Scandinavian Journal of Medicine & Science in Sports最新文献

{"title":"MyotonPRO Is Not Comparable to Shear Wave Elastography in the Measurement of Rectus Femoris Muscle Stiffness due to Interference of Subcutaneous Adipose Tissue.","authors":"Cameron D Ley,Eduardo Martinez Valdes,Conall F Murtagh,Jonathan Power,Lee Nobes,Barry Drust","doi":"10.1111/sms.70095","DOIUrl":"https://doi.org/10.1111/sms.70095","url":null,"abstract":"Tissue biomechanical properties are important for optimizing musculoskeletal performance and reducing injury risk. The MyotonPRO was developed as a simple, portable, noninvasive, and highly reliable method for the estimation of muscle stiffness. It has not, however, been comprehensively validated against shear wave elastography (SWE), a validated ultrasound-based method for assessing tissue stiffness. To assess this, 20 participants completed two visits in which rectus femoris (RF) stiffness was measured twice with the MyotonPRO device and SWE at three distinct muscle regions (proximal, medial, and distal), three muscle lengths (relaxed-REL, neutral-NEU, and passively stretched-PAST), and four depths (skin-SKIN, fascia-FAS, superficial muscle-SUP, and deep muscle-DEEP). Additionally, subcutaneous adipose tissue thickness (SAT) was recorded at each location under every condition using B-mode ultrasound imaging. When pooling the regions in REL, the MyotonPRO exhibited a weak significant negative correlation with SWE in DEEP (r = -0.27, p = 0.020), but not at SKIN, FAS, or SUP. In NEU and PAST, stiffness estimated by the MyotonPRO had a moderate positive relationship with SWE in the SKIN (r = 0.66, p < 0.001; r = 0.60, p < 0.001), but weaker relationships with deeper tissue (FAS, r = 0.26, p = 0.023; r = 0.20, p = 0.069; SUP, r = 0.24, p = 0.036; r = 0.26, p = 0.023; DEEP, r = 0.315, p = 0.008; r = 0.454, p < 0.001, respectively). Stiffness measured by the MyotonPRO exhibited significant moderate-to-strong negative correlations with SAT in every region under every condition, except for medially in REL. These results suggest that the two methods cannot be used interchangeably to estimate the stiffness of the RF muscle.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"37 1","pages":"e70095"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Active Are Women in the First Year of Motherhood? A Systematic Review of Device-Measured Physical Activity.","authors":"Freja Hauberg Hallen,Sebastian Dyrup Skejø,Rasmus Oestergaard Nielsen,Solvej Videbæk Bueno","doi":"10.1111/sms.70108","DOIUrl":"https://doi.org/10.1111/sms.70108","url":null,"abstract":"This systematic review summarizes previous findings of device-measured moderate- and vigorous-intensity physical activity (MVPA) in minutes per day from childbirth to 1 year postpartum. A systematic literature search was conducted in PubMed and Embase. Eligible studies reported device-measured MVPA at any time within the first 12 months postpartum in healthy parous women. Out of the 1437 studies identified, 15 studies were included, with study populations ranging from 20 to 532 women. MVPA was measured using various physical activity (PA) trackers, with ActiGraph devices being the most common (n = 10). Definitions of MVPA varied, utilizing counts per minute (cpm), Euclidean Norm Minus One (ENMO), metabolic equivalent tasks (METs), or proprietary algorithms. MVPA estimates ranged from 2.14 to 87.3 min/day. Most studies revealed an estimate of MVPA ≤ 27.6 min/day (n = 10), while four studies reported ≥ 55.5 min/day. MVPA estimates varied widely, with most studies reporting estimates below the World Health Organization recommendation of a minimum of 150 min MPA per week. Differences in study characteristics, tracker placement, data processing, and the cut-offs used to define MVPA likely contributed to variability, highlighting the need for standardized methodologies to improve comparability. Expanding our knowledge of postpartum PA can support new mothers in meeting health-enhancing PA recommendations.