ChemRN: Biomaterials (Topic)最新文献

{"title":"State of Art on Wearable Device to Assist Visually Impaired Person Navigation in Outdoor Environment","authors":"Amit Chaudhary, Dr. Prabhat Verma","doi":"10.2139/ssrn.3350316","DOIUrl":"https://doi.org/10.2139/ssrn.3350316","url":null,"abstract":"This paper presents a comprehensive survey of the wearable devices which are used to assist visually impaired persons during navigation in a known or unknown, indoor or outdoor environment. We have mainly focused on the advantages and disadvantages of each wearable device. This study is an effort to report the research community and users about the capabilities of these systems and the state of art in the assistive devices for visually impaired people.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125053449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RGD Conjugated Hyperbranched Cationic Amylopectin Nanoparticle as Hypoxia Inducible Factor-1α Targeting Carrier Promotes Neovascularization in Cerebral Infarction","authors":"Lingna Deng, Yanlin Wu, ShiHong Wen, Jiahao Luo, Lingli Long, Zhizhong Ye, Liqun Yang, David Y B Deng","doi":"10.2139/ssrn.3326756","DOIUrl":"https://doi.org/10.2139/ssrn.3326756","url":null,"abstract":"Promoting the regeneration of new blood vessels is a crucial treatment in cerebral infarction and hypoxia-inducible factor 1-α (HIF-1α) plays a pivotal role in the regulation of neovascularization. Nevertheless, the degradation of HIF-1α and poor homing into ischemic sites greatly limit its clinical application. In this study, we encapsulated mutant HIF-1α in RGD modified hyperbranched cationic amylopectin derivative conjugated with 3-(dimethylamino)-1-propylamine (RGD-DMAPA-Amyp) nanoparticles. RGD-DMAPA-Amyp nanoparticles exhibited good blood compatibility and low cytotoxicity in hemolysis and MTT assay, and in vivo study showed low concentrations of RGD-DMAPA-Amyp and DMAPA-Amyp had no significant toxicity to zebrafish embryos. Further to investigate the targeting ability of RGD-DMAPA-Amyp in human umbilical vein endothelial cells and rats model of transient middle cerebral artery occlusion, the in vitro and in vivo results showed RGD-DMAPA-Amyp could specifically bind to vascular endothelial cells. Moreover, the RGD-DMAPA-Amyp/HIF-1α administration significantly reduced the incidence of cerebral ischemia in zebrafish. The pro-angiogenic effect of RGD-DMAPA-Amyp/HIF-1α was evaluated on zebra fish model of vascular loss, RGD-DMAPA-Amyp/HIF-1α were found could improve the growth of subintestinal vessels (SIVs). Our results imply that RGD-DMAPA-Amyp/HIF-1α might alleviate cerebral infarction in vivo via promoting neovascularization and could potentially be a very promising approach for cerebral infarction or ischemic diseases.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115697020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Обґрунтування та розробка рецептур низьколактозного біологічно-активного молочного морозива (Grounding and Development of Low-Lactose Biologically Active Milk Ice Cream Formula)","authors":"A. Trubnikova, O. Chabanova, T. Sharahmatova, Sergej Bondar, S. Vikul","doi":"10.22178/POS.38-7","DOIUrl":"https://doi.org/10.22178/POS.38-7","url":null,"abstract":"Lactose intolerance is widespread in the world, although its frequency varies considerably in different countries. In Ukraine, 15-35% of the adult population suffer from this illness. For these people, it is necessary to develop special dairy products – lactose-free and low-lactose. A promising direction in the development of the dairy industry is the targeted production of exclusive ice cream types, intended for people intolerant to lactose. The article substantiates the expediency of the development of a low-lactose ice cream formulation of therapeutic and prophylactic purpose with antioxidant and pre-probiotic properties using secondary milk and plant material. The selection of the main components – liquid lactose-free protein concentrate (LFPC) and yoghurt base with reduced lactose and high protein content (YB) – was carried out according to foaming ability, foam stability, viscosity, antioxidant activity and organoleptic parameters. The ratio of LFPC / YB components was 60:40 (for a non-lactose concentrate, obtained by ultrafiltration