Schizophrenia Bulletin Open最新文献

{"title":"The association of antipsychotic postponement with 5-year outcomes of adolescent first-episode psychosis","authors":"Tomi Bergström, Tapio Gauffin","doi":"10.1093/schizbullopen/sgad032","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgad032","url":null,"abstract":"Abstract Background and Hypothesis Based on the need-adapted approach, delaying antipsychotics could help identify first-episode psychosis adolescents who might not require them. However, some individuals might need antipsychotics, and postponing could harm their prognosis. This nationwide register-based follow-up aimed to test these two hypotheses. Study Design All adolescents aged 13-20 with a psychotic disorder (ICD-10 codes: F20-F29) in Finland between 2003-2013 were identified (n=6,354) from national registers. For each case, a fixed 1825-day follow-up period was established from the onset of psychosis or until death. The outcome was considered \"good\" if adolescents did not die and had not received psychiatric treatment and/or disability allowances during the final year of follow-up. Testing the first hypothesis involved all antipsychotic treatment-naïve adolescents with first-episode psychosis (n=3714). The second hypothesis was tested with a sub-sample of only those who had received antipsychotics during follow-up (n=3258). To account for baseline confounders, hypotheses were tested via a stabilized inverse probability of treatment weighted generalized linear models with logit link function. Study Results Immediate antipsychotic treatment after the onset of psychosis was associated with poor five-year outcome (adjusted odds ratio [aOR]: 1.8, 95% CI: 1.6-2.1). There was no statistically significant association between antipsychotic postponement and treatment outcome in those who eventually received antipsychotic treatment (aOR: 1.02, 95%CI: 0.7-1.2, p: 0.8), thus not providing support for second hypothesis. Conclusions There is a significant subgroup of adolescent with psychosis who do not require immediate antipsychotic treatment. A more robust design is needed to evaluate the causality of the observed association.","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Trauma in Clozapine-Resistant Schizophrenia:Prevalence, and relationship with symptoms","authors":"Robert Dudley, Douglas Turkington, Naomi Coulthard, Melissa Pyle, Andrew Gumley, Matthias Schwannauer, David Kingdon, Anthony P Morrison","doi":"10.1093/schizbullopen/sgad030","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgad030","url":null,"abstract":"Abstract Background and hypothesis The role of early adversity and trauma is increasingly recognized in psychosis but treatments for trauma and its consequences are lacking. Psychological treatments need to understand the prevalence of these experiences, the relationship with specific symptoms and identify potentially tractable processes that may be targeted in therapy. It was hypothesized that greater adversity, and specifically abuse rather than neglect, would be associated with positive symptoms and specifically hallucinations. In addition, negative beliefs would mediate the relationship with positive symptoms. Study Design 292 patients with treatment resistant psychosis completed measures of early adversity as well as current symptoms of psychosis. Study Results Early adversity in the form of abuse and neglect were common in one third of the sample. Adversity was associated with higher levels of psychotic symptoms generally, and more so with positive rather than negative symptoms. Abuse rather than neglect was associated with positive but not with negative symptoms. Abuse rather than neglect was associated with hallucinations but not delusions. Abuse and neglect were related to negative beliefs about the self and negative beliefs about others. Mediation demonstrated a general relationship with adversity, negative self and other views and overall psychotic symptoms but not in relation to the specific experience of abuse and hallucinations. Females were more likely to be abused, but not neglected, than males. Conclusions Whilst most relationships were modest, they supported previous work indicating that adversity contributes to people with psychosis experiencing distressing symptoms especially hallucinations. Treatments need to address and target adversity.","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"52 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Smartphones to Identify Momentary Characteristics of Persecutory Ideation Associated With Functional Disability.","authors":"Benjamin Buck, Mary Wingerson, Justin S Tauscher, Matthew Enkema, Weichen Wang, Andrew T Campbell, Dror Ben-Zeev","doi":"10.1093/schizbullopen/sgad021","DOIUrl":"10.1093/schizbullopen/sgad021","url":null,"abstract":"<p><strong>Objectives: </strong>Though often a feature of schizophrenia-spectrum disorders, persecutory ideation (PI) is also common in other psychiatric disorders as well as among individuals who are otherwise healthy. Emerging technologies allow for a more thorough understanding of the momentary phenomenological characteristics that determine whether PI leads to significant distress and dysfunction. This study aims to identify the momentary phenomenological features of PI associated with distress, dysfunction, and need for clinical care.