Scandinavian Journal of Infectious Diseases最新文献_第7页

In memoriam--Professor Ragnar Norrby (1943-2014). 纪念——Ragnar Norrby教授(1943-2014)。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-08-01 DOI: 10.3109/00365548.2014.940699

Arne Tärnvik, Ola Weiland

引用次数: 0

The association between demographic factors and increased antibiotic consumption in Denmark 2001 to 2010. 2001年至2010年丹麦人口因素与抗生素消费增加之间的关系。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-08-01 Epub Date: 2014-05-16 DOI: 10.3109/00365548.2014.912347

Katrin Gaardbo Kuhn, Anette M Hammerum, Ulrich S Jensen

引用次数: 5

A sustained endemic outbreak of vancomycin-resistant Enterococcus faecium: A 30-month surveillance study. 耐万古霉素粪肠球菌持续地方性暴发:一项30个月的监测研究

Scandinavian Journal of Infectious Diseases Pub Date : 2014-08-01 Epub Date: 2014-05-16 DOI: 10.3109/00365548.2014.912348

Paola A Campos, Deivid W F Batistão, Paulo P Gontijo-Filho, Rosineide M Ribas

{"title":"A sustained endemic outbreak of vancomycin-resistant Enterococcus faecium: A 30-month surveillance study.","authors":"Paola A Campos, Deivid W F Batistão, Paulo P Gontijo-Filho, Rosineide M Ribas","doi":"10.3109/00365548.2014.912348","DOIUrl":"https://doi.org/10.3109/00365548.2014.912348","url":null,"abstract":"Background: The assessment of risk factors for the nosocomial acquisition of colonization and infection by vancomycin-resistant Enterococcus faecium (VREfm) is often problematic due to scarce data on antibiotic use. A 30-month prospective cohort study was conducted to characterize VREfm strains isolated during an outbreak and endemic period, identifying the risk factors, antibiotic consumption, and prevalence of virulence determinants.Methods: The study was conducted in a tertiary care hospital. A representative number (171 patients) of isolates that were classified as resistant to high-level vancomycin (minimum inhibitory concentration (MIC) ≥ 256 μg/ml) were investigated.Results: Among 171 colonized patients, 22 (12.9%) developed VRE infection. All VREfm isolates harboured vanA genes. Genes codifying virulence factors such as enterococcal surface protein (esp), aggregation substance 1 (asa1), and gelatinase (gelE) were detected in the VREfm studied. All patients infected with VRE had previously been colonized and became infected on average 14 days after colonization. Only previous use of aminoglycosides was a risk factor independently associated with VRE infection; however, glycopeptide consumption in defined daily doses (DDD) per 1000 patient-days was associated with the presence of this microorganism. The monthly colonization pressure ranged from 0.004% to 1.32% during the 30-month study period.Conclusions: We found a high incidence of VRE in a tertiary care hospital, independently associated with the prior use of aminoglycosides and the administration of glycopeptides.","PeriodicalId":21541,"journal":{"name":"Scandinavian Journal of Infectious Diseases","volume":"46 8","pages":"547-54"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365548.2014.912348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32346465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Need for improvements in the surveillance and management of chronic viral hepatitis in HIV patients followed in a Danish outpatient clinic. 需要改进的监测和管理的艾滋病患者慢性病毒性肝炎在丹麦的门诊诊所。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-08-01 Epub Date: 2014-06-16 DOI: 10.3109/00365548.2014.918648

Karen Lise Dahl Andersen, Carsten Schade Larsen, Mikkel Steen Petersen, Peter Derek Christian Leutscher