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"21 1","pages":"e70108"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Sports Injury Risks in CrossFit: A Prospective Cohort Study on Athletic Demographics, Training Profiles, Injury History, and Psychological Factors.","authors":"Aynollah Naderi,Maede Shokri,Mansoureh Mokaberian,Ulrika Tranaeus","doi":"10.1111/sms.70100","DOIUrl":"https://doi.org/10.1111/sms.70100","url":null,"abstract":"Improper training load management and inadequate recovery time significantly increase injury risk among CrossFit athletes, often influenced by psychological factors such as strong athletic identity, obsessive passion, perfectionistic concerns, and ineffective self-control strategies. Therefore, preventive strategies should not only focus on adjusting training loads but also on addressing the psychological dispositions that contribute to these behaviors. This study aims to explore the relationship between psychological factors-specifically passion, perfectionism, athletic identity, and self-control-and the risk of sports injuries among CrossFit athletes. Conducted as a prospective cohort study, the research involved 295 CrossFit athletes (mean age 29.5 ± 6.4 years; height 1.73 ± 0.1 m; weight 73.7 ± 13.1 kg; 44.4% women). Participants completed an online questionnaire covering demographics, training profiles, coaching status, injury histories, and psychological characteristics. Biweekly injury tracking over a 9-month period recorded the primary outcome of sports injuries, expressed as injuries per 1000 h of training. Over 9 months, 25.8% of athletes experienced injuries (totaling 94), resulting in an incidence rate of 2.04 injuries per 1000 training hours. Commonly injured areas included the shoulder (18.4%), lumbar spine (18.1%), and knee (17.4%). Our study revealed that athletes with prior injuries were 3.92 times more likely to sustain new injuries, and each additional weekly training hour increased injury risk by 35%. Conversely, higher self-control scores correlated with a 73% reduced injury risk. These findings emphasize the importance of incorporating both physical and psychological considerations in injury prevention strategies.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"52 1","pages":"e70100"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menstrual Cycle Effects on Sports Performance and Adaptations to Training: A Historical Perspective.","authors":"Anthony C Hackney,Mette Hansen,Anna Melin","doi":"10.1111/sms.70107","DOIUrl":"https://doi.org/10.1111/sms.70107","url":null,"abstract":"An ever-increasing number of girls and women worldwide are engaging in sports, which has promoted the incentive for scientific investigations into female exercise physiology. Recently, an area of female physiology garnering considerable interest has been the influence of the menstrual cycle on the responses to exercise-specifically, are sports performance or training affected by the phases of the cycle. Views on this issue have been a 'subject of debate' in the scientific community. We questioned whether this has always been the case or whether the science community's perspective on how the menstrual cycle may affect the sport and exercise performance of the female athlete has evolved over time. To address this point, we examined published peer-reviewed 'review articles' (narrative, descriptive, systematic, etc.) spanning 1984-2024 addressing the topic. In general, article authors conveyed one of three perspectives, that; (a) there is no effect/relationship; or (b) there is an effect/relationship, though selective to certain sports and physiological systems, and limited to a small influence overall; or (c) authors were ambivalent and inconclusive on the issue. Interestingly, no overarching consensus has been reached even though research on the topic has progressed and increased substantially over the last 40 years. The majority of the perspectives conveyed were that the hormonal changes across the menstrual cycle phases do not affect female sports performance or training. However, a small number of the review articles, both past and present, have asserted that hormonal changes with the menstrual cycle phases do affect performance in certain types of exercise activities and physiologic functions (e.g., strength), under certain conditions; but the evidence and consensus therein appears to be that the effect is small or trivial.