Revista de psiquiatria y salud mental最新文献_第3页

Clinical symptoms and social functioning in schizophrenia 精神分裂症的临床症状和社会功能

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2020.05.009

Maria Jose Escandell , Gemma Prat , Mar Garcia-Franco , Jose Ramón Martín-Martínez , Susana Ochoa , Ingrid Tortades , Sonia Vilamala , Marina Verdaguer-Rodríguez , Emma Casas-Anguera

{"title":"Clinical symptoms and social functioning in schizophrenia","authors":"Maria Jose Escandell , Gemma Prat , Mar Garcia-Franco , Jose Ramón Martín-Martínez , Susana Ochoa , Ingrid Tortades , Sonia Vilamala , Marina Verdaguer-Rodríguez , Emma Casas-Anguera","doi":"10.1016/j.rpsm.2020.05.009","DOIUrl":"10.1016/j.rpsm.2020.05.009","url":null,"abstract":"<div><h3>Introduction</h3><p>The aim of the present study was to assess the relationship between social functioning and clinical symptoms in people with schizophrenia, analyzing the influence of both global social functioning and the specific aspects of social functioning, assertiveness and communication skills in the explanation of type of symptoms.</p></div><div><h3>Material and methods</h3><p><span>A cross-sectional descriptive study composed of 125 people diagnosed with schizophrenia was performed. Patients were assessed with the Communication Skills Questionnaire (CSQ), the Gambrill and Richey Assertiveness Inventory (GR), the Global Assessment of Functioning Scale (GAF) and the Global Assessment of Social Functioning Scale (SOFAS), Social Functioning Scale (SFS), Life Skills Profile (LSP) scale and the </span>Clinical Global Impression scale for Schizophrenia (CGI-S).</p></div><div><h3>Results</h3><p>SOFAS, LSP and GR are related to each of the subscales and total scores of symptoms (<em>p</em>  <!-->0.05–0.001). The multiple regressions show that SOFAS and GR explained 59% of the total symptoms. SOFAS and GR, accounting for 65% of the variance, explain positive symptoms. GR and SOFAS explained 34% of the variance of negative symptoms. SOFAS, CSQ and LSP, accounting for 20% of the variance, explain depressive symptoms. SOFAS explained 46% of the variance of cognitive symptoms.</p></div><div><h3>Conclusions</h3><p>Our findings suggest the usefulness of social functioning assessment in the explanation of clinical symptoms in people with schizophrenia. Moreover, our results point out that not only negative and cognitive symptoms, but also positive and depressive symptoms, should be taken into account in the rehabilitation process in order to improve patient adaptation in the community.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 4","pages":"Pages 251-258"},"PeriodicalIF":9.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38185057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valproate, obesity and other causes of clozapine poor metabolism in the context of rapid titration may explain clozapine-induced myocarditis: A re-analysis of a Turkish case series 丙戊酸盐、肥胖和其他氯氮平代谢不良的原因在快速滴定的背景下可以解释氯氮平诱导的心肌炎:对土耳其病例系列的重新分析

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2021.10.003

Aygün Ertuğrul , A. Elif Anıl Yağcıoğlu , Esen Ağaoğlu , Ahmet Alp Karakaşlı , Sertaç Ak , M. Kâzım Yazıcı , Jose de Leon

{"title":"Valproate, obesity and other causes of clozapine poor metabolism in the context of rapid titration may explain clozapine-induced myocarditis: A re-analysis of a Turkish case series","authors":"Aygün Ertuğrul , A. Elif Anıl Yağcıoğlu , Esen Ağaoğlu , Ahmet Alp Karakaşlı , Sertaç Ak , M. Kâzım Yazıcı , Jose de Leon","doi":"10.1016/j.rpsm.2021.10.003","DOIUrl":"10.1016/j.rpsm.2021.10.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Clozapine-induced myocarditis or any clozapine-induced inflammation may be a hypersensitivity reaction due to titration that was too rapid for the patient's clozapine metabolism. Clozapine metabolism is influenced by ancestry, sex, smoking and the presence of confounders including obesity, infections, and inhibitors (e.g., valproate) causing the patient to behave as a clozapine poor metabolizer (PM). A published study in a Turkish hospital identified 1 case of clozapine-induced pancreatitis and hepatitis and 9 cases of clozapine-induced myocarditis. To explore the hypothesis that the 10 patients were clozapine PMs, their serum clozapine concentrations were investigated using concentration-to-dose (C/D) ratios and their titrations carefully reviewed.</p></div><div><h3>Methods</h3><p>Dividing the trough serum concentration by the dose produces the clozapine C/D ratio. The dose required to reach 350ng/ml was considered the minimum therapeutic dosage and was used to classify patients according to clozapine PM status. Titration speed was assessed.</p></div><div><h3>Results</h3><p>All 10 patients were possibly clozapine PMs (3 of them had as minimum therapeutic doses: 72, 82 or 83mg/day). Nine of the 10 patients may have behaved as clozapine PMs due to obesity and/or valproate co-prescription during titration. One also had an undiagnosed infection. Of the 10 patients, 9 had at least 1 of 3 factors: too-rapid titration in the first or second weeks, or a final dosage that was too high.</p></div><div><h3>Conclusions</h3><p>Future studies using clozapine levels and considering the role of clozapine PM status should explore whether or not all cases of clozapine-induced inflammation could be explained by lack of individualized titration.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 4","pages":"Pages 281-286"},"PeriodicalIF":9.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73953733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A Covid-19 outbreak in a Spanish long-term psychiatric hospital led to infections in 6 clozapine patients: elevations in their plasma clozapine levels 西班牙一家长期精神病院爆发的Covid-19疫情导致6名氯氮平患者感染:血浆氯氮平水平升高

