Scottish Medical Journal最新文献_第8页

Multicentric analysis of the perceptions and knowledge of digital health amongst undergraduate medical students 本科医学生对数字健康认知和知识的多中心分析

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-03-03 DOI: 10.1177/00369330221080749

Mohamed Nauzan Mohamed Nazeer, H. Baig, A. Subeh, Q. Khan, Saad Atif Majeed, Mohammad Ashraf

{"title":"Multicentric analysis of the perceptions and knowledge of digital health amongst undergraduate medical students","authors":"Mohamed Nauzan Mohamed Nazeer, H. Baig, A. Subeh, Q. Khan, Saad Atif Majeed, Mohammad Ashraf","doi":"10.1177/00369330221080749","DOIUrl":"https://doi.org/10.1177/00369330221080749","url":null,"abstract":"Introduction Digital health (DH) is continuously evolving by use of information and communications technology to improve healthcare provision, thereby reshaping systems and clinical practices. Recent studies identified an overwhelming lack of awareness of DH within the profession. This study aimed to analyse student perceptions and knowledge of DH to assess confidence in its use to develop greater DH awareness and literacy. Methods Students enrolled in undergraduate medical degrees were invited to take part in an online survey assessing aspects of DH including demography, familiarity, attitudes, level of knowledge and confidence. Anonymised data was collated and subsequently analysed to review DH awareness. Results A total of 143 students participated from nine British universities with 28.7% of respondents admitting low levels of familiarity of DH concepts. Students anticipated negative repercussions of DH including reduced data security (42.7%) and deterioration in doctor-patient relationship (30%); while improvements in healthcare access and health-outcomes are expected by 89.5% and 68.5%, respectively. 71.4% of participants believed they had minimal experience of exposure to DH and 76% believed they did not possess the necessary skills to utilise DH. Only 3.5% of students had some exposure to DH teaching during their course. Conclusion There is an important requirement to address the lack of knowledge and exposure of students to DH, particularly as the world targets the COVID-19 pandemic. DH is forming the basis of the ‘new normal’ in healthcare, however the full potential of DH cannot be achieved unless there is an increase in its teaching incorporated into medical school curricula.","PeriodicalId":21683,"journal":{"name":"Scottish Medical Journal","volume":"67 1","pages":"56 - 63"},"PeriodicalIF":2.7,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42096931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Extra-peritoneal Laparoscopic Resection of Benign Prostate Adenoma >150 CC with preservation of posterior wall of prostatic urethra: Dundee Technique and early outcomes. 保留前列腺尿道后壁的腹腔镜下> 150cc良性前列腺腺瘤切除术:Dundee技术及早期结果

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 Epub Date: 2021-12-23 DOI: 10.1177/00369330211068123

Hollie A Clements, Ghulam Nabi

{"title":"Extra-peritoneal Laparoscopic Resection of Benign Prostate Adenoma >150 CC with preservation of posterior wall of prostatic urethra: Dundee Technique and early outcomes.","authors":"Hollie A Clements, Ghulam Nabi","doi":"10.1177/00369330211068123","DOIUrl":"https://doi.org/10.1177/00369330211068123","url":null,"abstract":"Background: There are limited options for men with large benign prostates (>150cc) and bladder outflow obstruction due to benign prostatic hyperplasia (BPH). Management options include surgery (open or minimal access) and endoscopic procedures. There is a paucity of literature on outcomes for prostates >150cc.Methods: In this case series we describe a step-by-step, illustrated, modified extra-peritoneal technique of laparoscopic prostatectomy with preservation of the posterior prostatic urethra. This involves creation of extra-peritoneal space, transverse incision of prostate capsule, progressive adenoma dissection, resection, and closure of the capsule.Results: Ten patients underwent this procedure between 2015 and 2019. The mean age was 72.4 years and mean prostate size was 215.5cc. Mean procedure duration was 200 min and there were no intraoperative complications. Most patients were discharged on postoperative day 1. Mean intraoperative blood loss was 120 ml with no patient requiring blood transfusion. At follow up (mean 37 months) no patients had residual symptoms of BPH.Conclusion: We describe a novel extraperitoneal laparoscopic technique for benign prostates of >150cc with very good outcomes. The transferability of this technique to centres with laparoscopic expertise at minimal extra cost and future adaptability in the robotic setting are some of the advantages of this technique.","PeriodicalId":21683,"journal":{"name":"Scottish Medical Journal","volume":"67 1","pages":"30-37"},"PeriodicalIF":2.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39750239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A call to introduce newborn screening for spinal muscular atrophy (SMA) in Scotland. 呼吁在苏格兰引入新生儿脊髓性肌萎缩症(SMA)筛查。

