RUDN Journal of Medicine最新文献

{"title":"Neuroprotective effect of extracellular vesicles obtained from human glial derivatives on the model of glutamate excitotoxicity","authors":"Margarita O. Shedenkova, Anastasia Guryanova, Anastasiia K. Sudina, Egor Guguchkin, Evgeny Karpulevich, Timur Fatkhudinov, Dmitry Goldshtein, Diana Salikhova","doi":"10.22363/2313-0245-2025-29-4-436-453","DOIUrl":"https://doi.org/10.22363/2313-0245-2025-29-4-436-453","url":null,"abstract":"Relevance. Modern research in the field of biomedicine leads to the development of therapeutic drugs based on extracellular vesicles, which are defined as sources of production, as well as targeted modification. In the presented work, for the first time, transcriptome profiling of primary culture of cortical neurons under the influence of extracellular vesicles obtained from glial cells during glutamate excitotoxicity was carried out in order to determine differentially expressed genes. Materials and Methods. Extracellular vesicles were obtained from the conditioned medium of human glial progenitor cells using ultracentrifugation. Model of glutamate excitotoxicity, distributed on the first cultured cortical neurons of cells (P0) with the addition of 100 μM glutamate. Sequencing of prepared libraries of electronic technologies on the NextSeq 1000 platform (Illumina, USA) using the NextSeq 1000/2000 P2 (200 cycles) v3 reagent kit supplemented with 2 % Phix (Illumina) as an internal control. The criterion for statistical innovation of gene expression change between officially recognized FDR 0.05. Results and Discussion. Transcriptome analysis showed that the addition of extracellular vesicles during glutamate excitotoxicity leads to increased expression of 190 genes and decreased expression of 309 genes (p value 0.05 and |FC| 1.5). Gene analysis using the Gene Onthology database showed that genes with increased expression are consistently classified by biological processes. The most represented were: regeneration, reorganization of the extracellular matrix and cytoskeleton, maintenance of homeostasis, activation of the PI3K-Akt pathway and response to cellular stress. Genes with reduced expression were consistently classified into groups: calcium transport, regulation of neuronal processes, apoptosis, glutathergic synapse. These data can indicate that. Extracellular vesicles trigger survival processes in nerve cells when exposed to glutamate and inhibit pathways associated with the entry of substances and glutamate into the cell. Conclusions. Extracellular vesicles enhance the expression of genes with survival and inhibit genes, resulting in calcium transport and apoptosis. The results of the study show the promise of using extracellular vesicles of glial origin as a basis for developing new therapeutic approaches to individual neurological diseases.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"29 4","pages":"436-453"},"PeriodicalIF":0.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spleen white pulp structural and cellular composition in experimental furosemide-­induced hypomagnesemia","authors":"M. Smetanina, N. Chuchkova, N. V. Kormilina, K. Pazinenko","doi":"10.22363/2313-0245-2024-28-1-114-122","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-114-122","url":null,"abstract":"Relevance. Magnesium deficiency in the blood (hypomagnesemia) is due to many reasons, among which loop diuretics (furosemide) occupy acertain place. The role of the spleen in this process has not been determined. The aim of the work was to elucidate the effect of furosemide-­induced hypomagnesemia on the immune structures of the white pulp of rat spleen. Materials and Methods. Furosemide (Lasix® Aventis Pharma Ltd, India) was injected daily intraperitoneally at adose of 30 mg/kg to the experimental group of white outbred rats for 6 days, animals of the control group received an injection of 0.9% NaCl. Investigated: blood serum for the content of magnesium, calcium, sodium and iron; serial sections of the white pulp of the spleen after staining with hematoxylin and eosin to assess the structure and azure-­II-eosin to assess the cellular composition. With amicroscope magnification of 280 times, the ratio (in%) of primary (PLNS) and secondary lymphoid nodules of the spleen (SLNS) was calculated, the following were measured (µm): the diameter of the germinal center (GC), the width of the mantle and marginal zone, the diameter of the periarteriolar lymphoid sheath (PALS). In GC, the peripheral zone of lymphoid nodules, PALS at amagnification of 1500 times per field of view (100 μm2) was counted and presented as apercentage of the number of lymphocytes; macrophages; cells, mitotic and apoptotic elements. Morphometric analysis was carried out using Image ProPlus6.0 software (Media Cybernetics, USA). Statistical processing was carried out using the Statistica 10.0 software package with the determination of the arithmetic mean (M) and its error (m). Results and Discussion. The administration of furosemide led