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2022.06.001

Manuel Arrojo-Romero , Maria Rosario Codesido-Barcala , Jose de Leon

引用次数: 10

Different measures for auditory hallucinations in populations with psychosis. The Validation of the Spanish versions of the Auditory Vocal Hallucination Rating Scale (AVHRS) and the Positive and Useful Voices Inquiry (PUVI) 精神病人群中不同的幻听测量方法。西班牙语版听觉幻听评定量表(AVHRS)和积极有用声音问卷(PUVI)的验证

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2020.03.002

Esther Lorente-Rovira , Eva Grasa , Susana Ochoa , Iluminada Corripio , Trinidad Peláez , Raquel López-Carrilero , Ángela Gutiérrez-Gea , María Morano-Guillén , José M. Villagrán , Agna A. Bartels-Velthuis , Jack A. Jenner , Julio Sanjuán

{"title":"Different measures for auditory hallucinations in populations with psychosis. The Validation of the Spanish versions of the Auditory Vocal Hallucination Rating Scale (AVHRS) and the Positive and Useful Voices Inquiry (PUVI)","authors":"Esther Lorente-Rovira , Eva Grasa , Susana Ochoa , Iluminada Corripio , Trinidad Peláez , Raquel López-Carrilero , Ángela Gutiérrez-Gea , María Morano-Guillén , José M. Villagrán , Agna A. Bartels-Velthuis , Jack A. Jenner , Julio Sanjuán","doi":"10.1016/j.rpsm.2020.03.002","DOIUrl":"10.1016/j.rpsm.2020.03.002","url":null,"abstract":"<div><h3>Introduction</h3><p>An updated summary of the most used instruments assessing auditory hallucinations in population with psychosis, allows us to underline the scarceness and need of Spanish versions of important instruments. The aim of the study is to examine the psychometric characteristics of two different and complementary instruments for assessing auditory hallucinations, the Spanish version of the Auditory Vocal Hallucination Scale (AVHRS) and the Spanish version of the Positive and Useful Voices Inquiry (PUVI).</p></div><div><h3>Materials and methods</h3><p>A sample of 68 patients from four different centres, with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder presenting with auditory hallucinations were included. Apart from the AVHRS and the PUVI, the Psychotic Symptom Rating Scales-Auditory Hallucinations subscale (PSYRATS-AH) and the Positive and Negative Syndrome Scale (PANSS) were also administered to all patients, plus an acceptability questionnaire.</p></div><div><h3>Results</h3><p>The Spanish version of the AVHRS showed a good internal consistency, a moderate to high inter-rater reliability, a medium to moderate test–retest reliability, and a good convergent and discriminant validity. The Spanish version of the PUVI showed a good internal consistency and a heterogeneous, but in general moderate, test–retest reliability.</p></div><div><h3>Conclusions</h3><p>The Spanish versions of the AVHRS and the PUVI have good psychometric properties and are well accepted among patients.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 4","pages":"Pages 259-271"},"PeriodicalIF":9.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38006396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clozapine-induced myocarditis in Russia: Animal studies but no clinical studies 氯氮平引起的心肌炎在俄罗斯:动物研究但没有临床研究

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2021.09.001

Oleg O. Kirilochev , Carlos De las Cuevas , Jose de Leon

引用次数: 2

Here we go again! Subtyping diagnosis and refining treatments 又来了!分型诊断和细化治疗

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2022.11.001

Javier Vázquez-Bourgon

引用次数: 0

A clozapine's uncharted voyage: Five years and a pandemic after the end of mandatory haematological notifications to the Spanish medicines agency 氯氮平的未知航程:西班牙药品管理局强制血液学通报结束后的五年和大流行

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-10-01 DOI: 10.1016/j.rpsm.2022.04.001

Pilar Andres-Olivera , Concha Turrion , Emilio Fernandez-Egea , Jesus Perez

引用次数: 1

Validación y adaptación española de la Escala de Actitudes Estigmatizadoras hacia la Salud Mental entre Iguales (Peer Mental Health Stigmatization Scale, PMHSS-24) 同伴心理健康污名化量表(PMHSS-24)的西班牙验证和适应

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-07-01 DOI: 10.1016/j.rpsm.2020.06.004

