Revista Brasileira de Hematologia e Hemoterapia最新文献

{"title":"Challenges in the diagnosis of iron deficiency anemia in aged people","authors":"Niele Silva de Moraes , Maria Stella Figueiredo","doi":"10.1016/j.bjhh.2017.03.005","DOIUrl":"10.1016/j.bjhh.2017.03.005","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 191-192"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.03.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35339664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythrovirus B19 induced persistent bicytopenia in a healthy child","authors":"Mili Jain, Gurleen Oberoi, Rashmi Kumar, Ashutosh Kumar","doi":"10.1016/j.bjhh.2017.04.002","DOIUrl":"10.1016/j.bjhh.2017.04.002","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 278-280"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35434638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with very severe anemia: a case series","authors":"Marco Cei , Alessandro Ferretti , Nicola Mumoli","doi":"10.1016/j.bjhh.2017.02.001","DOIUrl":"10.1016/j.bjhh.2017.02.001","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 285-287"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35434639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study","authors":"Gabriela Galindo-Rodríguez,&nbsp;José C. Jaime-Pérez,&nbsp;Mario C. Salinas-Carmona,&nbsp;Sandra N. González-Díaz,&nbsp;Ángeles Castro-Corona,&nbsp;Raúl Cavazos-González,&nbsp;Humberto Treviño-Villarreal,&nbsp;Alberto C. Heredia-Salazar,&nbsp;David Gómez-Almaguer","doi":"10.1016/j.bjhh.2016.11.006","DOIUrl":"10.1016/j.bjhh.2016.11.006","url":null,"abstract":"<div><h3>Background</h3><p><span>l</span>-Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti-<span>l</span>-asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity reactions, in which immunoglobulin E can also participate. This study investigated the presence of immunoglobulin G and immunoglobulin E anti-<span>l</span>-asparaginase antibodies and their clinical associations.</p></div><div><h3>Methods</h3><p>Under 16-year-old patients at diagnosis of B-cell acute lymphoblastic leukemia confirmed by flow cytometry and treated with a uniform <span>l</span>-asparaginase and chemotherapy protocol were studied. Immunoglobulin G anti-<span>l</span>-asparaginase antibodies were measured using an enzyme-linked immunosorbent assay. Intradermal and prick skin testing was performed to establish the presence of specific immunoglobulin E anti-<span>l</span>-asparaginase antibodies <em>in vivo</em>. Statistical analysis was used to investigate associations of these antibodies with relevant clinical events and outcomes.</p></div><div><h3>Results</h3><p>Fifty-one children were studied with 42 (82.35%) having anti-<span>l</span>-asparaginase antibodies. In this group immunoglobulin G antibodies alone were documented in 10 (23.8%) compared to immunoglobulin E alone in 18 (42.8%) patients. Immunoglobulin G together with immunoglobulin E were simultaneously present in 14 patients. Children who produced exclusively immunoglobulin G or no antibodies had a lower event-free survival (<em>p</em>-value<!--> <!-->=<!--> <!-->0.024). Eighteen children (35.3%) relapsed with five of nine of this group who had negative skin tests suffering additional relapses (range: 2–4), compared to none of the nine children who relapsed who had positive skin tests (<em>p</em>-value<!--> <!-->&lt;<!--> <!-->0.001).</p></div><div><h3>Conclusion</h3><p>Children with acute lymphoblastic leukemia and isolated immunoglobulin G anti-<span>l</span>-asparaginase antibodies had a higher relapse rate, whereas no additional relapses developed in children with immunoglobulin E anti-<span>l</span>-asparaginase antibodies after the first relapse.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 202-209"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.11.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35339668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow cytometry to identify bone-marrow relapse in blastic plasmacytoid dendritic cell neoplasm: a case report","authors":"Mariela Granero Farias ,&nbsp;Fabiane Spagnol Pedrazzani ,&nbsp;Luis Carlos Zanandrea Contin ,&nbsp;Ana Paula Alegretti ,&nbsp;Lisandra Della Costa Rigoni ,&nbsp;Liane Esteves Daudt","doi":"10.1016/j.bjhh.2017.04.005","DOIUrl":"10.1016/j.bjhh.2017.04.005","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 274-277"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35341117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the assessment of the Matos & Carvalho index by Hoffmann and Urrechaga","authors":"Januária F. Matos ,&nbsp;Luci M.S. Dusse ,&nbsp;Karina B.G. Borges ,&nbsp;Ricardo L.V. de Castro ,&nbsp;Wendel Coura-Vital ,&nbsp;Maria das G. Carvalho","doi":"10.1016/j.bjhh.2017.04.004","DOIUrl":"10.1016/j.bjhh.2017.04.004","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 290-291"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35434641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everolimus as a single agent in refractory or relapsed Hodgkin's lymphoma: the Brazilian Named Patient Program Experience","authors":"Talita Máira Bueno da Silveira da Rocha,&nbsp;Sergio Costa Fortier,&nbsp;Thais Rodrigues da Cunha Fischer,&nbsp;Guilherme Fleury Perini,&nbsp;Rafael Dezen Gaiolla,&nbsp;Laura Fogliatto,&nbsp;Marcia Torresan Delamain,&nbsp;Andressa Fragoso da Costa,&nbsp;Nelson Siqueira de Castro,&nbsp;Wolney Gois Barretos,&nbsp;Cármino Antonio de Souza,&nbsp;Valéria Buccheri,&nbsp;Carlos Sérgio Chiattone","doi":"10.1016/j.bjhh.2017.03.008","DOIUrl":"10.1016/j.bjhh.2017.03.008","url":null,"abstract":"<div><h3>Background</h3><p>Despite all the scientific progress that has been made on understanding the disease, prognosis for patients with relapsed and refractory Hodgkin's lymphoma remains poor and the treatment is palliative in the majority of the cases. Thus, the aim of this study was to present the results on the compassionate use of everolimus in a group of patients who were monitored at nine different centers in Brazil.</p></div><div><h3>Methods</h3><p>A 10-mg oral dose of everolimus was given to each patient daily. Response time was evaluated from the beginning of medication use until loss of response, toxicity or medical decision to cease treatment.</p></div><div><h3>Results</h3><p>Thirty-three patients were evaluated. The median age at the beginning of medication administration was 29 years. Patients had received a median of five prior therapies. Overall response rate was 45.4%, with 13 patients achieving partial response, two achieved clinical response, 14 remained with stable disease, two had disease progression, and two were not evaluated. Patients received a median of 14 cycles. Progression-free survival was nine months, and overall survival was estimated to be 36 months. Three patients used the medication for more than four years. The most frequently reported adverse events were thrombocytopenia and hypercholesterolemia. Three patients had pulmonary toxicity. Grade III and IV adverse events occurred in 39% of the patients.</p></div><div><h3>Conclusion</h3><p>Everolimus was found to provide a response in a group of patients with refractory or relapsed Hodgkin's lymphoma who had adequate tolerability to the drug.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 216-222"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.03.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35341109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusting thresholds of serum ferritin for iron deficiency: a moving target","authors":"Flávio Augusto Naoum","doi":"10.1016/j.bjhh.2017.03.002","DOIUrl":"10.1016/j.bjhh.2017.03.002","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 189-190"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35339663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New agents in relapsed/refractory Hodgkin's lymphoma","authors":"Irene Biasoli,&nbsp;Nelson Spector","doi":"10.1016/j.bjhh.2017.05.003","DOIUrl":"10.1016/j.bjhh.2017.05.003","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 193-196"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35339666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partnership of the Sociedade Brasileira de Oncologia Pediátrica and International Society of Pediatric Oncology to improve nutritional care for children with cancer in Brazil","authors":"Karina Viani ,&nbsp;Vicente Odone Filho ,&nbsp;Sima Ferman ,&nbsp;Teresa Cristina Cardoso Fonseca ,&nbsp;Vanessa da Cunha Oliveira ,&nbsp;Priscila dos Santos Maia Lemos ,&nbsp;Ronald D. Barr ,&nbsp;Elena J. Ladas","doi":"10.1016/j.bjhh.2016.10.003","DOIUrl":"10.1016/j.bjhh.2016.10.003","url":null,"abstract":"<div><p>The authors present a proposal of a partnership between the Sociedade Brasileira de Oncologia Pediátrica (SOBOPE) and the International Society of Pediatric Oncology (SIOP) to promote the standardization and improvement of nutritional care of kids under cancer treatment in Brazil. The results of the first meeting in Brazil as well as plans for future meetings are described.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 3","pages":"Pages 266-268"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35341115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}