to adecrease in magnesium in the blood serum by 1.6 times (p0.05). In the white pulp of the spleen of animals of the experimental group, the proportion of SLNS decreased by 18.14%, the number of SLNS increased by 42.5% (p0.05). The diameter of SLNS increased insignificantly, the diameter of GC and the width of the marginal zone significantly increased by 27.1 and 24.8%, respectively. The proportion of macrophages increased by 20.6% in GC SLNS, and by 17.0% in PALS. The highest increase in the proportion of cells with signs of apoptosis was found in the periarteriolar lymphoid sheath of experimental animals - 34.6% (p0.05). Conclusion. Furosemide loading causes the development of dyselementosis, with the most significant loss of magnesium (hypomagnesemia) and has apronounced effect on the immune parameters of the spleen, represented by white pulp structures. Therefore, correction of the elemental status and monitoring of the state of the spleen in hypomagnesemia caused by the use of loop diuretics is anecessary element in the prevention of complications associated with the use of diuretic drugs.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"91 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated approach to the diagnosis, treatment and prevention of caries in early and preschool age children","authors":"D.A. Simonenko, V. A. Zhurbenko, A. E. Karlash","doi":"10.22363/2313-0245-2024-28-1-23-34","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-23-34","url":null,"abstract":"Relevance. Dental caries, according to World Health Organization, is one of the most common diseases in children throughout the world. In the absence of timely diagnosis and treatment, the carious process can affect not only the efficiency of chewing function, but also speech, smile and, as a consequence, psychosocial adaptation, as well as the quality of life of the child and family. Despite the fact that the etiological factors have been well known for many years, reducing the number of teeth affected by caries in children still remains an urgent task. This article is a review of information sources about the prevalence, etiology and integrated approach to the diagnosis, treatment and prevention of dental caries in children. The authors analyzed scientific data in the search engines PubMed, Google Scholar and eLibrary. Conclusion . Based on the literature review, a number of modern trends were identified that define a series of key hypotheses that summarize the accumulated material and confirm the prospects and relevance of the problem. The goal is to help clinicians recognize common patterns of caries in children and make appropriate decisions regarding the diagnosis, treatment and prevention of carious lesions, taking into account available methods, materials, knowledge, age and patient history. It is also important to create a comfortable and safe environment during the appointment, as unfamiliarity with a new physical interaction can provoke anxiety as a standard response to uncertainty, which often results in childhood dental phobia, contributing to behavioral resistance to return visits. In general, based on the analysis, we can conclude that the use of an integrated approach to diagnosis and treatment has great potential for achieving better results in working with dental patients of early and preschool age, the development and improvement of which should remain a priority to ensure more complete and effective treatment of children and maintaining their health in the long term.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"13 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of neuromuscular block monitoring and hand grip strength assessment for patients undergoing emergency abdominal surgery","authors":"Neelam Dhunputh, M. V. Petrova, Victor V. Moroz, A. V. Butrov, Marat F. Magomedov","doi":"10.22363/2313-0245-2024-28-1-104-113","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-104-113","url":null,"abstract":"Relevance. The hand grip strength measurement together with neuromuscular block monitoring played an important role during surgery. They both helped in losing less time during surgery and also facilitate the task of the surgeon. The aim of this study was to reduce time on intubation, facilitate the task of the surgeon and to limit post-surgical pain. In rehabilitation, hand grip strength helps in determining further recuperation measures after asurgery. There are three fundamental principles for an anesthesiologist to ensure that the patient after combined endotracheal anesthesia can be extubated, the first one is to ask the patient to move his head forward, the second one is to ask the patient whether the intubation tube is disturbing him in his mouth and the third most important one is to make the patient hold his wrist very firmly. Materials and Methods. Monitoring of muscle relaxant on induction, intra and post-surgery is carried out using aTOF Watch SX in coordination with handgrip strength measurement on 46 patients aged from 18 to 60 