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"113 1","pages":"e70107"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fitness, Weight Status and Executive Functions in Adolescents: A Cluster Analysis","authors":"Alberto Grao‐Cruces, Fátima Martín‐Acosta, Miguel Vaquero‐Solís, Abel Ruiz‐Hermosa, Daniel Camiletti‐Moirón, David Sánchez‐Oliva","doi":"10.1111/sms.70098","DOIUrl":"https://doi.org/10.1111/sms.70098","url":null,"abstract":"Low levels of physical fitness and the prevalence of obesity represent significant public health concerns that may adversely affect executive functions in adolescents. This study aimed to examine the associations between physical fitness and weight status clusters and executive functions in adolescents. A total of 1156 secondary school students aged 12–14 years participated in the study. Cluster analysis was conducted using field‐measured cardiorespiratory fitness (CRF), muscular fitness (MF), and body mass index (BMI). Core executive functions, including inhibitory control, cognitive flexibility, and working memory, were assessed using computerized tests. Five profiles were identified: (1) Thin &amp; Unfit, (2) Normal weight &amp; Fit, (3) Fat &amp; Strong, (4) Fat &amp; Unfit, and (5) Thin &amp; Aerobic. Participants with profiles characterized by higher CRF and MF levels and lower BMI demonstrated superior executive function compared to those with unfit profiles. This study underscores the importance of maintaining adequate levels of physical fitness and appropriate weight status in adolescents to support optimal performance of core executive functions. Furthermore, it highlights the interplay of the three components in mitigating the adverse effects of deficiencies in any one component.Trial Registration: <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://clinicaltrials.gov\">Clinicaltrials.gov</jats:ext-link> identifier: NCT05891054 and NCT06254638","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"68 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hormonal Contraceptive Use and Self‐Reported Symptomatic Experiences Attributed to the Menstrual Cycle or Hormonal Contraceptive Use in Norwegian Women: The Effect of Training Categories and Age Groups ‐ The FENDURA Project","authors":"John Owen Osborne, Jonas H. Storvand, Tina P. Engseth, Guro S. Solli, Bente Morseth, Madison Y. Taylor, Boye Welde, Kirsty J. Elliott‐Sale, Erik P. Andersson, Øyvind Sandbakk, Dionne A. Noordhof","doi":"10.1111/sms.70096","DOIUrl":"https://doi.org/10.1111/sms.70096","url":null,"abstract":"The aims of the current study were to (1) report the prevalence of hormonal contraceptive (HC) use among Norwegian women across different training categories and age groups; (2) compare the frequency and severity of cycle‐related symptoms across differing training categories and age groups; and (3) describe the bleeding pattern and prevalence of menstrual disorder/disturbances among non‐HC users. A sample of 2059 Norwegian women completed a survey reporting: weekly training volume; current HC usage, type, and reasons for use; cycle‐related symptom frequency and severity; and the prevalence of menstrual disorders/disturbances. Respondents were categorized by age (youth: 13–20; young adults: 21–30; older adults: 31–50 years) and training category (minimal: 0; low: &lt; 5; moderate: 5–9; high: ≥ 9 h·week<jats:sup>−1</jats:sup>). Half (51.6%) of respondents reported current HC usage, predominantly long‐acting reversible contraception or combined oral contraceptives. Young adults had the highest prevalence of HC use (62.7%) compared to youth (48.4%) and older adults (43.8%), although no differences in usage were seen across training categories. HC users reported fewer and less severe cycle‐related symptoms compared to non‐users. A third (30.8%) of non‐HC users had experienced a menstrual disorder/disturbance, with no significant differences observed across training categories or age groups. In conclusion, HC use is widespread among Norwegian women, with no differences between training categories. This similar HC prevalence suggests that HC research conducted in female cohorts may be generalizable, independent of training category. However, attention should be paid to participants' age due to differences in HC use between age groups.