Romanian Medical Journal最新文献

{"title":"Diagnostic and therapeutic particularities in a case of familial hypercholesterolemia secundary to a new mutation in the APOB gene","authors":"Cristian Minulescu, N. Petcu","doi":"10.37897/rmj.2022.1.5","DOIUrl":"https://doi.org/10.37897/rmj.2022.1.5","url":null,"abstract":"Throughout the hereby article I will detail the case of a five-years old patient diagnosed with a new form of familial hypercholesterolemia. This way we wish to highlight the importance of swift diagnosis of all forms of familial dyslipidaemia. A particularity of this pathology is the long amount of time when no symptoms are present, thus creating the false impression that it is a benign, and very well tolerated condition. Currently the incidence of familial dyslipidaemia is continuously increasing, posing a real public health issue, both due to the complications it displays, and the degree of disability it produces to the patients. That is why it is extremely important that the lipidic profile be included in the package of regular laboratory tests of the paediatric practice.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78953979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentists, members of the French Resistance movement during the World War II","authors":"S. Drafta, M. Burlibașa, V. Perieanu, Raluca Costea, O. Eftene, N. Măru, A. Ștețiu, M. Perieanu, M. V. Bucur, I. Beuran, M. Malița, M. Dina, ioana-Cristina neagoe, D. Bodnar, R. Costea, C. Ionescu","doi":"10.37897/rmj.2022.1.7","DOIUrl":"https://doi.org/10.37897/rmj.2022.1.7","url":null,"abstract":"The Resistance was a reaffirmation of France's independence and individuality, as well as a struggle to regain freedom and, above all, national integrity. In fact, many historians appreciate that the French Resistance could have achieved more if it had been more effectively integrated into Allied plans and strategies. Thus, in this material we tried to present some short biographies of dentists who worked in the French Resistance against the German occupation troops, some of them even paying with their lives for the courage they showed.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90726940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management of intestinal obstruction during pregnancy","authors":"Bogdan-Gabriel Maxim, B. Cimpoca-Raptis, A. Ciobanu, C. Gică, Mihaela Demetrian, G. Peltecu, R. Botezatu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.6","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.6","url":null,"abstract":"Acute intestinal obstruction in pregnancy is a rare, unusual, and very challenging non obstetric surgical pathology linked with great fetal-maternal morbidity and mortality. It is estimated that a surgeon may encounter and resolve 1 to 2 cases in his career. Bowel obstruction is difficult to diagnose because signs and symptoms such as pain, vomiting, abdominal distention, and constipation are frequently attributed to normal pregnancy. On the other hand, gravidity requires immediately, in case of suspicion of grave abdominal pathology, such as bowel obstruction, that surgery should not be delayed.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75741373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory bowel disease in pregnancy","authors":"D. Cudalbă, A. Ciobanu, C. Gică, Mihaela Demetrian, B. Cimpoca-Raptis, G. Peltecu, R. Botezatu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.15","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.15","url":null,"abstract":"Inflammatory bowel disease (IBD), with its two main forms, Crohn’s disease, and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. It is frequently diagnosed during childbearing years and its overlapping with pregnancy adds more complexity to the management of the disease. This review article aims to summarize what is acknowledged so far regarding IBD in pregnancy, providing up-to-date information. A systematic literature electronic search for journal articles and guidelines regarding IBD during pregnancy was undertaken. The most favorable pregnancy outcomes for pregnant women with IBD occur when the disease is in remission both at the time of conception and during the pregnancy. Most of IBD medication is considered safe during pregnancy and continuing therapy in pregnancy is fundamental for achieving optimal outcomes. Proper management of active IBD in pregnancy requires multidisciplinary care to lower adverse outcomes. There is insufficient knowledge among patients regarding how their pregnancy outcomes could be optimized.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79126176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urolithiasis – a challenge during pregnancy","authors":"Miliana Cretu, A. Ciobanu, C. Gică, Mihaela Demetrian, B. Cimpoca-Raptis, G. Peltecu, R. Botezatu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.18","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.18","url":null,"abstract":"Urolithiasis during pregnancy is a rare condition despite the prolithogenic state determined by the physiological changes in the urinary system. The incidence is similar among pregnant women and the general female population, pregnancy not being a risk factor for the appearance of kidney stones. Urolithiasis is a challenge for the obstetrician because diagnosis and treatment require a particular approach in order not to harm the fetus. Ultrasonography is the first choice for diagnosing kidney stones even though it has a reduced sensibility. The first line of treatment in renal colic is expectant management. If this is ineffective, then urological interventions are being taken into consideration. Left untreated, urolithiasis exposes the pregnancy and the baby to higher risks of complications.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80366330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer – a real medical challenge when diagnosed during pregnancy","authors":"T. Cioroba, R. Botezatu, A. Ciobanu, C. Gică, Mihaela Demetrian, B. Cimpoca-Raptis, G. Peltecu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.9","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.9","url":null,"abstract":"One of the most common malignancies diagnosed during pregnancy is cervical cancer. If a local examination and a Papsmear have not been done for screening, when some symptoms appear during pregnancy, they might be easily mistaken for pregnancy early related complaints. The treatment of cervical cancer during pregnancy should take into consideration many factors including the size of the tumor, lymph node involvement, gestational age, the wish of pregnancy continuation and fertility preservation. All these factors make the optimal treatment decision difficult to be taken and suggest that a multidisciplinary team including an obstetrician, neonatologist, medical oncologist, psychologist, pathologist, and radiologist, is necessary for the best management. This article reviews the existing studies, guidelines and recommendations regarding the diagnosis and management of cervical cancer during pregnancy.