{"title":"Need for improvements in the surveillance and management of chronic viral hepatitis in HIV patients followed in a Danish outpatient clinic.","authors":"Karen Lise Dahl Andersen, Carsten Schade Larsen, Mikkel Steen Petersen, Peter Derek Christian Leutscher","doi":"10.3109/00365548.2014.918648","DOIUrl":"https://doi.org/10.3109/00365548.2014.918648","url":null,"abstract":"Objectives: The aim of this study was to assess hepatitis B virus (HBV) and hepatitis C virus (HCV) surveillance and management in HIV patients currently followed in an outpatient clinic at a Danish University Hospital.Methods: Patient data, including demographic characteristics, clinical findings, and hepatitis serology, were reviewed at baseline. Patients with incomplete or non-updated serology within the last 2 y were retested in the next 6 months, and the results were reviewed again at follow-up.Results: At baseline, 84% and 74% of the 574 HIV patients were found to have incomplete and/or non-updated HBV and HCV serology, respectively. At follow-up, updated HBV serology was achieved in 535 (93%) patients; 15 (3%) patients were found to have a chronic active infection and 156 (27%) had a resolved infection, whereas 65 (11%) were vaccinated against HBV and 299 (52%) were non-immune. No patients were found to have developed chronic HBV infection following HIV diagnosis (equal to 3649 patient-y). Updated HCV serology revealed that 25 (4%) had a chronic active HCV infection and 15 (3%) had a resolved HCV infection. The anti-HCV incidence rate was 0.27/100 patient-y. A liver pathology assessment had not been performed within the last 2 y in 80% of the HBV and 32% of the HCV co-infected patients.Conclusions: Hepatitis screening and assessment had been inadequately performed. New cases of chronic hepatitis seem to occur infrequently. However, a more proactive hepatitis surveillance and management strategy integrated into the overall HIV health care program is warranted.","PeriodicalId":21541,"journal":{"name":"Scandinavian Journal of Infectious Diseases","volume":"46 8","pages":"578-84"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365548.2014.918648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32428090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Daptomycin-induced rhabdomyolysis and acute liver injury. 达托霉素诱导的横纹肌溶解和急性肝损伤。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-07-01 Epub Date: 2014-05-07 DOI: 10.3109/00365548.2014.901555

S Travis King, Erica D Walker, Colleen G Cannon, Richard W Finley

引用次数: 13

Tubercular vertebral osteomyelitis. 结核性椎体骨髓炎。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-07-01 Epub Date: 2014-05-05 DOI: 10.3109/00365548.2014.901556

Ajaz Nabi Koul, Gulam Nabi Dhobi

引用次数: 1

Cellular fibronectin expression in chronic hepatitis C virus patients. 慢性丙型肝炎病毒患者细胞纤维连接蛋白的表达。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-07-01 Epub Date: 2014-05-16 DOI: 10.3109/00365548.2014.907499

Mohamed S Abdel-Latif, Eltahir K M Almahal, Noha M T Ragab, Mostafa F Omar, Mohammed S M Afifi

{"title":"Cellular fibronectin expression in chronic hepatitis C virus patients.","authors":"Mohamed S Abdel-Latif, Eltahir K M Almahal, Noha M T Ragab, Mostafa F Omar, Mohammed S M Afifi","doi":"10.3109/00365548.2014.907499","DOIUrl":"https://doi.org/10.3109/00365548.2014.907499","url":null,"abstract":"Background: Hepatitis C virus (HCV) is associated with fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and end-stage liver disease. In the normal liver, fibronectin plays crucial roles in various cellular functions, including cell adhesion, migration, proliferation, and differentiation. Increased expression of fibronectin is associated with areas of physiological or pathological tissue remodeling, including wound healing and tissue repair. The aim of the current study was to correlate the cellular fibronectin expression level in peripheral blood fibrocytes of chronic HCV patients with the severity of liver fibrosis as detected by liver biopsy.Methods: The present study was conducted on 20 fibrotic liver cases with detectable HCV RNA, 10 HCV cirrhotic liver cases, and 10 control subjects of matched age and sex. Cellular fibronectin RNA was detected by PCR.Results: The mean level of cellular fibronectin expression in cases with liver fibrosis was significantly higher than the corresponding level in cases with liver cirrhosis (p = 0.019). Control individuals did not express cellular fibronectin. There was also a significant correlation between the Metavir score and cellular fibronectin RNA, APRI, and FIB-4 scores. However, based on the area under the curve (AUC) values, cellular fibronectin showed a lower diagnostic performance than APRI and FIB-4 scores.Conclusions: Cellular fibronectin RNA showed satisfactory reproducibility and could be used to differentiate HCV fibrotic liver (F1-F3) and HCV cirrhotic liver (F4) from normal liver (F0).","PeriodicalId":21541,"journal":{"name":"Scandinavian Journal of Infectious Diseases","volume":"46 7","pages":"508-14"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365548.2014.907499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32346917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Joint failure after steroid therapy in tuberculous encephalitis. 结核性脑炎类固醇治疗后关节衰竭。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-07-01 Epub Date: 2014-04-22 DOI: 10.3109/00365548.2014.898334

Christoph Ziskoven, Joachim Richter, Thilo Patzer, Jörn Kircher, Rüdiger Krauspe

引用次数: 0

Risk factors of severe hand, foot and mouth disease: a meta-analysis. 严重手足口病的危险因素:荟萃分析

Scandinavian Journal of Infectious Diseases Pub Date : 2014-07-01 Epub Date: 2014-05-16 DOI: 10.3109/00365548.2014.907929

Yirong Fang, Shuiping Wang, Lijie Zhang, Zhinan Guo, Zhaohui Huang, Chunyu Tu, Bao-Ping Zhu