years of BMI of 18-30 kg/m² 15min before endotracheal intubation and 15min, 45min and 210min post extubation by using adynamometer “MEGEON 34090” to help us understand whether after extubation muscle strength changes and to what extent. Also, pre-anesthesiology protocol, combined endotracheal protocol, Microsoft excel advanced, monitoring of hemodynamics, ECG, PEEP, PCO2, PO2, respiratory volume using Drager Fabius. Results and Discussion. The results showed that to reach deep muscle relaxation both atracurium benzilate (FKP Kursk Biofabric company, Kursk, Russia) at TOF 0 took 258.5± 83.5 secs and Cisatracurium benzilate (ZAO Obninsk Chemical pharmaceutical company, Obninsk, Russia) at TOF0-252.4±100.1 secs in emergency patients and basically hand grip strength also was lesser as compared to planned cholecystectomy patients. Conclusion. Rehabilitation was necessary for patients undergoing massive abdominal emergency surgeries underlying the fact that on apain scale 10/10 post surgery, further treatments should be implemented to reduce pain, reduce residual neuromuscular block and muscle weakness after extubation at TOF 90-95%.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"21 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techniques for conservative treatment of peri-implantitis","authors":"Lyubov A. Burlakova, A. Dymnikov","doi":"10.22363/2313-0245-2024-28-1-57-67","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-57-67","url":null,"abstract":"Relevance. Dental implants are widely used to restore the patient’s teeth. They have become aworthy alternative to removable dentures. With the accumulation of clinical experience, the indications for dental implantation expanded, and as aresult, the evaluation of long-term results became possible. In parallel with the expansion of clinical use of dental implants and the introduction of the technology into everyday practice, the experience of complications and errors accumulated, and from single publications in the 1990s, at the very beginning of development, to large-­scale studies in the 10s. And if in the early period of implantology development the success of treatment was mainly associated with implant survival, then modern research focuses on the state of tissues around the implant, and the influence of processes in them on the overall outcome of treatment. One of the main complications is inflammation of peri-implant tissues - peri-implantitis. Modern authors define peri-implantitis as an inflammatory process affecting the tissues around afunctionally integrated implant, resulting in loss of supporting bone. Continued bone loss around the implant can significantly impair implant stability and function. The authors review the scientific literature describing experimental conservative treatment protocols for peri-implantitis and attempts to achieve osseointegration. Conclusion. The reviewed literature advocated various methods of surgical regenerative treatment for peri-implantitis, including the use of bone substitutes, methods of detoxification of implant surfaces, and the administration of antimicrobial agents. There are many different protocols for the treatment of peri-implantitis; they all share the same goal of reducing disease progression and bone loss by eliminating bacterial infection. The controversy over the proper approach to treating peri-implantitis and restoring osseointegration clearly demonstrates the need for more research to answer this question.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"7 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of various adhesive systems’ bond strength for bracket placement","authors":"Hayan Almokaddam, N. Tuturov, I. Katbeh","doi":"10.22363/2313-0245-2024-28-1-35-45","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-35-45","url":null,"abstract":"Relevance . Today, the dental market offers a large selection of adhesive systems developed based on various concepts. Improving adhesive technology in orthodontic practice is aimed at simplifying methods of use, improving the composition and ability of adhesion of orthodontic elements to the tooth structure. The aim of this study is to compare the shear bonding strength of different generations of adhesive systems for metal brackets placement. Materials and Methods . The study sample consisted of 40 recently extracted human upper premolars. The premolars were divided into four groups 10 each. The first group used the bond Transbond XT 3M Unitek (USA), the second - Beauty Ortho Bond (Japan), the third - Tetric N bond Universal (Vivapen) (USA) with acid etching with phosphoric acid (LI), the fourth - Tetric N bond Universal (Vivapen) (USA) without acid etching with phosphoric acid. The study used metal brackets for upper premolars (Gemini Bracket MBT, 3M Unitek, USA) with a micro-patterned base, the area of which was defined as 10.61 mm2. Mechanical shear strength tests were carried out using the Instron Universal Test machine (USA). One-way analysis of variance and the TUKEY test were