of buttermilk at FC = 4 and by diafiltration (DF = 7) UF buttermilk retentate) and LFPC / YB – 50:50 (for a lactose concentrate, obtained by ultrafiltration of buttermilk at FC = 5 and diafiltration (DF = 7) UF buttermilk retentate). Both samples had the best technological characteristics: foaming ability – 28% and 32%, respectively, foam resistance – 120 and 130 minutes, respectively. According to organoleptic parameters, the samples were similar, they had a pleasant sour-milk taste, a homogeneous consistency, a homogeneous white-yellow color, which is characteristic of sour milk ice cream. The antioxidant activity of the samples was 315 and 330 c. u., respectively. The rational mass fractions of the auxiliary components of a mixture of ice cream were determined: inulin – 4%; lactulose – 1%; ginger – 0,3%; citric acid – 0,15%; stabilizer – 0,2% (for LFPC (FC = 4) / YB) and 0,25% (for LFPC (FC = 5) / YB). The recipe composition of low-lactose biologically active ice cream was developed. The antioxidant activity of samples of a mixture of low-lactose ice cream and a mass fraction of lactose, which was 1.1-1.4% depending on the ratios of LFPC / YB, were determined.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120984570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling the Distribution of Lasers in Biological Tissues","authors":"T. Petrova, Z. Petrov","doi":"10.2139/ssrn.3339308","DOIUrl":"https://doi.org/10.2139/ssrn.3339308","url":null,"abstract":"For the time being there is no accurate theory about the spread of light in a structurally non-homogeneous medium whereas the experimental research is additionally hindered because of the necessity to maintain constant structural-dynamic parameters. In this respect numerical modelling of the processes of spreading of laser radiation plays increasingly important role.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129174427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Response in HIV Epidemics for Distinct Transmission Rates and for Saturated CTL Response","authors":"Ana R.M. Carvalho, Carla M.A. Pinto","doi":"10.2139/ssrn.3271342","DOIUrl":"https://doi.org/10.2139/ssrn.3271342","url":null,"abstract":"In this paper, we study the immune response in a fractional order model for HIV dynamics, for distinct disease transmission rates and saturated CTL response. Our goal is twofold: (i) to analyse the role of the order of the fractional derivative, α, on the efficacy of the immune response, (ii) to examine the immune response for distinct transmission functions, in the presence of saturated CTL response. We compute the reproduction number of the model and state the stability of the disease-free equilibrium. We discuss the results of the model from an epidemiological point of view.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124660097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-Trabecular Strain Evolution and Fracture Criteria in Human Trabecular Bone","authors":"M. Turunen, S. Cann, Erika Tudisco, G. Lovric, A. Patera, S. Hall, H. Isaksson","doi":"10.2139/ssrn.3435954","DOIUrl":"https://doi.org/10.2139/ssrn.3435954","url":null,"abstract":"To understand the most detrimental characteristics behind bone fractures, it is key to understand the local strain limits and its relation to failure sites locally and globally. Digital volume correlation is an emerging technique to study strains in the trabecular bone structure under loading. The aim of this study was to investigate the three-dimensional strain distributions as well as damage criterion at the sub-trabecular level in trabecular bone tissue using different image resolutions. Human cadaver trabecular bone samples were compressed <i>in situ</i> until failure, while imaging with high-resolution synchrotron radiation X-ray tomography. Digital volume correlation was used to determine the strains inside the trabeculae in cracking (where fractures are about to occur) and non-cracking regions. Bone tissue was found to withstand locally very high compressive or tensile strains (~10%) without immediately resulting in a fracture. Thus, local strains in close vicinity of developing cracks were higher than previously reported for a whole trabecular structure and similar as reported for single isolated trabeculae. Current