{"title":"Risk factors of severe hand, foot and mouth disease: a meta-analysis.","authors":"Yirong Fang, Shuiping Wang, Lijie Zhang, Zhinan Guo, Zhaohui Huang, Chunyu Tu, Bao-Ping Zhu","doi":"10.3109/00365548.2014.907929","DOIUrl":"https://doi.org/10.3109/00365548.2014.907929","url":null,"abstract":"Background: In recent years, outbreaks of hand, foot and mouth disease (HFMD) have increased, and more and more severe cases have appeared. We conducted a meta-analysis to generate large-scale evidence on the risk factors of severe HFMD.Methods: PubMed, Elsevier Science Direct, China National Knowledge Infrastructure (CNKI), and Wanfang (Chinese) were searched to identify relevant articles. All analyses were performed using Stata 11.0.Results: We conducted a meta-analysis of 19 separate studies. Duration of fever ≥ 3 days (odds ratio (OR) 10.09, 95% confidence interval (CI) 6.22-16.35), body temperature ≥ 37.5°C (OR 4.91, 95% CI 1.26-19.18), lethargy (OR 7.75, 95% CI 3.78-15.89), hyperglycemia (OR 2.77, 95% CI 2.06-3.71), vomiting (OR 8.83, 95% CI 1.05-74.57), increased neutrophil count (weighted mean difference (WMD) 0.61, 95% CI 0.52-0.70), enterovirus 71 (EV71) infection (OR 5.13, 95% CI 3.11- 8.46), young age (WMD - 0.44, 95% CI - 0.69 to -0.19), and home care (OR 1.65, 95% CI 1.26-2.17) were significantly related to the risk of severe HFMD. We also found that a confirmed diagnosis at first visit to hospital significantly decreased the risk of severe HFMD (OR 0.30, 95% CI 0.09-0.99). We did not find an association between oral rash (OR 1.07, 95% CI 0.82-1.39), increased leukocyte count (WMD 0.51, 95% CI - 0.05-1.06), male sex (OR 1.06, 95% CI 0.91-1.24), or living in a rural area (OR 1.39, 95% CI 0.95-2.02) and the risk of severe HFMD.Conclusions: Duration of fever ≥ 3 days, body temperature ≥ 37.5°C, lethargy, hyperglycemia, vomiting, increased neutrophil count, EV71 infection, and young age are risk factors for severe HFMD. A confirmed diagnosis at first visit to hospital can significantly decrease the risk of severe HFMD.","PeriodicalId":21541,"journal":{"name":"Scandinavian Journal of Infectious Diseases","volume":"46 7","pages":"515-22"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365548.2014.907929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32347010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

A simple intervention to reduce inappropriate ciprofloxacin prescribing in the emergency department. 一个简单的干预措施，以减少不适当的环丙沙星处方在急诊科。

Scandinavian Journal of Infectious Diseases Pub Date : 2014-07-01 Epub Date: 2014-02-20 DOI: 10.3109/00365548.2014.880187

Mark Fagan, Morten Lindbæk, Harald Reiso, Dag Berild

{"title":"A simple intervention to reduce inappropriate ciprofloxacin prescribing in the emergency department.","authors":"Mark Fagan, Morten Lindbæk, Harald Reiso, Dag Berild","doi":"10.3109/00365548.2014.880187","DOIUrl":"https://doi.org/10.3109/00365548.2014.880187","url":null,"abstract":"Background: According to Norwegian guidelines for antibiotic use in primary care, ciprofloxacin is reserved for complicated urinary tract infections (UTI). Despite these recommendations, ciprofloxacin use has increased in Norway in recent years. We aimed to reduce inappropriate ciprofloxacin prescribing in the emergency department.Methods: An intervention study was performed by removing ciprofloxacin from the local antibiotic formulary and including a suggestion list for antibiotic use with all point of care urine dipstick testing in an emergency department. An emergency department in the neighbouring county served as the control. Prescriptions for UTI were registered 1 y prior to and 1 y after the intervention.Results: In the targeted emergency department, there was a significant (p < 0.0001) reduction in ciprofloxacin prescribing for cystitis, while the use of mecillinam increased (p = 0.042). In the control department, prescribing of ciprofloxacin doubled (p < 0.0001).Conclusions: An intervention based on a therapy suggestion list and on limiting the availability of ciprofloxacin in the local formulary, resulted in treatment more in line with national guidelines by reducing ciprofloxacin and increasing mecillinam prescribing.","PeriodicalId":21541,"journal":{"name":"Scandinavian Journal of Infectious Diseases","volume":"46 7","pages":"481-5"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365548.2014.880187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32138579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19