Bioinformatics and Biomedical Research Journal最新文献_第2页

The Art of Mesenchymal Stem Cells in Liver Fibrosis Management 间充质干细胞在肝纤维化治疗中的应用

Bioinformatics and Biomedical Research Journal Pub Date : 2021-07-01 DOI: 10.11594/bbrj.03.02.03

Farid Amansyah, Dito Anurogo

引用次数: 0

The Role of Phytochelatin Synthase in Phytoremediation Agent: Structural Conservation of Phytochelatin (PC) Synthase to Maintain Its Activity as Heavy Metal Detoxification in Plant 植物螯合素合成酶在植物修复中的作用:植物螯合素合成酶的结构保护以维持其在植物体内重金属脱毒的活性

Bioinformatics and Biomedical Research Journal Pub Date : 2020-12-22 DOI: 10.11594/bbrj.03.02.02

V. Vidayanti, G. Permatasari

{"title":"The Role of Phytochelatin Synthase in Phytoremediation Agent: Structural Conservation of Phytochelatin (PC) Synthase to Maintain Its Activity as Heavy Metal Detoxification in Plant","authors":"V. Vidayanti, G. Permatasari","doi":"10.11594/bbrj.03.02.02","DOIUrl":"https://doi.org/10.11594/bbrj.03.02.02","url":null,"abstract":"Phytochelatin (PC) Enzyme has crucial role in heavy metal detoxification and homeostasis in plants. This study aimed to evaluate the genetic variation of PC synthase related to its activity based on structural comparison. We evaluated PC genes and protein sequences from 6 plants namely, Brassicasp., Amaranthussp., Noccaeasp., Arabidopsissp., Nicotianasp., and Pterissp. All sequences were aligned based on CLUSTALW matrix for DN sequences and MUSCLE algorithm for protein sequences. Data were clustered using MEGA Software for similarity clustering. Selected data were further modeled using SWISSMODEL to evaluate the 3D-structural analysis based on homology modeling. Thus, all protein models were superimposed and evaluated the structure comparison based on RMSD data. The result showed that genetic variation of PC gene is high among species. But it is clustered for the same species has similar sequence. In addition, protein sequences also showed the high diversity among species and it is still clustered basedon their genus. RMSD data showed that PC synthase from 6 plant has similar structure and tend to conserved even there is genetic variation or amino acid modification. We concluded that structural of PC gene is more conserved than its sequences. It is important to keep its function among species.","PeriodicalId":214181,"journal":{"name":"Bioinformatics and Biomedical Research Journal","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131426012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlation Between Education Level, Knowledge and Motivation in Volunteer Performance: a Post-Study on Action Research in Developing Educator Volunteers for COVID-19 Based on community empowerment using a tiered and online platform in Indonesia 教育水平、知识和动机与志愿者表现的相关性:基于社区赋权的印尼分层在线平台教育工作者志愿者应对COVID-19行动研究的后研究

Bioinformatics and Biomedical Research Journal Pub Date : 2020-12-20 DOI: 10.11594/bbrj.03.02.01

Siti Khuzaiyah, Nur Izzah Priyogo, Gigih Setianto

{"title":"The Correlation Between Education Level, Knowledge and Motivation in Volunteer Performance: a Post-Study on Action Research in Developing Educator Volunteers for COVID-19 Based on community empowerment using a tiered and online platform in Indonesia","authors":"Siti Khuzaiyah, Nur Izzah Priyogo, Gigih Setianto","doi":"10.11594/bbrj.03.02.01","DOIUrl":"https://doi.org/10.11594/bbrj.03.02.01","url":null,"abstract":"COVID-19 infection is spreading globally, including in Indonesia. The corona-virus transmits so quickly; there is panic in the community to avoid transmission. Stakeholders could develop educator volunteers based on community empowerment to increase public knowledge so that they can prevent transmission of the Corona Virus. Aims. This study aimed to determine the correlation between education level, knowledge and motivation in volunteer performance after training on developing educator volunteers of COVID-19. Methods. This study was action research with a post-test evaluation approach The population in this study were 250 educator volunteers of COVID-19. The sampling technique used a Slovin formula with the total sample was 50 people. The data were analyzed using the Pearson chi-square test and Spearman rank. Results. There was a significant correlation between motivation for volunteer performance (p-value 0.014). Meanwhile, the education and knowledge variables did not have a substantial correlation on volunteer performance with p-value 0.917 and 0.243, respectively. Conclusions. Mental and material support from Muhammadiyah Board (as the leader) are needed for volunteers so that they are motivated to carry out their roles as educator volunteers of COVID-19.","PeriodicalId":214181,"journal":{"name":"Bioinformatics and Biomedical Research Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132766447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Medication Error Factors, Safety Guideline System, Flow of Drug Usage, and Code of Conduct to Prevent Medication Error 用药差错因素、用药安全指南体系、用药流程与预防用药差错行为规范

Bioinformatics and Biomedical Research Journal Pub Date : 2018-06-06 DOI: 10.11594/bbrj.01.02.01

Arvidareyna Panca, N. Fitriasari, Wiwik Supartiwi

{"title":"Medication Error Factors, Safety Guideline System, Flow of Drug Usage, and Code of Conduct to Prevent Medication Error","authors":"Arvidareyna Panca, N. Fitriasari, Wiwik Supartiwi","doi":"10.11594/bbrj.01.02.01","DOIUrl":"https://doi.org/10.11594/bbrj.01.02.01","url":null,"abstract":"Medication error is any preventable event that may lead inappropriate drug service or patient harm while the drug administration is in control of the healthcare professional or patient. This study aimed to analyze the factor that may lead the medication error and identify the medication error solution to pharmaceutical installation in research hospital, Indonesia. This study used an action research method. The research subject included doctor, pharmacist, pharmaceutical engineering personnel and nurses. Action research involves six process: diagnosis, reconnaissance, action plan, action, evaluation and monitoring the subject. Diagnosis were obtained from primary and secondary data. Primary data were obtained by interview, observation, and Focus Group Discussion (FGD). Secondary data were obtained from adverse event and near-miss events in medication error data in pharmacy installation. The results indicated that there were four major factor of medication error. First, prescribing error is an unclear written prescription, incomplete administration and unavailable prescription. Second, transcribe error is a misread of prescription drug that lead to mistreatment. Third, dispensing error is involved the misreading of prescription drug by pharmacist, wrong dose, wrong quantity of drugs, and incompetent pharmacist personnel. Fourth, administration error is an incorrect administration by hospital personnel. In conclusion, the establishment of safety guideline is important to medication error in pharmaceutical installation. The safety guidelines consist of the policy and standard operational procedure, flowchart of outpatient service, code of conduct of pharmacy safety and monitoring to ensure the quality of medical service.","PeriodicalId":214181,"journal":{"name":"Bioinformatics and Biomedical Research Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128540491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6