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 Epub Date: 2022-02-11 DOI: 10.1177/00369330221078994

Thomas H Gillingwater, Catherine McWilliam, Iain Horrocks, Kenneth McWilliam, Mark Hamilton, Elaine Fletcher, Nicola Williams, Sarah Smith, Simon H Parson

{"title":"A call to introduce newborn screening for spinal muscular atrophy (SMA) in Scotland.","authors":"Thomas H Gillingwater, Catherine McWilliam, Iain Horrocks, Kenneth McWilliam, Mark Hamilton, Elaine Fletcher, Nicola Williams, Sarah Smith, Simon H Parson","doi":"10.1177/00369330221078994","DOIUrl":"https://doi.org/10.1177/00369330221078994","url":null,"abstract":"The recent development of three effective therapies for patients with spinal muscular atrophy (SMA) – Nusinersen (Spinraza), Onasemnogene abeparvovec (Zolgensma) and Risdiplam (Evrysdi) - arguably represents one of the great medical achievements of the 21 st century. 1 These treatments, which all work via restoring levels of the SMN protein, have revolutionised the outlook for patients with an otherwise incurable, and mostly fatal, condition. However, all three treat-ments come at a signi ﬁ cant ﬁ nancial cost For example, Zolgensma (often referred to as “ the world ’ s most expensive drug ” ) has a list price of nearly £1.8m per dose. Moreover, a large body of pre-clinical research, supported by emerging data from patient clinical trials, makes clear that the effective-ness of all current SMA therapies is largely determined by how early therapy can be delivered. 1,2 Thus, pre-symptomatic treatment of patients results in signi ﬁ cantly better outcomes both in terms of patient bene ﬁ ts and ﬁ nancial return on investment - than starting treatment after symptom onset. If then follows identify SMA patients onset hence exists:","PeriodicalId":21683,"journal":{"name":"Scottish Medical Journal","volume":"67 1","pages":"46-47"},"PeriodicalIF":2.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/94/10.1177_00369330221078994.PMC9036156.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39909768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of lung cancer biomarkers profile for the decision of targeted therapy in EBUS-TBNA cytological samples. 评估EBUS-TBNA细胞学样本中肺癌生物标志物谱以决定靶向治疗。

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 Epub Date: 2022-02-11 DOI: 10.1177/00369330221078995

Aslıhan Gürün Kaya, Aydın Çiledağ, Serhat Erol, Miraç Öz, Deniz Doğan Mülazımoğlu, Özlem Işık, Hilal Özakıncı, Fatma Çiftçi, Elif Şen, Koray Ceyhan, Akın Kaya, Demet Karnak, Gökhan Çelik, Savaş İsmail

{"title":"Evaluation of lung cancer biomarkers profile for the decision of targeted therapy in EBUS-TBNA cytological samples.","authors":"Aslıhan Gürün Kaya, Aydın Çiledağ, Serhat Erol, Miraç Öz, Deniz Doğan Mülazımoğlu, Özlem Işık, Hilal Özakıncı, Fatma Çiftçi, Elif Şen, Koray Ceyhan, Akın Kaya, Demet Karnak, Gökhan Çelik, Savaş İsmail","doi":"10.1177/00369330221078995","DOIUrl":"https://doi.org/10.1177/00369330221078995","url":null,"abstract":"Background: Guidelines recommend performing biomarker tests for epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), BRAF and ROS proto-oncogene-1(ROS1) genes and protein expression of programmed death ligand-1(PD-L1) in patients with non-small lung cell carcinoma (NSCLC). Studies reported that endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) can provide sufficient material for cancer biomarker analyses, but there are still concerns about the subject.Aim: The purpose of the study was to assess the adequacy of EBUS-TBNA for testing lung cancer biomarkers.Methods: We retrospectively reviewed patients with NSCLC whose EBUS-TBNA was analysed for EGFR, ALK, ROS-1, BRAF and PD-L1 expression between December 2011 and December 2020.Results: A total of 394 patients were enrolled in the study. EGFR mutation and ALK fusion were the most common studied biomarkers. EBUS-TBNA adequacy rate for biomarker tests was found 99.0% for EGFR, 99.1 for ALK, 97.2% for ROS1, 100% for BRAF and 99.3% for PD-L1 testing. Multivariate analysis revealed the histological type, history of treatment for NSCL, size, or 18-fluorodeoxyglucose uptake of sampled lesion did not show any association with TBNA adequacy for biomarker testing.Conclusion: EBUS-TBNA can provide adequate material for biomarker testing for EGFR, ALK, ROS-1, BRAF and PD-L1 expression.","PeriodicalId":21683,"journal":{"name":"Scottish Medical Journal","volume":"67 1","pages":"18-27"},"PeriodicalIF":2.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39909770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Robotic Millin's Prostatectomy: Revisiting an age-old technique for treating benign prostate hyperplasia in large glands 机器人米林前列腺切除术:重访治疗大腺体良性前列腺增生的古老技术

