Revista Brasileira de Farmacognosia最新文献_第6页

Antithrombotic Activity of the Steroids and ent-Kaurane Diterpenoids from Canna indica Rhizomes 美人蕉根茎中甾体和对-考兰二萜的抗血栓活性研究

Revista Brasileira de Farmacognosia Pub Date : 2023-11-03 DOI: 10.1007/s43450-023-00472-w

Thi Van Anh Nguyen, Thi Minh Hang Nguyen, Hong Luyen Le, Duc Huy Bui

引用次数: 0

Evaluation of (–)-α-Bisabolol Toxicity in Drosophila melanogaster and Human Blood Peripheral Mononuclear and Red Cells (-)-α-双abolol对黑胃果蝇和人外周血单核细胞及红细胞的毒性评价

Revista Brasileira de Farmacognosia Pub Date : 2023-11-03 DOI: 10.1007/s43450-023-00473-9

Gerlânia de Oliveira Leite, Bruna Bayer Palma, Michele Rorato Sagrillo, Larissa Finger Schaffer, Israel Junio Martins dos Santos, Roselei Fachinetto, Caroline Wagner

引用次数: 0

Co-administration of Acarbose with Aqueous Extract of Root and Leaf of Sphenocentrum jollyanum Accelerates Wound Closure in Type 2 Diabetic Rats 阿卡波糖与黄芩根叶水提物共给药加速2型糖尿病大鼠伤口愈合

Revista Brasileira de Farmacognosia Pub Date : 2023-10-31 DOI: 10.1007/s43450-023-00475-7

Oluwakemi Adeleke, Stephen Adefegha, Ganiyu Oboh

引用次数: 0

Anxiolytic and Hypoglycemic Effect of Pectins from Galician Lemon Citrus Fruit on Adult Zebrafish (Danio rerio): An In Vivo and In Sílico Approach 加利西亚柠檬柑橘果胶对成年斑马鱼(Danio rerio)的抗焦虑和降血糖作用:体内和体内Sílico方法

Revista Brasileira de Farmacognosia Pub Date : 2023-10-30 DOI: 10.1007/s43450-023-00477-5

Amanda Maria Barros Alves, Sonia Maria Costa Siqueria, Nadia Aguiar Portela Pinheiro, Alissa Ellen Queiroz Ribeiro Campos, Jane Eire Silva Alencar de Menezes, Maria Kueirislene Amâncio Ferreira, Icaro Gusmão Pinto Vieira, Antonio Wlisses da Silva, Márcia Machado Marinho, Emmanuel Silva Marinho, Hélcio Silva dos Santos

引用次数: 0

Enhanced Bioactive Constituents and Improved AMPK and GLUT Dependent Glucose Uptake Effect of Thunbergia laurifolia Leaves by Calcium Chloride and Yeast Extract Elicitors in Postharvest Treatment 采后氯化钙和酵母浸出物激发剂增强了松子叶的生物活性成分，改善了AMPK和GLUT依赖的葡萄糖摄取效应

Revista Brasileira de Farmacognosia Pub Date : 2023-10-29 DOI: 10.1007/s43450-023-00468-6

Rattanathorn Choonong, Jakkrit Jabsanthia, Varinda Waewaram, Khunkhang Butdapheng, Waraporn Putalun

引用次数: 0

Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats 螺旋藻和百里醌对甲氨蝶呤所致大鼠肝损伤的保护作用

Revista Brasileira de Farmacognosia Pub Date : 2023-10-29 DOI: 10.1007/s43450-023-00470-y

Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman, Mohamed Aboubakr

{"title":"Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats","authors":"Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman, Mohamed Aboubakr","doi":"10.1007/s43450-023-00470-y","DOIUrl":"https://doi.org/10.1007/s43450-023-00470-y","url":null,"abstract":"Abstract Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer. The purpose of this research was to examine if the administration of Arthrospira platensis (Spirulina) and/or thymoquinone could ameliorate the liver injury resulting from methotrexate. The rats were randomly assigned to seven groups, each containing seven rats. The groups included a control group that received only saline, a group that received A. platensis orally at a dose of 500 mg/kg, a group that received thymoquinone orally at a dose of 10 mg/kg, a group that received a single i.p. dose of 20 mg/kg methotrexate, a group that received both A. platensis and methotrexate, a group that received both thymoquinone and methotrexate, and a group that received A. platensis , thymoquinone, and methotrexate. The injection of methotrexate caused an increase in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triacylglycerides, and low-density lipoprotein-cholesterol, and a decrease in high-density lipoprotein-cholesterol (HDL-cholesterol). The liver tissues also showed an increase in malondialdehyde and a decrease in reduced glutathione, superoxide dismutase, and catalase, along with pathological lesions and increased expression of TNF-α and caspase-3. However, administration of A. platensis and thymoquinone alone or in combination reduced the toxicity and apoptosis induced by methotrexate. Graphical Abstract","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":"28 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136157524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Cytotoxic Potential of Ethanol Extract of Dictyopteris acrostichoides Against Human Cancer Cells 双翼蝶醇提物对人癌细胞的体外细胞毒性研究