</p><p><strong>Methods: </strong>A total of 231 individuals with at least moderate PI from 43 US states participated in a study involving 30 days of data collection using a smartphone data collection system combining ecological momentary assessment and passive sensors, wherein they reported on occurrence of PI as well as related appraisals, responses, and cooccurring states. Most (<i>N</i> = 120, 51.9%) participants reported never having received treatment for their PI, while 50 participants had received inpatient treatment (21.6%), and 60 (26.4%) had received outpatient care only.</p><p><strong>Results: </strong>Individuals with greater functional disability did not differ in PI frequency but were more likely at the moment to describe threats as important to them, to ruminate about those threats, to experience distress related to them, and to change their behavior in response. Groups based on treatment-seeking patterns largely did not differ in baseline measures or momentary phenomenology of PI as assessed by self-report or passive sensors.</p><p><strong>Conclusions: </strong>Smartphone data collection allows for granular assessment of PI-related phenomena. Functional disability is associated with differences in appraisals of and responses to PI at the moment.</p>","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"4 1","pages":"sgad021"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/0f/sgad021.PMC10439515.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10424324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive-Behavioral Social Skills Training: Outcome of a Randomized Controlled Trial for Youth at Risk of Psychosis.","authors":"Jean Addington, Lu Liu, Amy Braun, Kali Brummitt, Kristin S Cadenhead, Barbara A Cornblatt, Jason L Holden, Eric Granholm","doi":"10.1093/schizbullopen/sgad020","DOIUrl":"10.1093/schizbullopen/sgad020","url":null,"abstract":"<p><strong>Aim: </strong>Difficulties in social functioning have been observed in youth at clinical high-risk (CHR) of psychosis even in those who do not go on to develop a psychotic illness. Few treatment studies have attempted to improve social functioning in this population. The aim of this study was to conduct a randomized trial comparing the effects of Cognitive-Behavioral Social Skills Training (CBSST) with a supportive therapy (ST).</p><p><strong>Methods: </strong>Both CBSST and ST were weekly group therapies, delivered over 18 weeks. This was a 2-arm trial with single-blinded ratings and intention-to-treat analyses. Assessments occurred at baseline, end-of-treatment, and 12 months after the baseline assessment. The primary outcome was social and role functioning and defeatist performance attitudes were the secondary outcome. Attenuated positive and negative symptoms, anxiety, depression, self-efficacy, and beliefs about self and others were examined as exploratory outcomes.</p><p><strong>Results: </strong>There were no significant differences between the 2 groups at baseline or either of the 2 follow-ups. However, at follow-ups, in each group there were significant improvements in clinical symptoms. These could not be attributed to group treatment since there was no control or wait-list group.</p><p><strong>Conclusions: </strong>Since poor social functioning is one of the most observed difficulties in CHR individuals, and a decline in social functioning may be a significant predictor of later transition to psychosis, future work will be needed to find effective treatments for this decline in functioning for CHR youth.</p>","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"4 1","pages":"sgad020"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10405668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Specific Associations Between Childhood Victimization Profiles and Positive Psychosis Symptoms: The Mediating Roles of Anxiety, Depression, and Schema.","authors":"Georgina L Barnes, Richard Emsley, Philippa Garety, Amy Hardy","doi":"10.1093/schizbullopen/sgad017","DOIUrl":"10.1093/schizbullopen/sgad017","url":null,"abstract":"<p><strong>Background: </strong>Childhood trauma is a risk factor for psychosis. It is proposed this is due to traumatic events giving rise to psychological mechanisms that are implicated in the development and maintenance of symptoms. Investigation of the psychological mechanisms accounting for relationships between trauma and psychosis will be assisted by focusing on specific trauma profiles, hallucination modalities, and delusion subtypes.</p><p><strong>Study design: </strong>In 171 adults with schizophrenia-spectrum diagnoses and high-conviction delusions, associations between childhood trauma classes, and hallucination and delusion factors, were tested using structural equation models (SEMs). Anxiety, depression, and negative schema were examined as potential mediators of trauma class-psychosis symptom factor links.</p><p><strong>Study results: </strong>Significant associations were found between the emotional abuse/neglect and poly-victimization classes with persecutory delusions and delusions of influence, that were all mediated through anxiety (β = 1.24-0.23, <i>P</i> = < .05). There was an association between the physical abuse class and grandiose/religious delusions that was not explained by the mediators (β = 1.86, <i>P</i> = < .05). Trauma class was not significantly associated with any hallucination modality (β = 0.004-1.46, <i>P</i> = > .05).</p><p><strong>Conclusions: </strong>In a sample of people with strongly held delusions, this study demonstrates that childhood victimization is associated with delusions of influence and grandiose beliefs, as well as with persecutory delusions in psychosis. Consistent with previous findings, the potent, mediating role of anxiety supports affective pathway theories and the utility of targeting threat-related processes when treating trauma effects in psychosis.