Science and Technology Indonesia最新文献_第9页

Increasing the Solubility and Anti-Inflammatory Activity of Curcumin by Cocrystallization 共结晶提高姜黄素的溶解度和抗炎活性

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.501-508

Yudi Wicaksono, Kuni Zu’aimah Barikah, Amanda Della Yudatama, Havidhatul Maulia, N. Nuri, D. Setyawan

{"title":"Increasing the Solubility and Anti-Inflammatory Activity of Curcumin by Cocrystallization","authors":"Yudi Wicaksono, Kuni Zu’aimah Barikah, Amanda Della Yudatama, Havidhatul Maulia, N. Nuri, D. Setyawan","doi":"10.26554/sti.2023.8.3.501-508","DOIUrl":"https://doi.org/10.26554/sti.2023.8.3.501-508","url":null,"abstract":"Curcumin (CUR) is a polyphenolic compound that exhibits potent anti-inflammatory activity. However, only a tiny amount of CUR is absorbed during oral administration, which is because CUR is difficult to dissolve in water. The aim of the research was to increase the solubility of CUR through the cocrystallization technique using isonicotinamide coformer (INIC) by solvent evaporation. Cocrystal characterization was carried out using a powder X-ray diffractometer (PXRD), a differential scanning calorimeter (DSC), a Fourier transform infrared spectrometer (FTIR), and a scanning electron microscope (SEM). Solubility was evaluated using the shaking method, while the anti-inflammatory activity test was carried out using the carrageenan induced mouse leg edema method. The resulting CUR-INIC (1:1) cocrystal has a diffractogram with new diffraction peaks of 2theta at 15.00, 16.22, and 22.89◦ compared to the individual diffractograms of CUR and INIC. In the cocrystal, CUR and INIC form intermolecular interactions of hydrogen bonds, resulting in a new solid phase with a melting point of 160.1◦C. The solubility of the CUR-INIC cocrystal in water was 73.1±0.23 ug/mL, which increased 14 times compared to the solubility of initial CUR, which was only 5.05±0.07 ug/mL. The CUR-INIC cocrystal showed a percentage of edema inhibition in mice (5 hours) 130% more potent than that of initial CUR. Therefore, CUR-INIC cocrystals can be used to improve CUR solubility to obtain more excellent anti-inflammatory effects.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46237939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Sumatera Bentonite by Ammonium-impregnated as a Coagulant for Cassava Wastewater Treatment 浸铵絮凝剂Sumatera膨润土处理木薯废水的优化

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.443-450

Yusuf Mathiinul Hakim, M. Khakim, Amatullah Hanifah, R. Mohadi

引用次数: 0

Catalytic Oxidative Desulfurization of 4-Methyldibenzothiophene by Ni/Al Modified Titanium Dioxide and Zinc Oxide Ni/Al改性二氧化钛和氧化锌对4-甲基二苯并噻吩的催化氧化脱硫

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.414-421

R. Mohadi, N. Palapa, Sahrul Wibiyan, M. Mardiyanto, Rohmatullaili Rohmatullaili, Erni Salasia Fitri, A. Lesbani

{"title":"Catalytic Oxidative Desulfurization of 4-Methyldibenzothiophene by Ni/Al Modified Titanium Dioxide and Zinc Oxide","authors":"R. Mohadi, N. Palapa, Sahrul Wibiyan, M. Mardiyanto, Rohmatullaili Rohmatullaili, Erni Salasia Fitri, A. Lesbani","doi":"10.26554/sti.2023.8.3.414-421","DOIUrl":"https://doi.org/10.26554/sti.2023.8.3.414-421","url":null,"abstract":"In this study, composite layer double hydroxide-metal oxide catalysts (Ni/Al-TiO2 and Ni/Al-ZnO) were successfully prepared and utilized for the oxidative desulfurization of dibenzothiophene. The catalysts were characterized using XRD, FTIR, and SEM-EDS analysis. The diffraction patterns confirmed the successful synthesis of the composite materials, while the FTIR spectra exhibited absorption bands at specific wavenumbers 3480 cm-1, 1630 cm-1, 1376 cm-1, 830 cm-1, 775 cm-1, and 683 cm-1. The surface morphology of the catalysts showed variations, with Ni/Al-LDH having a smooth particle surface and long particle shape, while Ni/Al-ZnO and Ni/Al-TiO2 formed grain-like or aggregated structures. EDS analysis confirmed the presence of Ni/Al, Ti, and Zn elements in the composites, with Ti and Zn accounting for 29.3% and 10.7% of the composite mass, respectively. The optimized reaction conditions included a reaction time of 40 minutes, catalyst dosage of 0.25 g, temperature of 50°C, and the use of n-hexane as the solvent. The catalysts demonstrated a heterogeneous nature and proved to be reusable, as the conversion of dibenzothiophene remained above 90% even after three catalytic reactions, with Ni/Al-TiO2 and Ni/Al-ZnO composites maintaining conversion rates of 99.36% and 99.32%, respectively.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41377731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spectrophotometric Change of Butterfly Pea (Clitoria ternatea L.) Flower Extract in Various Metal Ion Solutions During Storage 蝴蝶豌豆(Clitoria ternatea L.)的光度变化花提取物在不同金属离子溶液中的贮藏

