Hazal Türkmen, Oguz Dikenelli, C. Eraslan, Mehmet Cem Çalli, S. Özbek
{"title":"Harnessing the Power of BERT in the Turkish Clinical Domain: Pretraining Approaches for Limited Data Scenarios","authors":"Hazal Türkmen, Oguz Dikenelli, C. Eraslan, Mehmet Cem Çalli, S. Özbek","doi":"10.48550/arXiv.2305.03788","DOIUrl":"https://doi.org/10.48550/arXiv.2305.03788","url":null,"abstract":"Recent advancements in natural language processing (NLP) have been driven by large language models (LLMs), thereby revolutionizing the field. Our study investigates the impact of diverse pre-training strategies on the performance of Turkish clinical language models in a multi-label classification task involving radiology reports, with a focus on overcoming language resource limitations. Additionally, for the first time, we evaluated the simultaneous pre-training approach by utilizing limited clinical task data. We developed four models: TurkRadBERT-task v1, TurkRadBERT-task v2, TurkRadBERT-sim v1, and TurkRadBERT-sim v2. Our results revealed superior performance from BERTurk and TurkRadBERT-task v1, both of which leverage a broad general-domain corpus. Although task-adaptive pre-training is capable of identifying domain-specific patterns, it may be prone to overfitting because of the constraints of the task-specific corpus. Our findings highlight the importance of domain-specific vocabulary during pre-training to improve performance. They also affirmed that a combination of general domain knowledge and task-specific fine-tuning is crucial for optimal performance across various categories. This study offers key insights for future research on pre-training techniques in the clinical domain, particularly for low-resource languages.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115165341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Giorgi, Augustin Toma, Ronald Xie, Sondra S. Chen, Kevin R. An, Grace X. Zheng, Bo Wang
{"title":"WangLab at MEDIQA-Chat 2023: Clinical Note Generation from Doctor-Patient Conversations using Large Language Models","authors":"John Giorgi, Augustin Toma, Ronald Xie, Sondra S. Chen, Kevin R. An, Grace X. Zheng, Bo Wang","doi":"10.18653/v1/2023.clinicalnlp-1.36","DOIUrl":"https://doi.org/10.18653/v1/2023.clinicalnlp-1.36","url":null,"abstract":"This paper describes our submission to the MEDIQA-Chat 2023 shared task for automatic clinical note generation from doctor-patient conversations. We report results for two approaches: the first fine-tunes a pre-trained language model (PLM) on the shared task data, and the second uses few-shot in-context learning (ICL) with a large language model (LLM). Both achieve high performance as measured by automatic metrics (e.g. ROUGE, BERTScore) and ranked second and first, respectively, of all submissions to the shared task. Expert human scrutiny indicates that notes generated via the ICL-based approach with GPT-4 are preferred about as often as human-written notes, making it a promising path toward automated note generation from doctor-patient conversations.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130624136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lifeng Han, G. Erofeev, I. Sorokina, S. Gladkoff, G. Nenadic
{"title":"Investigating Massive Multilingual Pre-Trained Machine Translation Models for Clinical Domain via Transfer Learning","authors":"Lifeng Han, G. Erofeev, I. Sorokina, S. Gladkoff, G. Nenadic","doi":"10.18653/v1/2023.clinicalnlp-1.5","DOIUrl":"https://doi.org/10.18653/v1/2023.clinicalnlp-1.5","url":null,"abstract":"Massively multilingual pre-trained language models (MMPLMs) are developed in recent years demonstrating superpowers and the pre-knowledge they acquire for downstream tasks.This work investigates whether MMPLMs can be applied to clinical domain machine translation (MT) towards entirely unseen languages via transfer learning.We carry out an experimental investigation using Meta-AI’s MMPLMs “wmt21-dense-24-wide-en-X and X-en (WMT21fb)” which were pre-trained on 7 language pairs and 14 translation directions including English to Czech, German, Hausa, Icelandic, Japanese, Russian, and Chinese, and the opposite direction.We fine-tune these MMPLMs towards English-Spanish language pair which did not exist at all in their original pre-trained corpora both implicitly and explicitly.We prepare carefully aligned clinical domain data for this fine-tuning, which is different from their original mixed domain knowledge.Our experimental result shows that the fine-tuning is very successful using just 250k well-aligned in-domain EN-ES segments for three sub-task translation testings: clinical cases, clinical terms, and ontology concepts. It achieves very close evaluation scores to another MMPLM NLLB from Meta-AI, which included Spanish as a high-resource setting in the pre-training.To the best of our knowledge, this is the first work on using MMPLMs towards clinical domain transfer-learning NMT successfully for totally unseen languages during pre-training.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116504745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Lewis, Myle Ott, Jingfei Du, Veselin Stoyanov
