频率特异性微电流改善硬皮病的手部功能和雷诺氏症状:两项初步研究的结果

IF 4.7 2区 医学 Q1 RHEUMATOLOGY
Walter M Gregory, Katherine Bagley, Sookhoe Eng, Carolyn McMakin, Francesco Del Galdo
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引用次数: 0

摘要

目的评价频率特异性微电流治疗对改善系统性硬化症患者手功能和缓解雷诺氏症状的疗效。方法17例患者分别在1天或2天内接受针对手部瘢痕、毛细血管和雷诺氏病的微电流频率治疗,时间分别为60分钟和45分钟。治疗前后采用Cochin手功能评分问卷评估疗效,并采用视觉模拟量表评估雷诺症状的严重程度。两项研究均观察到手部功能的改善,在第二项先导研究中显著改善,平均改善38% (95% CI 22%-55%, p = 0.002),在两项联合研究中平均改善40% (95% CI 26%-55%, p = 0.0001)。治疗前后的平均雷诺VAS评分有显著改善,分别为18分(满分100分),95% CI为3.3-33分,p = 0.016。一部分患者的手部功能得到了很大的改善,一些特定的任务从几乎不可能完成到能够毫无困难地完成。结论在45分钟至1小时的治疗时间内,手部功能的改善程度是显著的。需要进一步的随机对照研究来证实这些结果,并需要长期随访来确定这些变化是否可以维持,以及重复治疗是否可以产生进一步的改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frequency specific microcurrent improves hand function and Raynaud’s symptoms in scleroderma: results of two pilot studies
Objectives To evaluate the efficacy of frequency specific microcurrent as a treatment designed to improve hand function and alleviate Raynaud’s symptoms in patients with systemic sclerosis. Methods Seventeen patients were treated in two separate pilot studies for 60 and 45 min respectively over 1 or 2 days with microcurrent frequencies specific to scarring in the hands and capillaries, and to Raynaud’s disease. Efficacy was evaluated using the Cochin hand function score questionnaire before and after treatment, and a visual analogue scale to evaluate the severity of the Raynaud’s symptoms. Results Improvement in hand function was observed in both studies, being significant in the second pilot study with an average improvement of 38% (95% CI 22%-55%, p = 0.002) and in both studies combined with an average improvement of 40% (95% CI 26%-55%, p = 0.0001). There was a significant improvement in mean Raynaud’s VAS scores pre-and post-treatment of 18 points (out of 100), 95% CI 3.3–33 points, p = .016. A proportion of patients achieved very substantial improvements in hand function, with particular tasks improving from being nearly impossible to do to being able to be performed without difficulty. Conclusions The degree of improvement in hand function obtained over a very short treatment period of 45 min to 1 h was significant. Further randomised, controlled studies are needed to confirm these results, and longer-term follow-up will be required to establish whether the changes are maintained, and whether repeated treatments can produce further improvements.
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来源期刊
Rheumatology
Rheumatology 医学-风湿病学
CiteScore
9.40
自引率
7.30%
发文量
1091
审稿时长
2 months
期刊介绍: Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.
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