</p>","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"4 1","pages":"sgad017"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: Differences Based on Deficit Syndrome, Persistence, and Transition Status.","authors":"Tanya Tran, Michael J Spilka, Ian M Raugh, Gregory P Strauss, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Matcheri Keshavan, Daniel H Mathalon, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, William S Stone, Ming T Tsuang, Elaine F Walker, Scott W Woods, Jean M Addington","doi":"10.1093/schizbullopen/sgad014","DOIUrl":"10.1093/schizbullopen/sgad014","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Negative symptom trajectory in clinical high risk (CHR) for psychosis is ill defined. This study aimed to better characterize longitudinal patterns of change in negative symptoms, moderators of change, and differences in trajectories according to clinical subgroups. We hypothesized that negative symptom course will be nonlinear in CHR. Clinical subgroups known to be more severe variants of psychotic illness-deficit syndrome (DS), persistent negative syndrome (PNS), and acute psychosis onset-were expected to show more severe baseline symptoms, slower rates of change, and less stable rates of symptom resolution.</p><p><strong>Study design: </strong>Linear, curvilinear, and stepwise growth curve models, with and without moderators, were fitted to negative symptom ratings from the NAPLS-3 CHR dataset (<i>N</i> = 699) and within clinical subgroups.</p><p><strong>Study results: </strong>Negative symptoms followed a downward curvilinear trend, with marked improvement 0-6 months that subsequently stabilized (6-24 months), particularly among those with lower IQ and functioning. Clinical subgroups had higher baseline ratings, but distinct symptom courses; DS vs non-DS: more rapid initial improvement, similar stability of improvements; PNS vs non-PNS: similar rates of initial improvement and stability; transition vs no transition: slower rate of initial improvement, with greater stability of this rate.</p><p><strong>Conclusions: </strong>Continuous, frequent monitoring of negative symptoms in CHR is justified by 2 important study implications: (1) The initial 6 months of CHR program enrollment may be a key window for improving negative symptoms as less improvement is likely afterwards, (2) Early identification of clinical subgroups may inform distinct negative symptom trajectories and treatment needs.</p>","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"4 1","pages":"sgad014"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/06/sgad014.PMC10287168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review.","authors":"Jean Addington, Amanda Chao, Amy Braun, Madeline Miller, Megan S Farris","doi":"10.1093/schizbullopen/sgad006","DOIUrl":"10.1093/schizbullopen/sgad006","url":null,"abstract":"<p><p>A key issue in both research and clinical work with youth at clinical high risk (CHR) of psychosis is that there are clearly heterogenous clinical outcomes in addition to the development of psychosis. Thus, it is important to capture the psychopathologic outcomes of the CHR group and develop a core outcomes assessment set that may help in dissecting the heterogeneity and aid progress toward new treatments. In assessing psychopathology and often poor social and role functioning, we may be missing the important perspectives of the CHR individuals themselves. It is important to consider the perspectives of youth at CHR by using patient-reported outcome measures (PROMs). This systematic review of PROMs in CHR was conducted based on a comprehensive search of several databases and followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Sixty-four publications were included in the review examining PROMs for symptoms, functioning, quality of life, self-perceptions, stress, and resilience. Typically, PROMs were not the primary focus of the studies reviewed. The PROMs summarized here fit with results published elsewhere in the literature based on interviewer measures. However, very few of the measures used were validated for CHR or for youth. There are several recommendations for determining a core set of PROMs for use with CHR.</p>","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"4 1","pages":"sgad006"},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/fd/sgad006.PMC10069322.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9259205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of baseline anxiety on drug placebo separation and drug/placebo response in an acute schizophrenia clinical trial – a post hoc analysis","authors":"Alan Kott, Stephen Brannan, Xingmei Wang, David Daniel","doi":"10.1093/schizbullopen/sgad003","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgad003","url":null,"abstract":"Abstract Objective We sought to evaluate the impact of baseline anxiety levels on drug placebo separation and drug and placebo response in acutely psychotic schizophrenic subjects. Methods In this post-hoc analysis, modified intent-to-treat PANSS data were obtained from a phase 2, multi-center, 5 week, randomized, double-blind, placebo controlled trial of KarXT in hospitalized adults with DSM-5 schizophrenia experiencing an acute exacerbation or relapse of symptoms. We investigated the impact of anxiety on drug placebo separation and drug and placebo response