Revue d'Electroencéphalographie et de Neurophysiologie Clinique最新文献

{"title":"","authors":"S. Garrel","doi":"10.1016/S0370-4475(87)80095-3","DOIUrl":"10.1016/S0370-4475(87)80095-3","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Page 456"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80095-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"95798452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"F. Mauguière","doi":"10.1016/S0370-4475(87)80101-6","DOIUrl":"10.1016/S0370-4475(87)80101-6","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Pages 459-460"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80101-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86232603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etudes correlatives multiples sur biopsies stereotaxiques de tumeurs cerebrales","authors":"A.L. Benabid ,&nbsp;J. de Rougemont ,&nbsp;M. Decorps ,&nbsp;C. Remy ,&nbsp;J.F. Le Bas ,&nbsp;C. Chauvin ,&nbsp;J.L. Leviel ,&nbsp;M.F. Nissou ,&nbsp;M. Jacrot ,&nbsp;C. Mouriquand ,&nbsp;B. Pasquier ,&nbsp;G. Baghadi ,&nbsp;J.P. Chirossel","doi":"10.1016/S0370-4475(87)80086-2","DOIUrl":"10.1016/S0370-4475(87)80086-2","url":null,"abstract":"<div><p>La possibilité de réaliser au même site des prélèvements multiples et de repérer spatialement ce site permet d'exploiter intensivement les biopsies stéréotaxiques de tumeurs cérébrales, en corrélant les résultats anatomopathologiques avec d'autres mesures effectuées au même endroit (impédance électrique, absorption des rayons X) ou sur d'autres prélèvements (temps de relaxation RMN, teneur en eau, acides nucléiques). Ces prélèvements se prêtent par ailleurs à de nombreuses expériences de cancérologie en biologie cellulaire (cultures de cellules, greffes sur souris nudes) ou moléculaire (hybridation des ADN et ARN avec des sondes nucléiques spécifiques). Nous avons pu ainsi: 1) étudier les correspondances diagnostiques entre anatomopathologie et histologie qui montrent les domaines où les interprétations divergent et ceux où elles sont équivalentes; 2) montrer que les temps de relaxation RMN T1 et T2 sont deux fois plus longs dans les tissus tumoraux par rapport au tissu sain; 3) montrer que l'impédance électrique est abaissée d'un facteur 2 dans les tumeurs cérébrales; 4) montrer l'absence de séquences virales et l'existence d'un pattern d'association oncogénique dans les tumeurs cérébrales, par des méthodes d'hybridation de sondes; 5) établir des lignées cellulaires continues dont la tumorégénécité a été étudiée par greffe sur souris nude. La pratique des biopsies stéréotaxiques apparaît donc, grâce à une exploitation rationnelle et intense, comme un outil de recherche important dans ce domaine qui reste peu sensible aux diverses approches thérapeutiques.</p></div><div><p>The opportunity of having several samples at the same site which could be spatially localized allows an intensive exploitation of stereotactic biopsies of brain tumors: the pathological data may be correlated to other measures, performed at the same site (electrical impedance X ray absorption coefficient) or on other samples (NMR relaxation times, water content, nucleic acids). These samples are available for oncology experiments in cellular biology (cell cultures, grafts on nude mice) or in molecular biology (DNA and RNA hybridization with specific nucleic acid probes). We were therefore able: 1) to study the diagnostic homologies between pathology and histology examinations; 2) to show that T1 and T2 NMR relaxation times are 2 times longer in tumor tissues than in normal brain; 3) to show that the electrical impedance is decreased by a factor 2 in brain tumors; 4) to show the absence of integrated viral genomic sequences and the existence of oncogenes association patterns in brain tumors by hybridization of specific sequences; 5) to establish permanent cell lines, the tumorigenicity of which is assayed by grafting on nude mice. Therefore, stereotactic biopsies appear to be, provided they are intensively and rationally exploited, a major research tool in an area which remains unsensitive to the various therapeutic approaches.</p></div>","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Pages 401-410"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80086-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13595424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liste des lecteurs — 1987","authors":"","doi":"10.1016/S0370-4475(87)80105-3","DOIUrl":"https://doi.org/10.1016/S0370-4475(87)80105-3","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Page 465"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80105-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91592919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"L. Garcia Larrea,&nbsp;F. Mauguière","doi":"10.1016/S0370-4475(87)80102-8","DOIUrl":"10.1016/S0370-4475(87)80102-8","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Pages 460-461"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80102-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77608079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"S. Garrel","doi":"10.1016/S0370-4475(87)80096-5","DOIUrl":"10.1016/S0370-4475(87)80096-5","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Page 456"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80096-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107946297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"J. Krieger","doi":"10.1016/S0370-4475(87)80097-7","DOIUrl":"10.1016/S0370-4475(87)80097-7","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Page 457"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80097-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85107076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"B. Gueguen","doi":"10.1016/S0370-4475(87)80092-8","DOIUrl":"10.1016/S0370-4475(87)80092-8","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Page 455"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80092-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"104453872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index des Auteurs","authors":"","doi":"10.1016/S0370-4475(87)80106-5","DOIUrl":"https://doi.org/10.1016/S0370-4475(87)80106-5","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Pages 467-469"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80106-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91592918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"F. Mauguière","doi":"10.1016/S0370-4475(87)80103-X","DOIUrl":"https://doi.org/10.1016/S0370-4475(87)80103-X","url":null,"abstract":"","PeriodicalId":21476,"journal":{"name":"Revue d'Electroencéphalographie et de Neurophysiologie Clinique","volume":"17 4","pages":"Pages 461-462"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0370-4475(87)80103-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136596815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}