literature investigating bone fractures at the tissue level seem to underestimate the maximum strain magnitudes in trabecular bone. We similarly report lower strains when downscaling our images (reducing the resolution); this suggests that the observed strains are dependent on the resolution at which they are investigated. Furthermore, the local strain magnitudes at the crack regions correlate with global parameters (global yield strain, average tissue mineral density and bone volume fraction). The trabecular thickness appears to be an important predictor for where the structure will break, as it fails at the weakest link. In summary, this first study to investigate the local strains in a trabecular structure at sub-trabecula resolution in human bone confirms the high strain magnitudes reported for single trabeculae under loading and more importantly extends the translation to the whole trabecular structure.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133545842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Di-Self-Crosslinking Hsmssa Hydrogel Combined with Colⅰ Constructed Biomimetic Injectable Cartilage Filling Scaffold","authors":"Ya Yao, X. Li, Peilei Wang, Yang Xu, Gonggong Lu, Qing Jiang, Yong Sun, Yujiang Fan, Xing‐dong Zhang","doi":"10.2139/ssrn.3548855","DOIUrl":"https://doi.org/10.2139/ssrn.3548855","url":null,"abstract":"Injectable hydrogels have attracted increasing attention because of convenient clinical operation, non-invasive surgical procedure and seamless filling of irregular defects. Here, injectable di-self-crosslinking HSMSSA hydrogel was formed via fast thiol/maleimide click chemistry reaction and thiol oxidation reaction as primary and secondary self-crosslinking network, respectively. Molecular weight and precursor concentration significantly affected physichemical properties and biological functions of hydrogels. Although this HSMSSA gel (0.1M, 10 mg/mL) had excellent injectability, collagen-like mechanical properties and optimal chondrocytes proliferation efficiency in vitro, and could greatly promote cartilaginous tissue formation in vivo, the lack of adhesion sites resulted in an untenable situation in maintaining effective connections among newborn cell clusters. However, the biomimetic injectable di-self-crosslinking blend hydrogel by combined injectable HSMSSA and bioactive Col I presented excellent biological function in biocompatibility, resistance to degradation, chondrocytes adhesion and proliferation, especially for multiples ascending genes expression level associated with hyaline cartilage formation and polyproteoglycan secretion, which might be an excellent potential clinical treatment strategy for constructing injectable cartilage repair filler by combining expanded autologous chondrocytes.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126294728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Functional Prodrug Equipped With Hyaluronic Acid Micelles for Stimuli-Release and Overcoming Doxorubicin Resistance","authors":"Lipeng Qiu, Kamel S. Ahmed, Mengqin Zhu, Yan Zhang, Miaomiao Long, Huijie Zhang, Jiamin Xu, Wen-jun Fang, Jinghua Chen","doi":"10.2139/ssrn.3873681","DOIUrl":"https://doi.org/10.2139/ssrn.3873681","url":null,"abstract":"Multidrug resistance (MDR) is the main challenge faced by cancer chemotherapy. Drug-conjugate offers a promising strategy for breast cancer therapy. In this regard, we developed a DNVM multifunctional drug delivery system by crosslinking doxorubicin (DOX) and vitamin E succinate (VES) with a pH-sensitive hydrazone bond and then encapsulated the DOX-NN-VES prodrug into pH-sensitive hyaluronic acid-2-(octadecyloxy)-1,3-dioxan-5-amine (HOD) micelles. DOX resistant MCF-7/ADR cell were adopted as a model to study the capability and mechanism of MDR reversal. DNVM exhibited much higher cytotoxicity and cell uptake efficiency compared with that of acid-insensitive DOX-VES loaded HOD micelles (DVSM) and DOX loaded HOD micelles (DOXM), indicating the better capacity of DNVM for the reversal of MDR. Moreover, DNVM prevented drug efflux more effectively, inhibited the expression of P-gp, induced excessive production of reactive oxygen species and affected the expression of apoptosis-related proteins. <i>In vivo</i> experiments showed that DNVM significantly inhibited the tumor growth with no obvious changes in the body weight of MCF-7/ADR cells-bearing nude mice. The results suggested that the “double gain” DNVM can synergistically enhance the efficacy of chemotherapeutics for DOX resistant tumor cells and has the potential to overcome tumor MDR.