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.367-372

A. Marpaung, Dania Pustikarini

{"title":"Spectrophotometric Change of Butterfly Pea (Clitoria ternatea L.) Flower Extract in Various Metal Ion Solutions During Storage","authors":"A. Marpaung, Dania Pustikarini","doi":"10.26554/sti.2023.8.3.367-372","DOIUrl":"https://doi.org/10.26554/sti.2023.8.3.367-372","url":null,"abstract":"This study aimed to investigate the effect of six chloride salts on butterfly pea flower extract’s anthocyanins stability. The salts were NaCl, KCl, CaCl2, MgCl2, FeCl3, and AlCl3. The samples were analyzed using a UV-Vis spectrophotometer to observe color degradation and change in hue during storage. The extraction of anthocyanins was done using a modified method, and the solutions were stored in dark vials at room temperature. The degradation kinetics of benzene derivatives, acyl groups, non-anthocyanin flavonoid, flavylium cation, quinonoidal base and anionic quinonoidal base were evaluated using the first-order reaction, and the half-life was calculated. The effect of metal ions was studied by analyzing the change in absorbance of each band using regression analysis and a slope test. The results showed that monovalent (Na+ and K+) and divalent (Ca2+ and Mg2+) ions did not result in a significant shift in the spectrogram. Trivalent metal ions (Al3+ and Fe3+) had limited interaction with the anthocyanins, heightened the brown color, and decreased the overall color quality. K+, Ca2+, Mg2+, Al3+, and Fe3+ ions showed the ability to improve the stability of the extract’s color, while Na+ tended to accelerate color degradation. The pattern of changes in the spectrogram during storage suggests that color degradation occurs in two ways: the unfolding of hydrophobic interactions and the deacylation of anthocyanin. Trivalent metal ions showed the best stability performance, with Fe3+ preventing the unfolding of hydrophobic interactions and Al3+ hindering the deacylation. The combination of the two is highly likely to improve the color stability of the butterfly pea flower extract. However, both increase the browning index, thus decreasing color quality. This research highlights the potential of adding cations to improve the color stability of the butterfly pea flower extract, making it a more attractive food coloring agent.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43402258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxyapatite-ZnO Biomimetic Toothpaste Formulation from Rice Snail Shell Waste 稻壳废弃物制备羟基磷灰石- zno仿生牙膏

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.486-493

Wisaeni Intannia, Charlena Charlena, I. Suparto

{"title":"Hydroxyapatite-ZnO Biomimetic Toothpaste Formulation from Rice Snail Shell Waste","authors":"Wisaeni Intannia, Charlena Charlena, I. Suparto","doi":"10.26554/sti.2023.8.3.486-493","DOIUrl":"https://doi.org/10.26554/sti.2023.8.3.486-493","url":null,"abstract":"Toothpaste is a preparation for dental treatment to clean, beautify, and replace minerals that decay from the surface of the teeth. Prevention of damage to the mineral layer of the teeth, the addition of remineralizing agents to toothpaste preparations in the form of hydroxyapatite-ZnO composites is carried out. This study aims to synthesize and characterize hydroxyapatite-ZnO, as well as to formulate hydroxyapatite-ZnO toothpaste from rice field conch shell waste. Hydroxyapatite-ZnO composites have been successfully synthesized using the sol-gel method and characterized using X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), and Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). The XRD result obtained a crystal size of 59.90 nm with a crystallinity percentage of 68.85%. The absorption band at a wave number of 452 cm−1 is an indication that the ZnO compound has been successfully combined with hydroxyapatite. SEM-EDX analysis showed that the morphology of the compound was granular with a rough surface, uneven size, and shape. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41337525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On Distance Vertex Irregular Total k-Labeling 关于距离顶点不规则全k标记

