Rheumatology最新文献_第4页

Efficacy of tocilizumab monotherapy after ultrashort glucocorticoid administration to treat giant cell arteritis: three year follow-up 超短时间糖皮质激素治疗巨细胞动脉炎后托珠单抗单药治疗的疗效：三年随访

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-06 DOI: 10.1093/rheumatology/keaf317

Lisa Christ, Luca Seitz, Godehard Scholz, Lukas Bütikofer, Florian Kollert, Stephan Reichenbach, Peter M Villiger

{"title":"Efficacy of tocilizumab monotherapy after ultrashort glucocorticoid administration to treat giant cell arteritis: three year follow-up","authors":"Lisa Christ, Luca Seitz, Godehard Scholz, Lukas Bütikofer, Florian Kollert, Stephan Reichenbach, Peter M Villiger","doi":"10.1093/rheumatology/keaf317","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf317","url":null,"abstract":"Objectives The GUSTO (GCA treatment with Ultra-Short glucocorticoids (GC) and TOcilizumab (TCZ)) trial was set up to evaluate the efficacy and safety of a 52-week TCZ-monotherapy after a 3-day GC-pulse in new-onset GCA. The presented data show the maintenance effect of the GUSTO protocol over 3 years and the effectiveness or retreatment with TCZ after relapse. Methods Eighteen patients with newly diagnosed GCA received 500 mg methylprednisolone intravenously for 3 consecutive days followed by TCZ monotherapy from day 3 until week 52 in a single-arm, single-center, open-label clinical trial. Patients in clinical remission stopped TCZ at week 52. Maintenance of efficacy included the proportion of patients with complete lasting remission of disease at week 208. Results Median age was 72 (interquartile range 67-75) years at inclusion and 15/18 patients complained of cranial symptoms. At week 52, 13/18 patients were in relapse-free remission and entered the follow-up study. Minor relapses were observed in 2/13 patients at weeks 72, 187 and 200. In both patients, remission was achieved after restart of TCZ monotherapy. At week 208, 11/18 patients stayed in relapse-free remission; 11/13 patients remained in drug-free remission for 156 weeks. Conclusion Drug-free remission was maintained in all but two patients entering long-term extension. This relapse rate is substantially lower than reported in the randomized-controlled trials. Patient characteristics (exclusively new diagnoses), and the intensive initial treatment may explain the lasting remission.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"28 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of TNF inhibitors on the risk of cancer recurrence in patients with ankylosing spondylitis: a nested case-control study TNF抑制剂对强直性脊柱炎患者癌症复发风险的影响：一项巢式病例对照研究

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-06 DOI: 10.1093/rheumatology/keaf313

Oh Chan Kwon, Hye Sun Lee, So Young Jeon, Min-Chan Park

{"title":"Effect of TNF inhibitors on the risk of cancer recurrence in patients with ankylosing spondylitis: a nested case-control study","authors":"Oh Chan Kwon, Hye Sun Lee, So Young Jeon, Min-Chan Park","doi":"10.1093/rheumatology/keaf313","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf313","url":null,"abstract":"Objective To investigate the effect of tumour necrosis factor inhibitors (TNFi) on the risk of cancer recurrence in patients with ankylosing spondylitis (AS) and a history of cancer. Methods We conducted a nested case-control study using a cohort derived from a nationwide database. The cohort consisted of patients with AS and a history of cancer after AS diagnosis. We determined cases of cancer recurrence and selected controls at a ratio of 1:1, matched for age, sex, date of index cancer diagnosis, and follow-up time. Multivariable conditional logistic regression analysis was used to assess the effect of TNFi exposure on the risk of cancer recurrence. Results A total of 2,574 patients with AS and a history of cancer were included in the cohort. Among these, cancer recurred in 394 (15.3%) patients. The incidence rate of cancer recurrence was 4.87 (95% confidence interval [CI] 4.40–5.34)/100 person-years. From this cohort, 254 cases and age-, sex-, index date-, and follow-up time-matched 254 controls were included for the nested case-control study. The proportion of patients exposed to TNFi did not differ between the cases and controls (24.8% vs. 24.4%, p = 0.918). In the multivariable conditional logistic regression analysis, TNFi exposure was not associated with an increased risk of cancer recurrence (adjusted odds ratio 1.157, 95% CI 0.734–1.825, p = 0.531). Conclusion TNFi exposure was not associated with an increased risk of cancer recurrence in patients with AS. Our findings suggest that TNFi may be used with caution in patients with AS and a history of cancer.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting PTGDS inhibits pro-inflammatory fibroblasts against skin fibrosis in systemic sclerosis 靶向PTGDS抑制系统性硬化症皮肤纤维化的促炎成纤维细胞

