Scandinavian journal of haematology最新文献_第6页

True idiopathic splenomegaly--a distinct clinical entity. 真正的特发性脾肿大——一个独特的临床实体。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02318.x

C S Hesdorffer, B J Macfarlane, M A Sandler, S C Grant, F Ziady

{"title":"True idiopathic splenomegaly--a distinct clinical entity.","authors":"C S Hesdorffer, B J Macfarlane, M A Sandler, S C Grant, F Ziady","doi":"10.1111/j.1600-0609.1986.tb02318.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb02318.x","url":null,"abstract":"10 asymptomatic young male patients with moderate splenomegaly detected at a routine examination are presented. The history and clinical examination failed to reveal the aetiology of the splenomegaly. Further investigations, including screening for blood dyscrasias, clotting abnormalities and reticuloendothelial abnormalities were likewise unrevealing. Liver biopsies, rectal biopsies for bilharzia and bone marrow aspirates for Gaucher's Disease were found to be normal. Serology for malaria and Ebstein Barr Virus infection was also negative. Positive immunofluorescent tests for IgG antibodies specific for cytomegalovirus were found in 5 patients. We consider that these patients have splenomegaly which is not of a specific nature, but may be associated with a severe antigeneic response to the previous cytomegalovirus infection. In view of the otherwise negative findings these patients should be considered to have 'True Idiopathic Splenomegaly', a term which would indicate the benign nature of the splenic enlargement. This diagnosis should be considered in the differential diagnosis of asymptomatic patients who have splenomegaly of undetermined origin.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"37 4","pages":"310-5"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb02318.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14157756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

High-dose therapy followed by autologous bone marrow transplantation (ABMT) in previously untreated non-Hodgkin's lymphoma. 高剂量治疗后自体骨髓移植(ABMT)先前未治疗的非霍奇金淋巴瘤。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02325.x

S Tura, P Mazza, F Gherlinzoni, P Ricci, G Visani, G Bandini, A Zaccaria, G Rosti, F Lauria, M Baccarani

{"title":"High-dose therapy followed by autologous bone marrow transplantation (ABMT) in previously untreated non-Hodgkin's lymphoma.","authors":"S Tura, P Mazza, F Gherlinzoni, P Ricci, G Visani, G Bandini, A Zaccaria, G Rosti, F Lauria, M Baccarani","doi":"10.1111/j.1600-0609.1986.tb02325.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb02325.x","url":null,"abstract":"13 previously untreated patients with poor prognosis non-Hodgkin's lymphoma (NHL) underwent high-dose therapy followed by autologous bone marrow transplantation (ABMT). All patients experienced a great cytoreductive effect and 9 of them reached a complete remission (mean duration 32 months). The best results were observed in patients with more limited disease and in those without symptoms. 7 patients still remain in complete unmantained remission 15-46 months from the transplant. The probability of survival is 74% at 46 months. No therapy-related deaths were recorded. In differentiating our preliminary approach, we propose high dose therapy followed by ABMT as induction phase in patients with stage II and as consolidation after first line therapy in patients with stages III-IV. Further studies are warranted to determine which type of lymphoma may benefit more and which conditioning regimens may improve the remission rate.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"37 4","pages":"347-52"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb02325.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14660695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Cytochrome b and FAD content in polymorphonuclear leucocytes in a family with X-linked chronic granulomatous disease. x连锁慢性肉芽肿病家族多形核白细胞细胞色素b和FAD含量

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02322.x

S Riccardi, D Giordano, F Schettini, D De Mattia, T Lovecchio, N Santoro, R Fumarulo