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.479-485

D. E. Wijayanti, N. Hidayat, D. Indriati, A. Alghofari, S. Slamin

引用次数: 0

Synthesis, Characterization of Chitosan-ZnO/CuO Nanoparticles Film, and its Effect as an Antibacterial Agent of Escherichia coli 壳聚糖ZnO/CuO纳米粒子膜的合成、表征及其对大肠杆菌的抗菌作用

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.373-381

A. Fatoni, A. Rendowati, Lasmaryna Sirumapea, Lidya Miranti, Siti Masitoh, N. Hidayati

{"title":"Synthesis, Characterization of Chitosan-ZnO/CuO Nanoparticles Film, and its Effect as an Antibacterial Agent of Escherichia coli","authors":"A. Fatoni, A. Rendowati, Lasmaryna Sirumapea, Lidya Miranti, Siti Masitoh, N. Hidayati","doi":"10.26554/sti.2023.8.3.373-381","DOIUrl":"https://doi.org/10.26554/sti.2023.8.3.373-381","url":null,"abstract":"The film of chitosan- ZnO/CuO nanoparticles was synthesized. This study were the synthesis and characterization of the chitosan-ZnO/CuO nanoparticles film and its effect as an antibacterial of Escherichia coli. The ZnO, CuO, and ZnO/CuO were biosynthesized by biological method and for the synthesis of the chitosan-ZnO/CuO nanoparticles film, the casting method was adopted. The product was analyzed by FTIR spectroscopy, X-ray diffraction (XRD), and Scanning Electron Microscope (SEM), respectively. The product of chitosan-ZnO/CuO nanoparticles film as paper disk and agar disk diffusion method was selected to study an antibacterial agent of this product. The Zn-O or Cu-O group was observed at a peak between 468-675 cm−1 for ZnO and 503 and 619 cm−1 for CuO nanoparticles, respectively. ZnO, CuO, and ZnO/CuO nanoparticles are in the crystalline form and it has a crystallite size of 13.21, 13.21, and 11.49 nm respectively. After interacting with chitosan, the metal nanoparticles such as ZnO, CuO, and ZnO/CuO nanoparticles can change the crystalline form of chitosan to be amorphous form. The addition of ZnO, CuO, and ZnO/CuO nanoparticles in the chitosan will change the surface morphology of chitosan. Chitosan-ZnO/CuO nanoparticles film can inhibit the growth of Escherichia coli bacteria.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44946729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Okra Mucilage Extract as A Co-Surfactant Increased the Curcumin Nanoemulsion Stability and Encapsulation Efficiency 秋葵黏液提取物作为辅助表面活性剂提高了姜黄素纳米乳的稳定性和包封效率

Science and Technology Indonesia Pub Date : 2023-07-06 DOI: 10.26554/sti.2023.8.3.509-515

Elna Putri, Ellya Indahyanti, Diah Mardiana, Maria L A D Lestari, Z. Ningsih

{"title":"Okra Mucilage Extract as A Co-Surfactant Increased the Curcumin Nanoemulsion Stability and Encapsulation Efficiency","authors":"Elna Putri, Ellya Indahyanti, Diah Mardiana, Maria L A D Lestari, Z. Ningsih","doi":"10.26554/sti.2023.8.3.509-515","DOIUrl":"https://doi.org/10.26554/sti.2023.8.3.509-515","url":null,"abstract":"Curcumin has various bio-functional properties; however, curcumin poor bioavailability reduces its efficacy. Nanoemulsion delivery system is an alternative method improving curcumin bioavailability in which surfactant and oil used, play an important role in determining nanoemulsion properties. Several studies on curcumin nanoemulsions apply synthetic surfactants which can be harmful if they are added excessively. This study aims to use a natural emulsifying agent, namely okra mucilage extract (OME), and determine its effectiveness as co surfactant. OME is safe to use as an emulsifying agent because it is natural, harmless, safe, biodegradable and eco-friendly. Liquid-liquid and microwave extraction methods were used to obtain OME which was further identified using Fourier Transfer Infrared Spectroscopy (FTIR). Meanwhile, sonication method was used to produce curcumin nano-emulsion (CurN). The particle size and polydispersity index of curcumin nano-emulsion were measured using Particle Size Analyzer (PSA) with Dynamic Light Scattering (DLS) technique, while the morphology of the nanoemulsion was observed using a Digital Imaging Microscope and Confocal Laser Scanning Microscope (CLSM). The results showed that the addition of 0.0160 g OME at a ratio of 1:5 (OME: Tween 80) in the preparation of 5 mL of CurN was able to reduce the particle size and polydispersity index from 740.80 ± 9.70 nm to 289.20 ± 2.23 and 0.340 ± 0.005 to 0.165 ± 0.008 respectively. OME increased the encapsulation efficiency from 77.93 ± 6.59% to 87.17 ± 1.12% which was confirmed by the augmentation of the fluorescence intensity of curcumin from 192.82 to 388.55. The addition of OME also maintained the stability of the CurN up to 14 days of storage at 4°C.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47620221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bootstrap-Aggregating in Random Forest Model for Classification of Corn Plant Diseases and Pests 一种用于玉米病虫害分类的Bootstrap聚集随机森林模型

