Polycystic ovary syndrome and the risk of endometrial, ovarian and breast cancer: An updated meta-analysis

IF 1.4 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Scottish Medical Journal Pub Date : 2022-06-09 DOI:10.1177/00369330221107099

Zhen Li, Yuhua Wang, Linlin Wang, Dingtao Hu, Ying Teng, Tingyu Zhang, Ziye Yan, Fang Wang, Y. Zou

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引用次数: 9

Abstract

Background and Aims This updated meta-analysis aimed to further quantify the risk of endometrial, ovarian, and breast cancer in patients with polycystic ovary syndrome (PCOS), thus providing updated and more reliable estimates. Methods and Results We identified relevant articles by searching electronic databases of PubMed, Embase, Web of Science, and Chinese Biological Medical Literature (CBM) published up to March 20, 2021. The pooled effect estimates and their 95% confidence intervals (CIs) were calculated using the random-effect model or the fixed-effect model. A total of 26 eligible studies were included. We found that PCOS was significantly associated with endometrial cancer (odds ratios [OR]: 3.66, 95%CI: 2.05–6.54, P < 0.001), but not with ovarian or breast cancer (OR: 1.23, 95%CI: 0.99–1.53, P = 0.059; OR: 0.94, 95%CI: 0.78–1.14, P = 0.551, respectively). However, in subgroups of high-quality studies, cohort studies, younger women (54 years or less or premenopausal), and studies with unadjusted body mass index (BMI), PCOS patients had a significantly higher risk of ovarian cancer. Conclusion These results indicated that PCOS is a significant risk factor for endometrial cancer independent of BMI, but not for breast cancer. PCOS may increase the risk of ovarian cancer in younger women.

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多囊卵巢综合征与子宫内膜癌、卵巢癌和乳腺癌风险的最新荟萃分析

背景和目的这项更新的荟萃分析旨在进一步量化多囊卵巢综合征（PCOS）患者患子宫内膜癌、卵巢癌和乳腺癌的风险，从而提供更新的、更可靠的估计。方法和结果我们通过检索截至2021年3月20日发表的PubMed、Embase、Web of Science和中国生物医学文献（CBM）的电子数据库来识别相关文章。使用随机效应模型或固定效应模型计算合并效应估计值及其95%置信区间（CI）。共纳入26项符合条件的研究。我们发现PCOS与子宫内膜癌症显著相关（比值比[OR]：3.66，95%CI:2.05–6.54，P < 0.001），但与卵巢或乳腺癌症无关（or:1.23，95%CI:0.99–1.53，P = 0.059；或：0.94，95%置信区间：0.78–1.14，P = 分别为0.551）。然而，在高质量研究、队列研究、年轻女性（54岁或54岁以下或绝经前）和未调整体重指数（BMI）的研究的亚组中，PCOS患者患卵巢癌症的风险显著较高。结论PCOS是癌症的重要危险因素，与BMI无关，但与癌症无关。PCOS可能会增加年轻女性患卵巢癌症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scottish Medical Journal 医学-医学：内科

CiteScore

4.80

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： A unique international information source for the latest news and issues concerning the Scottish medical community. Contributions are drawn from Scotland and its medical institutions, through an array of international authors. In addition to original papers, Scottish Medical Journal publishes commissioned educational review articles, case reports, historical articles, and sponsoring society abstracts.This journal is a member of the Committee on Publications Ethics (COPE).