{"title":"Cytochrome b and FAD content in polymorphonuclear leucocytes in a family with X-linked chronic granulomatous disease.","authors":"S Riccardi, D Giordano, F Schettini, D De Mattia, T Lovecchio, N Santoro, R Fumarulo","doi":"10.1111/j.1600-0609.1986.tb02322.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb02322.x","url":null,"abstract":"Chronic granulomatous disease (CGD), an immunodeficiency syndrome characterized by extreme susceptibility to bacterial infections, is due to a defect of the respiratory burst in human phagocytes. NADPH oxidase, the enzyme that catalyzes the reduction of oxygen and the release of oxidative radicals, was studied in polymorphonuclear leucocytes (PMNs) in a family affected by an x-linked inheritance form at high penetrance of the disease. The contents of cytochrome b, suggested as the terminal component of the oxidase electron transport chain, and FAD, the hypothetical proximal component of the chain, were determined in patients and in carriers. Cytochrome b showed the typical behaviour of x-linked CGD: total absence in patients, intermediate values in carriers. FAD content evaluated on plasma membranes was less decreased than cytochrome b. Carriers also showed a decrease of this flavoprotein. Cytochrome b and FAD contents were compared to NBT test and superoxide production: a clear correlation was observed for the cytochrome b, but FAD plasma membrane evaluation could also be an interesting tool for the metabolic characterization of the disease in patients and in carriers.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"37 4","pages":"333-6"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb02322.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14904308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Specificity and diagnostic implications of the reactivity pattern of a panel of monoclonal antibodies against myeloid leukemia cells. 一组抗髓性白血病细胞单克隆抗体反应模式的特异性和诊断意义。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02321.x

R B Andreasen, P Biberfeld, A Ost, P Reizenstein, L Olsson

{"title":"Specificity and diagnostic implications of the reactivity pattern of a panel of monoclonal antibodies against myeloid leukemia cells.","authors":"R B Andreasen, P Biberfeld, A Ost, P Reizenstein, L Olsson","doi":"10.1111/j.1600-0609.1986.tb02321.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb02321.x","url":null,"abstract":"The immunological phenotypes of leukemia cell samples from 60 patients, of whom 54 had acute myeloid leukemia (AML), were assessed with a panel of monoclonal antibodies (Mabs) with specificity for the following epitopes: Epitopes associated with myeloid leukemia cells, Epitopes expressed only on immature myeloid cells (or subsets) and on monocytes, Epitopes only expressed on granulocytes or on granulocytes and mature myeloid cells (promyelocytes, myelocytes and monocytes), Epitopes on HLA-class II (DR) and HLA-class I molecules and on insulin receptors. This panel of Mabs proved useful to identify leukemia cells in blood and to assess their myeloid origin. The panel of Mabs was found also to be useful for immunophenotyping of leukemia cells. Furthermore, the analysis revealed considerable variations in the immunological phenotype of AML cells, reflecting antigenic heterogeneity within the individual leukemia cell population as well as abnormal or no expression of histocompatibility antigens and insulin receptors in some samples. Some of the Mabs bound preferentially to subgroups in the French-American-British (FAB) classification.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"37 4","pages":"323-32"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb02321.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13577678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Thrombocytopenia and pseudothrombocytopenia: a clinical and laboratory problem. 血小板减少症和假性血小板减少症:一个临床和实验室问题。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02324.x

T Nilsson, B Norberg

引用次数: 14

Pipobroman therapy of essential thrombocythemia. 原发性血小板增多症的Pipobroman治疗。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02317.x

M G Mazzucconi, M Francesconi, A Chistolini, E Falcione, A Ferrari, M C Tirindelli, F Mandelli

引用次数: 35

Partial response of meningeal myeloma to craniospinal radiotherapy. 脑膜骨髓瘤对颅脊髓放射治疗的部分反应。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02327.x

B Brenner, A Nagler, A Viener, R Sharon, A Carter

引用次数: 9

The use of hydroxocobalamin in the Schilling test. 羟钴胺素在席林试验中的应用。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02323.x

J Wallis, D M Clark, B J Bain

引用次数: 3

Thrombotic thrombocytopenic purpura unresponsive to plasma infusion and plasma exchange, but responsive to splenectomy. 血栓性血小板减少性紫癜对血浆输注和血浆置换无反应，但对脾切除术有反应。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02320.x

A D Sturgess, B H Chong

引用次数: 7

Lymphocyte subpopulations in megaloblastic anaemia due to vitamin B-12 deficiency. 维生素B-12缺乏症引起巨幼细胞贫血的淋巴细胞亚群。

Scandinavian journal of haematology Pub Date : 1986-10-01 DOI: 10.1111/j.1600-0609.1986.tb02319.x

C A Gogos, K N Kapatais-Zoumbos, N C Zoumbos

引用次数: 14