{"title":"[Physiopathology and management of chronic urticaria].","authors":"Johan Schwab, Florian Stehlin, Yannick D Muller","doi":"10.53738/REVMED.2025.21.912.642","DOIUrl":"10.53738/REVMED.2025.21.912.642","url":null,"abstract":"<p><p>Chronic urticaria manifests as itchy, transient and migrating wheals and/or angioedema lasting more than 6 weeks. It can be classified as spontaneous or inducible by physical factors. It is secondary to mast cell activation due to autoallergy (type I) or autoimmunity (type IIb). While the initial work-up consists essentially in evaluating the presence of biomarkers, it can be completed according to comorbidities and factors identified with history and physical examination. Second generation antihistamines up to four-times the standard dose are the cornerstone of the management. This initial management can be undertaken by primary care physicians. Specialists should be involved in the presence of physical factors, resistance to antihistamines, or atypical lesions.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"642-647"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julien Dereme, Maxime Ringwald, Grégoire Stalder, Camillo Ribi
{"title":"[Indolent systemic mastocytosis : an overview in 2025].","authors":"Julien Dereme, Maxime Ringwald, Grégoire Stalder, Camillo Ribi","doi":"10.53738/REVMED.2025.21.912.654","DOIUrl":"10.53738/REVMED.2025.21.912.654","url":null,"abstract":"<p><p>Mast cells (MC) play an important role in the defense against microbial agents, parasites and venoms. The term mastocytosis encompasses a group of diseases characterized by abnormal MC accumulation, divided into cutaneous and systemic forms. The diagnosis of indolent systemic mastocytosis (ISM) is supported by the presence of MC clusters in bone marrow and/or extracutaneous organs, elevated serum tryptase levels, altered expression of MC surface markers, and presence of an activating c-KIT mutation. Patients with ISM carry an increased risk of severe anaphylaxis, particularly to hymenoptera stings. Management of ISM includes symptomatic treatment, avoidance of triggering factors, desensitization and off-label omalizumab. Novel tyrosine kinase inhibitors targeting the mutated c-KIT are promising in refractory ISM and advanced mastocytosis.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"654-659"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Use of democratic tools on health issues in Switzerland].","authors":"Claire-Marie Schertz, Morgane Jotterand","doi":"10.53738/REVMED.2025.21.912.699","DOIUrl":"10.53738/REVMED.2025.21.912.699","url":null,"abstract":"<p><p>The Swiss institutional framework allows for the active participation of citizens in democratic life. However, its modalities deserve to be better known in order to be better mastered, in particular with a view to transmitting a scientific message to the political world. This article focuses on the various democratic tools and the evolution of their use over time on health issues, since the birth of modern Switzerland. It highlights the increase in the number of optional referendums and popular initiatives over the past 35 years on health topics, reflecting the concerns of the population. But for what effects? There are many avenues for reflection that are open.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"699-704"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Latest advances in diagnosis and therapy of giant cell arteritis (Horton's disease)].","authors":"Edwin Curraj, Camillo Ribi","doi":"10.53738/REVMED.2025.21.912.648","DOIUrl":"10.53738/REVMED.2025.21.912.648","url":null,"abstract":"<p><p>Giant cell arteritis (GCA, Horton's disease) is a subacute vasculitis of large-size arteries. GCA affects individuals above 50 years and its frequency increases with age. The key elements for diagnosis are clinical presentation, elevated inflammatory markers, imaging, and histology. Temporal artery biopsy is the gold standard for confirming GCA, but is gradually being replaced by non-invasive imaging techniques such as Doppler ultrasound and positron emission tomography. While corticosteroids remain the cornerstone of treatment, new therapies are helping to reduce their dosage and duration of use. In this review, the key aspects of diagnosing and treating GCA, based on the latest recommendations are discussed in this article.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"648-653"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Health Democracy: a national or cantonal issue in Switzerland ?]","authors":"Stéfanie Monod, Laurent Kurth","doi":"10.53738/REVMED.2025.21.912.688","DOIUrl":"10.53738/REVMED.2025.21.912.688","url":null,"abstract":"<p><p>Western health systems are facing unprecedented challenges related to an aging population and climate issues. While the need for care will grow significantly, our societies will have to arbitrate the allocation of both, financial and human resources. Choices will have to be made, making it essential for citizens and patients to participate strongly. In Switzerland, a federal state renowned for its direct democracy, we can ask ourselves at what political level these health democracy issues are situated. Is it primarily the federal or cantonal level? This article discusses, based on the analysis of the distribution of health competences between the Confederation and the canton, the complexity of the governance of the Swiss health system and the opportunities to strengthen this health democracy.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"688-693"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Faire du neuf avec du vieux.","authors":"Jörg D Seebach","doi":"10.53738/REVMED.2025.21.912.639","DOIUrl":"https://doi.org/10.53738/REVMED.2025.21.912.639","url":null,"abstract":"","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"639-640"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Démocratie sanitaire : des enjeux aussi pour le système de santé suisse.","authors":"Stéfanie Monod, Jacques Cornuz","doi":"10.53738/REVMED.2025.21.912.677","DOIUrl":"https://doi.org/10.53738/REVMED.2025.21.912.677","url":null,"abstract":"","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 912","pages":"677-678"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myriam Lamrayah, Soufiene Krifa, Mattéo Reymond, Antoine David, Alexandra Calmy, Laurence Toutous Trellu
{"title":"[Pharmaceutical challenges concerning Penicillin G : an example with the treatment of syphilis].","authors":"Myriam Lamrayah, Soufiene Krifa, Mattéo Reymond, Antoine David, Alexandra Calmy, Laurence Toutous Trellu","doi":"10.53738/REVMED.2025.21.911.587","DOIUrl":"https://doi.org/10.53738/REVMED.2025.21.911.587","url":null,"abstract":"<p><p>Discovered in the early 20th century, penicillin gained prominence during World War II, enabling the treatment of infections that were previously fatal. Now one of the most widely used families of antibiotics, penicillins and their derivatives are considered essential medications by the WHO, being the main reference for empirical treatment of respiratory infections or specific ones such as syphilis. Regular shortages of benzathine benzylpenicillin hinder the proper management of this sexually transmitted infection. Hospital pharmacies adapt to both local and international constraints. Here, the logistics set up by the pharmacy at HUG (Geneva University Hospitals) are illustrated to prevent any risk of supply disruptions, thanks to interprofessional collaboration.</p>","PeriodicalId":21286,"journal":{"name":"Revue medicale suisse","volume":"21 911","pages":"587-591"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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