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-06 DOI: 10.1093/rheumatology/keaf276

Dan Fang, Xiandun Yuan, Jingkun Yi, Zhaohua Li, Xiaoyu Li, Wei Guo, Jinlin Wang, Rong Mu

{"title":"Targeting PTGDS inhibits pro-inflammatory fibroblasts against skin fibrosis in systemic sclerosis","authors":"Dan Fang, Xiandun Yuan, Jingkun Yi, Zhaohua Li, Xiaoyu Li, Wei Guo, Jinlin Wang, Rong Mu","doi":"10.1093/rheumatology/keaf276","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf276","url":null,"abstract":"Objectives Immune dysregulation signiﬁcantly contributes to skin fibrosis in systemic sclerosis (SSc), with pro-inflammatory fibroblasts playing a pivotal role in this process. Prostaglandin D2 Synthase (PTGDS) has garnered interest due to its enriched expression in pro-inflammatory fibroblasts associated with skin fibrosis. This study aims to elucidate the role of PTGDS in skin fibrosis of SSc and evaluate its potential as a therapeutic target. Methods PTGDS expression in skin tissues from SSc patients was analyzed through bioinformatics and validated using immunohistochemistry, RT-PCR, and Western blotting. The biological role of PTGDS in fibroblast inflammatory priming was examined using PTGDS-overexpressed BJ cells and the PTGDS inhibitor AT56 in vitro. The therapeutic effect of targeting PTGDS in skin inflammation and fibrosis was validated using a bleomycin (BLM)-induced skin fibrosis mouse model. Results PTGDS expression levels were significantly elevated in the dermal fibroblasts of SSc patients. In vitro, overexpression of PTGDS resulted in the upregulation of various chemokines in skin fibroblasts, subsequently enhancing the migration of CD4+ T cells, particularly the Th2 subset, which was effectively reversed by inhibition of PTGDS with the inhibitor AT56. PTGDS-overexpressed fibroblasts promoted Th2 cell infiltration and skin fibrosis and oral administration of AT56 significantly attenuated BLM-induced skin inflammation and fibrosis in vivo. Conclusion PTGDS-induced pro-inflammatory fibroblasts caused Th2 cell infiltration and skin fibrosis. Inhibition of PTGDS attenuated the inflammation and fibrosis in the skin. These results demonstrate that PTGDS is a critical regulator in the pro-inflammatory function of skin fibroblasts, providing a promising therapeutic target for SSc.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee osteoarthritis 基于mri的患者特异性nomogram早期膝骨关节炎诊断风险分层

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-06 DOI: 10.1093/rheumatology/keaf319