in 2 ways. In the first set of analyses, we dichotomized the data based on the absence or presence of anxiety symptoms. In the second set of analyses, we categorized subjects by levels of anxiety. All analyses were conducted using generalized linear models with normal distribution and identity link function. Results On average, subjects entering the trial were suffering from a moderate level of anxiety. Subjects with no baseline anxiety had a significant increase in placebo response, a decrease in drug response and did not separate drug from placebo. With increasing levels of baseline anxiety, a larger drug placebo difference was observed. Discussion Our analyses identified that absence of anxiety at baseline was associated with a loss of signal at end of treatment between drug and placebo driven by a differential effect on placebo and treatment response. The effect observed was not related to the overall baseline symptom severity and was not mediated by improvement in anxiety itself. Interpretation of the results are caveated by the retrospective nature of the analyses.","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135694560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is the Prevalence of Visual Hallucinations in a First-Episode Psychosis Population? A Systematic Review and Meta-analysis of the Literature","authors":"Sophie Allen, Thomas Goodall, Chris Jones, Rachel James, Andrew Surtees","doi":"10.1093/schizbullopen/sgad002","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgad002","url":null,"abstract":"Abstract Background and Hypothesis This systematic review and meta-analysis review the literature regarding the prevalence of visual hallucinations in patients with first-episode psychosis. Previous reviews have focused on the prevalence of visual hallucinations in a general psychosis population, highlighting a weighted prevalence of 27%. However, no reviews have focused specifically on the experiences of those with a first episode of psychosis. Understanding “first-episode” experiences is crucial, as intervention during this “critical period” is thought to define long-term outcome. Therefore, it is important that the prevalence of different symptoms during this period is accurately represented. Study Design Systematic searches yielded 15 studies to be meta-analyzed. Information to calculate event rates was extracted. Studies were rated for their methodological quality using a risk of bias tool. The quality of included studies varied; generalizability bias was the domain with the most risk of bias. Study Results Prevalence rates were synthesized from the 15 papers included in the final analysis, which generated a weighted prevalence estimate of 33% of people with first-episode psychosis experiencing visual hallucinations. Subgroup analyses were carried out and did not demonstrate significant associations. Conclusions This meta-analysis provides a robust estimate of 33% for the prevalence of visual hallucinations in first-episode psychosis; highlighting that visual hallucinations are relatively common experiences.","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135077607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative impact of morphometric features in schizophrenia in two independent samples","authors":"Rosa Lee-Hughes, Thomas M Lancaster","doi":"10.1093/schizbullopen/sgad031","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgad031","url":null,"abstract":"Abstract Schizophrenia and bipolar disorder share a common structural brain alteration profile. However, there is considerable between- and within-diagnosis variability in these features, which may underestimate informative individual differences. Using a recently established morphometric risk score (MRS) approach, we aim to provide confirmation that individual MRS scores are higher in individuals with a psychosis diagnosis, helping to parse individual heterogeneity. Using the Human Connectome Project Early Psychosis (N = 124), we estimate MRS for psychosis and specifically for bipolar/schizophrenia using T1-weighted MRI data and prior meta-analysis effect sizes. We confirm associations in an independent replication sample (N = 69). We assess (1) the impact of diagnosis on these MRS, (2) compare effect sizes of MRS to all individual, cytoarchitecturally defined brain regions, and (3) perform negative control analyses to assess MRS specificity. The MRS specifically for SCZ was higher in the whole psychosis group (Cohen’s d = 0.56; P = 0.003) and outperformed any single region of interest in standardized mean difference (ZMRS&amp;gt;75 ROIS = 2.597; P = 0.009) and correlated with previously reported effect sizes (PSPIN/SHUFFLE &amp;lt; 0.005). MRS without Enhancing Neuroimaging Genomics through Meta-Analysis weights did not delineate groups with empirically null associations (t = 2.29; P = 0.02). We replicate MRS specifically for SCZ associations in the independent sample. Akin to polygenic risk scoring and individual allele effect sizes, these observations suggest that assessing the combined impact of regional structural alterations may be more informative than any single cytoarchitecturally constrained cortical region, where well-powered, meta-analytical samples are informative in the delineation of diagnosis and within psychosis case differences, in smaller independent samples.","PeriodicalId":21348,"journal":{"name":"Schizophrenia Bulletin Open","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135562750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}