{"title":"Pretrained Language Models for Biomedical and Clinical Tasks: Understanding and Extending the State-of-the-Art","authors":"Patrick Lewis, Myle Ott, Jingfei Du, Veselin Stoyanov","doi":"10.18653/v1/2020.clinicalnlp-1.17","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.17","url":null,"abstract":"A large array of pretrained models are available to the biomedical NLP (BioNLP) community. Finding the best model for a particular task can be difficult and time-consuming. For many applications in the biomedical and clinical domains, it is crucial that models can be built quickly and are highly accurate. We present a large-scale study across 18 established biomedical and clinical NLP tasks to determine which of several popular open-source biomedical and clinical NLP models work well in different settings. Furthermore, we apply recent advances in pretraining to train new biomedical language models, and carefully investigate the effect of various design choices on downstream performance. Our best models perform well in all of our benchmarks, and set new State-of-the-Art in 9 tasks. We release these models in the hope that they can help the community to speed up and increase the accuracy of BioNLP and text mining applications.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127187933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Narayanan, Kaivalya Mannam, S. Rajan, P. Rangan
{"title":"Evaluation of Transfer Learning for Adverse Drug Event (ADE) and Medication Entity Extraction","authors":"S. Narayanan, Kaivalya Mannam, S. Rajan, P. Rangan","doi":"10.18653/v1/2020.clinicalnlp-1.6","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.6","url":null,"abstract":"We evaluate several biomedical contextual embeddings (based on BERT, ELMo, and Flair) for the detection of medication entities such as Drugs and Adverse Drug Events (ADE) from Electronic Health Records (EHR) using the 2018 ADE and Medication Extraction (Track 2) n2c2 data-set. We identify best practices for transfer learning, such as language-model fine-tuning and scalar mix. Our transfer learning models achieve strong performance in the overall task (F1=92.91%) as well as in ADE identification (F1=53.08%). Flair-based embeddings out-perform in the identification of context-dependent entities such as ADE. BERT-based embeddings out-perform in recognizing clinical terminology such as Drug and Form entities. ELMo-based embeddings deliver competitive performance in all entities. We develop a sentence-augmentation method for enhanced ADE identification benefiting BERT-based and ELMo-based models by up to 3.13% in F1 gains. Finally, we show that a simple ensemble of these models out-paces most current methods in ADE extraction (F1=55.77%).","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130341149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How You Ask Matters: The Effect of Paraphrastic Questions to BERT Performance on a Clinical SQuAD Dataset","authors":"Sungrim Moon, Jungwei Fan","doi":"10.18653/v1/2020.clinicalnlp-1.13","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.13","url":null,"abstract":"Reading comprehension style question-answering (QA) based on patient-specific documents represents a growing area in clinical NLP with plentiful applications. Bidirectional Encoder Representations from Transformers (BERT) and its derivatives lead the state-of-the-art accuracy on the task, but most evaluation has treated the data as a pre-mixture without systematically looking into the potential effect of imperfect train/test questions. The current study seeks to address this gap by experimenting with full versus partial train/test data consisting of paraphrastic questions. Our key findings include 1) training with all pooled question variants yielded best accuracy, 2) the accuracy varied widely, from 0.74 to 0.80, when trained with each single question variant, and 3) questions of similar lexical/syntactic structure tended to induce identical answers. The results suggest that how you ask questions matters in BERT-based QA, especially at the training stage.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125745509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yifan Peng, Sungwon Lee, D. Elton, Thomas C. Shen, Yuxing Tang, Qingyu Chen, Shuai Wang, Yingying Zhu, R. Summers, Zhiyong Lu