used to examine significant differences in adhesive strength and shear strength between study groups. Results and Discussion. The highest adhesive shear strength was established when using the Transbond XT adhesive system (12.28 MPa) and the Tetric N Bond Universal system using the total etching (12.66 MPa) and self-etching (11.44 MPa) techniques; statistically significant differences between these adhesives were not detected. The second group of Beauty Ortho Bond (5.34 MPa) demonstrated the lowest adhesion force among the studied adhesives, with a statistically significant difference from the other groups. Conclusion : This study concluded that there are no notable differences in the comparison of the universal system with or without etching with the Transbond system. Regarding the use of the beauty Ortho bond, it obtained the lowest strength with significant difference from the remaining groups.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"85 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the development of vulvar lichen sclerosus","authors":"Ekaterina V. Kolesnikova, A. V. Zharov, Lyudmila K. Osipova, Artem I. Dupleev","doi":"10.22363/2313-0245-2024-28-1-76-85","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-76-85","url":null,"abstract":"Relevance. The issue of timely diagnosis and treatment of vulvar lichen sclerosus has become especially acute in recent years due to the “rejuvenation” of the disease and the risk of its malignancy. In this regard, it is urgent to search for effective methods for predicting and early detection of the disease. The aim of the study - to develop amodel for predicting vulvar lichen sclerosus based on established clinical and anamnestic risk factors. Materials and Methods. The prospective case-control study included 404 women aged 20 to 70 years, of which 344 were patients with vulvar lichen sclerosus and 60 were women without vulvar diseases. At the first stage, acomparative statistical correlation analysis of the clinical and anamnestic data of the subjects was carried out using the Spearman correlation coefficient (R0.15), Chi-square tests, Phi and Cramer statistics, the Mann-­Whitney U test and the Student t test (p 0.05). The data obtained were used to develop aneural network model for predicting vulvar lichen sclerosus in the second stage of the study. Results and Discussion. Based on established reliably significant (p0.05) obstetric-­gynecological, somatic, infectious, hygienic and household factors influencing the risk of developing vulvar lichen sclerosus (Rindicator - from 0.16 to 0.38 confirms the statistical significance of correlations), aneural network model for predicting vulvar lichen sclerosus was developed (the percentage of correct classification on the test sample is the maximum possible value - 100%) and acomputer program was written that automates the procedure for predicting the disease. Conclusion. The neural network model for predicting the disease, developed on the basis of reliably (p0.05) significant risk factors for vulvar lichen sclerosus, has high prognostic properties, and acomputer program written on its basis allows the doctor in amatter of minutes to identify the patient at risk for the development of vulvar lichen sclerosus and give she needs preventive recommendations aimed at preventing or early detection of the disease.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"17 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of child behavior management in forming positive associations with the dentist","authors":"Karina N. Lupeychinkova, Daria S. Sorokina, V. A. Zhurbenko, A. E. Karlash","doi":"10.22363/2313-0245-2024-28-1-46-56","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-46-56","url":null,"abstract":"Relevance. The psychological adaptation of achild to adental appointment is of particular relevance today. This study analyzes the literature on the role of child behavior management in pediatric dentistry. The causes of dental fear, its manifestations and consequences are considered. Also, various methods of adaptation of the child and the results of studies evaluating the effectiveness of such methods are analyzed. The goal is to find out which ways of managing achild’s behavior are able to form positive associations with dentists as well as overcome anxiety and fear of treatment. Conclusion. The results of the literature analysis show that even the simplest methods of interaction with children are effective in reducing anxiety and fear before visiting adentist. In addition, working with parents and using various forms of interactive communication helps to create apositive atmosphere in the dental clinic and form apositive experience for children. In general, based on the analysis, it can be concluded that the control of the child’s behavior has great potential to achieve better results in the work of adentist. The development and improvement of methods of controlling the behavior of children in dentistry should remain apriority to ensure more complete and effective treatment, as well as maintaining their health in the long term.