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133106719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molybdenum - A Novel Biodegradable Implant Material for Structural Applications?","authors":"Christian Redlich, P. Quadbeck, Julia Czechner, B. Wegener, M. Thieme, B. Kieback","doi":"10.2139/ssrn.3448957","DOIUrl":"https://doi.org/10.2139/ssrn.3448957","url":null,"abstract":"Molybdenum as a potentially new biodegradable material was investigated. Degradation behavior of commercially high purity molybdenum was observed in simulated physiological salt solutions (Kokubo's SBF with/without TRIS-HCl, Cu2+ addition and 0.9 % NaCl solution). Potentiodynamic polarization, immersion mass loss and ion concentration measurements paired with REM/EDX analysis reveal gradual dissolution of molybdenum in the proper order of magnitude for stent application, associated with formation of thin, non-passivating corrosion products. The underlying corrosion mechanism is discussed as well as a comparison to literature data. However, formation of calcium phosphates (CaP) in SBF significantly decreases corrosion rates. In-situ polarization was found to be a potential way for overcoming this problem and simultaneously enhancing corrosion above the benchmark for a degradable stent material. A first in-vitro cytotoxicity assessment for HFIB fibroblasts in direct contact to corroding molybdenum did not show any signs for decreased cell viability. Thus, molybdenum appears to be a promising novel biodegradable metal for structural applications.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123015868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protease-Triggered Release of Stabilized CXCL12 from Coated Biomaterials for Improved Implant Integration and Wound Healing","authors":"Sabrina Spiller, Tom Wippold, K. Bellmann-Sickert, S. Franz, A. Saalbach, U. Anderegg, A. Beck‐Sickinger","doi":"10.2139/ssrn.3813473","DOIUrl":"https://doi.org/10.2139/ssrn.3813473","url":null,"abstract":"Biomaterials are designed to improve impaired healing of injured tissue. To accomplish better cell integration and to accelerate revascularization, it is suggested to coat implant surfaces with bio-functional proteins. Here, a mussel-derived surface-binding peptide was coupled to the chemokine CXCL12 (stromal cell-derived factor 1α), a chemokine that activates the CXCR4 and consequently recruits tissue specific stem and progenitor cells. CXCL12 variants with either non-releasable or protease-mediated release properties were designed and compared. Whereas CXCL12 was stabilized at the N-terminus for protease resistance, a C-terminal linker was designed that allowed specific cleavage-mediated release by matrix metalloproteinase 9 and 2, as both enzymes are frequently found in wound fluid. These surface adhesive CXCL12 derivatives were produced by expressed protein ligation and subsequent refolding. Functionality of the modified chemokines was assessed by inositol phosphate accumulation assay and cell migration assays. Increased migration of keratinocytes as well as the activation of the downstream signaling cascade by the PI3K-Akt and Ras-Raf-Erk1/2 pathway have been demonstrated. Immobilization to biomaterials was studied for titanium surfaces and PCL-<i>co</i>-LC scaffolds. Osteoblast-like cells spread significantly more on titanium, coated with the modified chemokine, indicating increased cell adhesion. Accelerated wound closure in an <i>ex vivo</i> wound healing assay has been shown with coated PCL- co -LC scaffolds on porcine skin grafts. After 24 h, a significantly improved CXCL12-specific growth stimulation of the epithelial tips has been observed. The presented data emphasizes a successful translation of protein-coated biomaterials for bone as well as for skin regeneration.","PeriodicalId":216437,"journal":{"name":"ChemRN: Biomaterials (Topic)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115406126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}