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 DOI: 10.1177/00369330221080750

Venkata Rm Kusuma, D. Moschonas, M. Perry, K. Patil

引用次数: 1

Scottish Cardiac Society 30^th Annual General Meeting Friday 24^th September 2021. 苏格兰心脏病学会第 30 届年度大会 2021 年 9 月 24 日星期五。

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 DOI: 10.1177/00369330211066529

引用次数: 0

Integrated bioinformatic analysis of key biomarkers and signalling pathways in psoriasis. 银屑病关键生物标志物和信号通路的综合生物信息学分析。

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 Epub Date: 2022-02-11 DOI: 10.1177/00369330221078993

Suwei Tang, Wencheng Jiang, Ping Xu, Shaoqiong Xie, Mingxia Wang, Chunjie Gao, Jiajing Lu, Yang Yang

{"title":"Integrated bioinformatic analysis of key biomarkers and signalling pathways in psoriasis.","authors":"Suwei Tang, Wencheng Jiang, Ping Xu, Shaoqiong Xie, Mingxia Wang, Chunjie Gao, Jiajing Lu, Yang Yang","doi":"10.1177/00369330221078993","DOIUrl":"10.1177/00369330221078993","url":null,"abstract":"Background and aims: Psoriasis is a relatively common autoimmune inflammatory skin disease with a chronic etiology. Since psoriasis is still incurable, it is necessary to identify the molecular mechanisms of psoriasis. The present study was designed to detect novel biomarkers and pathways associated with psoriasis incidence, and provide new insights into treatment of psoriasis.Methods and results: Differentially expressed genes (DEGs) associated with psoriasis in the Gene Expression Omnibus (GEO) database were identified, and their functional roles and interactions were then annotated and evaluated through GO, KEGG, and gene set variation (GSVA) analyses. In total 197 psoriasis-related DEGs were identified and found to primarily be associated with the NOD-like receptor, IL-17, and cytokine-cytokine receptor interaction signalling pathways. GSVA revealed significant differences between normal and lesional groups (P < 0.05), while PPI network analyses identified CXCL10 as the hub gene with the highest degree value, whereas IRF7, IFIT3, OAS1, GBP1, and ISG15 were promising candidate genes for the therapeutic treatment of psoriasis.Conclusion: The findings of the present integrated bioinformatics may enhance our understanding of the molecular events occurring in psoriasis, and these candidate genes and pathways together may prove to be therapeutic targets for psoriasis.","PeriodicalId":21683,"journal":{"name":"Scottish Medical Journal","volume":"67 1","pages":"7-17"},"PeriodicalIF":2.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39909767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scottish Paediatric Society St Andrew's Day Paediatic Symposium 2020. 2020年苏格兰儿科学会圣安德鲁日儿科研讨会

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 DOI: 10.1177/00369330211068774

引用次数: 0

ABSTRACT SUBMISSION - Autumn Meeting - 29 October 2021. 提交摘要-秋季会议-2021年10月29日

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 DOI: 10.1177/00369330221074572

引用次数: 0

Scottish Paediatric Society Summer Meeting 2021. 苏格兰儿科学会2021年夏季会议

IF 2.7 4区医学

Scottish Medical Journal Pub Date : 2022-02-01 DOI: 10.1177/00369330211068776

引用次数: 0