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"117 S15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic field application in bone tissue regeneration: issue current status and prospects for method development","authors":"A. Muraev, George G. Manukyan, K. Salekh, A. Bonartsev, A. V. Volkov","doi":"10.22363/2313-0245-2024-28-1-9-22","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-9-22","url":null,"abstract":"Relevance. Magnets have long been used to treat various diseases, especially in inflammatory processes. According to existing historical data, magnetotherapy was already used in ancient times by the Chinese, Egyptians and Greeks. Different magnetic field strengths affect cells in different ways, with medium-strength magnetic fields being the most widely used. The review presents a brief history and current state of the issue of using a magnetic field in bone tissue regeneration. Modern knowledge about the mechanisms of physiological and reparative regeneration, restoration of bone tissue is clarified, and modern areas of bone tissue engineering are considered, taking into account the characteristics of microcirculation and the effect of a magnetic field on the physiology of bone tissue and reparative regeneration. One of the key findings of the review is that the magnetic field improves bone tissue repair by influencing the metabolic behavior of cells. Studies show that magnetotherapy promotes the activation of cellular processes, accelerates the formation of new bone tissue and improves its quality. It is also noted that the magnetic field has a positive effect on microcirculation, improving the blood supply to tissues and facilitating a better supply of nutrients to the site of injury. This contributes to faster wound healing and early rehabilitation of patients. Conclusion. Magnetotherapy is one of the effective physical and rehabilitation methods of treatment that will become increasingly important in modern medicine. However, further research is needed to better understand the mechanisms of action of a magnetic field on bone tissue and to determine the optimal parameters for its application.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"16 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric, somatic and infectious risk factors for vulva sclerotic lichen","authors":"Lyudmila K. Osipova, Ekaterina V. Kolesnikova, A. V. Zharov, M. A. Penzhoyan","doi":"10.22363/2313-0245-2024-28-1-86-103","DOIUrl":"https://doi.org/10.22363/2313-0245-2024-28-1-86-103","url":null,"abstract":"Relevance. Until now, disputes among scientists about its etiology, pathogenesis, nomenclature and risk factors for the development of vulvar lichen sclerosis have not subsided, which actualizes the need for scientific research aimed at solving these problems. The aim of the study - to establish statistically significant clinical and anamnestic risk factors for vulvar lichen sclerosis. Materials and Methods. An electronic database was formed with data from 344 patients with lichen sclerosus of the vulva and 60 women without vulvar diseases aged 20-70 years on hereditary, obstetric-­gynecological, somatic and infectious history. Astatistical comparative correlation analysis of the obtained data was carried out using the Spearman correlation coefficient (R0.15), nonparametric Mann - Whitney U test and Student t test (p0.05), Chi-square tests, Phi and Cramer statistics. Results and Discussion. Statistically significant (p0.05) risk factors for the development of vulvar lichen sclerosus (R, in descending order) were established: the presence of fibrocystic mastopathy (-0.29); late menarche (15 years and older) (-0.28); onset of menopause (-0.25); recurrent vulvo-­vaginal infections (-0.18); recurrent bacterial vaginosis (-0.18); autoimmune thyroiditis(-0.16) and stage II obesity (-0.16). Also, the average number of abortions and births (1.23 and 1.49, respectively) in the group of patients with lichen sclerosis of the vulva is statistically significantly greater (p0.05) than the average value (0.27 and 1.13, respectively) in control group. Conclusion. The data obtained on the impact of obesity and autoimmune thyroiditis on the risk of developing vulvar sclerotic lichen are consistent with the results of global studies and confirm the association of the disease with autoimmune and metabolic disorders. Recurrent vulvo-­vaginal infections and dysbiotic processes in the vagina can be both acause and aconsequence of vulvar lichen. The relationship between fibrocystic mastopathy and vulvar lichen sclerosus remains debatable and requires further research. Late menarche, the onset of menopause, alarge number of abortions and childbirth can also be considered triggers for vulvar lichen sclerosus in patients with agenetic predisposition to the disease.","PeriodicalId":21324,"journal":{"name":"RUDN Journal of Medicine","volume":"21 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}