Jesús de la Higuera-Romero , Andrea Candelas-Muñoz , Andrea Jiménez-González , Cristina Castañeda-Jiménez , Paula Fuica-Pereg , María Zurita-Carrasco , Eloísa Martínez-Fernandez-Repeto , Cristina Senín-Calderón

{"title":"Validación y adaptación española de la Escala de Actitudes Estigmatizadoras hacia la Salud Mental entre Iguales (Peer Mental Health Stigmatization Scale, PMHSS-24)","authors":"Jesús de la Higuera-Romero , Andrea Candelas-Muñoz , Andrea Jiménez-González , Cristina Castañeda-Jiménez , Paula Fuica-Pereg , María Zurita-Carrasco , Eloísa Martínez-Fernandez-Repeto , Cristina Senín-Calderón","doi":"10.1016/j.rpsm.2020.06.004","DOIUrl":"10.1016/j.rpsm.2020.06.004","url":null,"abstract":"<div><h3>Introduction</h3><p>There is currently a growing interest in interventions aimed at the reduction of stigma towards people with emotional difficulties in adolescents. Unfortunately, the number of scales available in Spanish to assess stigma at these ages is limited. This paper aims to adapt and validate the scale of stigmatizing attitudes towards mental health among peers (Peer Mental Health Stigmatization Scale PMHSS-24).</p></div><div><h3>Material and methods</h3><p>A total of 443 adolescents (46.6% female and 53.7% male) between 13 and 17 years of age participated (<em>M</em><sub>age</sub>  =.83) in the 3rd and 4th grades of Obligatory Secondary Education. The internal consistency of the test was calculated, an exploratory factorial analysis (EFA) was performed with half of the sample and a confirmatory one (CFA) with the other half, and the invariance of measurement of the scale through sex was found.</p></div><div><h3>Results</h3><p>The EFA showed a two-factor structure for the negative scale (53% of the variance explained) and another 2for the positive scale (62% of the variance explained). The CFA corroborated the factor structure with appropriate goodness-of-fit indicators (CFI>.95; NNFI>.95, SRMR<.08, RMSEA<.08). Factor loads ranged from .49 to .89, with α factor correlation between <em>r</em>=.53 and .45. Both subscales exhibited optimal alpha values (negative .94 and positive .81). The scale was invariant between the sexes.</p></div><div><h3>Conclusions</h3><p>The data suggest that PMHSS-24 may be a useful scale for the initial screening of the stereotypes exhibited by adolescents toward people with mental illness.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 3","pages":"Pages 176-184"},"PeriodicalIF":9.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38198560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pedro Enrique Muñoz Rodríguez: un psiquiatra social en tiempos de confusión 佩德罗·恩里克munoz rodriguez:混乱时期的社会精神病学家

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-07-01 DOI: 10.1016/j.rpsm.2022.05.007

Luis Salvador-Carulla , Antonio Bulbena Vilarrasa

引用次数: 0

Comparación de la discapacidad entre trastornos mentales graves y comunes usando la escala WHODAS 2.0 使用WHODAS 2.0量表比较严重和常见精神障碍的残疾情况

IF 9.2 3区医学

Revista de psiquiatria y salud mental Pub Date : 2022-07-01 DOI: 10.1016/j.rpsm.2021.08.004

Elena Hernando-Merino , Enrique Baca-Garcia , Maria Luisa Barrigón

{"title":"Comparación de la discapacidad entre trastornos mentales graves y comunes usando la escala WHODAS 2.0","authors":"Elena Hernando-Merino , Enrique Baca-Garcia , Maria Luisa Barrigón","doi":"10.1016/j.rpsm.2021.08.004","DOIUrl":"10.1016/j.rpsm.2021.08.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Mental disorders are among the leading causes of disability worldwide. Despite the fact that severe mental disorders (SMD) are associated with high disability, the impact of common mental disorders (CMD) is not negligible. In this work, we compare the disability measured with the WHODAS 2.0 scale of both diagnostic groups at the Mental Health Nurse facility.</p></div><div><h3>Material and methods</h3><p>Sociodemographic data, clinical diagnosis and disability scores were collected, using the WHODAS 2.0 scale, of the patients attended by the Mental Health specialist nurse at the Infanta Elena de Valdemoro Hospital (Madrid) and disability was compared in patients with SMD and CMD, using the Student <em>t</em> test.</p></div><div><h3>Results</h3><p>Our study sample consisted of 133 patients. Patients with CMD showed greater disability compared to patients with SMD. It was observed that the disability associated with CMD is higher, compared to SMD, this difference being significant for the domain of work (<em>p</em>  =0.041).</p></div><div><h3>Conclusions</h3><p>In this study we showed that the level of disability associated with CMD was higher in certain areas compared to SMD, this difference was of special relevance for the «Work» and «Participation» domains. This may serve to adapt the interventions aimed at these people and improve their quality of life.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 3","pages":"Pages 205-210"},"PeriodicalIF":9.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39446441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4