohammad I Ghanbar, Sonye K Danoff","doi":"10.1055/s-0044-1785536","DOIUrl":"10.1055/s-0044-1785536","url":null,"abstract":"Antisynthetase syndrome (ASyS) is now a widely recognized entity within the spectrum of idiopathic inflammatory myopathies. Initially described in patients with a triad of myositis, arthritis, and interstitial lung disease (ILD), its presentation can be diverse. Additional common symptoms experienced by patients with ASyS include Raynaud's phenomenon, mechanic's hand, and fever. Although there is a significant overlap with polymyositis and dermatomyositis, the key distinction lies in the presence of antisynthetase antibodies (ASAs). Up to 10 ASAs have been identified to correlate with a presentation of ASyS, each having manifestations that may slightly differ from others. Despite the proposal of three classification criteria to aid diagnosis, the heterogeneous nature of patient presentations poses challenges. ILD confers a significant burden in patients with ASyS, sometimes manifesting in isolation. Notably, ILD is also often the initial presentation of ASyS, requiring pulmonologists to remain vigilant for an accurate diagnosis. This article will comprehensively review the various aspects of ASyS, including disease presentation, diagnosis, management, and clinical course, with a primary focus on its pulmonary manifestations.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"365-385"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0