Revista Brasileira de Farmacognosia Pub Date : 2023-10-24 DOI: 10.1007/s43450-023-00474-8

Eman Zekry Attia, Iman A. M. Abdel-Rahman, Omar M. Aly, Hani Saber, Mohammed I. Rushdi, Usama Ramadan Abdelmohsen

{"title":"In Vitro Cytotoxic Potential of Ethanol Extract of Dictyopteris acrostichoides Against Human Cancer Cells","authors":"Eman Zekry Attia, Iman A. M. Abdel-Rahman, Omar M. Aly, Hani Saber, Mohammed I. Rushdi, Usama Ramadan Abdelmohsen","doi":"10.1007/s43450-023-00474-8","DOIUrl":"https://doi.org/10.1007/s43450-023-00474-8","url":null,"abstract":"Abstract Ethanol extracts of Caulerpa racemose (Forsskål) J.Agardh, 1873, Dictyopteris acrostichoides (J.Agardh) Bornet, 1885, Halimeda opuntia (Linnaeus) J.V.Lamouroux, 1816, and Polycladia myrica (S.G.Gmelin) Draima, Ballesteros, F.Rousseau & T.Thibaut, 2010, were tested for their cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma cell lines. Dictyopteris acrostichoides displayed cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma with IC 50 values of 11.65, 9.28, and 16.86 µg/ml, respectively, in comparison to doxorubicin as a positive control (IC 50 5.72, 5.17, and 5.81 µg/ml, respectively). Metabolic profiling of the D. acrostichoides extract characterized seventeen metabolites. In silico analysis indicated 1-(3-oxo-undecyldisulfanyl)-undecan-3-one was the most active epidermal growth factor receptor inhibitor, while 1-(3-oxo-undecyldisulfanyl)-undecan-3-one and di(3-acetoxy-5-undecenyl) disulfide were the most active vascular endothelial growth factor inhibitors. Furthermore, the ethanol extract of D. acrostichoides was tested against epidermal growth factor receptor kinase (IC 50 0.11 µg/ml) compared to lapatinib as a positive control (IC 50 0.03 µg/ml), and against vascular endothelial growth factor (IC 50 0.276 µg/ml) compared to sorafenib as a positive control (IC 50 0.049 µg/ml). Graphical Abstract","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diuretic, Saluretic, and Ca2+-Sparing Effect of the Polygala cyparissias Methanol Extract, a Native Brazilian Medicinal Plant 巴西本土药用植物聚脂草甲醇提取物的利尿、降盐和Ca2+节约作用

Revista Brasileira de Farmacognosia Pub Date : 2023-10-24 DOI: 10.1007/s43450-023-00476-6

Priscila de Souza, Camile C. Cechinel-Zanchett, Tuani Aimê K. dos Santos Melo, Isadora Leal Figueiredo, Valdir Cechinel-Filho, Luiz Carlos Klein-Junior

引用次数: 0

Spectroscopical Analysis of Andean Plant Species with Anti-inflammatory, Antioxidant, and Antibacterial Activities 具有抗炎、抗氧化和抗菌活性的安第斯植物的光谱分析

Revista Brasileira de Farmacognosia Pub Date : 2023-10-18 DOI: 10.1007/s43450-023-00469-5

Luis Apaza Ticona, Belén Hervás Povo, Ángel Rumbero Sánchez

引用次数: 0

Synthesis of Natural Product Derivatives as Larvicides Against Aedes aegypti 埃及伊蚊杀幼虫天然产物衍生物的合成

Revista Brasileira de Farmacognosia Pub Date : 2023-10-18 DOI: 10.1007/s43450-023-00445-z

Luana Marilia Santos Oliveira, Thaysnara Batista Brito, Jose Guedes de Sena Filho, Sócrates Cabral de Holanda Cavalcanti

引用次数: 0