Science and Technology Indonesia Pub Date : 2023-04-15 DOI: 10.26554/sti.2023.8.2.288-297

Y. Resti, C. Irsan, Jeremy Firdaus Latif, I. Yani, Novi Rustiana Dewi

{"title":"A Bootstrap-Aggregating in Random Forest Model for Classification of Corn Plant Diseases and Pests","authors":"Y. Resti, C. Irsan, Jeremy Firdaus Latif, I. Yani, Novi Rustiana Dewi","doi":"10.26554/sti.2023.8.2.288-297","DOIUrl":"https://doi.org/10.26554/sti.2023.8.2.288-297","url":null,"abstract":"Control of diseases and pests of maize plants is a significant challenge to ensure global food security, self-sufficiency, and sustainable agriculture. Classification or early detection of diseases and pests of corn plants is intended to assist the control process. Random forest is a classification model in tree-based statistical learning in making decisions. This approach is an ensemble method that generates many decision trees and makes classification decisions based on the majority of trees selecting the same class. However, tree-based methods are often unstable when small changes or disturbances exist in the learning data. Such instability can produce significant variances and affect model performance. This study classifies diseases and pests of the corn plant using a random forest method based on bootstrap-aggregating. It fits multiple models of a single random forest, then combines the predictions from all models and determines the final result using majority voting. The results showed that the bootstrap aggregating could improve the classification of diseases and pests of maize using a random forest if the number of trees is optimal.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43973739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation and Evaluation of Azithromycin Dihydrate Solid Dispersion with Esther of Polyethylene Glycol-6000 and Stearic Acid Using A Co-Grinding Technique 聚乙二醇-6000 -硬脂酸共磨法制备二水阿奇霉素固体分散体及评价

Science and Technology Indonesia Pub Date : 2023-04-15 DOI: 10.26554/sti.2023.8.2.312-320

M. Mardiyanto, Budi Untari, A. Mara, Nauval Hady Prasetyo

{"title":"Formulation and Evaluation of Azithromycin Dihydrate Solid Dispersion with Esther of Polyethylene Glycol-6000 and Stearic Acid Using A Co-Grinding Technique","authors":"M. Mardiyanto, Budi Untari, A. Mara, Nauval Hady Prasetyo","doi":"10.26554/sti.2023.8.2.312-320","DOIUrl":"https://doi.org/10.26554/sti.2023.8.2.312-320","url":null,"abstract":"Azithromycin is a narrow-spectrum bacterial growth inhibitory antibiotic derived from macrolides with low dissolution in water. Several methods have been carried out to increase the dissolution of medicinal substances, one of which is solid dispersion. Solid dispersions are mixtures consisting of one or more active substances in an inert carrier. The purpose of this study was to determine the effect of formatting solid dispersions with PEG 6000 polymer and stearic acid on increasing the dissolution rate of azithromycin. The method of formatting solid dispersions uses the co-grinding method. Solid dispersion of azithromycin was prepared in four formulas with variations in the amount of PEG 6000. Tests carried out on solid dispersion samples of azithromycin were XRD, FTIR, SEM, solubility tests, and dissolution tests. Test results on azithromycin solid dispersions prepared by co-grinding showed that there was an effect of the amount of PEG 6000 on decreasing the intensity of azithromycin crystals, there was no chemical interaction between azithromycin and the carrier, differences in the morphology of pure azithromycin powder and solid dispersions, and an increase in the dissolution of solid dispersions in medium SIF.","PeriodicalId":21644,"journal":{"name":"Science and Technology Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44159390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0