Science China Life Sciences最新文献_第9页

Exaptation of pectoral fins for olfaction in the spiny red gurnard (Chelidonichthys spinosus) through an ancient receptor. 刺红鳕胸鳍通过一种古老的受体产生嗅觉。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-15 DOI: 10.1007/s11427-024-2746-7

Lisen Li, Deqian Fan, Chenglong Zhu, Zhuoya Liu, Wenji Huang, Peidong Xin, Huishan Yue, Mengying Li, Yufei Wang, Wenjie Xu, Jiangmin Zheng, Ye Li, Ziwei Yu, Jianzhong Ling, Qiang Qiu, Wen Wang, Chenguang Feng, Xiaojing Song, Kun Wang

引用次数: 0

Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects. 现代玉米近交系的基因组分析揭示了多样性和选择性育种效应。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-15 DOI: 10.1007/s11427-024-2725-1

Kaijian Fan, Mohsin Ali, Kunhui He, Yingwei Feng, Tingxi Yu, Hao Zhang, Tai An, Weiwei Zeng, Junjie Fu, Ying Zhou, Yanfang Heng, Fei Gu, Jiankang Wang, Changling Huang, Liang Li, Huihui Li

引用次数: 0

Selenium metabolism and selenoproteins function in brain and encephalopathy. 硒在大脑和脑病中的代谢和硒蛋白功能。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-12 DOI: 10.1007/s11427-023-2621-7

Nan Li, Zhonghao Zhang, Liming Shen, Guoli Song, Jing Tian, Qiong Liu, Jiazuan Ni

{"title":"Selenium metabolism and selenoproteins function in brain and encephalopathy.","authors":"Nan Li, Zhonghao Zhang, Liming Shen, Guoli Song, Jing Tian, Qiong Liu, Jiazuan Ni","doi":"10.1007/s11427-023-2621-7","DOIUrl":"https://doi.org/10.1007/s11427-023-2621-7","url":null,"abstract":"Selenium (Se) is an essential trace element of the utmost importance to human health. Its deficiency induces various disorders. Se species can be absorbed by organisms and metabolized to hydrogen selenide for the biosynthesis of selenoproteins, selenonucleic acids, or selenosugars. Se in mammals mainly acts as selenoproteins to exert their biological functions. The brain ranks highest in the specific hierarchy of organs to maintain the level of Se and the expression of selenoproteins under the circumstances of Se deficiency. Dyshomeostasis of Se and dysregulation of selenoproteins result in encephalopathy such as Alzheimer's disease, Parkinson's disease, depression, amyotrophic lateral sclerosis, and multiple sclerosis. This review provides a summary and discussion of Se metabolism, selenoprotein function, and their roles in modulating brain diseases based on the most currently published literature. It focuses on how Se is utilized and transported to the brain, how selenoproteins are biosynthesized and function physiologically in the brain, and how selenoproteins are involved in neurodegenerative diseases. At the end of this review, the perspectives and problems are outlined regarding Se and selenoproteins in the regulation of encephalopathy.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research landmarks on the 60th anniversary of Epstein-Barr virus. Epstein-Barr 病毒 60 周年研究里程碑。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-04 DOI: 10.1007/s11427-024-2766-0

Lan-Yi Zhong, Chu Xie, Le-Le Zhang, Yan-Lin Yang, Yuan-Tao Liu, Ge-Xin Zhao, Guo-Long Bu, Xian-Shu Tian, Zi-Ying Jiang, Bo-Yu Yuan, Peng-Lin Li, Pei-Huang Wu, Wei-Hua Jia, Christian Münz, Benjamin E Gewurz, Qian Zhong, Cong Sun, Mu-Sheng Zeng

引用次数: 0

Innovative genome editing in plants: a transposase and CRISPR combination approach. 创新的植物基因组编辑：转座酶和 CRISPR 组合方法。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 DOI: 10.1007/s11427-024-2729-2

Hamza Sohail, Iqra Noor, Xuehao Chen, Xiaodong Yang

引用次数: 0

COVID-19 vaccine updates for people under different conditions. 针对不同人群的 COVID-19 疫苗更新。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-07-29 DOI: 10.1007/s11427-024-2643-1

Yijiao Huang, Weiyang Wang, Yan Liu, Zai Wang, Bin Cao

{"title":"COVID-19 vaccine updates for people under different conditions.","authors":"Yijiao Huang, Weiyang Wang, Yan Liu, Zai Wang, Bin Cao","doi":"10.1007/s11427-024-2643-1","DOIUrl":"10.1007/s11427-024-2643-1","url":null,"abstract":"SARS-CoV-2 has caused global waves of infection since December 2019 and continues to persist today. The emergence of SARS-CoV-2 variants with strong immune evasion capabilities has compromised the effectiveness of existing vaccines against breakthrough infections. Therefore, it is important to determine the best utilization strategies for different demographic groups given the variety of vaccine options available. In this review, we will discuss the protective efficacy of vaccines during different stages of the epidemic and emphasize the importance of timely updates to target prevalent variants, which can significantly improve immune protection. While it is recognized that vaccine effectiveness may be lower in certain populations such as the elderly, individuals with chronic comorbidities (e.g., diabetes with poor blood glucose control, those on maintenance dialysis), or those who are immunocompromised compared to the general population, administering multiple doses can result in a strong protective immune response that outweighs potential risks. However, caution should be exercised when considering vaccines that might trigger an intense immune response in populations prone to inflammatory flare or other complications. In conclusion, individuals with special conditions require enhanced and more effective immunization strategies to prevent infection or reinfection, as well as to avoid the potential development of long COVID.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2323-2343"},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development. CRISPR/RfxCas13d 介导的小鼠胚胎发育中高效 RNA 敲除策略。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.1007/s11427-023-2572-6