{"title":"Automatic recognition of abdominal lymph nodes from clinical text","authors":"Yifan Peng, Sungwon Lee, D. Elton, Thomas C. Shen, Yuxing Tang, Qingyu Chen, Shuai Wang, Yingying Zhu, R. Summers, Zhiyong Lu","doi":"10.18653/v1/2020.clinicalnlp-1.12","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.12","url":null,"abstract":"Lymph node status plays a pivotal role in the treatment of cancer. The extraction of lymph nodes from radiology text reports enables large-scale training of lymph node detection on MRI. In this work, we first propose an ontology of 41 types of abdominal lymph nodes with a hierarchical relationship. We then introduce an end-to-end approach based on the combination of rules and transformer-based methods to detect these abdominal lymph node mentions and classify their types from the MRI radiology reports. We demonstrate the superior performance of a model fine-tuned on MRI reports using BlueBERT, called MriBERT. We find that MriBERT outperforms the rule-based labeler (0.957 vs 0.644 in micro weighted F1-score) as well as other BERT-based variations (0.913 - 0.928). We make the code and MriBERT publicly available at https://github.com/ncbi-nlp/bluebert, with the hope that this method can facilitate the development of medical report annotators to produce labels from scratch at scale.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133412095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MeDAL: Medical Abbreviation Disambiguation Dataset for Natural Language Understanding Pretraining","authors":"Zhi Wen, Xing Han Lu, Siva Reddy","doi":"10.18653/v1/2020.clinicalnlp-1.15","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.15","url":null,"abstract":"One of the biggest challenges that prohibit the use of many current NLP methods in clinical settings is the availability of public datasets. In this work, we present MeDAL, a large medical text dataset curated for abbreviation disambiguation, designed for natural language understanding pre-training in the medical domain. We pre-trained several models of common architectures on this dataset and empirically showed that such pre-training leads to improved performance and convergence speed when fine-tuning on downstream medical tasks.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115099924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extracting Semantic Aspects for Structured Representation of Clinical Trial Eligibility Criteria","authors":"Tirthankar Dasgupta, Ishani Mondal, Abir Naskar, Lipika Dey","doi":"10.18653/v1/2020.clinicalnlp-1.27","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.27","url":null,"abstract":"Eligibility criteria in the clinical trials specify the characteristics that a patient must or must not possess in order to be treated according to a standard clinical care guideline. As the process of manual eligibility determination is time-consuming, automatic structuring of the eligibility criteria into various semantic categories or aspects is the need of the hour. Existing methods use hand-crafted rules and feature-based statistical machine learning methods to dynamically induce semantic aspects. However, in order to deal with paucity of aspect-annotated clinical trials data, we propose a novel weakly-supervised co-training based method which can exploit a large pool of unlabeled criteria sentences to augment the limited supervised training data, and consequently enhance the performance. Experiments with 0.2M criteria sentences show that the proposed approach outperforms the competitive supervised baselines by 12% in terms of micro-averaged F1 score for all the aspects. Probing deeper into analysis, we observe domain-specific information boosts up the performance by a significant margin.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124754130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knowledge Grounded Conversational Symptom Detection with Graph Memory Networks","authors":"Hongyin Luo, Shang-Wen Li, James R. Glass","doi":"10.18653/v1/2020.clinicalnlp-1.16","DOIUrl":"https://doi.org/10.18653/v1/2020.clinicalnlp-1.16","url":null,"abstract":"In this work, we propose a novel goal-oriented dialog task, automatic symptom detection. We build a system that can interact with patients through dialog to detect and collect clinical symptoms automatically, which can save a doctor’s time interviewing the patient. Given a set of explicit symptoms provided by the patient to initiate a dialog for diagnosing, the system is trained to collect implicit symptoms by asking questions, in order to collect more information for making an accurate diagnosis. After getting the reply from the patient for each question, the system also decides whether current information is enough for a human doctor to make a diagnosis. To achieve this goal, we propose two neural models and a training pipeline for the multi-step reasoning task. We also build a knowledge graph as additional inputs to further improve model performance. Experiments show that our model significantly outperforms the baseline by 4%, discovering 67% of implicit symptoms on average with a limited number of questions.","PeriodicalId":216954,"journal":{"name":"Clinical Natural Language Processing Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129333729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}