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80649120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing surgical complications after cesarean section: Vaginal birth after cesarean section. Identifying the ideal candidate","authors":"R. Botezatu, G. Peltecu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.21","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.21","url":null,"abstract":"Vaginal birth after cesarean section (VBAC) is worldwide accepted and encouraged. Currently, in Romania due to increased cesarean section rate especially for maternal request, a high number of patients with scarred uterus is seeking for VBAC at subsequent pregnancies. Because of specific complications of trial of labor after cesarean section (TOLAC), risks and benefits need to be individualized for each specific candidate. This study is about VBAC in Filantropia Clinical Hospital from Bucharest and how we are selecting the ideal candidate.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82024101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hernia and pregnancy: A symbiosis of two bumps","authors":"C. Mugescu, A. Ciobanu, C. Gică, Mihaela Demetrian, B. Cimpoca-Raptis, G. Peltecu, R. Botezatu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.7","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.7","url":null,"abstract":"One of the most common surgical entities, globally, is hernia. Even though it affects female population less often than men and its occurrence is rather exceptional during pregnancy, it must not be neglected, especially due to the difficulties in diagnosing this entity correctly in the gestation period. We conducted a review article based on data from 13 papers published between 2015 and 2021 which assessed the challenge of hernia diagnosis during pregnancy, available and recommended investigations for a proper diagnosis, potential complications that hernia might cause in pregnant patients, the appropriate treatment during pregnancy and the ideal moment for surgery, if necessary. It appears to be widely acknowledged that it is best to uphold surgical repair of hernia until after delivery. Nevertheless, there is no clinical guideline available on this matter and the existing studies are either case-reports or have used rather small group of patients, therefore future studies are of utmost necessity.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89676532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous hemoperitoneum in pregnancy","authors":"Ruxandra-Patricia Nitica, A. Ciobanu, C. Gică, Mihaela Demetrian, B. Cimpoca-Raptis, G. Peltecu, R. Botezatu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.5","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.5","url":null,"abstract":"Spontaneous hemoperitoneum in pregnancy (SHP) is an uncommon, but very critical complication when present in pregnancy, leading to important morbidity and mortality for both mother and fetus. The etiology includes a large spectrum of causes, not taking into consideration trauma or other pathologies not pregnancy related. One of the most frequent triggers is the rupture of the varicose veins around the uterus that can occur either spontaneously or during labor, that can be associated with the unfortunate event of delivery of a stillborn baby. Endometriosis has been suspected to be also implicated in the apparition of spontaneous hemoperitoneum in pregnant women due to the fragility of the tissues associated with endometriosis chronic inflammation (ruptured endometrioma, intraabdominal adhesions, decidualization at the site of endometriotic implants). Even the operative vaginal delivery can conduct to this complication, but the cases described in the literature were also associated with lesion of endometriosis at the bleeding site. Moreover, assisted reproductive procedures (IVF-ET) is incriminated as one of the possible etiologies. The improvements in the resuscitation, operative and anesthetic management of these cases have lowered the maternal mortality, but perinatal mortality still has a high value (31%). Symptoms as acute or subacute abdominal pain, that can be associated or not with hypovolemic shock and signs of fetal affliction, identified as heart decelerations, should raise a question mark regarding the possibility of a hemoperitoneum. Electronic research for subject related reviews and articles has been made, using PubMed, Medline, Cochrane Data Base and also the current international guidelines regarding the management of hemoperitoneum in pregnancy, recommended by Obstetrics and Gynecology Societies in United States and United Kingdom. Adequate case management as hematologic analysis, abdominal ultrasound, CT scan or MRI should reveal free intrabdominal fluid and estimate the blood loss, which can then be confirmed by paracentesis or by direct urgent laparotomy or laparoscopy. The aim of the current review is to raise awareness of this rare, but potentially fatal, complication in pregnancy and its most appropriate management, according to the current information presented in the medical literature.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78573857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leiomyomas in pregnancy","authors":"Ana Maria Huszti, A. Ciobanu, C. Gică, Mihaela Demetrian, B. Cimpoca-Raptis, G. Peltecu, R. Botezatu, N. Gică, A. Panaitescu","doi":"10.37897/rmj.2022.s2.8","DOIUrl":"https://doi.org/10.37897/rmj.2022.s2.8","url":null,"abstract":"Uterine fibroids are the most common benign tumors affecting female genital tract, responsible for a high morbidity across fertile age women, with a prevalence of 0,1-11% among pregnant women. Although generally asymptomatic, they can lead to a series of symptoms and complications such as pain, infertility, miscarriages, antenatal bleeding, postpartum hemorrhage, preterm labor, fetal malpresentation, placental abruptio and high cesarean section rates. The purpose of review is to update information regarding fibroids specifications and their correlation with pregnancy outcomes as well as fibroids management during pregnancy. Because of uterine fibroids heterogeneity and lack of large, randomized trials there are encountered discrepancies among studies, but it was observed that uterine fibroids increase the risks of negative obstetrical outcomes, especially when it goes to large, multiple, submucous and retroplacental myomas. Conservative management during pregnancy is advised, but in special situations myomectomy could be recommended and possible. Trial of labor should be offered to pregnant women even if they have large uterine fibroids, or previous myomectomy excepting fibroids obstructing the birth canal or patients who underwent extensive surgery for fibroids removal.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90954487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}