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"4 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post‐COVID‐19 Condition in Track and Field Master Athletes: Severity, Symptoms, and Associations With Quality of Life and C‐Reactive Protein Levels","authors":"Boyi Zhang, Marijke Grau, Christian Puta, Daniel Arvidsson, Michael Arz, Jonas Böcker, Philip Chilibeck, Scott C. Forbes, Claudia Kaiser‐Stolz, Natalie McLaurin, Eri Miyamoto‐Mikami, Dominik Pesta, Willi Pustowalow, Hirofumi Tanaka, Jörn Rittweger, Wilhelm Bloch","doi":"10.1111/sms.70106","DOIUrl":"https://doi.org/10.1111/sms.70106","url":null,"abstract":"Here, we assessed the prevalence of post‐COVID‐condition (PCC, also known as long‐COVID) and investigated its associations with health‐related quality of life and immune‐related biomarkers in track and field masters athletes (MAs). A total of 216 MAs (114 males, 102 females; age: 58.3 ± 11.9 vs. 56.6 ± 11.7 years; BMI: 23.6 [22.2–24.8] vs. 21.3 [20.0–23.6] kg/m<jats:sup>2</jats:sup>) reported their post‐COVID‐conditions via the Post‐COVID Syndrome Questionnaire (PCSQ). In a subgroup of 108 MAs, fasting blood samples were collected to assess C‐reactive protein (CRP) levels as a biomarker of immune status (MAs‐CRP). Based on their PCSQ sum score, MAs were divided into three groups: no/mild, moderate, and severe. Associations between PCC severity and sex, athletic specialty, and competition level were evaluated using Fisher's exact test. Forty‐six (21%) MAs were identified with clinically relevant moderate‐to‐severe post‐COVID‐19 conditions (PCSQ score &gt; 10.75). The most frequently reported symptoms included musculoskeletal pain (15%), sleep disturbance (13%), sensory or respiratory symptoms (11%), fatigue (11%), and flu‐like symptoms (11%). PCC prevalence did not differ by sex, athletic specialties, training load, or prior competition level (all <jats:italic>p</jats:italic> &gt; 0.05). MAs with moderate‐to‐severe PCC had significantly lower physical and mental component scores of quality of life compared with those with no or mild symptoms (<jats:italic>p</jats:italic> &lt; 0.05). In the MAs‐CRP subgroup, self‐reported cardiac ailments and flu‐like symptoms were significantly and positively associated with CRP levels (Spearman <jats:italic>ρ</jats:italic> = 0.27–0.30, all <jats:italic>p</jats:italic> &lt; 0.01). Post‐COVID‐19 condition is associated with reduced quality of life in track and field masters athletes, independent of sex, prior competition levels, and training characteristics. Furthermore, low‐grade inflammation based on CRP levels was associated with self‐reported cardiac and flu‐like symptoms.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"37 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Do Fluctuations in Endogenous Sex Hormones Affect Breast Pain in Female Athletes?","authors":"Brooke R. Brisbine, Jocelyn K. Mara, Alannah K. A. McKay, Louise M. Burke, Rachel McCormick, Rachel Harris, Clare Minahan, Kathryn E. Ackerman, Celeste E. Coltman","doi":"10.1111/sms.70101","DOIUrl":"https://doi.org/10.1111/sms.70101","url":null,"abstract":"Cyclic breast pain (mastalgia) is speculatively associated with hormonal fluctuations during the menstrual cycle. No research to date has quantified this effect through circulating concentrations of estradiol and progesterone in a sample of female athletes. Such data are essential for understanding how hormonal changes contribute to the incidence and severity of cyclic breast pain, with implications for enhancing breast pain management and athletic performance in women's sport. Twenty‐four female Australian First Nation athletes from the National Rugby League Indigenous Women's Academy pathways program participated in a Female Athlete Research Camp. Over 5 weeks, participants completed a daily survey about their experience of breast pain and, at three approximate phases of the menstrual cycle (Phases 1, 2, and 4), presented to the laboratory for venous blood samples to track circulating estradiol and progesterone concentrations. Average mastalgia ratings spiked during the commencement of the menstrual period and 14–26 h prior to ovulation. Higher levels of estradiol and progesterone were associated with a decreased likelihood of experiencing mastalgia; elevated progesterone