Zhijian Yang, Huiwen Lu, Zhaowei Lin, Weiwen Zhu, Haopeng Guo, Chao Xie

{"title":"MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee osteoarthritis","authors":"Zhijian Yang, Huiwen Lu, Zhaowei Lin, Weiwen Zhu, Haopeng Guo, Chao Xie","doi":"10.1093/rheumatology/keaf319","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf319","url":null,"abstract":"Objectives This study is to develop a risk stratification nomogram for early-stage osteoarthritis (OA) based on magnetic resonance imaging (MRI), especially with potential sequences of MRI called T1rho and T2 mapping. Methods Cartilages diagnosed with early-stage OA or normal were collected and allocated into training or validation cohorts after the MRI. Eleven predictors were determined as candidate predictors for OA-anatomical signature-nomogram (OA-ASN). The performance of OA-ASN was evaluated using the concordance index (C-index), the area under the receiver operating characteristic curve (AUC), calibration plots, decision curve analysis (DCA), and clinical impact curve (CIC). Results A total of 199 patients were evaluated. Of these, 79 (39.7%) had early OA. infrapatellar fat pad (IPFP), T1 rho, and T2 mapping were independently associated with early-stage OA at multivariable analysis. The nomogram incorporating these variables displayed excellent discrimination (C-index, 0.975; 95% CI: 0.951, 0.999) in the training sample (n = 115) and bootstrap validation (C-index, 0.96), while C-index was 0.904 (95% CI: 0.840, 0.959) in the validation cohort (n = 84). The calibration plots showed favorable consistency between the prediction of the nomogram and actual observations in both the training and validation cohorts. The DCA and CIC showed that the nomogram was clinically useful. Conclusions A smaller volume of IPFP, T1ρ value &gt; 33, and T2 mapping &gt; 35.04 were significantly associated with OA. The OA-ASN demonstrated excellent predictive outcomes with easy-accessible and simple observational screening methods based on physiological MRI, which can provide individual treatment strategies.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"39 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher frequencies of age-associated B-cells in early arthritis are linked to atherosclerosis and immune circuits—a potential role as a biomarker for risk stratification 早期关节炎中年龄相关b细胞的高频率与动脉粥样硬化和免疫回路有关，这是风险分层的潜在生物标志物

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-06 DOI: 10.1093/rheumatology/keaf318

Daniel Miranda-Prieto, Mercedes Alperi-López, Ángel I Pérez-Álvarez, Sara Alonso-Castro, Ana Suárez, Javier Rodríguez-Carrio

{"title":"Higher frequencies of age-associated B-cells in early arthritis are linked to atherosclerosis and immune circuits—a potential role as a biomarker for risk stratification","authors":"Daniel Miranda-Prieto, Mercedes Alperi-López, Ángel I Pérez-Álvarez, Sara Alonso-Castro, Ana Suárez, Javier Rodríguez-Carrio","doi":"10.1093/rheumatology/keaf318","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf318","url":null,"abstract":"Objective Immune dysregulation may play a role in cardiovascular (CV) risk excess in rheumatoid arthritis (RA). However, exact mediators are unknown. Age-associated B cells (ABCs) have emerged as multi-faceted pro-inflammatory mediators, also in the atherosclerosis microenvironment, but their role in autoimmunity is ill-defined. Our aim was to evaluate ABCs frequencies in the earliest stages of inflammatory arthritis and their potential role as biomarkers of atherosclerosis. Methods ABCs were quantified by flow cytometry in 58 early RA patients, 11 individuals with clinical-suspect arthralgia (CSA) and 33 healthy controls (HC). Atherosclerosis occurrence was measured by Doppler-ultrasound. Cytokines were measured by multiplex immunoassays. Cardiometabolic-related proteins were evaluated using high-throughput targeted proteomics. Results Circulating ABCs were increased in RA patients compared with HC within the CD19+ and PBMCs pools (p = 0.013 and p &lt; 0.001, respectively). Higher ABCs median frequency was found in CSA. ABCs frequency was unrelated to disease features and traditional CV risk factors but negatively associated with good therapeutic outcomes upon csDMARD at 6 and 12 months. ABCs frequency was positively correlated with proinflammatory cytokines (IFNg, TNF, IL-6 and IL-21) and proteomic signatures related to B- and T-cell responses as well as cellular pathways linked to atherosclerosis. ABCs predicted atherosclerosis burden in RA patients after adjusting for confounders. Furthermore, adding ABCs strata significantly improved risk stratification over conventional instruments. Conclusions Higher frequencies of ABCs are an early event along arthritis course, linked to therapeutic outcomes, inflammatory milieu and atherosclerosis burden. ABCs may be a missing link between humoral responses and atherosclerosis in autoimmunity.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"43 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of systemic lupus erythematosus onset in sisters with Lynch syndrome carrying MSH2 mutation. 携带MSH2突变的Lynch综合征姐妹发生系统性红斑狼疮1例。

IF 4.7 2区医学

Rheumatology Pub Date : 2025-06-05 DOI: 10.1093/rheumatology/keaf310

Maaya Fukumura, Koji Kitagori, Tsuneo Sasai, Ryosuke Hiwa, Hideaki Tsuji, Mirei Shirakashi, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Akio Morinobu

