Lymphocyte subpopulations in megaloblastic anaemia due to vitamin B-12 deficiency.

C A Gogos, K N Kapatais-Zoumbos, N C Zoumbos
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引用次数: 14

Abstract

Lymphocyte subpopulations were measured in the blood of 17 patients with megaloblastic anaemia due to vitamin B-12 deficiency. 14 patients had pernicious anaemia and 3 others were gastrectomized. By using monoclonal antibodies recognizing T cell surface markers and immunofluorescence microscopy, we found a significant decrease in the number of circulating suppressor T cells and an increase in the ratio of helper to suppressor T lymphocytes in pernicious anaemia patients. This finding may be related to other immune abnormalities found in pernicious anaemia, e.g. the presence of multiple autoantibodies.

维生素B-12缺乏症引起巨幼细胞贫血的淋巴细胞亚群。
本文对17例因维生素B-12缺乏症引起的巨幼细胞贫血患者血液中的淋巴细胞亚群进行了测定。恶性贫血14例,胃切除3例。通过识别T细胞表面标记的单克隆抗体和免疫荧光显微镜,我们发现恶性贫血患者循环抑制性T细胞数量显著减少,辅助T细胞与抑制性T细胞的比例显著增加。这一发现可能与恶性贫血中发现的其他免疫异常有关,例如多种自身抗体的存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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