levels were also linked to a reduction in mastalgia severity. These effects were highly interdependent, such that the effect that progesterone had on mastalgia was dependent on the value of estradiol, and vice versa. This study provides the first quantitative evidence that circulating estradiol and progesterone levels influence the occurrence and severity of cyclic breast pain in female athletes. These findings support the development of targeted strategies for managing mastalgia, ultimately promoting well‐being and enhancing performance for women in sport.","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"27 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Injury Incidence Between Player Positions Across All Rugby Formats—A Systematic Review and Meta‐Analysis","authors":"Matias Vaajala, Juho Laaksonen, Rasmus Liukkonen, Oskari Pakarinen, Ilari Kuitunen","doi":"10.1111/sms.70102","DOIUrl":"https://doi.org/10.1111/sms.70102","url":null,"abstract":"Rugby is a high‐intensity contact sport with a high incidence of injuries. The aim of this systematic review and meta‐analysis was to compare the injury incidences between forwards and backs in all rugby formats (Rugby Union, Seven, and League). The PubMed (National Library of Medicine), Web of Science (Clarivate), Scopus (Elsevier), and SPORTDiscus (EBSCO) databases were searched from inception to October 10, 2024. A study was eligible if the number of rugby injuries per exposure time for backs and forwards was reported. Incidence rate ratios (IRRs) with 95% confidence intervals (CI) were compared between forwards and backs. After screening 1514 studies, a total of 49 studies were included. The total exposure time was 902 280 player‐hours for backs and 1 127 610 player‐hours for forwards. Forwards had a slightly higher incidence of injuries in Rugby Union (IRR 1.03, CI 1.00–1.06) and Rugby League (IRR 1.31, CI 1.23–1.41). However, forwards had a lower overall incidence of injuries in Rugby Sevens (pooled IRR 0.78, CI 0.73–0.85). Strain injuries and injuries caused by tackling, running, or collision were more common in backs across rugby formats. In addition to a more standardized definition of injuries and more comprehensive subgroup analyses in future studies, different trends and patterns in injury occurrence regarding playing positions in all rugby formats should be further studied to develop more targeted injury prevention strategies in forwards and backs.Trial Registration: The study protocol was prospectively registered in the PROSPERO database (CRD42025645250)","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"31 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of miR-455-5p Modulation on Enhancing Tendon-Bone Interface Healing and Macrophage Polarization Following Anterior Cruciate Ligament Reconstruction.","authors":"Rui Geng, Gang Liu, Wei Chen, Weibo Zhou, Yaojun Lu, Hao Wu, Wenwei Liang, Chunhui Zhu","doi":"10.1111/sms.70097","DOIUrl":"https://doi.org/10.1111/sms.70097","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) have emerged as key regulators in physiological and pathological processes, including tendon-bone healing after anterior cruciate ligament reconstruction (ACLR). This study identifies the upregulation of miR-455-5p in tendon-bone interface tissues during early postoperative periods. Using a mouse ACLR model, we explored the impact of miR-455-5p inhibition on macrophage polarization and tendon-bone healing. Our in vitro and in vivo investigations demonstrate that blocking miR-455-5p promotes M2 macrophage polarization and anti-inflammatory cytokine production. Mice treated with miR-455-5p inhibitor exhibited enhanced bone formation, mature interface tissue, and superior mechanical properties. This study attributes the therapeutic benefits to miR-455-5p's interaction with the suppressor of cytokine signaling 3 (SOCS3), influencing the JAK2/STAT3 signaling pathway. These insights advance the understanding of miRNA-mediated regulation in ACLR recovery, highlighting potential therapeutic targets for improving post-surgical outcomes.</p>","PeriodicalId":21466,"journal":{"name":"Scandinavian Journal of Medicine & Science in Sports","volume":"35 7","pages":"e70097"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}