HIV流行中不同传播率和饱和CTL反应的免疫反应

Ana R.M. Carvalho, Carla M.A. Pinto
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摘要

在本文中,我们研究了HIV动力学的分数阶模型中不同疾病传播率和饱和CTL反应的免疫反应。我们的目标是双重的:(i)分析分数阶导数α的顺序对免疫反应功效的作用,(ii)在饱和CTL反应存在的情况下检查免疫反应的不同传递功能。我们计算了模型的复制数,并说明了无病平衡的稳定性。我们从流行病学的角度讨论模型的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immune Response in HIV Epidemics for Distinct Transmission Rates and for Saturated CTL Response
In this paper, we study the immune response in a fractional order model for HIV dynamics, for distinct disease transmission rates and saturated CTL response. Our goal is twofold: (i) to analyse the role of the order of the fractional derivative, α, on the efficacy of the immune response, (ii) to examine the immune response for distinct transmission functions, in the presence of saturated CTL response. We compute the reproduction number of the model and state the stability of the disease-free equilibrium. We discuss the results of the model from an epidemiological point of view.
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