Lin Zhang, Shi-Meng Cao, Hao Wu, Meng Yan, Jinsong Li, Ling-Ling Chen

引用次数: 0

Versatile and efficient mammalian genome editing with Type I-C CRISPR System of Desulfovibrio vulgaris. 利用普通脱硫弧菌的 I-C 型 CRISPR 系统进行多功能、高效的哺乳动物基因组编辑。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI: 10.1007/s11427-023-2682-5

Pan Li, Dingcai Dong, Fei Gao, Yuyang Xie, Honglin Huang, Siwei Sun, Zhao Ma, Cheng He, Jinsheng Lai, Xuguang Du, Sen Wu

{"title":"Versatile and efficient mammalian genome editing with Type I-C CRISPR System of Desulfovibrio vulgaris.","authors":"Pan Li, Dingcai Dong, Fei Gao, Yuyang Xie, Honglin Huang, Siwei Sun, Zhao Ma, Cheng He, Jinsheng Lai, Xuguang Du, Sen Wu","doi":"10.1007/s11427-023-2682-5","DOIUrl":"10.1007/s11427-023-2682-5","url":null,"abstract":"CRISPR-Cas tools for mammalian genome editing typically rely on single Cas9 or Cas12a proteins. While type I CRISPR systems in Class I may offer greater specificity and versatility, they are not well-developed for genome editing. Here, we present an alternative type I-C CRISPR system from Desulfovibrio vulgaris (Dvu) for efficient and precise genome editing in mammalian cells and animals. We optimized the Dvu type I-C editing complex to generate precise deletions at multiple loci in various cell lines and pig primary fibroblast cells using a paired PAM-in crRNA strategy. These edited pig cells can serve as donors for generating transgenic cloned piglets. The Dvu type I-C editor also enabled precise large fragment replacements with homology-directed repair. Additionally, we adapted the Dvu-Cascade effector for cytosine and adenine base editing, developing Dvu-CBE and Dvu-ABE systems. These systems efficiently induced C-to-T and A-to-G substitutions in human genes without double-strand breaks. Off-target analysis confirmed the high specificity of the Dvu type I-C editor. Our findings demonstrate the Dvu type I-C editor's potential for diverse mammalian genome editing applications, including deletions, fragment replacement, and base editing, with high efficiency and specificity for biomedicine and agriculture.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2471-2487"},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone. 激活 PGC-1α 介导的线粒体谷氨酰胺代谢途径可减轻产前过量泼尼松诱导的雌性后代骨关节炎。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-08-21 DOI: 10.1007/s11427-023-2593-4

Qingxian Li, Fan Zhang, Yongguo Dai, Liang Liu, Liaobin Chen, Hui Wang

{"title":"Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone.","authors":"Qingxian Li, Fan Zhang, Yongguo Dai, Liang Liu, Liaobin Chen, Hui Wang","doi":"10.1007/s11427-023-2593-4","DOIUrl":"10.1007/s11427-023-2593-4","url":null,"abstract":"Osteoarthritis is a chronic, age-related joint disease. Previous studies have shown that osteoarthritis develops during intrauterine development. Prednisone is frequently used to treat pregnancies complicated by autoimmune diseases. However, limited research has been conducted on the enduring effects of prednisone use during pregnancy on the offspring. In this study, we investigated the effect of excessive prednisone exposure on cartilage development and susceptibility to osteoarthritis in the offspring. We found that prenatal prednisone exposure (PPE) impaired cartilage extracellular matrix (ECM) synthesis, resulting in poor cartilage pathology in female offspring during the adult period, which was further exacerbated after long-distance running stimulation. Additionally, PPE suppressed cartilage development during the intrauterine period. Tracing back to the intrauterine period, we found that Pred, rather than prednisone, decreased glutamine metabolic flux, which resulted in increased oxidative stress, and decreased histone acetylation, and expression of cartilage phenotypic genes. Further, PGC-1α-mediated mitochondrial biogenesis, while PPE caused hypermethylation in the promoter region of PGC-1α and decreased its expression in fetal cartilage by activating the glucocorticoid receptor, resulting in a reduction of glutamine flux controlled by mitochondrial biogenesis. Additionally, overexpression of PGC-1α (either pharmacological or through lentiviral transfection) reversed PPE- and Pred-induced cartilage ECM synthesis impairment. In summary, this study demonstrated that PPE causes chondrodysplasia in female offspring and increases their susceptibility to postnatal osteoarthritis. Hence, targeting PGC-1α early on could be a potential intervention strategy for PPE-induced osteoarthritis susceptibility.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2382-2397"},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zika virus infection induces glycometabolic disorder in northern pig-tailed macaques. 寨卡病毒感染会诱发北方猪尾猕猴糖代谢紊乱。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-08-30 DOI: 10.1007/s11427-024-2663-6

Qing Li, Ren-Hua Yang, Yan Hu, Bei-Bei Tang, Ying-Jie Jiang, Chang-Bo Zheng, Tian-Zhang Song

引用次数: 0