引用次数: 0

Left ventricular pseudoaneurysm occurring 7 months after systemic lupus erythematosus-related acute myocarditis: a case report. 系统性红斑狼疮相关性急性心肌炎后7个月发生左心室假性动脉瘤1例。

IF 4.7 2区医学

Rheumatology Pub Date : 2025-06-05 DOI: 10.1093/rheumatology/keaf296

Mengyun Wu, Chaoji Zhang, Di Wu

引用次数: 0

Single-centre comparison of non-familial, familial and monogenic lupus 非家族性、家族性和单基因狼疮的单中心比较

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-04 DOI: 10.1093/rheumatology/keaf304

Jalila Alshekaili, Batool S H Al Lawati, Zahran Althuhli, Warda Al-Azri, Almundher Al-Maawali, Samiya Al-Rashdi, Farida Al-Mamari, Mahmood Al-Kindi, Hamad Al Balushi, Mohammed Al-Rawahi, Murtadha Al-Khabori, Matthew C Cook

{"title":"Single-centre comparison of non-familial, familial and monogenic lupus","authors":"Jalila Alshekaili, Batool S H Al Lawati, Zahran Althuhli, Warda Al-Azri, Almundher Al-Maawali, Samiya Al-Rashdi, Farida Al-Mamari, Mahmood Al-Kindi, Hamad Al Balushi, Mohammed Al-Rawahi, Murtadha Al-Khabori, Matthew C Cook","doi":"10.1093/rheumatology/keaf304","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf304","url":null,"abstract":"Objectives There is a significant genetic contribution to systemic lupus erythematosus (SLE). Monogenic SLE is a distinct form of SLE. We investigated whether familial or known monogenic lupus cases are distinguishable from non-familial lupus by clinical or laboratory phenotype in a population with high rates of consanguinity. Patients and methods We performed a retrospective case-control study on 24 multiplex families, comprising 62 cases, and 95 non-familial lupus controls. Demographic and Systemic Lupus International Collaborating Clinics criteria were compared between the two groups. Familial cases were also evaluated by whole exome sequencing and cellular phenotyping. Statistical analysis was performed using R Studio. Results Familial and non-familial lupus cases were similar although familial cases were younger at presentation (18 y vs 26 y, OR = 0.91, p= 1.61x10-5), a higher prevalence of synovitis (OR = 2.7, p= 0.013) and lower prevalence of high level of dsDNA antibodies (OR = 0.25, p= 1.9x10-3). Exome sequencing of a subset yielded a diagnostic rate of 36%. Monogenic lupus were distinguished from other familial cases by an even younger age at presentation (6 y vs 19 y, OR = 0.82, p = 2.13 x10−3), non-biased male to female ratio (p = 0.077) and expansion of exhausted CD4+ T cells (CD4+CD45RA+PD-1+) (p = 1.7x10−4). Conclusion Overall, clinical phenotype is a poor indicator of familial or monogenic lupus. Familial lupus and monogenic familial lupus (MoFL) tend to present at a younger age than the Non-MoFL, exhibit less female bias, and in some cases, are distinguished by a lymphocyte signature. Consanguinity increases the rate of monogenic familial lupus, and these cases can present in adulthood.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"4 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency specific microcurrent improves hand function and Raynaud’s symptoms in scleroderma: results of two pilot studies 频率特异性微电流改善硬皮病的手部功能和雷诺氏症状：两项初步研究的结果

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-04 DOI: 10.1093/rheumatology/keaf301

Walter M Gregory, Katherine Bagley, Sookhoe Eng, Carolyn McMakin, Francesco Del Galdo

{"title":"Frequency specific microcurrent improves hand function and Raynaud’s symptoms in scleroderma: results of two pilot studies","authors":"Walter M Gregory, Katherine Bagley, Sookhoe Eng, Carolyn McMakin, Francesco Del Galdo","doi":"10.1093/rheumatology/keaf301","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf301","url":null,"abstract":"Objectives To evaluate the efficacy of frequency specific microcurrent as a treatment designed to improve hand function and alleviate Raynaud’s symptoms in patients with systemic sclerosis. Methods Seventeen patients were treated in two separate pilot studies for 60 and 45 min respectively over 1 or 2 days with microcurrent frequencies specific to scarring in the hands and capillaries, and to Raynaud’s disease. Efficacy was evaluated using the Cochin hand function score questionnaire before and after treatment, and a visual analogue scale to evaluate the severity of the Raynaud’s symptoms. Results Improvement in hand function was observed in both studies, being significant in the second pilot study with an average improvement of 38% (95% CI 22%-55%, p = 0.002) and in both studies combined with an average improvement of 40% (95% CI 26%-55%, p = 0.0001). There was a significant improvement in mean Raynaud’s VAS scores pre-and post-treatment of 18 points (out of 100), 95% CI 3.3–33 points, p = .016. A proportion of patients achieved very substantial improvements in hand function, with particular tasks improving from being nearly impossible to do to being able to be performed without difficulty. Conclusions The degree of improvement in hand function obtained over a very short treatment period of 45 min to 1 h was significant. Further randomised, controlled studies are needed to confirm these results, and longer-term follow-up will be required to establish whether the changes are maintained, and whether repeated treatments can produce further improvements.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"41 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and ultrasound features of a cohort of psoriasis patients without musculoskeletal symptoms: a prospective and multicenter study 无肌肉骨骼症状的银屑病患者队列的临床和超声特征：一项前瞻性和多中心研究

IF 5.5 2区医学

Rheumatology Pub Date : 2025-06-04 DOI: 10.1093/rheumatology/keaf307

Ana Belén Azuaga, Andrea Cuervo, Delia Reina, Paula Estrada Alarcón, Lourdes Mateo, María Aparicio, Mireia Moreno, Marta Arévalo, Ana Láiz, Patricia Moya, Lucía Alascio, Josep Riera, José U Scher, Juan D Cañete, Julio Ramírez

{"title":"Clinical and ultrasound features of a cohort of psoriasis patients without musculoskeletal symptoms: a prospective and multicenter study","authors":"Ana Belén Azuaga, Andrea Cuervo, Delia Reina, Paula Estrada Alarcón, Lourdes Mateo, María Aparicio, Mireia Moreno, Marta Arévalo, Ana Láiz, Patricia Moya, Lucía Alascio, Josep Riera, José U Scher, Juan D Cañete, Julio Ramírez","doi":"10.1093/rheumatology/keaf307","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf307","url":null,"abstract":"Objectives To evaluate clinical and ultrasound (US) features related to psoriatic arthritis (PsA) development in psoriasis (PsO), patients without musculoskeletal (MSK) symptoms and no systemic treatment. Methods Prospective study including PsO patients followed by dermatologists. Clinical, and US data were collected at baseline and during follow-up by rheumatologists. Results Seventy-eight patients with PsO were included. Mean disease duration was 15.1 years (SD ± 13.4); most had mild PsO (82%), onychopathy was present in 36 (39.7%) and overweight/obesity in 38 patients (48.7%). In the US evaluation, 9 patients (11.5%) had Power Doppler grade 1 at joints, 56.4% had calcifications and 30.4% bursitis at enthesis. Sixty patients completed the study. After a median of 76.60 months (IQR 39.34-85.25), 34 patients (56.6%) developed MSK symptoms. They had higher BMI (p = 0.013), abdominal circumference (p = 0.022), scored higher for pain (p = 0.047) and fatigue (p = 0.011). Their baseline US showed a higher total US score (p = 0.037). Five patients (8.3%) developed MSK inflammatory symptoms, and 4 met CASPAR criteria (5,5%). The mean time from baseline to PsA diagnosis was 20.20 months (SD ± 12.02). US bursitis was present in 80% of patients developing inflammatory symptoms (p = 0.049). Conclusions In a cohort of patients with mild PsO, systemic therapy-naïve and no MSK symptoms, incidence of PsA was 1% per year. US bursitis at enthesis was related to the development of symptoms suggestive of PsA. Patients who developed MSK symptoms had higher BMI, fatigue and pain VAS scores at baseline and could constitute a subgroup with higher risk for transition to PsA.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"42 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0